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INGRID PAMELA EHRENFELD SLATER

ASSOCIATE PROFESSOR

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Líneas de Investigación


Rol of inflammation in the malignant behavior of human breast cancer cells and tumor microenvironment. Biomarker in Cancer Inflammation and immunity innnate response

Educación

  •  Biologia Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007
  •  Patologia, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2002
  •  Medical Technology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    MEDICINA

    VALDIVIA, Chile

    2010 - A la fecha

Experiencia Profesional

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    VALDIVIA, Chile

    2007 - 2014

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    VALDIVIA, Chile

    2014 - A la fecha

  •   Directora Escuela de Graduados Facultad de Medicina Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2018 - A la fecha

Formación de Capital Humano


Bryan Hinrichsen. “Inflammation in CNS Remyelination: Can Macrophage Polarization Shape the Contribution of Pericytes in OPC Differentiation?". Candidate of PhD in
Cellular and molecular biology. Co-advisor. **(Francisco Rivera Advisor). In course (2019)

Iraidi Ramos. ASOCIACION ENTRE LA DIETA PROINFLAMATORIA Y LOS NIVELES DE KLK3 EN PACIENTES CON CANCER DE MAMA: UN ESTUDIO PILOTO DE CASOS Y CONTROLES. Candidate of PhD in Medical Science. In course (2019)

Francisco Olivares. La activación de GPR30/GPER-1 modula los niveles de calicreínas asociadas a peptidasas (KLKs); posible utilidad como biomarcadores en el cáncer de mama estrógeno sensible. Undergraduate Medical technology thesis. 2019

Cinthia Mellado. Productive infection by Herpes Simplex Virus Type 1 alters the levels of KLK6 and its effects neuroinflammatories through the PAR1 and PAR2 receptors in the Central Nervous System. Candidate of PhD in Microbiology. In course.

Teresa Ross. Rol del receptor B1 de cininas en la transición epitelio mesenquima de las celulas de cáncer de mam. Candidate a Master of Science. In course.

Felipe Bustamante. Roles no canónicos de ? -SNAP en la patogenia de desórdenes del desarrollo neural: Actividad AMPK en células madre neurales. Candidate of PhD in Biomedicine. In course.

Beatriz Teuber. " B1R y la activación the uPA/uPAR in breast cancer" Undergraduate Medical Technology thesis. 2017

Erwin Budinich. “Rol of kinin B1 receptor to induces the epithelial-mesenchymal and mesenchymal-epithelial transition in breast cáncer cells”. Master of Sciences. 2016.

Francisca Pavicic. “The activation of kinin B1 receptor induces the secretion and/or expression of VEGF and metalloproteases in tumoral microenvironment cells”. Master of Sciences. 2015.

Francisco Córdova. S-nitrosylation regulates ELAM-1 and the ICAM-1 expression on the endothelial surface in response to IL-8. UACh. Medical Technology. 2016.

Alejandra Aguilar. Mechanisms of regulation of ICAM-1 involved eNOS activation at the onset of the inflammatory response. Doctorate Program in Veterinary Sciences. In course.

Daniela Ruiz Ulloa. “ Mechanism of transactivation of epidermal growth factor receptor (EGFR), use by kinin B1 receptor stimulation in breast cancer cell”. Medical Technology.

Erwin Budinich E. ''Rol of kinin B1 receptor in the epithelial-mesenchymal transition of breast cáncer cells''. Biochemistry. 2013.

Yessica Andrade. “Effect of B1 receptor activation by transactivation of EGFR in the phosphorylation of MAPKs JNK y p38, AKT y mTOR in breast cáncer cells. Medical Technology. 2013.

Carlos Borquez. “ The kinin B1 receptor agonist induces the expression of tisular kallikrein in breast cáncer cells”. Medical Technology. 2012.

Manuel Barría. “Level expression of adhesión molecules, ELAM-1 and PECAM-1 in endothelial cells stimulated with Bradykinin 1 receptor agonist. Medical Technology. 2008.


Premios y Distinciones

  •   ¿Can tumoral cells talk with the endothelial cells?

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2014

    This work was realized by Maribel Muñoz and Abigail Vásquez of " Instituto Superior de Administración y Turismo " (Valdivia) and they studied the effect of conditioned medium from estrogen sensitive breast cancer cell lines in the S-nitrosylation of endothelial proteins; these protein controls the endothelial barrier and the vascular permeability.


 

Article (40)

Antibacterial and cytotoxic evaluation of copper and zinc oxide nanoparticles as a potential disinfectant material of connections in implant provisional abutments: An in-vitro study
Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
Constant-moderate versus high-intensity interval training on heart adiponectin levels in high-fat fed mice: a preventive and treatment approach
Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation
Involvement of Kallikrein-Related Peptidases in Nervous System Disorders
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma.
Role of NO and S-nitrosylation in the Expression of Endothelial Adhesion Proteins That Regulate Leukocyte and Tumor Cell Adhesion
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A3 Adenosine Receptor activation under hypoxia.
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly
Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome.
The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner
Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling
Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling
The Adenosine A(3) Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia
alpha-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility
GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer
Activation of the human keratinocyte B1 bradykinin receptor induces expression and secretion of metalloproteases 2 and 9 by transactivation of epidermal growth factor receptor
The calcium-activated potassium channel KCa3.1 plays a central role in the chemotactic response of mammalian neutrophils
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil
Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B-1 receptor: functional relevance to angiogenesis
Kinin B-1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1
Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin
Bioregulation of Kallikrein-related Peptidases 6, 10 and 11 by the Kinin B-1 Receptor in Breast Cancer Cells
Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria
S-nitrosation of proteins: An emergent regulatory mechanism in microvascular permeability and vascular function
Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma
Activation of kinin B-1 receptor increases the release of metalloproteases-2 and-9 from both estrogen-sensitive and -insensitive breast cancer cells
Kinin B-1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family
Postnatal expression of V-2 vasopressin receptor splice variants in the rat cerebellum
Stimulation of the bradykinin B-1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway
Activation of kinin B(1) receptor triggers differentiation of cultured human keratinocytes
Activation of kinin B-1 receptors induces chemotaxis of human neutrophils
Modulation of renal kallikrein by a high potassium diet in rats with intense proteinuria
Differential distribution of the vasopressin V-2 receptor along the rat nephron during renal ontogeny and maturation
Kinin B2 receptor-coupled signal transduction in human cultured keratinocytes
Effect of mycophenolate mofetil on kallikrein expression in the kidney of 516 nephrectomized rats
Renal kallikrein-kinin system (KK) compromise in a 5/6 renal ablation model modulated by mycophenolate mofetil (MMF).
Temporospatial changes of kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus

Abstract (7)

Analysis of GOLPH3 depletion on protein glycosylation in human glioblastoma multiforme T98G cells
Study of the role of extracellular adenosine on chemoresistance in glioblastoma stem-like cells
Kinins and their receptors, a new autocrine-paracrine signaling pathway that contributes to breast cancer malignancy
Kinin B1 but not B2 receptor agonists induce human neutrophil chemotaxis
Expression of CD40 and the mitogenic peptide hormone receptors vasopressin V1 and kinin B1 and B2 receptors in psoriatic epidermis
Kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus
Characterization and distribution of renal bradykinin and vasopressin receptors

BookReview (1)

Classical kallikreins and kinins in Cancer

Proyecto (24)

Development of nanobodies directed to human kallikrein-related peptidase 4 (KLK4)=> Analysis of its immunomodulatory properties in ovarian cancer
Gestational chronodisruption programs the adult offspring pineal gland in rats altering development of the melatonin circadian rhythm=> assessing the impact of melatonin restoration in adult chronic disease onset.
Rejuvenated Brain Network – ReBrainNet
Rejuvenated Brain Network – ReBrainNet.
Grant Provision Program Innovation Fund for Competitiveness Innovation (Programa Provisión Fondo de Innovación para la Competitividad), Región de los Ríos, Chile. Implementation of a regional strategy for the early detection of breast cancer.
Interdisciplinary Network for Naturopathic Regeneration - Net4NatuRe
Interdisciplinary Network for Naturopathic Regeneration - Net4NatuRe.
Prevención y Diagnóstico precoz del cancer de mama
“Kinin B1 receptor stimulation shifts breast tumor microenvironment cells (endothelial and tumoral) towards a dissemination promoting state”
CANONICAL AND NON-CANONICAL ROLES OF .-SNAP IN THE PATHOGENESIS OF NEURODEVELOPMENTAL DISORDERS=> FOCUS ON MODULATION OF AUTOPHAGY AND AMPK SIGNALING.
Golgi proteome in cancer=> identification of new therapeutic targets
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process
“Golgi proteome in cancer: identification of new therapeutic targets”.
“Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process”
“Regulation of human neutrophil function by the bradykinin B1 receptor”
Regulation of human neutrophil function by the bradykinin B1 receptor”.
Modulation of the malignant behavior of human breast cancer cells by the bradykinin B1 receptor
“Modulation of the malignant behavior of human breast cancer cells by the bradykinin B1 receptor”.
"The kin receptor B1 regulates the invasive ability of cells derived from MCF-7 breast cancer."
“El receptor B1 de cininas regula la capacidad invasiva de las células derivadas de cáncer de mama MCF-7”
“Modulación de la respuesta inflamatoria y antineoplasica del leucocito neutrófilo humano por el receptor B1 de cininas”
“Modulación de la respuesta inflamatoria y antineoplasica del leucocito neutrófilo humano por el receptor B1 de cininas”.
“Role of the kin receptor B1 in the activation of neutrophil leukocyte "
“Canonical and non-canonical roles of α-SNAP in the pathogenesis of neurodevelopmental disorders: focus on modulation of autophagy and AMPK signaling”

Review (3)

Skeletal muscle adiponectin induction in obesity and exercise
S-nitrosylation and its role in breast cancer angiogenesis and metastasis
Kinin receptors as targets for cancer therapy
63
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

20
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

8
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

5
Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

5
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

5
Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

4
Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

3
Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

2
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

2
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

2
José Rocha

Research Assistant

Evolutionary Biology

Centro de investigación i-mar

Puerto Montt, Chile

2
Cesar Toledo

Estudiante de posgrado Doctorado en Ciencias Agropecuarias

Ciencias Agropecuarias y Acuícolas

Universidad Católica de Temuco

Temuco, Chile

2
CAROLINA AÑAZCO

Investigadora

Universidad San Sebastián

Valdivia, Chile

1
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Javier Ojeda

Docente instructor en el INstituto de Ciencias Clínicas Veterinarias.

Universidad Austral de Chile

Valdivia, Chile

1
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Francisco Rivera

Associate Professor / Principal Investigator

institute of Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

1
Sergio Martínez

Academic

Universidad Austral de Chile

Valdivia, Chile

1
Claudio Henríquez

Auxiliar Professor

Farmacology and Morphophysiology

Universidad Austral de Chile

Valdivia, Chile

1
MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Ronald Jara

Docente

Universidad Austral de Chile

valdivia, Chile

1
María Pinto

Nanobodies generation manager of preclinical assays

Medicina

Universidad Austral de Chile

Isla Teja, Valdivia, Chile

1
Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

1
Pedro Chana

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

1
María Paz Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gloria Arriagada

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Ivan Conejeros

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

1
Guillermo Valenzuela

Investigador Posdoctoral

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile