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Diego Fernando Garcia Diaz

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Obesity, inflammation, Thermogenesis, Polyphenols, Native species, Nutrigenomics

Educación

  •  Molecular biotechnology engineering, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Molecular biotechnology engineering, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Nutrition and Metabolism, Universidad de Navarra. España, 2006
  •  Physiology and Food Science, Universidad de Navarra. Chile, 2010
  •  Business and Administration, UNIVERSIDAD DEL DESARROLLO. Chile, 2018

Experiencia Académica

  •   Assitant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2010 - 2017

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2017 - A la fecha

  •   Director de Departamento Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile/Department of Nutrition

    Santiago, Chile

    2010 - 2017

  •   Associate Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2017 - A la fecha

  •   Director de Departamento Full Time

    Universidad de Chile / Departamento de Nutricion

    Santiago, Chile

    2021 - A la fecha

Formación de Capital Humano


Director of project “Estudio de la suplementación con extracto de cáscara de granada o micropartículas de extracto de cáscara de granada (Punica granatum var. Wonderful) sobre la termogénesis en un modelo de ratón con obesidad inducida por dieta alta en grasa” for Nutrition and Foods PhD degree, University of Chile (Francisca Echeverria, 2019 – 2021)

Director of project “Efecto de un tratamiento in vivo con extracto de Berberis microphylla en el gasto energético, biogénesis y dinámica mitocondrial en tejido adiposo pardo” for Master in Human Nutrition degree, INTA-University of Chile (Amanda Ramirez, 2017 – 2020)

Co-Director of project: “Queratosis Actínica, Hidroperóxidos Plasmáticos y Alimentación” for Master in Biological Sciences, Nutrition mention degree, University of Chile (Paula Klein, 2015 – 2017)

Co-director of project: “Efecto de la quercetina sobre la expresión génica relacionada con el metabolismo energético en diferentes tejidos de ratas alimentadas con una dieta hipercolesterolemica” for Veterinary degree, University of Chile (Nicole de la Jara Bravo, 2015 – 2016).

Director of project: “Evaluación del efecto de calafate (berberis microphylla) sobre modelos in vivo e in vitro de resistencia a insulina inducida por obesidad” for Biotechnology PhD degree, Pontifica Universidad Catolica de Valparaiso (Jessica Soto Covasich, 2014 – 2017)

Director of project: “Estudio del efecto de extractos de Quillaja saponaria sobre el perfil metabólico, inflamación e insulino-resistencia en un modelo de obesidad in vivo” for Biochemist degree, University of Chile (Claudia Parra Ruiz, 2014 – 2016)

Co-director of project: “Expresión de microRNA-22 y microRNA-150 en células mononucleares periféricas de pacientes con Diabetes Mellitus Tipo 1 y su relación con la autoinmunidad y características clínicas de la enfermedad” for Master in Genetics degree, University of Chile (Santiago Estrella, 2014 - 2015)

Director of project: “Estudio de los potenciales efectos anti-inflamatorios de extractos de Maqui y Calafate en un modelo in vitro de inflamación ligada a obesidad” for Master in Biochemistry and Biochemist degrees, University of Chile (Marjorie Reyes Farias, 2013 - 2015)

Co-director of project: “Expresión de miRNAS en Pacientes con Diabetes Tipo 1: Posible Asociación con Autoinmunidad e Inflamación” for Master in Biological Sciences degree, University of Chile (Carolina Pizarro Acevedo, 2012 - 2015)

Co-Director of project: “Metilación de sitios CpG en el promotor del gen del factor de necrosis tumoral alfa (TNF-?) y su correlación con niveles circulantes de TNF-?, homocisteína y folatos en pacientes con diabetes mellitus tipo 1” for Master in Nutrition and Foods degree, University of Chile (Viviana Arroyo Jossue, 2014 - 2015)

Director of project: “Extractos de Maqui y Calafate inhiben mecanismos inflamatorios característicos del desarrollo de obesidad, en un modelo in vitro de adipocitos y macrófagos humanos” for Biochemist degree, University of Chile (Angelica Ovalle Marin, 2013 – 2015)

Co-director of project: “Polimorfismos de los ligandos de PDCD1: Posibles haplotipos asociados a DM1 y niveles séricos de PDL1 y PDL2” for Molecular Biotechnology Engineering degree, University of Chile (Carolina Pizarro Acevedo, 2010 - 2011)


