Man

PATRICIA VERÓNICA BURGOS HITSCHFELD

Associate Professor & Sub-Director CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Líneas de Investigación


I study the interplay between endo/lysosomes, autophagy and UPS system and how the unbalance of these processes contribute to disease development.

Educación

  •  Biological Sciences, Cell & Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
  •  BIOQUIMICO, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    2010 - 2017

  •   Associate Professor & SubDirector CEBICEM Full Time

    Universidad San Sebastián

    Medicine & Science

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2010 - 2015

  •   Postdoctoral Fellow Full Time

    Barbara Davis Center for Childhood Diabetes, Universidad de Colorado

    Denver, Estados Unidos

    2003 - 2005

  •   Postdoctoral Fellow Full Time

    National Institutes of Health

    Bethesda, Estados Unidos

    2005 - 2008

  •   Research Fellow Full Time

    National Institutes of Health

    Bethesda, Chile

    2008 - 2010

  •   Associate Professor & Sub-Director CEBICEM Full Time

    Universidad San Sebastián

    Santiago, Chile

    2017 - A la fecha

  •   Associate Professor Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2015 - 2017

Formación de Capital Humano


Co-Advisor PhD Thesis “Effect of a-SNAP M105I mutation on the regulation of authophagy in interneuron progenitor cells” Maxs Méndez, UAndes.
Thesis in progress, advisor Dr. Federico Batiz

Advisor PhD Thesis “Phatogenic role of immunoproteasome in Obesity” Nicolás Albornoz, Universidad San Sebastián.
Thesis in progress

Co-Advisor PhD Thesis “Saturated and polyunsaturated fatty acids regulate the autophagic flux modulating inflammation in hypothalamic astrocytes affecting hypothalamic neurons function” Flavia Cifuentes, PUC.
Thesis in progress, advisor Dra. Eugenia Morselli

Advisor PhD Thesis “Role of the endo-lysosomal pathway in chemoresistance of ovarian cancer cells to cisplatin” Cristobal Cerda, Universidad San Sebastián. Thesis in progress

Advisor PhD Thesis “Role of UBL domain phosphorylation on HERPUD1 during aging” Gabriela Vargas, Universidad San Sebastián.
Thesis in progress

Advisor Undergraduated Thesis (Biochemistry School, USS) “Función de PINK1 en la estabilización de Herpud1 en un modelo de cáncer de mama subtipo triple negativo” Mauricio Adasme, USS, 2020

Advisor Undergraduated Thesis (Biochemistry School, USS) “ERAD/EDEM1 como blanco de terapia viral contra el cáncer de mama triple negativo” Camila Concha, USS, 2020

Advisor Undergraduated Thesis (Medical Technology School, UACh) “Identification of novel modulators of Amyloid Precursor Protein” Susanne Campos, UACh, 2019

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Sensing of ER stress by the preautophagosomal membrane” Omar Cortés, UACh, 2019

Advisor Undergraduated Thesis (Biochemistry School, USS) “Role of HERPUD1 on autophagosomal formation during endoplasmic reticulum stress” Jorge Catalán, USS, 2018

Advisor PhD Thesis “Functional role of the ubiquitinome in the control of the amyloid precursor protein (APP)”, Hianara Bustamante, UACh, 2018

Advisor Master Thesis “Caracterization de la interacción molecular entre la proteína precursora del amiloide y la GTPasa monomerica Rab1A a nivel de retículo endoplásmico: posibles implicancias en macroautofagia” Cristobal Cerda, UACh, 2017

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Identificación de genes del ubiquitinoma como posibles reguladores de la proteína precursora del amiloide en la enfermedad de Alzheimer”, Yorka Cheuquemilla, UACh, 2017
Co-Advisor PhD Thesis “Alteración de la maquinaria ERAD durante infección por Virus Herpes Simplex tipo 1 en células de tipo neuronal”, Marukel Salamin, UACh, 2017
Advisor Dra. Carola Otth

Co-Advisor PhD Thesis “The role of ascorbic acid in the trafficking of the sodium-dependent vitamin C transporter 2 (SVCT2) and the altered neuronal glucose uptake modulation in Hungtington´s disease”, Adriana Covarrubias, UACh, 2016
Advisor Dra. Maite Castro

Advisor PhD Thesis “Functional crosstalk between ERAD and lysosomes: possible implications in cellular plasticity”, Claudia Yefi, UACh, 2016

Advisor PhD Thesis “Beclin-1 and Atg5 Control Amyloid Precursor protein metabolism through differential lysosomal degradative mechanisms”, Alexis González, UACh, 2015

Advisor Undergraduated Thesis (Medical Technology School, UACh) “Función de la degradación de proteínas asociado a retículo endoplásmico en el control de los niveles de la proteína precursora del amiloide” Gustavo Leal, UACh, 2015

Co-Advisor Master Thesis “Characterization of the cytoskeletal-associated protein Arc in the productive infection with Herpes Simplex Virus Type 1” Mariela Muñoz, UACh, 2015
Advisor Dra. Carola Otth

Co-Advisor Master Thesis “Dynamic remodeling of the endosomal system by Herpes Simplex Virus Type 1” Francisca Acuña, UACh, 2015
Advisor Dra. Carola Otth

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Contribution of GSK3? in the amyloid precursor protein metabolism” Rafael Barraza, UACh, 2015

Co-Advisor Undergraduated Thesis (Biochemistry School, UACh) “Role of M105I mutation in ?-SNAP in its interaction with lipid membranes” Cristián Parga, UACh, 2015

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Molecular determinants of Amyloid Precursor Protein degradation through autophagy” Vanessa Muñoz, UACh, 2015

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Role of endoplasmic reticulum and the plasma membrane in the generation of A? peptide” Viviana Cavieres, UACh, 2014

Co-Advisor Undergraduated Thesis (Biochemistry School, UACh) “Structural and functional characterization of tyrosine cargo-binding sites on ?1?-subunit of adaptor protein complex AP-1A”, Breyan Ross, UACh, 2013
Advisor Dr. Gonzalo Mardones

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Biochemical and morphological characterization of the role of ubiquitylation and ESCRT machinery in the degradation of amyloid precursor C-terminal fragment C99 through the endo/lysosomal system” Hianara Bustamante, UACh, 2013

Advisor Undergraduated Thesis (Biochemistry School, UACh) “Biochemical and morphological characterization of amyloid precursor protein through the endo/lysosomal system” Andrés Rivera-Dictter, UACh, 2012


Difusión y Transferencia


Outreach Activities

(2020) La importancia de mantener el cuerpo activo y evitar la obesidad (The importance of keeping the body active avoiding obesity) , Departamento de Ciencias, Colegio Técnico Profesional APRENDER, La Pintana, 12 noviembre

(2020) Podcast La Tercera: Convertirse en Científica (Becoming a Scientist) https://www.latercera.com/podcast/noticia/la-jornada-convertirse-en-cientifica/2257W6OWZ5AVZO4KOS3Z2PDYWE/
https://open.spotify.com/show/3mBKX565WfB3fAspr9cmF9

(2020) Encuentros del Mercurio Low Carb y Salud (Low Carb and Health) https://encuentros.elmercurio.com/low-carb-y-salud/

(2020) Nota del Mercurio Low Carb y Salud (Low Carb and Health) ; Sección Vida- Ciencia-Tecnología https://digital.elmercurio.com/2020/11/04/A/5H3SF23U/0M3SJHAR

(2020) Dieta baja en carbohidratos mejora la salud y puede ayudar a revertir enfermedades derivadas de la obesidad (Low-carbohydrate diet improves health and can help reverse obesity-related diseases), Crónica de Chillán
https://www.litoralpress.cl/sitio/Prensa_Detalles.cshtml?LPKey=viyaf.Moe.Xx.%C3%9C.D1.J.Krhgi.B.A.Z7.L1vs.B.F/.Vun.Sxue.Nkwm2.U.%C3%96

(2020) Dieta baja en carbohidratos mejora la salud y puede ayudar a revertir enfermedades derivadas de la obesidad (Low-carbohydrate diet improves health and can help reverse obesity-related diseases), Crónica de Chillán, El Austral de Los Ríos https://www.litoralpress.cl/sitio/Prensa_Detalles.cshtml?LPKey=vrepbk.Ql.I.P.Fi.Udack.Lb.K3.Qd0li.Z.C.Hac.E.S.Ci7/d.G.G.Hd.Q.%C3%96

(2020) Dieta baja en carbohidratos mejora la salud y puede ayudar a revertir enfermedades derivadas de la obesidad (Low-carbohydrate diet improves health and can help reverse obesity-related diseases) , Crónica de Chillán, El Austral de Osorno https://www.litoralpress.cl/sitio/Prensa_Detalles.cshtml?LPKey=.Ut.I.Bjp.Ku.U.Pu.F.K.Hz.G5.C8.R.Y.T.M.Smctu.N.T.A.K.K.Tt.G.R.Klrjbc.%C3%96

(2020) Temas de Interés USS https://www.uss.cl/blog/dieta-baja-carbohidratos/

(2020) Avanzan investigaciones sobre cómo eliminar la basura celular tóxica (how to eliminate toxic cellular waste), Periódico USS Edición 36, https://www.uss.cl/archivos-mail/wp-content/uploads/2020/09/PERIODICUSS_ONLINE_36.pdf

(2020) Covid-19: Científica que estudia cloroquina advierte de riesgos de uso domestico del fármaco LINK https://www.elmostrador.cl/cultura/2020/04/02/covid-19-cientifica-que-estudia-cloroquina-advierte-de-riesgos-de-uso-domestico-del-farmaco/

(2020) Estudian efectos de la obesidad en la aparición de enfermedades neurodegenerativas LINK https://www.elmostrador.cl/agenda-pais/2020/02/21/estudian-efectos-de-la-obesidad-en-la-aparicion-de-enfermedades-neurodegenerativas/

(2020) Programa Exploradores TVN LINK https://www.24horas.cl/programas/exploradores/exploradores-2020---miercoles-16-de-enero-3861753

(2019) Organizer Symposium Organelle Cell Biology for Latinoamerican connections XXXIII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile Speakers: Alfonso González (CEBICEM, USS), Jorge Cancino (CEBICEM, USS), LuisDaSilva (Sao Paulo University), Matias Ostrowski (Universidad de Buenos Aires), 25-29 noviembre Puerto Varas, Chile https://www.uss.cl/blog/investigadores-cebicem-uss-organizaron-simposio-biologia-celular/

(2018) Organizer Talk at Universidad San Sebastián “Translating Cell Biology” by Franck Perez, Research Director of the Institute Curie, Paris, France August 3, Link https://www.uss.cl/blog/research-meeting-translating-cell-biology/

(2018) Organizer Talk at Universidad San Sebastián, “Autophagy 101: How intermittent fasting could help us age more slowly” by Maho Hamasaki, Graduate School of Medicine, Osaka University, Japan

(2018) Autofagia ayudaría a prevenir patologías como el Alzheimer https://www.elsur.cl/impresa/2018/02/24/full/cuerpo-principal/16/
http://www.carechile.cl/estudio-sobre-autofagia-difunden-el-sur-de-concepcion-y-la-estrella-de-valparaiso/
http://www.carechile.cl/medios-de-prensa-publican-articulo-sobre-autofagia-y-mal-de-alzheimer/

(2018) Exploradores: del átomo al Cosmos; Nuevas estrategias contra el cáncer https://www.youtube.com/watch?v=AGM6hu0HKx0&feature=emb_title

(2018) Súper descubrimiento: las neuronas pueden eliminar la proteina que provoca Alzheimer LINK http://www.lun.com/Pages/NewsDetail.aspx?dt=2018-03-27&PaginaId=4&bodyid=0

(2018) Chilenos investigan reciclaje celular LINK http://www.carechile.cl/estudian-reciclaje-intracelular-para-prevenir-enfermedades-neurodegenerativas/
https://www.estrellavalpo.cl/impresa/2018/03/07/full/edicion-especial/5/

(2017) Investigadora CARE-UC en CEBICEM https://www.youtube.com/watch?v=hOB1glE5qwg&feature=emb_title

(2017) Identifican molécula en la Hierva de San Juan que alarga la vida de neuronas LINK http://www.lun.com/Pages/NewsDetail.aspx?dt=2017-12-07&PaginaId=8&bodyid=0

(2016) Conferencia Inaugural XXII Semana Nacional de la Ciencia y la Tecnología, Región de Los Ríos “Aprendamos a reciclar viajando al interior de la célula”

