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Sergio Agustín Mezzano Abedrapo

Catedratico

Universidad Austral de Chile

Valdivia, Chile

Mecanismos celulares y moleculares de fibrosis e inflamación en nefropatías: Rol de Gremlin Inmunopatogenia de enfermedades glomerulares Progresión de Enfermedad Renal Crónica Nefropatía Diabética: Microambiente inflamatorio y mecanismos progresión.

Medicina Interna, Nefrología, CONACEM. Chile, 1987
Fellow American College of Physicians, American College of Physicians.. Estados Unidos, 2001
Fellow American Society of Nephrology, American Society of Nephrology. Estados Unidos, 2004
Especialista en Medicina Interna, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1975
Post doctoral research fellow Nephrology, Universidad de Cincinnati. Estados Unidos, 1982

Profesor Asistente Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

1979 - 1984
Beca Investigación en Nefrología clínica Full Time

Universidad de Cincinnati

Medicina

Cincinnati, Estados Unidos

1980 - 1982
Jefe de Departamento Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

1983 - 1987
Profesor Asociado Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

1984 - 1990
Profesor Titular Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

1990 - 2009
Director Oficina de Investigación Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

1990 - 2000
Jefe Unidad de Nefrología Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

2001 - A la fecha
Profesor Catedrático Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Valdivia, Chile

2009 - A la fecha
Profesor Visitante Full Time

Universidad de Torino

Hospital Giovanni Batista Molinette

Torino, Italia

1991 - 1991
Profesor Visitante Full Time

Rockefeller University

Medicina

New York, Estados Unidos

1988 - 1988

Medico Tratante Medicina Interna Full Time

Servicio Nacional de Salud

Valdivia, Chile

1975 - 1979
Medico Tratante Unidad de Cuidados Intensivos Part Time

Servicio Nacional de Salud

Valdivia, Chile

1975 - 1979
Director Médico Valdivia Other

Nephrocare Fresenius Chile

Valdivia, Chile

2010 - A la fecha
Académico Convenio Docente Asistencial UACH-Servicio de Salud Valdivia Full Time

Universidad Austral de Chile

Valdivia, Chile

1982 - A la fecha

1. Como Profesor de Medicina Interna y Nefrología, desde año 1985, he participado como profesor Responsable y Profesor Colaborador en Cursos de Semiología, Clínica Médica, Internado de Medicina y particularmente como Responsable Curso de Nefrología, a alumnos de pregrado, Escuela de Medicina, UACH.

2. En mi calidad de Profesor Titular y Catedrático, y como Director del Programa Especialización en Nefrología desde 1995, he participado en la formación de los siguientes especialistas :Guillermo Rojas 1995; Claudio Flores 1997; Patricia Diaz 1998; Claudio Aros 1999;; Rocío Sáenz 2002; Carolina Muñoz 2004; Herman Schneider 2004; Alejandra Carrasco 2006; Erick Zúñiga 2007; Jorge H. Mukdsi 2007; Javier Ramírez 2008; Guisselle Carvajal 2008; Fernando Pereira 2008; Mauricio Álvarez 2009; Juan Velásquez 2010; Andrea Hernández 2010; Gustavo Jeldres 2011; Francisca Carriquiry 2011; Marcelo Salvatici 2009; Rodrigo Mansilla Barrientos 2012; Celeste Fulgeri 2013; Alexander Ballesteros 2013; Rodrigo Cortez 2015; Lizzy Orellana 2015; Daniela Ubilla 2017; Francisco García 2018; Patricio Herrera 2018; Marina Leiva 2019; Gustavo Navarro 2019; Rodolfo Carmona 2019; Carolina Wittwer 2020 y Francisco Rodríguez 2020.

3. Profesor Responsable Programa Doctorado Ciencias Médicas, habiendo colaborado en la formación de al menos 10 alumnos del programa y como Patrocinante o Copatrocinante de 6 alumnos de dicho Programa: Dra. Alejandra Droguett; Dra. Carolina Lavoz; Dra. Paola Krall; Dr. Lucas Opazo; Dra. Vanessa Marchant y candidato a Doctor Marcelo Aguilar

Durante mi vida académica he siso invitado como conferenciante y profesor visitante a numerosos congresos y diferentes servicios de nefrología entre los cuales destaco el Congreso Chileno de Nefrología, Congreso Latinoamericano de Nefrología, Congreso Americano de Nefrología (Renal Week) y Congreso Mundial de Nefrología.
Listado de conferencias últimos 5 años:
99. Nuevos aspectos clínicos y patogénicos del síndrome nefrítico. I Congreso Internacional de Nefrología, 20-22 Febrero 2015, Quito, Ecuador
100. Nefropatía Diabética patogénica prevención y tratamiento. I Congreso Internacional de Nefrología, 20-22 Febrero 2015, Quito, Ecuador
101. Nefropatía Membranosa: Tratamiento. VIII Congreso Paraguayo de Nefrología 23-25 Septiembre 2015, Asunción, Paraguay
102. Nefropatía Diabética: Cómo evitamos la progresión. VIII Congreso Paraguayo de Nefrología, 23-25 Septiembre 2015, Asunción, Paraguay
103. Presentación de casos clínicos de Enfermedades Glomerulares. VIII Congreso Paraguayo de Nefrología, 23-25 Septiembre 2015. Asunción Paraguay
104. Nefropatía Diabética: Nuevos aspectos patogénicos. XXXII Congreso Chileno Conjunto de las Sociedades de Nefrología e Hipertensión, 25- 28 Noviembre 2015, Viña del Mar, Chile
105. Mediadores de daño renal en paciente diabético. Primeras Jornadas Universitarias de Tecnología e innovación en diabetes, Universidad de Antofagasta, 4-7 de mayo 2016, Antofagasta, Chile
106. I Jornada de Fisiología Celular y Cáncer, Universidad Católica del Maule, Chile, 8 de noviembre 2017, Talca, Chile
107. Actualización en Glomerulonefritis. XLVIII Congreso Nacional de la Sociedad Española de Nefrología, IX Congreso Iberoamericano de Nefrología, 16-19 noviembre 2018, Madrid, España
108. Actualización de Nefropatía Diabética. XL Congreso Chileno Medicina Interna, 2-4 Septiembre 2019, Santiago Chile
109. Rol de la Inflamación en la Nefropatía Diabética. XXXVI Congreso de la Sociedad Chilena de Nefrología, Hipertensión y Trasplante. 16-18 Octubre 2019, Coquimbo, Chile

Research Award

ACADEMIA CHILENA DE MEDICINA

Chile, 1999

Premio a la Investigación
International Medal Award

National Kidney Foundation

Estados Unidos, 2002

Primer Nefrólogo chileno en obtener este reconocimiento por la National Kidney Foundation
Presidente Sociedad Latinoamericana de Nefrología e Hipertensión

Sociedad Latinoamericana Nefrología e Hipertension

Chile, 2004

Primer Presidente Chileno de la Sociedad Latinoamericana de Nefrología. Desde 2002 a 2004
Miembro Consejo KDIGO

Kidney Disease Improving Global outcomes

Chile, 2003

Miembro consejo asesor
Co-editor

Kidney International Edicion Española

España, 2004

Co-editor
Miembro Comite Editorial

Clinical Journal of The american Society of Nephrology

Estados Unidos, 2005

Miembro Comité editorial
Premio Dr. Eduardo Katz

Sociedad Chilena de Nefrología

Chile, 2005

Premio Trayectoria
Laureate Award

American College of Physicians. Chilean Charper

Estados Unidos, 2007

premio trayectoria
Miembro de Honor

Sociedad española de Nefrología

España, 2007

Miembro de honor
Premio Dr. Victor Raul Miatello

Sociedad Latinoamericana de Nefrología e Hipertension

Chile, 2009

Premio Trayectoria conferido por primera vez a un nefrólogo chileno
Catedrático

UNIVERSIDAD AUSTRAL DE CHILE

Chile, 2010

Premio Trayectoria Académica como uno de los cuatro catedráticos electos de la Universidad Austral de Chile, junto a los Drs. Manfred Mc Neef, esteban Rodríguez y Juan Carlos Slebe
Premio Conferencia Sociedad Médica santiago

Congreso Chileno de Medicina Interna

Chile, 2011

Premio Trayectoria
Council Member

International Society of Nephrology

Estados Unidos, 2013

Premio Trayectoria
Miembro correspondiente

Academia Chilena de Medicina

Chile, 2002

Conferencia de ingreso a la Academia Chilena de Medicina: Rol de la Proteinuria y Angiotensina II en la progresión de la enfermedad renal.
Traveling Scholarship

ACADEMIA CHILENA DE CIENCIAS

Chile, 1988

Beca para Estadía de investigación de 3 meses Universidad de Rockefeller, New York, USA
Estadía de Investigación

COMISION DE LAS COMUNIDADES EUROPEAS-CHILE

Chile, 1992

Estadía de 6 meses como Profesor visitante en la Universidad de Torino, Italia


Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response Marquez-Exposito, Laura; Rodrigues-Diez, Raul R.; Rayego-Mateos, Sandra; Fierro-Fernandez, Marta; Rodrigues-Diez, Raquel; Orejudo, Macarena; Santos-Sanchez, Laura; Blanco, Eva Maria; Laborda, Jorge; Mezzano, Sergio; Lamas, Santiago; Lavoz, Carolina; Ruiz-Ortega, Marta Article ISI FASEB JOURNAL (2021)
Quantifying Duration of Proteinuria Remission and Association with Clinical Outcome in IgA Nephropathy Canney, Mark; Barbour, Sean J.; Zheng, Yuyan; Coppo, Rosanna; Zhang, Hong; Liu, Zhi-Hong; Matsuzaki, Keiichi; Suzuki, Yusuke; Katafuchi, Ritsuko; Reich, Heather N.; Cattran, Daniel; Int Iga Nephropa Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)
Secondary antibody deficiency is associated with development of infection in kidney transplantation: Results of a multicenter study Sarmiento, Elizabeth; Jimenez, Maricela; di Natale, Marisa; Rodriguez-Ferrero, Marisa; Anaya, Fernando; Lopez-Hoyos, Marcos; Rodrigo, Emilio; Arias, Manuel; Perello, Manel; Seron, Daniel; Karanovic, Boris; Ezzahouri, Ikram; Mezzano, Sergio; Jaramillo, Maria; Calahorra, Leticia; Alarcon, Alba; Navarro, Joaquin; Munoz, Patricia; Carbone, Javier Article ISI TRANSPLANT INFECTIOUS DISEASE (2021)
Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes Opazo-Rios, Lucas; Sanchez Matus, Yenniffer; Rodrigues-Diez, Raul R.; Carpio, Daniel; Droguett, Alejandra; Egido, Jesus; Gomez-Guerrero, Carmen; Mezzano, Sergio Article ISI BMJ OPEN DIABETES RESEARCH & CARE (2020)
Could IL-17 be a Novel Therapeutic target in diabetic nephropathy? Lavoz C, Rayego-Mateos S, Orejudo M, Opazo-Ríos L, Marchant V, Marquez-Exposito L, Tejera-Muñoz A, Navarro-González JF, Droguett A, Ortiz A, Egido J, Mezzano S, Rodrigues-Diez RR, Ruiz-Ortega M. Article ISI Journal of Clinical Medicine (2020)
Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool Barbour, Sean J.; Canney, Mark; Coppo, Rosanna; Zhang, Hong; Liu, Zhi-Hong; Suzuki, Yusuke; Matsuzaki, Keiichi; Katafuchi, Ritsuko; Induruwage, Dilshani; Er, Lee; Reich, Heather N.; Feehally, John; Barratt, Jonathan L.; Cattran, Daniel C.; Int IgA Nephropathy Network Article ISI KIDNEY INTERNATIONAL (2020)
Lipotoxicity an Diabetic Nephropathy:Novel Mechanistic insight and therapeuthic oportinities Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy Rayego-Mateos S, Morgado-Pascual JL, Opazo Ríos L,Guerrero-Hue M, Garcia-Caballero C, Vásquez C, Mas S, Snanz AB, Herencia C, Mezzano S, Gómez-Guerrero C, Moreno J, Egido J. Article ISI International Journal of Molecular Science (2020)
Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes Cuarental, Leticia; Valino-Rivas, Lara; Mendonca, Luis; Saleem, Moin; Mezzano, Sergio; Belen Sanz, Ana; Ortiz, Alberto; Dolores Sanchez-Nino, Maria Article ISI Journal of Clinical Medicine (2020)
Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy Opazo-Ríos, Lucas; Plaza, Anita; Sánchez Matus, Yenniffer; Bernal, Susana; Lopez-Sanz, Laura; Jimenez-Castilla, Luna; Carpio, Daniel; Droguett, Alejandra; Mezzano, Sergio; Egido, Jesús; Gomez-Guerrero, Carmen Article Wos INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy Lavoz, C; Rodrigues-Diez, RR; Plaza, A; Carpio, D; Egido, J; Ruiz-Ortega, M; Mezzano, S Article ISI JOURNAL OF CLINICAL MEDICINE (2020)
VEGFR2 Blockage Improves Renal Damage in an Experimental Model of Tipe 2 Diabetic Nephropathy Lavoz C,Rodrigues-Diez RR, Plaza A, Carpio D,Egido J, Ruiz-Ortega M, Mezzano S. Article ISI Journal of Clinical Medicine (2020)
Evaluating a New International Risk-Prediction Tool in IgA Nephropathy Barbour, SJ; Coppo, R; Zhang, H; Liu, ZH; Suzuki, Y; Matsuzaki, K; Katafuchi, R; Er, L; Espino-Hernandez, G; Kim, SJ; Reich, HN; Feehally, J; Cattran, DC; Russo, ML; Troyanov, S; Cook, HT; Roberts, I; Tesar, V; Maixnerova, D; Lundberg, S; Gesualdo, L; Emma, F; Fuiano, L; Beltrame, G; Rollino, C; Amore, A; Camilla, R; Peruzzi, L; Praga, M; Feriozzi, S; Polci, R; Segoloni, G; Colla, L; Pani, A; Piras, D; Angioi, A; Cancarini, G; Ravera, S; Durlik, M; Moggia, E; Ballarin, J; Di Giulio, S; Pugliese, F; Serriello, I; Caliskan, Y; Sever, M; Kilicaslan, I; Locatelli, F; Del Vecchio, L; Wetzels, JFM; Peters, H; Berg, U; Carvalho, F; Ferreira, ACD; Maggio, M; Wiecek, A; Ots-Rosenberg, M; Magistroni, R; Topaloglu, R; Bilginer, Y; D'Amico, M; Stangou, M; Giacchino, F; Goumenos, D; Kalliakmani, P; Gerolymos, M; Galesic, K; Geddes, C; Siamopoulos, K; Balafa, O; Galliani, M; Stratta, P; Quaglia, M; Bergia, R; Cravero, R; Salvadori, M; Cirami, L; Fellstrorn, B; Smerud, HK; Ferrario, F; Stellato, T; Egido, J; Martin, C; Floege, J; Eitner, F; Lupo, A; Bernich, P; Mene, R; Morosetti, M; van Kooten, C; Rabelink, T; Reinders, MEJ; Grinyo, JMB; Cusinato, S; Benozzi, L; Savoldi, S; Licata, C; Mizerska-Wasiak, M; Martina, G; Messuerotti, A; Dal Canton, A; Esposito, C; Migotto, C; Triolo, G; Mariano, F; Pozzi, C; Boero, R; Bellur, S; Mazzucco, G; Giannakakis, C; Honsova, E; Sundelin, B; Di Palma, AM; Gutierrez, E; Asunis, AM; Barratt, J; Tardanico, R; Perkowska-Ptasinska, A; Terroba, JA; Fortunato, M; Pantzaki, A; Ozluk, Y; Steenbergen, E; Soderberg, M.; Riispere, Z; Furci, L; Orhan, D; Kipgen, D; Casartelli, D; Ljubanovic, DG; Gakiopoulou, H; Bertoni, E; Ortiz, PC; Karkoszka, H; Groene, HJ; Stoppacciaro, A; Bajema, I; Bruijn, J; Oliveras, XF; Maldyk, J; Loachim, E; Bavbek, N; Cook, T; Alpers, C; Berthoux, F; Bonsib, S; D'Agati, V; D'Amico, G; Emancipator, S; Emmal, F; Fervenza, F; Florquin, S; Fogo, A; Groene, H; Haas, M; Hill, P; Hogg, R; Hsu, S; Hunley, T; Hladunewich; Jennette, C; Joh, K; Julian, B; Kawamura, T; Lai, F; Leung, C; Li, L; Li, P; Liu, Z; Massat, A; Mackinnon, B; Mezzano, S; Schena, F; Tomino, Y; Walker, P; Wang, H; Weening, J; Yoshikawa, N; Zeng, CH; Shi, SF; Nogi, C; Suzuki, H; Koike, K; Hirano, K; Yokoo, T; Hanai, M; Fukami, K; Takahashi, K; Yuzawa, Y; Niwa, M; Yasuda, Y; Maruyama, S.; Ichikawa, D; Suzuki, T; Shirai, S; Fukuda, A; Fujimoto, S; Trimarchi, H Article ISI JAMA INTERNAL MEDICINE (2019)
Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis Droguett A.; Valderrama G.; Burgos M.E.; Carpio D.; Saka C.; Egido J.; Ruiz-Ortega M.; Mezzano S. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension Orejudo M.; Rodrigues-Diez R.R.; Rodrigues-Diez R.; Garcia-Redondo A.; Santos-SÃ¡nchez L.; RÃ¡ndez-Garbayo J.; Cannata-Ortiz P.; Ramos A.M.; Ortiz A.; Selgas R.; Mezzano S.; Lavoz C.; Ruiz-Ortega M. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy Lavoz C.; Matus Y.S.; Orejudo M.; Carpio J.D.; Droguett A.; Egido J.; Mezzano S.; Ruiz-Ortega M. Article ISI SCOPUS KIDNEY INTERNATIONAL (2019)
CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury Gonzalez-Guerrero, C; Morgado-Pascual, JL; Cannata-Ortiz, P; Ramos-Barron, MA; Gomez-Alamillo, C; Arias, M; Mezzano, S; Egido, J; Ruiz-Ortega, M; Ortiz, A; Ramos, AM Article ISI SCOPUS JOURNAL OF PATHOLOGY (2018)
Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation Rayego-Mateos, S; Morgado-Pascual, JL; Rodrigues-Diez, RR; Rodrigues-Diez, R; Falke, LL; Mezzano, S; Ortiz, A; Egido, J; Goldschmeding, R; Ruiz-Ortega, M Article ISI SCOPUS JOURNAL OF PATHOLOGY (2018)
Gremlin activates the Notch pathway linked to renal inflammation Lavoz, C; Poveda, J; Marquez-Exposito, L; Rayego-Mateos, S; Rodrigues-Diez, RR; Ortiz, A; Egido, J; Mezzano, S; Ruiz-Ortega, M Article ISI CLINICAL SCIENCE (2018)
Gremlin and renal diseases: ready to jump the fence to clinical utility? Mezzano, Sergio; Droguett, Alejandra; Lavoz, Carolina; Krall, Paola; Egido, Jesus; Ruiz-Ortega, Marta Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)
Gremlin regulates tubular epithelial to mesenchymal transition via VEGFR2: Potential role in renal fibrosis Marquez-Exposito L.; Lavoz C.; Rodrigues-Diez R.R.; Rayego-Mateos S.; Orejudo M.; Cantero-Navarro E.; Ortiz A.; Egido J.; Selgas R.; Mezzano S.; Ruiz-Ortega M. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2018)
Targeting inflammation in diabetc nephropathy: a tale of hope Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, Opazo L, Mezzano S, Egido J. Article ISI (2018)
Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy Bellur, Shubha S.; Lepeytre, Fanny; Vorobyeva, Olga; Troyanov, Stephan; Cook, H. Terence; Roberts, Ian S. D.; Int IgA Nephropathy Working Grp Article ISI KIDNEY INTERNATIONAL (2017)
Mitogen-activated Ptotein Kinase 14 promotes AKI Ortiz A, Husi H, Gonzalez-Lafuente L, Valiño-Rivas L, Fresno M, Sanz AB, Mullen W, Albalat A, Mezzano S, Vlahou T, Mischak H, Sanchez-Niño MD Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
The MEST score provides earlier risk prediction in IgA nephropathy Barbour SJ, Espino-Hernandez G, Reich HN, Coppo R, Roberts IS, Feehally J, Herzenberg AM, Cattran DC; Oxford Derivation, North American Validation and VALIGA Consortia; Oxford Derivation North American Validation and VALIGA Consortia. Article KIDNEY INTERNATIONAL (2016)
Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway Lavoz, C; Alique, M; Rodrigues-Diez, R; Pato J; Keri G; Mezzano S.; Egido, J; Ruiz-Ortega, M Article ISI SCOPUS Journal of Pathology (2015)
Lyso-Gb3 activates Notch1 in human podocytes Sanchez-Nino, MD; Carpio, D; Sanz, AB; Ruiz-Ortega, M; Mezzano S.; Ortiz A. Article ISI SCOPUS Human Molecular Genetics (2015)
Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin Cardenas, A; Campos J.; Ehrenfeld, P; Mezzano S.; Ruiz-Ortega, M; Figueroa, CD; Ardiles L. Article ISI SCOPUS Peptides (2015)
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan; Hancke, Juan L.; Brandan, Enrique Article ISI SCOPUS SKELETAL MUSCLE (2014)
Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells Rodrigues-Diez, R; Rodrigues-Diez, RR; Lavoz, C; Carvajal, G; Droguett A.; Garcia-Redondo, AB; Rodríguez I.; Ortiz A.; Egido, J; Mezzano S.; Ruiz-Ortega, M Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Translational study of the Notch pathway in hypertensive nephropathy Lavoz, C; Droguett A.; BURGOS, ME; Carpio, DJ; Ortiz A.; Egido, J; Mezzano S.; Ruiz-Ortega, M Article ISI SCOPUS NEFROLOGIA (2014)
Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice Droguett A.; Krall, P; BURGOS, ME; Valderrama, G; Carpio, D; Ardiles L.; Rodriguez-Diez, R; Kerr, B.; Walz, K; Ruiz-Ortega, M; Egido, J; Mezzano S. Article ISI SCOPUS PLOS ONE (2014)
Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria Ardiles L.; Cardenas, A; BURGOS, ME; Droguett A.; Ehrenfeld, P; Carpio, D; Mezzano S.; Figueroa, CD Article ISI SCOPUS American Journal of Physiology - Renal Physiology (2013)
Fn14 in podocytes and proteinuric kidney disease Sanchez-Nino, MD; Poveda J.; Sanz, AB; Mezzano S.; Carrasco S.; Fernandez-Fernandez, B; Burkly, LC; Nair, V; Kretzler, M; Hodgin, JB; Ruiz-Ortega, M; Selgas R.; Egido, J; Ortiz A. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2013)
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy Hookham, MB; O'Donovan, HC; Church, RH; Mercier-Zuber, A; Luzi, L; Curran, SP; Carew, RM; Droguett A.; Mezzano S.; Schubert, M; White, MF; Crean, JK; Brazil, DP Article ISI SCOPUS FEBS Journal (2013)
Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation Lavoz, C; Rodrigues-Diez, R; Benito-Martin, A; Rayego-Mateos, S; Rodrigues-Diez R.R.; Alique, M; Ortiz A.; Mezzano S.; Egido, J; Ruiz-Ortega, M Article ISI SCOPUS PLOS ONE (2012)
HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II Sanchez-Nio M.D.; Sanz A.B.; Sanchez-Lopez, E; Ruiz-Ortega, M; Benito-Martin, A; Saleem M.A.; Mathieson P.W.; Mezzano S.; Egido, J; Ortiz A. Article ISI SCOPUS Laboratory Investigation (2012)
Kidney disease: Improving global outcomes (KDIGO) glomerulonephritis work group. KDIGO clinical practice guideline for glomerulonephritis Cattran D.C.; Feehally J.; Cook H.T.; Liu Z.-H.; Fervenza F.C.; Mezzano S.A.; Floege J.; Nachman P.H.; Gipson D.S.; Praga M.; Glassock R.J.; Radhakrishnan J.; Hodson E.M.; Rovin B.H.; Jha V.; Troyanov S.; Li P.K.-T.; Wetzels J.F.M. Article SCOPUS Kidney International Supplements (2012)
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation Izquierdo M.C.; Sanz A.B.; Mezzano S.; Blanco, J; Carrasco S.; Sanchez-Nio M.D.; Benito-Martin, A; Ruiz-Ortega, M; Egido, J; Ortiz A. Article ISI SCOPUS Kidney International (2012)
EFFECT OF EPLERENONE ON HYPERTENSION-ASSOCIATED RENAL DAMAGE IN RATS: POTENTIAL ROLE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-gamma) Miana, M; de las Heras, N; Rodriguez, C; Sanz-Rosa, D; Martin-Fernandez, B; Mezzano S.; Lahera, V; Martinez-Gonzalez, J; Cachofeiro, V Article ISI JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2011)
Effect of eplerenone on hypertension-associated renal damage in rats: Potential role of peroxisome proliferator activated receptor gamma(PPAR-?) Miana, M; de las Heras, N; Martin-Fernandez, B; Lahera, V; Cachofeiro, V; Rodriguez, C; Martinez-Gonzalez, J; Sanz-Rosa, D; Mezzano S. Article SCOPUS Journal of Physiology and Pharmacology (2011)
The health system in Chile: the nephrologist perspective Ardiles L.G.; Mezzano S.; Poblete, H.; Ortiz, M; Elgueta S.; Cusumano A.M.; Vukusich A. Article ISI SCOPUS Journal of Nephrology (2011)
Role of the kidney in salt sensitive hypertension Ardiles L.; Mezzano S. Article ISI REVISTA MEDICA DE CHILE (2010)
Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-beta-Independent Process Diez, RR; Rodrigues-Diez, R; Lavoz, C; Rayego-Mateos, S; Civantos E.; Rodriguez-Vita, J; Mezzano S.; Ortiz A.; Egido, J; Ruiz-Ortega, M Article ISI SCOPUS PLOS ONE (2010)
Suppressors of Cytokine Signaling Abrogate Diabetic Nephropathy Ortiz-Munoz, G; Lopez-Parra, V; Lopez-Franco, O; Fernandez-Vizarra, P; Mallavia, B; Flores C.; Sanz A.; Blanco, J; Mezzano S.; Ortiz A.; Egido, J; Gomez-Guerrero, C Article ISI SCOPUS Journal of the American Society of Nephrology (2010)
The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults Coppo R.; Troyanov S.; Camilla, R; Hogg, RJ; Cattran, DC; Cook, HT; Feehally J.; Roberts, ISD; Amore, A; Alpers, CE; Barratt, J; Berthoux, F; Bonsib, S; Bruijn, JA; D'Agati, V; D'Amico, G.; Emancipator, SN; Emma F.; Ferrario, F; Fervenza, FC; Florquin S.; Fogo, AB; Geddes, CC; Groene, HJ; Haas, M; Herzenberg, AM; Hill, PA; Hsu, SI; Jennette, JC; Joh, K; Julian, BA; Kawamura, T; Lai, FM; Li, LS; Li, PK; Liu, ZH; Mezzano S.; Schena, FP; Tomino, Y; Walker, PD; Wang, HY; Weening, JJ; Yoshikawa, N; Zhang, H Article ISI SCOPUS Kidney International (2010)
Angiotensin-(1-7) and the G protein-coupled receptor Mas are key players in renal inflammation ESteban V; Egido, J; Ruiz-Ortega, M; Heringer-Walther S.; Wang Y.; Schultheiss H.-P.; Walther T.; Sterner-Kock A.; de Bruin R.; van den Engel S.; Mezzano S. Article SCOPUS PLOS ONE (2009)
Bariatric surgery in patients with focal segmental glomerulosclerosis secondary to obesity ramirez, j; Carpio, D; Mezzano S.; Mukdsi, J; Ardiles L. Article ISI NEFROLOGIA (2009)
Expression of gremlin, a bone morphogenetic protein antagonist, is associated with vascular calcification in uraemia Jara, A.; Chacon, C.; BURGOS, ME; Droguett A.; Valdivieso, A; Ortiz, M; Troncoso P.; Mezzano S. Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
The MIF Receptor CD74 in Diabetic Podocyte Injury Sanchez-Nino, MD; Sanz, AB; Ihalmo, P; Lassila, M; Holthofer H.; Mezzano S.; Aros, C.; Groop, PH; Saleem, MA; Mathieson, PW; Langham, R; Kretzler, M; Nair, V; Lemley, KV; Nelson RG; Mervaala, E; Mattinzoli, D; Rastaldi, MP; Ruiz-Ortega, M; Martin-Ventura, JL; Egido, J; Ortiz A. Article ISI SCOPUS JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility Roberts, ISD; Cook, HT; Troyanov S.; Alpers, CE; Amore, A; Barratt, J; Berthoux, F; Bonsib, S; Bruijn, JA; Cattran, DC; Coppo R.; D'Agati, V; D'Amico, G.; Emancipator, S; Emma F.; Feehally J.; Ferrario, F; Fervenza, FC; Florquin S.; Fogo, A; Geddes, CC; Groene, HJ; Haas, M; Herzenberg, AM; Hill, PA; Hogg, RJ; Hsu, SI; Jennette, JC; Joh, K; Julian, BA; Kawamura, T; Lai, FM; Li, LS; Li, PKT; Liu, ZH; Mackinnon, B; Mezzano S.; Schena, FP; Tomino, Y; Walker, PD; Wang, HY; Weening, JJ; Yoshikawa, N; Zhang, H Article ISI SCOPUS KIDNEY INTERNATIONAL (2009)
The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification Cattran, DC; Coppo R.; Cook, HT; Feehally J.; Roberts, ISD; Troyanov S.; Alpers, CE; Amore, A; Barratt, J; Berthoux, F; Bonsib, S; Bruijn, JA; D'Agati, V; D'Amico, G.; Emancipator, S; Emma F.; Ferrario, F; Fervenza, FC; Florquin S.; Fogo, A; Geddes, CC; Groene, HJ; Haas, M; Herzenberg, AM; Hill, PA; Hogg, RJ; Hsu, SI; Jennette, JC; Joh, K; Julian, BA; Kawamura, T; Lai, FM; Leung, CB; Li, LS; Li, PKT; Liu, ZH; Mackinnon, B; Mezzano S.; Schena, FP; Tomino, Y; Walker, PD; Wang, HY; Weening, JJ; Yoshikawa, N; Zhang, H Article ISI SCOPUS KIDNEY INTERNATIONAL (2009)
Co-regulation of Gremlin and Notch signalling in diabetic nephropathy Walsh, DW; Roxburgh, SA; McGettigan, P; Berthier, CC; Higgins, DG; Kretzler, M; Cohen, CD; Mezzano S.; Brazil, DP; Martin, F Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)
Ethnic Differences in HLA Antigens in Chilean Donors and Recipients: Data From the National Renal Transplantation Program Droguett, MA; Beltran, R; Ardiles, R; Raddatz, N; Labrana, C; Arenas, A.; Flores, J; Alruiz P; Mezzano S.; Ardiles L. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2008)
Gremlin: A novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy Carvajal, G; Droguett A.; BURGOS, ME; Aros, C.; Ardiles L.; Flores C.; Carpio, D; Ruiz-Ortega, M; Egido, J; Mezzano S. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2008)
IHG-1 amplifies TGF-beta 1 signaling and is increased in renal fibrosis Murphy, M; Docherty, NG; Griffin B.; Howlin, J; McArdle, E; McMahon, R.; Schmid H.; Kretzler, M; Droguett A.; Mezzano S.; Brady, HR; Furlong, F; Godson, C; Martin, F Article ISI SCOPUS JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways Rodrigues-Diez, R; Carvajal-Gonzalez, G; Sanchez-Lopez, E; Rodriguez-Vita, J; Diez, RR; Selgas R.; Ortiz A.; Egido, J; Mezzano S.; Ruiz-Ortega, M Article ISI SCOPUS PHARMACEUTICAL RESEARCH (2008)
Renal transplantation in Mapuche people Ardiles, R; Beltran, R; Jerez, V.; Droguett, MA; Mezzano S.; Ardiles L. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2008)
Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis Mezzano S.; Droguett A.; BURGOS, ME; Aros, C.; Ardiles L.; Flores C.; Carpio, D; Carvajal, G; Ruiz-Ortega, M; Egido, J Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2007)
Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats de las Hera, N; Ruiz-Ortega, M; Miana, M; Ruperez M; Sanz-Rosa, D; Aragoncillo, P; Mezzano S.; Cachofeiro, V; Egido, J; Lahera, V Article ISI SCOPUS JOURNAL OF HYPERTENSION (2007)
Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats Jara, A.; von Hoveling, A; Jara, X; BURGOS, ME; Valdivieso, A; Mezzano S.; Felsenfeld, AJ Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)
Long-term treatment with an ACE inhibitor or an AT(1) antagonist avoids hypertension-induced inflammation in the kidney ESteban V; Gallego-Delgado, J; Lazaro, A; Osende, J; Mezzano S.; Egido, J; Ruiz-Ortega, M Article ISI Journal of Nephrology (Milano) (2006)
Long-term treatment with an ACE inhibitor or an AT1 antagonist avoids hypertension-induced inflammation in the kidney ESteban V; Ruiz-Ortega, M; Gallego-Delgado, J; Lazaro, A; Egido, J; Osende, J; Mezzano S. Article SCOPUS Journal of Nephrology (Milano) (2006)
Renal health in Chile Escobar C.; Arce, I; Jara, A.; Mezzano S.; Ardiles L. Article ISI SCOPUS RENAL FAILURE (2006)
Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II de las Heras, N; Ruiz-Ortega, M; Ruperez M; Sanz-Rosa, D; Miana, M; Aragoncillo, P; Mezzano S.; Lahera, V; Egido, J; Cachofeiro, V Article ISI SCOPUS JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2006)
Antiphospholipid antibodies in idiopathic membranous nephropathy Ardiles L.; BLACKBURN, E; Alruiz P; Flores C.; Mezzano S. Article ISI REVISTA MEDICA DE CHILE (2005)
Correlation between C2 and AUC (0-4) in renal transplant patients treated with diltiazem. Aros CA, Schneider HO, Flores CA, Ardiles LA, Alruiz PA, Jerez V, Mezzano SA Article TRANSPLANTATION PROCEEDINGS (2005)
Early and sustained inhibition of nuclear factor-kappa B prevents hypertension in spontaneously hypertensive rats Rodriguez-Iturbe, B; Ferrebuz, A; Vanegas, V; Quiroz, Y; Mezzano S.; Vaziri, ND Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid H.; Henger, A; Kretzler, M; Droguett A.; Mezzano S.; Brady, HR Article ISI AMERICAN JOURNAL OF KIDNEY DISEASES (2005)
Human leukocyte antigens in indigenous (Mapuche) people in a regional renal transplantation program in Chile Droguett, MA; Oyarzun, MJ; Alruiz P; Jerez, V.; Mezzano S.; Ardiles L. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2005)
Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH? Batsford, SR; Mezzano S.; Mihatsch, M; Schiltz, E; Rodriguez-Iturbe, B Article ISI KIDNEY INTERNATIONAL (2005)
Late onset of familial nephrotic syndrome associated with a compound heterozygous mutation of the podocin-encoding gene. Ardiles LG., Carrasco AE, Carpio JD, Mezzano S Article Nephrology ( Carlton) (2005)
Long-term blood pressure control prevents oxidative renal injury Lazaro, A; Gallego-Delgado, J; Justo, P; ESteban V; Osende, J; Mezzano S.; Ortiz A.; Egido, J Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2005)
No gender-associated differences of cyclosporine pharmacokinetics in stable renal transplant patients treated with diltiazem. Aros CA, Ardiles LG, Schneider HO, Flores CA, Alruiz PA, Jerez VA, Mezzano SA Article TRANSPLANTATION PROCEEDINGS (2005)
Valsartan-induced hematocrit changes in renal transplant patients. Flores CA, Ardiles LA, Aros CA, Muñoz CC, Schneider HO, Ramírez JA, Jerez V, Valderrama MG, Mezzano SA Article TRANSPLANTATION PROCEEDINGS (2005)
Angiotensin II, via AT(1) and AT(2) receptors and NF-kappa B pathway, regulates the inflammatory response in unilateral ureteral obstruction ESteban V; Lorenzo O.; Ruperez M; Suzuki Y.; Mezzano S.; Blanco, J; Kretzler, M; Sugaya, T; Egido, J; Ruiz-Ortega, M Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)
NF-kappa B activation and overexpression of regulated genes in human diabetic nephropathy Mezzano S.; Aros, C.; Droguett A.; BURGOS, ME; Ardiles L.; Flores C.; Schneider H; Ruiz-Ortega, M; Egido, J Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2004)
Angiotensin II increases connective tissue growth factor in the kidney Ruperez M; Ruiz-Ortega, M; ESteban V; Lorenzo O.; Mezzano S.; Plaza, JJ; Egido, J Article ISI AMERICAN JOURNAL OF PATHOLOGY (2003)
Effect of simultaneous blockade of AT1 and AT2 receptors on the NF kappa B pathway and renal inflammatory response ESteban V; Ruperez M; Vita, JR; Lopez, ES; Mezzano S.; Plaza, JJ; Egido, J; Ruiz-Ortega, M Article ISI KIDNEY INTERNATIONAL (2003)
Expression of Smac/Diablo in tubular epithelial cells and during acute renal failure Justo, P; Sanz A.; Lorz, C; Gomez-Garre, D; Mezzano S.; Egido, J; Ortiz A. Article ISI KIDNEY INTERNATIONAL (2003)
Renal expression of angiotensin type 2 (AT2) receptors during kidney damage Ruiz-Ortega, M; ESteban V; Suzuki Y.; Ruperez M; Mezzano S.; Ardiles L.; Justo, P; Ortiz A.; Egido, J Article ISI KIDNEY INTERNATIONAL (2003)
Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy Mezzano S.; Droguett A.; BURGOS, ME; Ardiles, LG; Flores, CA; Aros, CA; CAORSI, I; Vio, CP; Ruiz-Ortega, M; Egido, J Article ISI KIDNEY INTERNATIONAL (2003)
Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney Ruiz-Ortega, M; Ruperez M; Lorenzo O.; ESteban V; Blanco, J; Mezzano S.; Egido, J Article ISI KIDNEY INTERNATIONAL (2002)
Effect of mycophenolate mofetil on kallikrein expression in the kidney of 516 nephrectomized rats Ardiles, LG; Ehrenfeld, P; Quiroz, Y; Rodriguez-Iturbe, B; Herrera-Acosta, J; Mezzano S.; Figueroa, CD Article ISI SCOPUS Kidney & Blood Pressure Research (2002)
Levofloxacin associated Achilles tendinitis. Report of four cases Aros, C.; Flores C.; Mezzano S. Article ISI REVISTA MEDICA DE CHILE (2002)
Angiotensin II and renal fibrosis Mezzano, SA; Ruiz-Ortega, M; Egido, J Article ISI HYPERTENSION (2001)
Renin-angiotensin system and renal damage: Emerging data on angiotensin II as a proinflammatory mediator Ruiz-Ortega, M; Lorenzo O.; Ruperez M; ESteban V; Mezzano S.; Egido, J Article ISI SCOPUS Contributions to Nephrology (2001)
Role of the renin-angiotensin system in vascular diseases - Expanding the field Ruiz-Ortega, M; Lorenzo O.; Ruperez M; ESteban V; Suzuki Y.; Mezzano S.; Plaza, JJ; Egido, J Article ISI HYPERTENSION (2001)
Tubular NF-kappa B and AP-1 activation in human proteinuric renal disease Mezzano, SA; Barria, M.; Droguett, MA; BURGOS, ME; Ardiles, LG; Flores C.; Egido, J Article ISI SCOPUS KIDNEY INTERNATIONAL (2001)
Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy Mezzano, SA; Droguett, MA; BURGOS, ME; Ardiles, LG; Aros, CA; CAORSI, I; Egido, J Article ISI SCOPUS KIDNEY INTERNATIONAL (2000)
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo Ardiles, L; Ramirez, P; Moya, P; Caorsi, I; Mezzano, S Article ISI NEPHRON (1999)
Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis Cu GA, Mezzano S, Bannan JD, Zabriskie JB. Article ISI Kidney Int (1999)
Tranexamic acid inhibits fibrinolysis, shortens the bleeding time and improves platelet function in patients with chronic renal failure. Mezzano D, Panes O, Muñoz B, Pais E, Tagle R, González F, Mezzano S, Barriga F, Pereira J. Article ISI J.Thromb Haemost. (1999)
Antibody to streptococcal zymogen in the serum of patients with acute glomerulonephritis: a multicentric study. Parra G, Rodríguez-Iturbe B, Batsford S, Vogt A, Mezzano S, Olavarría F, Exeni R, Laso M, Orta N Article ISI KIDNEY INTERNATIONAL (1998)
Anticardiolipin antibodies in classic pediatric hemolytic-uremic syndrome: A possible pathogenic role Ardiles, LG; Olavarria, F; Elgueta, M; Moya, P; Mezzano, S Article ISI NEPHRON (1998)
Immunohistochemical localization of IL-8 and TGF-beta in streptococcal glomerulonephritis. Mezzano S, Burgos ME, Olavarría F, Caorsi I. Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (1998)
Modification of the Pharmacokinetics of Cyclosporine A and Metabolites by the Concomitant Use of Neoral and Diltiazem or Ketoconazol in Stable Adult Kidney Transplants Foradori A, Mezzano S, Videla C, Pefaur J, Elberg A. Article ISI Transplant Proc . (1998)
Study of neoral kinetics in adult renal transplantation treated with diltiazem. Mezzano S, Flores C, Ardiles L, Foradori A, Elberg A. Article ISI TRANSPLANTATION PROCEEDINGS (1998)
Endothelial cell markers in chronic uremia: relationship with hemostatic defects and severity of renal failure. Mezzano D, Tagle R, Pais E, Panes O, Pérez M, Downey P, Muñoz B, Aranda E, Barja P, Thambo S, González F, Mezzano S, Pereira Article ISI J.Thromb Res (1997)
Incidence and studies on antigenic specificities of antineutrophil-cytoplasmic autoantibodies (ANCA) in poststreptococcal glomerulonephritis Ardiles LG, Valderrama G, Moya P, Mezzano S Article ISI Clin Nephrol (1997)
Role of streptococcal proteinase in acute post-streptococcal glomerulonephritis. Cu GA, Mezzano S, Zabriskie J Article ISI Adv Exp Med Biol. (1997)
Antineutrophil cytoplasmic antibodies and nonspecific ulcerative colitis Rojas G, Siegel F, Jorquera J, Ardiles L, Valderrama G, Mezzano S.Rev Article ISI Rev Med Chil . (1996)
Complete remission of nephrotic syndrome after steroid-chlorambucil in a previous failed short-term steroidal treatment of a primary membranous nephropathy Ardiles l, Mezzano S. Article ISI Clin Nephrol. (1996)
Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis. Mezzano D, Tagle R, Panes O, Pérez M, Downey P, Muñoz B, Aranda E, Barja P, Thambo S, González F, Mezzano S, Pereira J. Article ISI J.Thromb Haemost. (1996)
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. Mezzano S, Kunick M, Olavarría F, Ardiles L, Aranda E, Mezzano D, Article Nephron (1995)
Hepatitis C virus: results of detection in several high risk groups in the X region of Chile. Ibarra H, Riedemann S, Mezzano S, Toledo C, Reinhardt G, Núñez M, Becker J, Froesner G. Article REVISTA MEDICA DE CHILE (1995)
A study on the antigenic nature of circulating immune complexes in hemolytic uremic syndrome: no evidence of platelet membrane glycoproteins antigens Olavarría F, Pereira J, Mezzano S, Kunick M, Castillo A , Mezzano D Article Nephron (1994)
Detection of antineutrophil cytoplasmic antibodies in the classic form of hemolytic uremic syndrome Olavarría F, Mezzano S, Valderrama G et al Article Nephron (1994)
Hemolytic uremic syndrome in childhood : study of several factors otentially related with its genesis. Olavarría F, Mezzano S, Reinoso S, Delucchi A, Prado V, Article REVISTA MEDICA DE CHILE (1994)
Antineutrophil cytoplasmic autoantibodies in poststreptococcal nephritis Mezzano S, Valderrama G, Olavarría F, Ardiles L, Arriagada A, Castillo A, Caorsi I Article ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY (1993)
Detection of platelet activating factor in plasma of patients with streptococcal nephritis. Mezzano S, Kunick M, Olavarría F, Ardiles L, Montrucchio G, Silvestro L, Biancone L, Camussi G Article ISI CELLULOSE (1993)
Rapidly progressive glomerulonephritis without immune deposits: detection of neutrophil anticytoplasmic antibodies Castillo A, Valderrama G, Ardiles L, Caorsi I, Mezzano S Article ISI REVISTA MEDICA DE CHILE (1993)
Erythrocitosis associated to idiopathic membranous nephropathy. Case report Ardiles L, Mezzano S Article CELLULOSE (1992)
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. Mezzano S, Burgos E, Mahabir R, Kemeny E, Zabriskie JB Article ISI CELLULOSE (1992)
Glomerular localization of platelet factor 4 in streptococcal nephritis. Mezzano S, Burgos ME, Ardiles L, Olavarría F, Concha M, Caorsi I, Aranda E, Mezzano D.j Article CELLULOSE (1992)
Hepatitis C virus and renal transplant Ibarra H, Mezzano S, Riedemann S, Toledo C, Ardiles L, Reinhardt G, Castillo A Article ISI CELLULOSE (1992)
Small nuclear ribonucleoprotein polypeptides in rat sperm Brito M, Concha Il, Pessot CA, Mezzano S, Burzio LO Article CELLULOSE (1992)
Age influence on mononuclear phagocyte system Fc-receptor function in poststreptococcal nephritis Mezzano S, Lopez MI, Olavarría F, Ardiles L, Arriagada A, Elgueta S, Wegman ME, Fuentes S. Article CELLULOSE (1991)
Idiopathic membranous nephropathy associated with HLA-DRw3 and not related to monocyte-phagocyte system Fc receptor dysfunction, in father and son. Mezzano S, Rojas G, Ardiles L, Caorsi I, Bertoglio JC, Lopez MI, Kunick M, Elgueta S Article ISI CELLULOSE (1991)
Decrease in mean platelet survival time in acute poststreptococcal glomerulonephritis (APSGN). Mezzano S, Lopez MI, Olavarria F, Ardiles L, Mezzano D. Article ISI Clin nephrol (1990)
External iliac artery rupture as a manifestation of aspergillosis in a renal transplant recipient Ardiles L, Pisano R, Mezzano S, Corti D. Article ISI REVISTA MEDICA DE CHILE (1990)
Clinical course in 51 patients with idiopathic membranous glomerulopathy Ardiles L, Mezzano S, Arriagada A, Caorsi I. Article ISI REVISTA MEDICA DE CHILE (1989)
Presence of circulating immune complexes in the classic form of hemolytic uremic syndrome: a constant finding. Olavarria F, Mezzano S, Ardiles L, Lopez MI, Kunick M. Article ISI Nephron (1989)
[Kallikrein excretion in patients with nephritic and nephrotic syndromes Mezzano S, Vió CP, Ardiles L, Olavarría F Article ISI Revista Medica de (1988)
Atrial natriuretic factor Olavarría F, Castillo A, Ardiles L, Mezzano S Article ISI REVISTA CHILENA DE PEDIATRIA (1988)
RENAL-FUNCTION IN FULL-TERM NEWBORNS FOLLOWING NEONATAL ASPHYXIA - A PROSPECTIVE-STUDY OLAVARRIA, F; KRAUSE, S; BARRANCO, L; HERRMANN, F; PAEZ, V; MEZZANO, S; LEAL, N; LOPEZ, M Article ISI CLINICAL PEDIATRICS (1987)
IMMUNE THROMBOCYTOPENIC PURPURA ASSOCIATED WITH HEPATITIS-A IBARRA, H; ZAPATA, C; INOSTROZA, J; MEZZANO, S; RIEDEMANN, S Article ISI BLUT (1986)
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo Mezzano S, Olavarría F, Ardiles L, López MI Article ISI Clinical Nephrology (1986)
Analysis of a teaching-learning model with adult ambulatory patients Zapata C, Saldías F, Jiménez P, Bertoglio JC, Mezzano S, Sagardia M, Peña E, Frick P, Barria L, Kunstmann G Article ISI REVISTA MEDICA DE CHILE (1985)
Actividad de Calicreina Urinaria en Síndrome Hipoaldosteronismo Hiporeninémico. Mezzano S., González J., Hott H., Vio C. Article ISI REVISTA MEDICA DE CHILE (1984)
Analysis of humoral and cellular factors that contribute to impaired immune responsiveness in experimental uremia Mezzano S, Pesce AJ, Pollak VE, Michael JG. Article ISI Nephron (1984)
Detection of circulating immune complexes by immunoenzyme assay with solid phase Clq Mezzano S, López MI Article ISI Revista Medica de Chi (1984)
Glomerulopathies: pathogenic and developmental aspects Mezzano S, Caorsi I Article ISI REVISTA MEDICA DE CHILE (1984)
Focal segmental glomerulosclerosis. Clinical and histopathologic study in 14 patients Olavarria F, Caorsi I, Arriagada A, Mezzano S, Figueroa C Article ISI REVISTA MEDICA DE CHILE (1983)
Antibody production and antigenic specific suppression to bovine serum albumin in uremic rats Mezzano S, Pesce A, Peters T Jr, Pollak VE, Reed R, Michael G Article ISI Clinical Experimental Immunology (1982)
Acute diffuse poststreptococcal glomerulonephritis. Clinical, histopathological and follow-up study Olavarría F, Mezzano S, Caorsi I Article ISI REVISTA CHILENA DE PEDIATRIA (1980)
Idiopathic rapidly progressive glomerulonephritis treated with high-dose methylprednisolone Mezzano S, Arriagada A, Caorsi I. Article ISI REVISTA MEDICA DE CHILE (1980)
Acute renal failure due to post anesthetic rabdomyolysi Mezzano S Article ISI REVISTA MEDICA DE CHILE (1979)
Idiopathic membranous glomerulonephropathy. Clinical and histologic aspects in 10 cases Mezzano S, Caorsi I, González CB, Delannoy L, Andrade R Article ISI REVISTA MEDICA DE CHILE (1978)


GREMLIN REGULATES RENAL INFLAMMATION VIA VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 PATHWAY Alique, M; carolina c; Rodrigues-Diez, R; Egido, J; Mezzano S.; Ruiz-Ortega, M Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)
TUBULAR OVEREXPRESSION OF GREMLIN IN TRANSGENIC MICE AGGRAVATES RENAL DAMAGE IN DIABETIC NEPHROPATHY Droguett A.; Marchant, V.; Sánchez Y.; Valderrama, G; BURGOS, ME; Carpio, D; Kerr, B.; Ruiz-Ortega, M; Ejido, J; Mezzano S. Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)
GREMLIN MODULATES FIBROSIS IN RENAL CELLS VIA VEGFR2 PATHWAY AND INDEPENDENT OF ITS BMPS ANTAGONISTS EFFECTS Diez, RRR; Mezzano S.; Ruiz-Ortega, M; Diez, RR; Lavoz, C Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2013)
DIFFERENTIAL REGULATION BY ANGIOTENSIN II AND TGF-B1 OF NOTCH SIGNALING IN THE KIDNEY Lavoz, C; Rodrigues-Diez, R; Rayego-Mateos, S; Benito-Martin, A; Alique, M; Ortiz A.; Mezzano S.; Ruiz-Ortega, M Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)
Angiotensin II causes epithelial mesenchymal transdifferentiation via activation of Smad and MAPK signaling pathways Carvajal, G; Ruperez M; Sanchez-Lopez, E; Rodriguez-Vita, J; Rodrigues-Diez, R; ESteban V; Mezzano S.; Egido, J; Ruiz-Ortega, M Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)
Expression of gremlin in diabetic nephropathy in vivo and epithelial-mesenchymal transdifferentiation in vitro. Dolan, V; Murphy, M; Kretzler, M; Mezzano S.; Brady, HR Abstract ISI SCOTTISH MEDICAL JOURNAL (2006)
Combined treatment with angiotensin type 1 and type 2 receptor antagonists blocked NF-KB pathway and renal inflammatory infiltration ESteban V; Ruperez M; Rodriguez-Vita, J; Sanchez-Lopez, E; Mezzano S.; Egido, J; Ruiz-Ortega, M Abstract ISI JOURNAL OF HYPERTENSION (2003)
Renal kallikrein-kinin system (KK) compromise in a 5/6 renal ablation model modulated by mycophenolate mofetil (MMF). Ardiles L.; Figueroa, CD; Ehrenfeld, P; Quiroz, Y; Rodriguez-Iturbe, B; Herrera-Acosta, J; Mezzano S. Abstract ISI HYPERTENSION (2001)


Postinfectious Glomerulonephritis Bernardo Rodriguez-Iturbe, y Sergio Mezzano BookSection (2009)
Inmunosupresores e inmunorreguladores en enfermedad renal S.Mezzano, G. Mezzano y C. Aros BookSection (2005)
Nefropatía Crónica del Injerto Mezzano S., Aros C., Gatica A BookSection (2005)
Post-infectious glomerulonephritis Rodríguez-Iturbe B., Mezzano S BookSection (2005)
Glomerulopatías Primarias Mezzano S., Aros C BookSection (2002)
Nefropatía membranosa Mezzano S. BookSection (1997)
Pathogenesis of Glomerular Disease. 2.-Camussi G, Biancone L, Iorio E, Montrucchio G, Mezzano S: BookSection (1993)
Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA) in Poststreptococcal Nephritis (APSGN). Mezzano S., Valderrama G., Castillo A., Olavarría F., Ardiles L.,Caorsi I.: BookSection (1992)


Molecular Regulation of Notch Signaling by Gremlin Marquez-Exposito L.; Cantero-Navarro E.; R. Rodrigues-Diez R.; Orejudo M.; Tejera-MuÃ±oz A.; Tejedor L.; Rayego-Mateos S.; RÃ¡ndez-Carbayo J.; Santos-Sanchez L.; Mezzano S.; Lavoz C.; Ruiz-Ortega M. BookWhole SCOPUS Advances in Experimental Medicine and Biology (2020)
Regulation of vascular and renal cells by common mediators in health and disease: Role of the renin-angiotensin system in the pathophysiology of hypertension and cardiovascular disease Ruiz-Ortega, M; Rodrigues-Díez R.; Rayego S.; Rodrigues-Díez R.R.; Lavoz, C; Civantos E.; Carvajal, G; Mezzano S.; Ortiz A.; Egido, J BookWhole SCOPUS Cardiorenal Syndrome: Mechanisms, Risk and Treatment (2010)


Diabetic renal disease: The world kidney day in Chile [Enfermedad renal en la diabetes: A propósito del día mundial del riñón] Ardiles L.; Mezzano S. Editorial SCOPUS Revista Medica de Chile (2010)
Enfermedad renal en la diabetes: A propósito del día mundial del riñón Ardiles, Leopoldo; Mezzano, Sergio Editorial SCIELO REVISTA MEDICA DE CHILE (2010)


Diabetic renal disease: The World Kidney Day in Chile Ardiles L.; Mezzano S. EditorialMaterial ISI REVISTA MEDICA DE CHILE (2010)


Response to Yoshizawa et al. Batsford, SR; Mezzano S.; Mihatsch, M; Schiltz, E; Rodriguez-Iturbe, B Letter ISI KIDNEY INTERNATIONAL (2006)


GREMLIN: UN MEDIADOR PROFIBROTICO Y PROINFLAMATORIO INVOLUCRADO EN LA NEFROPATIA DIABETICA. Mezzano, Sergio Proyecto (2016)
GREMLIN: ¿UN NUEVO BIOMARCADOR RENAL PROFIBROTICO? SU ROL EN PATOLOGÍA RENAL HUMANA Y EXPERIMENTAL. Mezzano, Sergio Proyecto (2012)
FIBROSIS RENAL: ESTUDIO DE NUEVOS MEDIADORES DE TRANSDIFERENCIACIÓN EPITELIO-MESENQUIMAL (TEM). Mezzano, Sergio Proyecto (2008)
ESTUDIO DE LA TRANSDIFERENCIACION TUBULO-EPITELIAL EN ENFERMEDAD RENAL PROGRESIVA. ROL DE LA PROTEINURIA Y ANGIOTENSINA II Mezzano, S. Proyecto (2006)
Estudio de la Transdiferenciacion tubulo-epitelial en la enfermedad renal progresiva. Rol de la proteinuria y angiotensina II Mezzano, Sergio Proyecto (2004)
ESTUDIO DE LA TRANSDIFERENCIACIÓN TUBULO-EPITELIAL EN ENFERMEDAD RENAL PROGRESIVA. ROL DE LA PROTEINURIA Y ANGIOTENSINA II. Mezzano, Sergio Proyecto (2004)
Determinación in situ de Factores de Transcripción activados (NF-kB y AP1) y estudio de mecanismos apoptoticos en glomerulopatias proteinuricas Mezzano, Sergio Proyecto (2000)


Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy? Lavoz, C; Rayego-Mateos, S; Orejudo, M; Opazo-Rios, L; Marchant, V; Marquez-Exposito, L; Tejera-Munoz, A; Navarro-Gonzalez, JF; Droguett, A; Ortiz, A; Egido, J; Mezzano, S; Rodrigues-Diez, RR; Ruiz-Ortega, M Review ISI JOURNAL OF CLINICAL MEDICINE (2020)
Could Notch signaling pathway be a potential therapeutic option in renal diseases? Marquez-Exposito, L; Cantero-Navarro, E; Lavoz, C; Fierro-Fernaandez, M; Poveda, J; Rayego-Mateos, S; Rodrigues-Diez, RR; Morgado-Pascual, JL; Orejudo, M; Mezzano, S; Ruiz-Ortega, M Review ISI NEFROLOGIA (2018)
Targeting inflammation in diabetic nephropathy: a tale of hope Moreno J.A.; Gomez-Guerrero C.; Mas S.; Sanz A.B.; Lorenzo O.; Ruiz-Ortega M.; OPAZO L.; Mezzano S.; Egido J. Review ISI SCOPUS (2018)
Rol del riñón en la hipertensión sal-sensible Ardiles, Leopoldo; Mezzano, Sergio Review SCIELO REVISTA MEDICA DE CHILE (2010)
Connective tissue growth factor (CTGF): a key factor in the onset and progression of kidney damage Sanchez-Lopez, E; Diez, RR; Vita, JR; Mateos, SR; Diez, RRR; Garcia, ER; Barria, CL; Mezzano S.; Egido, J; Ortiz A.; Ruiz-Ortega, M; Selgas R. Review ISI NEFROLOGIA (2009)
Daño vascular en la enfermedad renal crónica Jara, Aquiles; Mezzano, Sergio Review SCIELO REVISTA MEDICA DE CHILE (2008)
Vascular damage in chronic kidney disease Jara, A.; Mezzano S. Review ISI REVISTA MEDICA DE CHILE (2008)
Chronic kidney disease: Classification, mechanisms of progression and strategies for renoprotection Mezzano S.; Aros, C. Review ISI REVISTA MEDICA DE CHILE (2005)

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Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Carolina Lavoz

Investigador principal

Medicina

Universidad Austral de Chile

Valdivia, Chile

J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

Claudio Flores

Académico

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Maria Droguett

Profesor Asociado

Medicina

Universidad Austral de Chile

Valdivia, Chile

Lucas Opazo

Postdoctoral Fellow

Renal, Vascular and Diabetes Research Lab

Instituto de Investigación Sanitaria Fundación Jiménez Díaz

Madrid, España

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

ARELI CÁRDENAS

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Maria Escobar

Consultora en Enfermedades no Transmisibles

Organización Panamericana de la Salud

Santiago, Chile

Eileen Blackburn

Médico Jefe de Laboratorio Clínico

Servicio de Laboratorio Clínico

Hospital Base Valdivia

Valdivia, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Natalia Raddatz

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Anita Plaza

Investigador

Medicina

Universidad Austral de Chile

Valdivia, Chile

Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

PABLO TRONCOSO

Profesor Asociado

Urología

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Miguel Barria

Académico

Inmunología y Parasitología

Universidad Austral de Chile

Valdivia, Chile

Sergio Agustín Mezzano Abedrapo

Líneas de Investigación

Educación

Medicina Interna, Nefrología, CONACEM. Chile, 1987

Fellow American College of Physicians, American College of Physicians.. Estados Unidos, 2001

Fellow American Society of Nephrology, American Society of Nephrology. Estados Unidos, 2004

Especialista en Medicina Interna, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1975

Post doctoral research fellow Nephrology, Universidad de Cincinnati. Estados Unidos, 1982

Experiencia Académica

Profesor Asistente Full Time

Beca Investigación en Nefrología clínica Full Time

Jefe de Departamento Full Time

Profesor Asociado Full Time

Profesor Titular Full Time

Director Oficina de Investigación Full Time

Jefe Unidad de Nefrología Full Time

Profesor Catedrático Full Time

Profesor Visitante Full Time

Profesor Visitante Full Time

Experiencia Profesional

Medico Tratante Medicina Interna Full Time

Medico Tratante Unidad de Cuidados Intensivos Part Time

Director Médico Valdivia Other

Académico Convenio Docente Asistencial UACH-Servicio de Salud Valdivia Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Research Award

International Medal Award

Presidente Sociedad Latinoamericana de Nefrología e Hipertensión

Miembro Consejo KDIGO

Co-editor

Miembro Comite Editorial

Premio Dr. Eduardo Katz

Laureate Award

Miembro de Honor

Premio Dr. Victor Raul Miatello

Catedrático

Premio Conferencia Sociedad Médica santiago

Council Member

Miembro correspondiente

Traveling Scholarship

Estadía de Investigación

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