Difusión y Transferencia


He realizado consistentemente actividades de difusion por distintos canales: prensa (escrita, radio, tv), en congresos relacionados a mi linea de investigacion, a traves de ventas de servicios, cursos, charlas en municipios, formando parte de sociedades cientificas, asi como tambien charlas en colegios a traves del Programa Explora


Premios y Distinciones

  •   Best translational work

    SOCHED

    Chile, 2013

    Best translational work at the XXIV Chilean Society of Endocrinology and Diabetes Congress: “Extractos de frutos nativos Chilenos, Maqui y Calafate, inhiben la expresión génica de marcadores de inflamación en adipocitos en un modelo in vitro de inflamación ligada a obesidad”, Reyes-Farias et al (November 2013)

  •   Inter American Network of Academies of Sciences Fellowship

    IANAS

    Chile, 2011

    Granted by the Inter American Network of Academies of Sciences Fellowship for conducting a short-term research stay in USA (IANAS, USA, 2011)

  •   Best research project

    Universidad de Navarra

    España, 2007

    Best research project, Master of Nutrition and Metabolism (University of Navarra, Spain, 2007)

  •   3rd Place, Best Entrepreneurship Projects

    UNIVERSIDAD DEL DESARROLLO

    Chile, 2019

    Invited to the “Demo Day” as one of the Best Entrepreneurship Projects among all versions of the MBA Program 2017-2018; 3rd Place (UDD, Jan 2019)

  •   Early Career Travel Grant

    IUNS

    Argentina, 2017

    Early Career Travel Grant to the IUNS 21st International Congress of Nutrition: “A Polyphenol-rich calafate extract reverts insulin resistance in mice fed with cafeteria diet” (Fundacion Iberoamericana de Nutricion, May 2017)

  •   IUNS Award

    IUNS

    Rep. Dominicana, 2015

    IUNS Award to one of the 5 top oral communications presented by students at the XVII Latin American Congress of Nutrition: “Folatos, homocisteina y estatus de metilacion del gen del factor de necrosis tumoral alfa en Chile”, Arroyo-Jousse et al (November 2015)

  •   Beca Doctoral Asociacion de Amigos de la Universidad de Navarra

    UNIVERSIDAD DE NAVARRA

    España, 2006

    Granted by the “Asociacion de Amigos de la Universidad de Navarra” for conducting doctoral studies (Spain, 2006-2008)

  •   Beca Magister Funcionario Publico

    Agencia Nacional de Investigacion y Desarrollo

    Chile, 2017

    Becas de Magister en Chile para Funcionarios/as del Sector Publico for conducting MBA studies at the Universidad del Desarrollo (CONICYT, May 2017)

  •   Best e-poster at the 2021 SOCHITAL Congress

    SOCIEDAD CHILENA DE TECNOLOGIA DE ALIMENTOS

    Chile, 2021

    Best e-poster at the 2021 SOCHITAL Congress: “El efecto antiobesogénico de un extracto de Berberis microphylla (calafate) en ratones alimentados con dieta alta en grasas es dependiente de la microbiota intestinal”, Duarte et al (November 2021)


 

Article (50)

Beneficial Effects of Bioactive Compounds Obtained from Agro-Industrial By-Products on Obesity and Metabolic Syndrome Components
Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress
n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity: Potential relationship with gut microbiota
Advances in Polyphenol Research from Chile: A Literature Review
Consumption of a calafate (Berberis microphylla) extract of modifies markers of immune response in lean and obese mice
Microencapsulated pomegranate peel extract induces mitochondrial complex IV activity and prevents mitochondrial cristae alteration in brown adipose tissue in mice fed on a high-fat diet
Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review
The administration of an extract from Berberis microphylla stimulates energy expenditure, thermogenesis and mitochondrial dynamics in mice brown adipose tissue
The treatment with an extract from Calafate (Berberis microphylla) induces transcript and protein expression of molecules involved in thermogenesis and adipocyte browning in adipose tissue from obese mice
Zinc Supplementation and Strength Exercise in Rats with Type 2 Diabetes: Akt and PTP1B Phosphorylation in Nonalcoholic Fatty Liver
A polyphenol-rich Calafate (Berberis microphylla) extract rescues glucose tolerance in mice fed with cafeteria diet
Body fat composition and miR-378 expression profiling in patients with type 1 diabetes
Maqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages
Overnutrition in Infants Is Associated With High Level of Leptin, Viral Coinfection and Increased Severity of Respiratory Infections: A Cross-Sectional Study
[High intensity interval training in teenagers].
Nutritional and non-nutritional agents that stimulate white adipose tissue browning
Expression of miR-155, miR-146a, and miR-326 in T1D patients from Chile: relationship with autoimmunity and inflammatory markers
miR15a and miR16 in Chilean type 1 diabetes patients: possible association with apoptosis, inflammatory, or autoimmunity markers
Chemically induced hypoxia promotes differential outcomes over preadipocyte- or adipocyte-macrophage communication
[Expression of miR-22 and miR-150 in type 1 diabetes mellitus: Possible relationship with autoimmunity and clinical characteristics].
Epigenetics in type 1 diabetes: TNFa gene promoter methylation status in Chilean patients with type 1 diabetes mellitus.
Extracts of Chilean native fruits inhibit oxidative stress, inflammation and insulin-resistance linked to the pathogenic interaction between adipocytes and macrophages
The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic beta-cells, glycemic control and inflammation: In vitro and in vivo studies.
[Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients].
Anthocyanins from Fermented Berry Beverages Inhibit Inflammation-Related Adiposity Response In Vitro
Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages
Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients
NUTRITIONAL STATUS AND BIOCHEMICAL MARKERS OF DEFICIENCY OR EXCESS OF MICRONUTRIENTS IN 4 TO 14 YEAR-OLD CHILEAN CHILDREN: A CRITICAL REVIEW
PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile
Vitamin C in the treatment and/or prevention of obesity
Vitamin C in the treatment and/or prevention of obesity.
Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes
Fat intake leads to differential response of rat adipocytes to glucose, insulin and ascorbic acid
Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats
Regulation by chronic-mild stress of glucocorticoids, monocyte chemoattractant protein-1 and adiposity in rats fed on a high-fat diet
Regulation by chronic-mild stress of glucocorticoids, monocyte chemoattractant protein-1 and adiposity in rats fed on a high-fat diet.
Vitamin C modulates the interaction between adipocytes and macrophages
Obesity induced by a pair-fed high fat sucrose diet=> methylation and expression pattern of genes related to energy homeostasis.
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes
Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters
Weight gain induced by an isocaloric pair-fed high fat diet=> A nutriepigenetic study on FASN and NDUFB6 gene promoters
Ascorbic acid oral treatment modifies lipolytic response and behavioural activity but not glucocorticoid metabolism in cafeteria diet-fed rats
Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes
High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats
Influence of dietary macronutrient composition on adiposity and cellularity of different fat depots in Wistar rats
Association between Fok I vitamin D receptor (VDR)gene polymorphism and plasmatic concentrations of transforming growth factor-beta(1) and interferon gamma in type 1 diabetes mellitus
Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers
Chronic mild stress induces variations in locomotive behavior and metabolic rates in high fat fed rats
VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile
Type 1 diabetes mellitus incidence in Santiago, Chile. Analysis by counties in the period 2000-2004

BookWhole (1)

Role of Saturated and Polyunsaturated Fat in Obesity-Related Inflammation

EditorialMaterial (1)

Molecular Basis of the Inflammation Related to Obesity

Proyecto (28)