(2016-2017) Video de experiencia en Explora https://youtu.be/9yX3vIZHWio
“Acercando la biología celular a niñas de Panguipulli”. Trabajo titulado “Efectos del maqui sobre la biogénesis lisosomal en células H4 de neuroglioma humano” publicado en Brotes Científicos, Revista de Investigaciones Escolares. https://xpolanco.cl/descarga/RevistaBrotesCientificos.pdf

(2014) Organizer 4th Cell Biology Summer Course UACh-Instituto Curie, Valdivia 20-25 January, 2014

(2014) Dra. Torrealba destaca trabajo de Hianara Bustamante, investigación premiada por la Fundación Chilena de Biología Celular tutoreada por Dra. Burgos https://www.latercera.com/noticia/lo-mejor-de-la-ciencia-chilena-en-2014/

Meetings

1. Alexis González, Vanessa Muñoz, Viviana Cavieres, Victor Cornejo, Yunan C. Januario, Ibeth González, Claudio Hetz, Luis Da Silva, Alejandro Rojas-Fenandez, Gonzalo A. Mardones and Patricia V. Burgos (2016) Autophasomes regulate degradation of APP intracelular C-terminal fragment b through the endo-lysosomal pathway. Keystone Symposia on Autophagy: Molecular and Physiological Mechanisms, Whisler, British Columbia, Canada.

2. Alexis González, Viviana Cavieres, Ibeth González, Claudia Yefi, Hianara Bustamante, Victor Cornejo, Claudio Hetz, Luis Da Silva, Rojas-Fenandez Alejandro, Gonzalo A. Mardones and Patricia V. Burgos (2015) Autophagy disruption accumulates amiloydogenic carboxy-terminal fragment ? (CTF?): a reinterpretation of the phenotype observed by depletion of TSG101. XXIX Annual Meeting of the Chilean Society for Cell Biology, October 22-29, Puerto Varas, CHILE

3. Claudia Yefi, Alexis González, Viviana Cavieres, José Martina, Rosa Puertollano, Rojas-Fernandez A, Gonzalo A. Mardones and Patricia V. Burgos (2015). Inhibition of ER-associated degradation pathway favors TFEB-dependent lysosomal biogenesis. XXIX Annual Meeting of the Chilean Society for Cell Biology, October 22-29, Puerto Varas, CHILE

4. Hianara Bustamante,Gonzalo A. Mardones and Patricia V. Burgos (2015). Role of N-Glycans in the early turnover and proteolytic processing of Amyloid Precursor Protein (APP). 23RD IUBMB Congress 44th Annual Meeting of SBBQ, Foz De Iguazú,Brasil.

5. Alexis González,Victor H. Cornejo, Claudio Hetz, Alfonso Gonzalez, Gonzalo Mardones and Patricia V. Burgos. (2015). Regulation of the endolysosomal pathway by Beclin-1 and its role in the proteolytic processing of the amyloid precursor protein. 25th International Society Neurochemistry ISN-APSN Joint Biennial Meeting in Cairns, Australia

6. Patricia V. Burgos (2015). Novel insights into the molecular mechanisms that mediated incorporation of the amyloid precursor protein into multivesicular bodies. 40TH FEBS Congress the biochemical Basis of Life, Berlin, Germany
7. Role of TFEB-mediated autophagy in the turnover and proteolytic processing of Amyloid Precursor Protein (APP) (2014) Alexis E. González, Vanessa Muñoz, José Martina, Gonzalo Mardones, Rosa Puertollano and Patricia V. Burgos. EMBO Workshop: Current advances in membrane trafficking: Implications for polarity and diseases, Puerto Natales, Chile

8. Inhibition of ERAD by tetrahydrohyperforin enhances degradation of immature Amyloid Precursor Protein through autophagy. Viviana A. Cavieres, Alexis González, Claudia Yefi, Hianara A. Bustamante, Vanessa C. Muñoz, Juan F. Caster, Marukel E. Salamín, Carola Otth, Carlos B. González, Gonzalo A. Mardones, Nibaldo C. Inestrosa and Patricia V. Burgos. (2014) EMBO Workshop: Current advances in membrane trafficking: Implications for polarity and diseases, Puerto Natales, Chile

9. Claudia Yefi, Alexis González, Viviana Cavieres, Hianara Bustamante, Gonzalo A. Mardones and Patricia V. Burgos. (2014) Endoplasmic reticulum-associated degradation controls the levels of Amyloid Precursor Protein. EMBO Workshop: Current advances in membrane trafficking: Implications for polarity and diseases, Puerto Natales, Chile

10. Cecilia Arriagada, Breyan H. Ross, Viviana Cavieres, Patricia V. Burgos and Gonzalo A. Mardones. (2013) Biochemical and cellular characterization of the Golgi apparatus protein GOLPH3 in human glioblastoma multiforme cells. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

11. Víctor Hugo Cornejo, Claudia Duran, Alexis González, Rafael Barraza, Andrea Paula-Lima, Patricia V. Burgos and Claudio Hetz. (2013) IRE1?/XBP-1 pathway controls APP metabolism and A? aggregation in experimental models of Alzheimer’s disease. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

12. Rafael R. Barraza, Viviana Cavieres, Patricia V. Burgos and Nibaldo C. Inestrosa. (2013) Acute depletion of GSK-3 modulates lysosomal biogenesis leading to a reduction in amyloid precursor protein (APP) levels. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

13. Adriana Covarrubias, Eduardo Papic, Patricia V. Burgos and Maite A. Castro. (2013) Intracellular trafficking of Sodium-dependent Vitamin C Transporter 2-SVCT2 is modulated by increased extracellular ascorbic acid concentration. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

14. Diego A. Acuña, Cecilia Arriagada, Breyan H. Ross, Viviana Cavieres, Patricia V. Burgos, Pamela Ehrenfeld and Gonzalo A. Mardones. (2013) Preliminary analysis of the Golgi apparatus proteome in human breast cancer cells. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

15. Cavieres V, Bustamante H, González A, Ostrowski M, Gonzalo Mardones and Patricia V. Burgos. (2013) Role of TSG101 and Rab27a in the incorporation of the amyloid precursor protein into multivesicular bodies. XXVII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

16. Alexis E. González, Victor H. Cornejo, Claudio Hetz, Gonzalo A. Mardones and Patricia V. Burgos. (2013) Depletion of Beclin-1 reduces the levels of carboxy terminal fragments of the amyloid precursor protein by a mechanism independent of macroautophagy. 53th Annual Meeting of American Society for Cell Biology, December 14-18, New Orleans, Louisiana, USA.

17. L. Bátiz, G. Marquez, G. C. Toro, A. Arcos, Z. D.Velásquez, M. P.Miró, L.Ojeda, C. Parga, C.Muñoz, V.Cavieres, P. V.Burgos, and R. I. Muñoz(2013) Defects in N-cadherin-based adherens junctions of radial glial cells precedes disruption of the ventricular zone in alpha-SNAP mutant mice. Society for Neuroscience, San Diego, CA, USA.

18. Hianara Bustamante, Andrés Rivera-Dictter, Viviana Cavieres, Alexis González, Vanessa Muñoz, Juan S. Bonifacino, Gonzalo A. Mardones and Patricia V. Burgos. (2012) Turnover of beta-amyloid precursor protein is regulated by two mechanisms at the plasma membrane: the ubiquitin-proteasome pathway and incorporation into multivesicular bodies. 10th International Congress on Cell Biology, 16th Meeting of the Brazilian Society for Cell Biology, July 25-28, Rio de Janeiro, BRAZIL. (Oral Presentation)

19. Hianara Bustamante, Andrés Rivera-Dictter, Viviana Cavieres, Alexis González, Vanessa Muñoz, Juan S. Bonifacino, Gonzalo A. Mardones and Patricia V. Burgos. (2012) Turnover of beta-amyloid membrane precursor is regulated by two mechanisms: the ubiquitin-proteasome pathway and incorporation into multivesicular bodies in an ESCRT dependent manner. The EMBO meeting, Setember 22-25, Nice, France

20. Alexis González, Hianara Bustamante, Viviana Cavieres, Vanessa Muñoz, Andrés Rivera-Dictter, Gonzalo A. Mardones and Patricia V. Burgos. (2012) Cellular stress enhances turnover of C99 dependent on proteasomal and lysosomal activities. XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE. (Oral Presentation)

21. Viviana Cavieres, Andrés Rivera-Dictter, Prabbuddha Sengupta, Gonzalo A. Mardones and Patricia V. Burgos. (2012) Controlled heterodimerization of C99 with organelle resident proteins provide information about its intracellular trafficking and location for its proteolytic cleavage by ?-secretase. XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

22. Vanessa Muñoz, Hianara Bustamante, Andrés Rivera-Dictter, Alexis Gonzalez, Viviana Cavieres, Gonzalo A. Mardones and Patricia V. Burgos. (2012) C99 is degraded by autophagy in an ubiquitin-dependent manner. XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

23. Hianara Bustamante, Andrés Rivera-Dictter, Viviana Cavieres, Alexis González, Vanessa Muñoz., Gonzalo A. Mardones and Patricia V. Burgos. (2012) Turnover of C99 requires incorporation into multivesicular bodies mediated by ESCRT machinery but independent of its ubiquitination. XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

24. Cheril Tapia-Rojas, Hianara Bustamante, Patricia V. Burgos and Nibaldo C. Inestrosa. (2012) Andrographolide activates the Wnt pathway and modulates the APP processing possibly by direct inhibiton of GSK3?. XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

25. Rivera-Dictter A., Bustamante H., Muñoz V., Cavieres V., Mardones G.A., Bonifacino J.S., Burgos P.V. (2011) Turnover of amyloid precursor protein carboxy terminal fragment beta (C99) in lysosomal compartments. 51th Annual Meeting of American Society for Cell Biology, Denver, CO, USA.

26. Bustamante H., Rivera-Dictter A., Cavieres V., Muñoz V., Mardones G.A. and Burgos P.V. (2011) Ubiquitin dependent proteasomal degradation of amyloid precursor protein carboxy terminal fragment competes against its cleavage by ?-secretase. XXV Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

27. Rivera-Dictter A., Bustamante H., Muñoz V., Cavieres V., Mardones G.A., Bonifacino J.S.and Burgos P.V. (2011) Turnover of amyloid precursor protein carboxy terminal fragment beta (C99) in lysosomal compartments. XXV Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, CHILE.

28. Mardones G.A., Burgos P.V, Lin Y., and Bonifacino J.S. (2010) Molecular and functional characterization of cargo-binding sites on ?-subunits of adaptor protein complexes. XXIV Annual Meeting of the Chilean Society for Cell Biology, Pucón, Chile

29. Prabhu Y., Burgos P.V., Schindler C., Farias G.G., Magadán J.G., and Bonifacino J.S. (2010) Adaptor Protein-2-mediated Endocytosis of the ?-secretase BACE1 is Dispensable for Amyloid Precursor Protein Processing. 50th Annual Meeting of American Society for Cell Biology, December 11-15, Philadelphia, PA, USA.

30. Burgos P.V, Prabhu Y., Lin Y., Tifft K., Mardones G.A., and Bonifacino J.S. (2010) Turnover of Amyloid Precursor Protein (APP): Lysosomal Degradation vs. Proteolytic Processing. 50th Annual Meeting of American Society for Cell Biology, December 11-15, Philadelphia, PA, USA.

Invited Speaker

1. Mecanismos regulatorios de autofagia en salud y enfermedad, Ciclo de Seminarios Científicos del Departamento de Ciencias Biomédicas de la Facultad de Medicina de la Universidad Católica del Norte, sede Coquimbo, 24 de Noviembre del 2020.
2. Non-cannonical roles of autophagy machinery in the intersection with the endosomal pathway, Departamento de Biologia Celular e Molecular
Centro de Pesquisa em Virologia
Faculdade de Medicina de Ribeirão Preto, Universidad de Sao Paulo, 29 octubre, 2020
3. Autophagy in Healthy & Diseased Brain, Lake Como School of Advanced Studies, Italy October 1-4, 2018 https://ahdb.lakecomoschool.org/
4. “Novel insights into the role of autophagy in organelle-quality control in health and disease” Ciclo de Seminarios Departamento de Biología Celular y Molecular, 5 diciembre, 2018
5. Two stories on the role of autophagy in the function of multivesicular bodies, School of Lie Sciences, Tsinghua Unversity, Beijing 11-21 octubre, 2017
6. Autophagy cooperates in the degradation of key molecular players in Alzheimer’s disease. Sociedad Argentina de Investigación en Bioquímica y Biología Molecular, 13-17 noviembre, 2017
7. Organizer and Speaker Workshop 2017 "1st Austral symposium on Ubiquitin-like proteins and proteostasis", 5-7 enero, Valdivia, Chile
8. Invited Speaker Symposium 2016 “Molecular Basis of Alzheimer´s Disease”, XXXIX Sociedad Bioquímica y Biología Molecular de Chile, 27-30 septiembre, Puerto Varas, Chile
9. Organizer and Speaker Symposium 2016 “Getting in and out the secretory pathway in a synchronized manner”, XXX Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile Speakers: Stephanie Misserey-Lenkei (Curie Institute), Gonzalo Mardones (UACh), Franck Perez (Curie Institute), Patricia Burgos (UACh), 2-6 noviembre Puerto Varas, Chile
10. Speaker Symposium 2016 “Taller de mujeres Científicas” XXX Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile Speakers: Cecilia Hidalgo (UChile), Pilar Parada (BioSigma), Pilar Carvallo (PUC), Patricia Burgos (UACh), 2-6 noviembre Puerto Varas, Chile
11. EMBO workshop "Actualizations in membrane trafficking in health and disease" 4–9 September 2016 in La Serena, Chile. Symposium Autophagy and Lysosomal diseases. Title of the talk: Use of siRNA screening to identify ubiquitin related pathways involved in the turnover of Amyloid Precursor Protein
12. Chair of SYMPOSIUM “Austral Cell Biology” (2015) Annual Meeting of the Chilean Society for Cell Biology, October 25-29, Puerto Varas, CHILE
13. “Proteostasis: ERAD and lysosomal biogenesis. 4th Cell Biology Summer Course UACh-Instituto Curie, Valdivia 20-25 January, 2014
14. “Lysosomes sense early disturbances of the secretory pathway independent of macroautophagy” Symposium: Novel aspects of lysosomes and autophagy: from autophagosome biogenesis to regulation of energy metabolism, protein turnover, and lysosome reformation. Reunión Anual Biología Celular de Chile, Pto. Varas, 2013
15. “Role of THH in APP processing, ERAD and autophagy" Closing Ceremony FONDEF DO7I1052 project. Pontificia Universidad Católica de Chile, 2013
16. “Proteostasis is highly controlled by a crosstalk between ERAD and lysosomal organelles: possible implications in Alzheimer´s Disease Pathogenesis”. Open Seminars in Basic Science. CECS 17-18 April, 2013
17. “Turnover of beta-amyloid membrane precursor is regulated by two mechanisms at the plasma membrane: the ubiquitin-proteasome pathway and incorporation into multivesicular bodies in an ESCRT dependent manner” 10th International Congress on Cell Biology, July 25-28, 2012, Rio de Janeiro, Brazil
18. “Dysfunction of protein degradation pathways in Alzheimer's disease: the case of Amyloid Precursor Protein" Physiology and Biophysics, ICBM, Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, 2011, Santiago, Chile
19. “Turnover of Amyloid Precursor Protein (APP): Lysosomal Degradation vs. Proteolytic Processing”. XXIV annual meeting of the Chilean Society for Cell Biology, 2010, Pucón, Chile
20. “The AP-4 complex mediates sorting and processing of the Alzheimer's Disease amyloid precursor protein”. Laboratoy for Neurodegenerative Disease Research at Ludwig-Maximilians-University, November 11th, 2008, Muenchen, Germany.

21. “The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network” Keystone Symposia in Alzheimer’s Disease, March 24-29, Keystone, 2008 Colorado, USA.

22. “The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network. 47th Annual Meeting of American Society for Cell Biology, December 1-5, 2007 Washington, DC, USA.


Premios y Distinciones

  •   Postdoctoral Visiting Fellow, John E. Fogarty International Center, NIH

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2005

    BECA POSTDOCTORAL PARA EL DESARROLLO DE INVESTIGACIÓN CIENTÏFICA

  •   Postdoctoral Visiting Fellow, Juvenile Diabetes Research Foundation International

    DIABETES INSTITUTES

    Chile, 2004

    BECA OTORGADA PARA EL ESTUDIO DE TRAFICO DE PROTEINAS EN CELULAS BETA-PANCREATICAS


 

Article (36)

Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression
GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation
Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport
Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit
KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner
Ascorbic acid increases SVCT2 localization at the plasma membrane by accelerating its trafficking from early secretory compartments and through the endocytic-recycling pathway
Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling
Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease
Autophagosomes Cooperate in the Degradation of Intracellular C-terminal Fragments of the Amyloid Precursor Protein via the MVB/lysosomal Pathway
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase
c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease
Distinct biochemical pools of Golgi phosphoprotein 3 in the human breast cancer cell lines MCF7 and MDA-MB-231
Inhibition of Wnt Signaling Induces Amyloidogenic Processing of Amyloid Precursor Protein and the Production and Aggregation of Amyloid-b (Ab) 42 Peptides
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4
Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the mu 3A Subunit of the AP-3 Adaptor Complex
Turnover of C99 is Controlled by a Crosstalk between ERAD and Ubiquitin-Independent Lysosomal Degradation in Human Neuroglioma Cells
Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration
Adaptor protein 2-mediated endocytosis of the beta-secretase BACE1 is dispensable for amyloid precursor protein processing
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing
AGAP2 regulates retrograde transport between early endosomes and the TGN
Crystallographic and Functional Analysis of the ESCRT-I/HIV-1 Gag PTAP Interaction
Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes
Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis
Canonical interaction of cyclin G-associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting
The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting
An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin
Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells
Antiribosomal P protein antibodies in Chilean SLE patients: no association with renal disease
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus

Abstract (1)

Interaction of human GOLPH3 with RAB1A and RAB1B: identification of a putative non-canonical effector

BookWhole (1)

New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment?

Note (1)

Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: Potential mechanism for Alzheimer’s disease therapy

Proyecto (17)

Herpes Simplex Virus type 1 infection disturbs ER homeostasis and neuronal proteostasis: a possible link with Alzheimer's Disease pathogenesis
Mechanisms of autophagy in obesity
Proyecto Basal Centro CARE UC
Selective catabolic degradation of endoplasmic reticulum by an Atg5-independent mechanism: identification of molecular players
Characterization of new protein interactions of the Golgi Protein GOLPH3 in Cancer Cell Lines: Identification of new therapeutic targets
Unidad de Cristalizacion de Proteinas
Tracking newly-synthesized APP through the secretory pathway with the RUSH system under normal and cellular stress conditions in neuronal cells
Unidad de Microscopia de fluorescencia para celulas vivas en alta resolucion
Use of siRNA screening to identify ubiquitin-related pathways involved in Alzheimers Disease
Canonical and non-canonical roles of a-SNAP in the pathogenesis of neurodevelopmental disorders: focus on modulation of autophagy and AMPK signaling
Golgi proteome in cancer: identification of new therapeutic targets
Protective degradation of amyloid precursor protein regulated by ER stress, ERAD, and sorting into lysosomes through MVBs and autophagosomes
Wnt Signaling Effects on Synaptic Structure and Function: Its Role in Neuroprotection Against the Amyloid-beta Peptide
''Molecular characterization of a new cargo-binding site on mu-subunits of adaptor protein complexes; implications for protein trafficking and cell physiology
Role of the multivesicular body/lysosomal pathway and ESCRT machinery in the turnover of the amyloid precursor protein; implications for amyloid-beta generation and Alzheimer's disease
Endocytic and recycling pathways in pancreatic b-cell secretory granules
Domain establishment mechanisms of plasma membrane proteins: studies in models of biomedical interest

Review (1)

Exosomes as Novel Regulators of Adult Neurogenic Niches
57
PATRICIA BURGOS

Associate Professor & Sub-Director CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

8
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

5
Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

4
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

3
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Gloria Arriagada

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

2
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2
Hianara Bustamante

Profesor Adjunto Ad-Honorem

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

2
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

2
Carolina Martin

Docente Auxiliar

Sede Puerto Montt

UNIVERSIDAD AUSTRAL DE CHILE

Puerto Montt, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Jorge Cancino

Assistant Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Guillermo Valenzuela

Investigador Posdoctoral

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Karina Cereceda

Investigador post doctoral

Diagnóstico

Fundación Arturo López Pérez

Providencia, Chile

1
Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
MARIO CALVO

Director de Instituto

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Paulina Troncoso

Inserción PhD

Investigación y Desarrollo

Neurognos SpA

Santiago, Chile