Man

Roberto Francisco Bravo Sagua

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Líneas de Investigación


Communication between the endoplasmic reticulum and mitocondria in the regulation of energy metabolism during cell senescence

Educación

  •  Master in Biochemical Toxicology & Molecular Diagnosis, UNIVERSIDAD DE CHILE. Chile, 2009
  •  PhD in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Bachelor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2006

Experiencia Académica

  •   Physiopathology Teacher Part Time

    UNIVERSIDAD ANDRES BELLO

    Santiago, Chile

    2015 - 2015

  •   Biology Teacher Part Time

    UNIVERSIDAD DE CIENCIAS DE LA INFORMATICA UCINF

    Faculty of Health Sciences

    Santiago, Chile

    2012 - 2012

  •   Teaching Assistant of Integrated Physiological and Pathological Chemistry Part Time

    UNIVERSIDAD DE CHILE

    Faculty of Chemical and Pharmaceutical Sciences

    Santiago, Chile

    2007 - 2009

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Institute of Nutrition and Food Technology (INTA)

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Asistente de Investigación Full Time

    Universidad de Chile

    Santiago, Chile

    2014 - 2015

  •   Asistente de Investigación Full Time

    Universidad de Chile

    Santiago, Chile

    2009 - 2010

  •   Investigador Postdoctoral Full Time

    Universidad de Chile

    Santiago, Chile

    2015 - 2017

  •   Tesista de Doctorado Full Time

    Universidad de Chile

    Santiago, Chile

    2011 - 2015

  •   Tesista de Magíster Full Time

    Universidad de Chile

    Santiago, Chile

    2008 - 2009

Formación de Capital Humano


PhD thesis director

2018 – present
Student: Lautaro Rigoberto Nabi Briones Suárez.
Thesis: “Pro-senescence communication between adipose and hepatic cells: role of the Calcium-sensing receptor”.
PhD in Nutrition and Food.
Co-director with Dr. Mariana Cifuentes Koster.
Institute of Nutrition and Food Technology (INTA), University of Chile.

Master's degree thesis director

2019 – present
Student: Pamela Romané Pino Seguel.
Tesis: “Effect of sucralose intake on mitochondrial function in a high-fat diet-induced liver steatosis model”.
Master's degree in Nutrition and Food, major in Human Nutrition.
Co-director with Dr. Rodrigo Troncoso Cotal.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2019 – present
Student: Omara Ghislaine Moya Galaz.
Tesis: “Sucralose as a disruptor of liver insulin sensitivity”.
Master's degree in Nutrition and Food, major in Human Nutrition.
Co-director with Dr. Rodrigo Troncoso Cotal.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2018 – 2020
Student: Luisa Amanda Ramírez Acuña.
Thesis: “Effect of calafate (Berberis microphylla) extract administration on energy expenditure, and mitochondrial function and dynamics of brown adipose tissue of obese mice”.
Master's degree in Nutrition and Food, major in Human Nutrition.
Co-director with Dr. Diego García Díaz.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2018 – 2019
Student: Juan Carlos Bórquez Pérez.
Thesis: “Sucralose effect on mitochondrial oxidative function in the human enterocyte cell line Caco-2”.
Master's degree in Nutrition and Food, major in Human Nutrition.
Co-director with Dr. Rodrigo Troncoso Cotal.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2017 – 2019
Student: Sofía Amaranta Sanhueza Gatica.
Thesis: “Effect of Calcium-sensing receptor activation on insulin signaling and mitochondrial morphology and function in human adipose cells”.
Master's degree in Nutrition and Food, major in Human Nutrition.
Co-director with Dr. Mariana Cifuentes Koster.
Institute of Nutrition and Food Technology (INTA), University of Chile.


Difusión y Transferencia


Talks in research centers

2018
Endoplasmic reticulum-mitochondria communication: from the molecules to the pathology.
Seminar of the Department of Cellular & Molecular Biology. June 20.
Faculty of Biological Sciences, Pontifical Catholic University of Chile.

2018
Endoplasmic reticulum-mitochondria communication: from the molecules to the pathology.
Seminar of the Department of Biochemistry and Molecular Biology. April 26.
Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2017
Mitochondrial metabolism in the adipose tissue: a new pathway of the Calcium-sensing receptor?
Scientific meeting. July 26.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2017
Metabolic regulation through the endoplasmic reticulum-mitochondria axis: from the cell to the pathology.
Seminar. April 6.
Advanced Center for Chronic Diseases (ACCDiS), University of Chile & Pontifical Catholic University of Chile.