Efeito do extrato de café verde (Coffea canephora) nas alterações locais e sistêmicas em modelo animal de carcinogênese colorretal
Red iberoamericana de investigación por la revalorización y validación biológica de materias primas y residuos agroindustriales para el desarrollo de ingredientes funcionales
Busqueda de productos de la metabolizacion de los polifenoles del fruto del Calafate (Berberis microphylla) con propiedades termogenicas sobre adipocitos in vitro
Jelly gums funcionales desarrollados a partir de extractos de berries nativos y residuos agroindustriales
Malnutricion por exceso como factor de riesgo en el curso clínico de la infección respiratoria por SARS-CoV-2 en niños y adolescentes
Microparticulas de extracto de cascara de granada en la prevención de esteatosis hepática y estrés oxidativo en ratones con obesidad inducida por dieta alta en grasa
Detección de sustancias dopantes en suplementos nutricionales que se comercializan en Chile
Detección de sustancias dopantes en suplementos nutricionales que se comercializan en Chile
Estudio de las propiedades del calafate como potenciador de la capacidad de respuesta inmune en tracto respiratorio de animales obesos
Estudio de las propiedades del calafate como potenciador de la capacidad de respuesta inmune en tracto respiratorio de animales obesos
Prevention of obesity and insulin-resistance in vivo through enhancement of mass and function of brown/beige adipose tissue induced by the consumption of a characterized polyphenol-rich extract from Calafate (Berberis microphylla)
Prevention of obesity and insulin-resistance in vivo through enhancement of mass and function of brown/beige adipose tissue induced by the consumption of a characterized polyphenol-rich extract from Calafate (Berberis microphylla)
Absorcion de polifenoles: efecto de la hipolactasia y de la administracion de la lactase exogena
Absorcion de polifenoles; efecto de la hipolactasia y de la administracion de la lactase exogena
Interaction between supplemental zinc and muscle-strength training as a key element to improve type-2 diabetes therapy
Interaction between supplemental zinc and muscle-strength training as a key element to improve type-2 diabetes therapy
Anthocyanins cyanidin- and delphinidin-3-glucoside treatments differentially modulates TNF-a-induced adipocytes lipolysis
Epigenética en la diabetes tipo 1=> expresión génica de microRNAs en células mononucleares periféricas de pacientes con diabetes tipo 1 e impacto de la vitamina D, TNFa e IL-6 sobre apoptosis e inflamación
Sustitucion de la materia grasa por ingredientes de origen vegetal y marino e incorporacion de compuestos bioactivos en cecinas
Type 1 Diabetes epigenetics: microRNA gene expression in peripheral mononuclear cells of Type 1 Diabetic patients and the impact of vitamin D, TNFa and IL-6 over apoptosis and inflammation
High throughput technology implementation for characterization, quantification and/or isolation of molecules of high interest in nutrition
Implementación de tecnología de punta para la caracterización, cuantificación y/o aislamiento de moléculas de alto interés en nutrición
Extractos de frutos nativos Chilenos inhiben mecanismos inflamatorios involucrados en el desarrollo de obesidad
Extracts of Chilean native fruits inhibit inflammatory mechanisms involved in obesity development
Papel de la regulación epigenética del ciclo celular en el desarrollo de obesidad
Proyecto de investigación aplicada en nutrigenómica de la obesidad
Ingredientes en la prevención de obesidad e insulino-resistencia=> mecanismos implicados
Interacción entre polimorfismos del receptor de vitamina D (VDR) y marcadores inmunogenéticos HLA-DQB1* en la Diabetes Tipo 1=> posible rol modulador de la vitamina D

Review (6)

Pulp, Leaf, Peel and Seed of Avocado Fruit: A Review of Bioactive Compounds and Healthy Benefits
A Review of the Potential of Chilean Native Berries in the Treatment of Obesity and its Related Features
Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review
Obesidad parental y modificaciones epigenéticas en la descendencia
La relación entre obesidad y complicaciones en el curso clínico de las enfermedades respiratorias virales en niños ¿un nuevo factor de riesgo a considerar?
Bioactive compounds and health benefits of exotic tropical red-black berries
65
Diego Garcia

Associate Professor

Nutricion

Universidad de Chile

Santiago, Chile

6
Paula Jiménez

Assistant professor

Nutrition

Universidad de Chile

Santiago, Chile

6
Lissette Duarte

Profesora Asistente

Nutrición

Universidad de Chile

Santiago, Chile

2
Cecilia Albala

Director, full professor

INTA/U CHILE

Santiago, Chile

2
Andres Bustamante

Académico

Nutrición

Universidad de Chile, Facultad de Medicina

Santiago, Chile

1
Francisco Zorondo

Profesor Asistente

Departamento de Gestión Agraria

Universidad de Santiago de Chile

Santiago, Chile

1
Maria Martinez

Profesor Auxiliar

Instituto de Farmacia

Universidad Austral de Chile

Valdivia, Chile

1
Solange Parra

PhD Student

Health and Wellbeing

University of Glasgow

Glasgow, Reino Unido

1
Paula García

Assistant Professor

Nutrition

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisca Echeverría

Profesora Asistente

Ciencias de la Salud

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MARIA TERESA PINO

Jefe de Área Nacional

AREA NACIONAL ALIMENTOS DEL FUTURO

INSTITUTO DE INVESTIGACIONES AGROPECUARIAS

Santiago, Chile

1
Francisca Rivas

Académica

Nutrición

Universidad de Chile

Santiago, Chile

1
Loreto Fuenzalida

Docente Investigador

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Francisco Pérez

DIRECTOR

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

1
Carolina Pizarro

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Vilma Quitral

Asesoría

Granotec

Santiago, Chile

1
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Fanny Petermann

Associate Professor

Facultad de Medicina

Universidad Diego Portales

Santiago, Chile

1
Claudia Troncoso

Profesor Asociado; jefa de Departamento de Salud Pública

Salud Pública

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
Maria Pando

Profesor asistente

Nutrición

Universidad de Chile

Santiago, Chile