Alvaro_elorza.jpg_thumb90

Alvaro Andres Elorza Godoy

ASSOCIATE PROFESSOR

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Líneas de Investigación


Mitochondrial Dynamics and Mitophagy In Erythropoiesis mtDNA as a driver of aging-associated diseases Stem Cells & Metabolic Reprogramming; Erythropoiesis & Copper Metabolism;

Educación

  •  PhD in Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Licence in Marine Sciences, UNIVERSIDAD CATOLICA DEL NORTE. Chile, 1994
  •  Marine Biologist, UNIVERSIDAD CATOLICA DEL NORTE. Chile, 2002
  •  Doctorat en Biologie-Santé, Universite Victor Segalen Bordeaux 2. Francia, 2004
  •  Administración de Empresas (MBA), UNIVERSIDAD ANDRES BELLO. Chile, 2018

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    ANDRES BELLO UNIVERSITY

    Faculty of Biological Sciences

    Santiago, Chile

    2009 - 2014

  •   POSTDOCTORAL ASSOCIATE Full Time

    TUFTS UNIVERSITY

    Faculty of Medicine

    Boston, Estados Unidos

    2004 - 2008

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD ANDRES BELLO

    Faculty of Biological Sciences

    Santiago, Chile

    2014 - 2018

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD ANDRES BELLO

    Faculty of Medicine

    Santiago, Chile

    2018 - A la fecha

  •   Application Scientist Full Time

    SEAHORSE BIOSCIENCE, INC

    Boston, Estados Unidos

    2008 - 2009

Experiencia Profesional

  •   Application Scientist Full Time

    Seahorse Bioscience, Inc

    Boston, Estados Unidos

    2008 - 2009

  •   Assistant Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2009 - 2014

  •   Associate Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2014 - A la fecha

Formación de Capital Humano


DOCTORADO

Celia Salazar, Doctorado en Ciencias Biomédicas
Profesor Co-tutor
“Estudio del gen HIGD2A en la biología del cáncer y la distribución dual de la proteína HIG2A entre la mitocondria y el núcleo”
Universidad Autónoma de Chile CHILE 2021

Gabriela Gomez Lillo, Doctorado en Biomedicina
“Estudio de características funcionales de la nueva proteína mitocondrial ERYM3 en la mitofagia”
UNAB CHILE En Ejecución

Andrea Matamoros Palacios
“Estudio Funcional de la proteína mitocondrial FAM162A en la mitofagia durante la eritropoyesis”
UNAB CHILE En Ejecución

Alvaro Gonzalez Ibañez, Doctorado en Biociencias Moleculares
“Rol de la dinámica mitocondrial en la eritropoyesis humana”
UNAB CHILE 2017

Germán Púas Villegas, Doctorado en Biotecnología
“Caracterización funcional de la proteína mitocondrial FAM162A en la degradación selectiva de mitocondrias por autofagia” UNAB CHILE
Aprobación Candidatura Oct. 2016. Renuncia al Programa Enero 2017

MAGISTER
Juan Pablo Soffia, Magister en Biotecnología y Ciencias de la Vida
“Estudio de la expresión génica de erym3 y su efecto en la biomasa mitocondrial"
UNAB CHILE En Ejecución

Pierina Mendoza Vazquez, Magister en Biotecnología
“Isoformas patológicas de la proteína Tau, truncada (Tau-D421) y fosforilada (Ser-396/404), alteran la bioenergética mitocondrial en la enfermedad de Alzheimer”
UNAB CHILE 2021

Paola Tiozzo-Lyon, Magister en Bioquímica
“Localización subcelular y análisis de la expresión génica durante la eritropoyeisis de ERYM3: Una nueva proteína putativa de la mitocondria”
UNAB CHILE 2020

Marcelo Muñoz, Magister en Biotecnología y Ciencias de la Vida
“Estudio Funcional de la Proteína Mitocondrial FAM162A sobre la Morfología y Bioenergética de las Mitocondrias y su Rol en la Mitofagia”
UNAB CHILE 2019

Yancing Rossel Mutis, Magister en Biotecnología
“Efecto del ion cobre sobre la función mitocondrial durante la eritropoyesis”
UNAB CHILE 2014

Erik L. Jensen Rojas, Magister en Biotecnología
“Efecto de la carencia del cobre sobre la fisiología mitocondrial y la eritropoyesis”
UNAB CHILE 2014

Robert Barroux, Magister en Biotecnologia
Profesor Patrocinante
“Análisis de los efectos del consumo de Calafate en el aumento sobre del tejido adiposo pardo y beige analizando actividad de UCP-1 en ratones obesos” U. de Chile CHILE En Ejecución

LICENCIATURAS
Shirly Amori Malleda. Memoria de Título y Licenciatura en Bioquímica.
“Efecto de la proteína mitocondrial FAM162A en la diferenciación eritroide y la síntesis de hemoglobina”
UNAB CHILE 2019

Alonso Pino, Ingenieria en Biotecnología, ” Participación del factor de transcripción CHOP-C/EBP-B en el sistema de reparación mitocondrial UPRmt en la eritropoyesis” UNAB CHILE 2016

Allan Libedisnky, Ingeniería en Biotecnología, "El Rol del Cobre en la Fisiología Celular" UNAB CHILE 2016

Gerardo Cortes, Licenciatura en Biología, “Envejecimiento y reprogramación metabólica” UNAB CHILE 2016

María Isabel Lasso de la Vega, Licenciatura en Biotecnología, “Rol de la carencia de cobre en la dinámica mitocondrial durante la eritropoyesis” UNIVERSIDAD LATINA DE PANAMA PANAMA 2013

Claudio E. Dapelo Sepúlveda, Licenciatura en Biología, “La utilización de un metabolito secundario de la via de las kynureninas como posible marcador de la enfermedad ELA” UNAB CHILE 2013

Salvador A. Rivera Ramirez, Ingeniería en Biotecnología, “La dinámica mitocondrial como proceso determinante en la fisiología mitocondrial y celular” UNAB CHILE 2012

CURSO INTERNACIONAL AVANZADO DE MITOCONDRIAS

Unveiling Mitochondria 2.0: An Advanced Postgraduate Course
Organizador, conferencista y Profesor. UNAB, Chile, 2013

Unveiling Mitochondria: An Advanced Postgraduate Course
Organizador, conferencista y Profesor. UNAB, Chile, 2011


Difusión y Transferencia


Funding:

Intramural:
2015-2018 Nucleo-UNAB DI-741-15/N, The Vascular-Neural-Muscle unit in sepsis-induced intensive care unit-acquired weakness.
Co-Investigator
2012-2015 Nucleo-UNAB DI-209-12/N, Mitochondria and Oxidative Stress in Pathologies.
Co-Investigator
2012-2014 Pilot Grant DI-60-12-R, Effect of copper overload on mitochondrial physiology in erythropoietic cells.
Principal Investigator.
2010-2012 Pilot Grant DI-10-10R, Role of Mitochondrial Dynamics in Erythropoiesis. Universidad Andres Bello.
Principal Investigator.
Extramural:

2018-2022 FONDECYT Regular 1180983. Targeting anemia through enhancing mitochondrial dynamics and mitophagy: Investigation of two novel
mitochondrial proteins. Principal Investigator
2016-2021: Millennium Institute P09-016-F “Immunology and immunotherapy”
Adjunct Investigator
2016-2019: Joint Canada-Israel Health Research Program 365953 “Mitochondrial contribution to innate immune pathways“
Associate Investigator
2014-2017: FONDECYT Regular 1140968 “Pathological forms of TAU impairs mitochondrial function in Alzheimer’s disease”
Co-Investigator
2012-2015 International Research Staff Exchange Scheme (IRES) “EULAMDIMA” (to investigators of Univ. Groningen (the Netherlands),
Univ. Heidelberg (Germany), UNAM (Mexico) & UNAB (Chile).
Associate Investigator.
2010-2014 FONDECYT Regular 1100995. Role of Mitochondrial Dynamics during differentiation, expansion and maturation of red blood cells.
Principal Investigator
2010-2011 EXPLORA-CONICYT ED14/044, Batteries on. Let´s take a look at our energy centrals. (Educational grant for middle and
high school students).
Director.
2000-2003 FONDECYT 2000073 grant for PhD Students: “Gene expression of nuclear-encoded mitochondrial proteins in superior plants.”
Pontifical Catholic University of Chile, Santiago-Chile.
Principal Investigator.


Premios y Distinciones

  •   Doctoral Fellowship

    P. UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2003

    PhD Program

  •   Doctoral Fellowship

    French Government through ECOS-CONICYT program

    Francia, 1999

    PhD Program

  •   Doctoral Fellowship

    CONICYT

    Chile, 1998

    PhD Program

  •   Doctoral Fellowship

    P. UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1997

    PhD Program

  •   Outstanding Student from Marine Faculty

    UNIVERSIDAD CATOLICA DEL NORTE

    Chile, 1994

    Reconocimiento al mejor alumno de la Facultad de Ciencias del Mar. Coquimbo, Chile


 

Article (44)

CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity
mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology
The administration of an extract from Berberis microphylla stimulates energy expenditure, thermogenesis and mitochondrial dynamics in mice brown adipose tissue
Biosystem analysis of the hypoxia inducible domain family member 2A: Implications in cancer biology
Cytosolic NUAK1 Enhances ATP Production by Maintaining Proper Glycolysis and Mitochondrial Function in Cancer Cells
Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics
Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5
Copper deficiency- induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells
The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
Imprinting of maternal thyroid hormones in the offspring
A new species of Liolaemus related to L. nigroviridis from the Andean highlands of Central Chile (Iguania, Liolaemidae)
Alternative RUNX1 Promoter Regulation by Wnt/beta-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors
Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained
Non-cytotoxic copper overload boosts mitochondrial energy metabolism to modulate cell proliferation and differentiation in the human erythroleukemic cell line K562
Two new Liolaemus lizards from the Andean highlands of Southern Chile (Squamata, Iguania, Liolaemidae)
Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells
Adaptive Responses of Mitochondria to Mild Copper Deprivation Involve Changes in Morphology, OXPHOS Remodeling and Bioenergetics
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells
Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: Implications for cell metabolism and growth in skeletal muscle of the fine flounder
A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets
The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo
High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria
Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis
Mitochondrial Uncoupling Protein 2 Inhibits Mast Cell Activation and Reduces Histamine Content
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
UCP2 Modulates Cell Proliferation through the MAPK/ERK Pathway during Erythropoiesis and Has No Effect on Heme Biosynthesis
A nuclear gene for the iron-sulfur subunit of mitochondrial complex II is specifically expressed during arabidopsis seed development and germination
Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP.
Identification and characterization of a novel tobacco mosaic virus resistance N gene homologue in Nicotiana tabacum plants
Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in arabidopsis, have distinct cell-specific expression patterns and promoter activities
The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana
Three different genes encode the iron-sulfur subunit of succinate dehydrogenase in Arabidopsis thaliana
Arquitectura del ovario de la langosta de Juan Fernández, Jasus frontalis
Ovary architecture of the Juan Fernández spiny rock lobster, Jasus frontalis Arquitectura del ovario de la langosta de Juan Fernández, Jasus frontalis
Stages of the molting cycle of the Juan Fernández lobster (Jasus frontalis Milne Edwards, 1837) Determinación de los estados del ciclo de muda de la langosta de Juan Fernández (Jasus frontalis Milne Edwards, 1837)

Abstract (4)

ADSC THERAPY FOR TREATMENT OF DIABETIC RETINOPATHY: THE BEST OR LAST RESOURCE?
Influence of Hyperglycemia on ADSC
Wnt/beta-catenin signaling enhances RUNX1 expression in leukemia cells and hematopoietic progenitors.
Novel islet respirometry assay reveals high levels of uncoupled respiration in rodent and human islets

Errata (1)

Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: Implications for cell metabolism and growth in skeletal muscle of the fine flounder (vol 186, pg 172, 2013)

Proyecto (25)

Targeting anemia through enhancing mitochondrial dynamics and mitophaghy=> Investigation of two novel mitochondrial proteins
Instituto Milenio en Inmunología e Inmunoterapia
Millennium Institute on Immunology and immunotherapy
Mitochondrial contribution to innate immune pathways
Mitochondrial contribution to innate immune pathways
The vascular-neural-muscle unit in sepsis-induced intensive care unit-acquired weakness
The Vascular-Neural-Muscle unit in sepsis-induced intensive care unit-acquired weakness
Pathological forms of TAU impairs mitochondrial function in Alzheimer’s disease
Pathological forms of TAU impairs mitochondrial function in Alzheimer’s disease
Effect of copper overload on mitochondrial physiology in erythropoietic cells
International Research Staff Exchange Scheme (IRES) “EULAMDIMA”
Joint European and Latin American Research Network on Diabetic Microangiopathy (EULAMDIMA)
Mitochondria and Oxidative Stress in Pathologies.
ROS y Patologias
Batteries on. Let´s take a look at our energy centrals. (Educational grant for middle and high school students)
Correlación entre la dinámica mitocondrial y el remodelamiento y estado energético de la OXPHOS en mamíferos
International colaboration
Pongamonos las Pilas! Una mirada a las centrales energeticas de las celulas
Role of Mitochondrial Dynamics during differentiation, expansion and maturation of red blood cells
Role of Mitochondrial Dynamics during differentiation, expansion and maturation of red blood cells
Role of mitochondrial dynamics in erythropoiesis
Role of Mitochondrial Dynamics in Erythropoiesis
Gene expression of nuclear-encoded mitochondrial proteins in superior plants.
Regulación de la expresan de genes nucleares de proteínas mitocondriales de plantas superiores
Biología de la reproducción y del desarrollo de la langosta de Juan Fernández Jasus frontales y del camarón de roca Rhynchocynetes typus
60
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

7
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

5
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

4
Maria Holuigue

Profesor Titular

Departamento de Genética Molecular y Microbiología

FACULTAD DE CIENCIAS BIOLÓGICAS, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Alvaro Becerra

Coordinador Academico

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

3
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Celia Salazar

Postdoctorado

Universidad Autónoma de Chile

Talca, Chile

3
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

2
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

2
Alvaro Gonzalez

Chief Technology Officer

Cellter

Santiago, Chile

2
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

2
Alfredo Molina

UNIVERSIDAD ANDRES BELLO

SANTIAGO, Chile

1
Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Hannetz Roschzttardtz

Profesor asistente

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Miguel Avila

Docente/Investigador

Universidad de las Américas

Santiago, Chile

1
Karen Bohmwald

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile

1
Nicole Cortés

Coordinadora de Estudios Clínicos

Laboratorio de Biología Celular, Molecular y Neurociencias, Corporación Centro Internacional de Biomedicina, ICC

Santiago, Chile

1
Luis Venegas

investigador post doctoral

Pediatria

Pontificia Universidad Catolica

Santiago, Chile

1
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Marlén Barreto

Profesor asociado

UNIVERSIDAD AUTONOMA DE CHILE

Santiago de Chile, Chile

1
Alejandro Arriagada

Coordinador y docente

Núcleo de Ciencias Biológicas

Universidad Mayor de Chile

Santiago, Chile

1
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

1
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Hannetz Roschzttardtz

Profesor asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

1
osvaldo yañez

Post Doctorado

Departamento de Ciencias y Tecnología Farmacéutica

Universidad de Chile

Santiago, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Rodolfo Paredes

Medical Education and Clinical Simulation Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
GRACIELA ARGÜELLO

Académico

Universidad Católica del Maule

Curicó, Chile

1
Claudia Stange

Titular Professor

Department of Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carlos Romero

Medico Intensivista

Medicina

Hospital Clinico Universidad de Chile

Santiago, Chile