2016
Calcium-sensing receptor and its effect on inflammation and adipogenesis in visceral preadipocytes: role of mitochondria.
Scientific meeting. January 20.
Institute of Nutrition and Food Technology (INTA), University of Chile.

2015
Caveolin-1 and Protein kinase A regulate ER-mitochondria communication during ER stress.
2nd ACCDiS Meeting. March 5.
Advanced Center for Chronic Diseases (ACCDiS), University of Chile & Pontifical Catholic University of Chile.

2014
Caveolin-1 impairs PKA signaling required for ER-mitochondria contact formation during the early stage of ER stress.
Nemesis Ring Annual Meeting. December 19.
Advanced Center for Chronic Diseases (ACCDiS) & Center of Molecular Studies of the Cell (CEMC), Faculty of Chemical and Pharmaceutical Sciences & Faculty de Medicine, University of Chile.

2011
ER-mitochondria coupling during early ER stress.
CEMC Annual Meeting. March 21.
Center of Molecular Studies of the Cell (CEMC), Faculty of Chemical and Pharmaceutical Sciences & Faculty de Medicine, University of Chile.

Outreach articles

2019
The fable of the ant and the grasshopper: The road to a healthy aging.
Magazine: Nutrición y vida.
Date: January 14.
Institute of Nutrition and Food Technology (INTA), University of Chile.

Activities for high school students

2018
Journeys of scientific initiation on chronic diseases for high school students from public schools.
Participation: Jury of student's projects and speaker in the closing ceremony, talk "Factors that determine a healthy aging".
Date: November 9.
Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile y Ministry of Environment, Chile.

2016
Scientific initiation for high school students from public schools from Independencia Municipality focused on cardiovascular diseases and cancer.
Participation: research project supervisor.
Duration: 4 sessions (2 h each).
Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2014
Portable laboratories of Biochemistry and molecular biology.
Participation: laboratory instructor.
Duration: 3 sessions (3 h each).
Allende-Connelly Foundation, University of Chile.

2011
Open Laboratories.
Participation: presenter.
Date: October 3.
Center of Molecular Studies of the Cell (CEMC), Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
National Week of Sciences and Technology.
National Commission for Scientific and Technological Research (CONICYT), Chile.

Activities for the general community

2020
Talks Explore at Home.
Participation: speaker, talk "How and why do we age?".
Duration: 1 h.
Audience: 6.147 viewers.
Date: May 8.
PAR Explora RM Norte, EXPLORA Program, CONICYT.

2018
Workshops on healthy eating.
Participation: speaker, talk "Junk food and health: how does fat affect aging and quality of life?"
Duration: 1 h.
Audience: 10 people.
Date: November 20.
Becarius (network of former US fellows) & Instituto Chileno Norteamericano.

Press releases

2019
“Planetary diet: the healthy and sustainable formula to feed the entire population”.
Interview on nutrition.
Date: December.
Diario Financiero.

2018
"Awards for the University Scientific Research".
Press note for the ceremony of the Santander - El Mercurio University Scientific Research Award.
Date: December22.
Page A18, Social life, El Mercurio.

2018
"Researching for a better quality of life during aging drives local investigators".
Press note for the Santander - El Mercurio University Scientific Research Award.
Date: December19.
Page A11, Life Science Technology, El Mercurio.

TV appearances
2019
“El país bajo en azúcar” / “The low-sugar country”.
TV show, reportage/documentary.
Date: November 26.
Executive producer: Atresmedia.
Channel: La Sexta, Spain.


Premios y Distinciones

  •   Best work in Basic Science

    SOCIEDAD CHILENA DE CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR

    Chile, 2016

    “Trimetazidina previene la disfuncion mitocondrial inducida por hipoxia en las celulas del musculo liso arterial pulmonar". Lavandero S, Parra V, Bravo-Sagua R, Verdejo HE, Chiong M, Castro PF.

  •   Hermann Niemeyer Medal

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2012

    Medal of Academic Excellence to graduate students in Chile, in biological sciences

  •   Highest Score in the Academic Aptitude Test (PAA)

    CONSEJO DE RECTORES DE LAS UNIVERSIDADES CHILENAS

    Chile, 2003

    Distinction for obtaining the highest score in the Mathematics part of the national university selection test

  •   Young Scientist of the South Cone

    Sociedade Brasileira de Bioquimica e Biologia Molecular

    Brasil, 2017

    To attend to the SBBq Annual Meeting, for young scientists of the south cone

  •   Young Scientist Program Fellowship

    International Union for Biochemistry and Molecular Biology & Sociedade Brasileira de Bioqui?mica e Biologia Molecular

    Brasil, 2015

    To attend to the satellite meeting of SBBq, for young scientists

  •   Abroad events scholarship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2014

    To attend to an international meeting, for PhD students of Chile

  •   Abroad PhD internships scholarship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2013

    To carry out an international internship, for PhD students of Chile

  •   PhD thesis support scholarship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2012

    To carry out a PhD thesis, for PhD students of Chile

  •   National events scholarship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2011

    To attend to a national meeting, for PhD students of Chile

  •   PhD scholarship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2010

    To carry out PhD studies, for PhD students of Chile

  •   Andrés Bello excellence scholarship

    UNIVERSIDAD DE CHILE

    Chile, 2003

    To carry out undergraduate studies, for students that obtained the highest score in the Mathematics part of the national university selection test

  •   Iberoamérica Santander University Research Scholarship

    Banco Santander

    Chile, 2018

    To visit a research center in Ibero-America, for young academics

  •   MitoEAGLE Scholarship

    European Cooperation in Science and Technology (COST)

    Bélgica, 2019

    To attend the MiP/MitoEAGLE Training School in Coimbra, Portugal, for young investigators

  •   University Scientific Research Award. 6th version: "Aging of the Chilean Population".

    DIARIO EL MERCURIO

    Chile, 2019

    First place, Category: Young Researcher. Award to medical non-clinical investigations in public health, focused on promotion, prevention and intervention in health


 

Article (20)

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress
Calcium transport and signaling in mitochondria
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells
Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology
Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling
Regulation of cardiomyocyte autophagy by calcium
Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis
Herp depletion protects from protein aggregation by up-regulating autophagy
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling

Review (7)

Enfermedades cardiovasculares y cáncer: ¿dos entidades mutuamente relacionadas?
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
ER-to-mitochondria miscommunication and metabolic diseases
Tumor Suppression and Promotion by Autophagy
Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration
Anabolic androgenic steroids and intracellular calcium signaling: A mini review on mechanisms and physiological implications
Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure

Proyecto (6)

Asociación entre el metabolismo energético celular y la calidad del envejecimiento en adultos mayores
Efecto de la sucralosa sobre el metabolismo hepático en ratones alimentados con dieta alta en grasa
RECEPTOR SENSOR DE CALCIO Y SUS EFECTOS SOBRE INFLAMACIÓN Y ADIPOGÉNESIS EN PREADIPOCITOS VISCERALES=> PAPEL DE LA MITOCONDRIA
EVALUATION OF RIGHT VENTRICULAR FUNCTION, VENTRICULAR REMODELING AND MICRO RNA PROFILING IN PATIENTS WITH PULMONARY ARTERY HYPERTENSION=> EFFECTS OF A FATTY ACID OXIDATION INHIBITOR
THE PROGNOSTIC ROLE OF LEFT ATRIAL AND VENTRICULAR FUNCTION AND ITS CORRELATION WITH MULTIPLE BIOMARKERS IN PATIENTS WITH NEW ATRIAL FIBRILLATION
RESISTENCIA A INSULINA EN LA DIABETES TIPO II=> ESTUDIO DE NUEVOS MECANISMOS FISIOPATOLOGICOS ASOCIADOS AL DETERIORO DE LA FUNCION CARDIACA

Article (4)

Autophagy and oxidative stress in non-communicable diseases=> A matter of the inflammatory state?
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an ATR and Akt-dependent mechanism.
Organelle communication=> signaling crossroads between homeostasis and disease.

BookWhole (2)

Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator

Comentario (1)

Polimorfismo Pro 72Arg del gen TP53 y enfermedad coronaria

Generic (1)

Science and Health Policies to Tackle Chronic Diseases in Chile
31
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

20
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

14
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

8
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

5
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

5
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

4
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

3
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

3
Andrea del Campo

Profesor Asistente, Investigador Principal

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Mario Bustamante

Docente

Universidad Mayor de Chile

Santiago, Chile

1
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
ramiro zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

1
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile