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Omar Hugo Porras Espinoza

Assistant professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Our research area in focused on cellular physiology connecting redox and metabolic homeostasis in cellular models for intestinal epithelial barriers. Currently we are working with digested and fermented food as diet input to determine functionality

Educación

  •  Doctor en Cs. Biomédicas, Universidad de Chile. Chile, 2006
  •  Bioquímico, Universidad de Chile. Chile, 2000

Experiencia Académica

  •   Profesor Asistente Full Time

    Universidad de Chile

    Instituto de Nutrición y Tecnología de los Alimentos

    Santiago, Chile

    2011 - A la fecha

Experiencia Profesional

  •   Postdoc Other

    Universidad de Chile

    Chile

    2008 - 2010

  •   Postdoc Full Time

    Karolinska Institutet

    Estocolmo, Suecia

    2006 - 2008

Formación de Capital Humano


Juan Pablo Benitez: Master Student in medical and biological sciences. 2015.
Helen Hernandez: Engineer in Biotechnology. 2015
Camila Donoso: Master in Nutrition and Food minor in Human Nutrition. Ready to finish by 2017
Ailynne Sepúlveda, Miltha Hidalgo and Vania Rodríguez, two master students in Nutrition and Food minor in Human Nutrition are completing the graduation process ( first semester 2019)

Currently, we have one MsC Student(Yarella Pizarro) and Two PhD Students (Miltha Hidalgo and Christine Kriendl)

Christian Sagredo, Daniela Rivas, Kurt Pohlhammer, Jorge Meza, Benjamin Armijo, Francisca Chávez, Guillermo Lagos, Jaime Acevedo, José Coronado and Mará Paz Hernández have been trained at my lab in techniques such as cellular culture and imaging recording in living cells. This academic activity is a pre-requirement to obtain their final degree in Biotechnology Engineering


Difusión y Transferencia


Since 2015, I have been in charge of outreach of the scientific meeting "ION IN THE VALLEY", which takes place in Paihuano, IV región, Chile. Our activivities have consisted in talks to students from local and public school from the zone. Currently, We are moving to integrate our initiatives with the comunity towards the creation of pedagogic enviroment designed to enrich the understanding of its local reality.

2018-2019 We have extended our collaborative connections with the Instituto Forestal located at Coyhaique, an extreme southern region of Chile and also with the Tarápaca University at the northern extrem of our country. We expect to shape a network for research the patrimonial/ancestral foods from patagonia to altiplanic environments and give scientific supported nutritional value to the communities that keep these living cultural items.


Premios y Distinciones

  •   Beca Doctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2004

    I received the conicyt fellowship between 2004-2006.

  •   Third place for best scientific poster

    KAROLINSKA INSTITUTE

    Chile, 2008

    During my postdoc at KI, I was honored in a scientific meeting, in which a evaluating comitee decided that my poster was one of the best


 

Article (22)

Epicatechin and quercetin exhibit in vitro antioxidant effect, improve biochemical parameters related to metabolic syndrome, and decrease cellular genotoxicity in humans
Sucralose Stimulates Mitochondrial Bioenergetics in Caco-2 Cells
Biological Redox Impact of Tocopherol Isomers Is Mediated by Fast Cytosolic Calcium Increases in Living Caco-2 Cells
Human umbilical artery endothelial cells from Large-for-Gestational-Age newborn have increased antioxidant efficiency and gene expression
Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity
Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells
Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors
Real-Time H2O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women
Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease.
Glutamate-induced metabolic changes influence the cytoplasmic redox state of hippocampal neurons
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death
Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients.
Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons.
Na+-Ca2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured Astrocytes
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis
ATP steal between cation pumps: A mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
Why glucose transport in the brain matters for PET
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy
Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells
Cytosolic [Ca2+] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells

Abstract (4)

Impact of Caffeic Acid and Quercetin on the Antioxidant Machinery Expression on Caco-2 Cells is Consistent with Changes in the Cytoplasmic Disulfide Transmission Capacity
Antioxidant and Anti-Inflammatory Effects of Dietary Polyphenols on a Cellular Model for Intestinal Epithelia
Foxo1 subcellular dynamic and its impact on redox homeostasis in endothelial cells
MATERNAL OBESITY IS ASSOCIATED WITH AN ALTERED ANTIOXIDANT SYSTEM IN THE UMBILICAL ARTERY ENDOTHELIUM: NEW INSIGHTS INTO VASCULAR FETAL PROGRAMMING BY MATERNAL OBESITY?

ConferenceProceedingWhole (2)

IMPLEMENTACIÓN DE UN ARREGLO DE CÉLULAS CACO-2 PARA EVALUAR LAS PROPIEDADES INMUNOMODULADORAS DE COMPUESTOS NUTRICIONALES
“¿Cuál es el impacto de la digestión sobre la bioactividad de los compuestos dietarios?

Proyecto (18)

Transfering and starting of Redoxcell technology, a platform to evaluate the redox impact of food matrices
Development of a core facility for the analysis of foods by incorporating physiological phenomena, such as digestion and fermentation, with Twinshime technology
Center for Advanced Research in Foods for Healthiness in life cycle (ABCVital)
Redoxcell: a platform for evaluating the antioxidant impact in living cells
Redoxcell=> una plataforma para el registro del impacto antioxidante en células vivas
Use of cells expressing a redox biosensor for evaluating the antioxidant capacity of molecules of nutritional and therapeutic interest
USO DE CÉLULAS QUE EXPRESAN UN BIOSENSOR REDOX PARA EVALUAR LA CAPACIDAD ANTIOXIDANTE DE MOLÉCULAS DE INTERÉS NUTRICIONAL Y TERAPÉUTICO
FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN
Functional alterations in IGF-1, BMP-2 and WNT signaling are distinctive of mesenchymal stem cells (MSCs) from the bone marrow of osteoporotic women
FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN
STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS
STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS
STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS.
STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS.
Study of the coupling mechanisms between neuronal activity and cellular metabolism in neurons performing coding under physiological and Alzheimer´s conditions
Patogenia de la muerte necrótica en células hepáticas=> disección de mecanismos moleculares
Mecanismos moleculares de la activación de GLUT1 por hipoxia.
Study of the regulatory axis XBP-1/FoXO1 in the redox homeostasis of endothelial cells and its repercussions on the net bioavailability of nitric oxide under physiopathological conditions

Review (2)

Revisiting the physiological benefits of legume consumption
A quantitative overview of glucose dynamics in the gliovascular unit
43
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

10
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

4
Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

2
Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Patricio Smith

Associate Professor

Medicine / Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

2
ivo carrasco

encargado investigación

Universidad de Valparaíso

Valparaíso, Chile

2
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Christine Kreindl

Instructor

Ciencias de salud

Universidad Autónoma de Chile

Santiago, Chile

1
Camila Donoso

Tesista Doctorado Nutrición y Alimentos

Laboratorio de Investigación en Nutrición y Actividad Física

Instituto de Nutrición y Tecnología de Alimentos

Santiago, Chile

1
Andrea del Campo

Profesor Asistente, Investigador Principal

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Becerra

Coordinador Academico

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
JUAN RODRIGUEZ

FULL PROFESSOR

LABORATORY OF CELL BIOLOGY

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

1
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Carlos Jara

Jefe de Laboratorio - Estrés Oxidativo

Universidad de Valparaíso

Reñaca, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile