Man

Alvaro Alejandro Becerra Farfan

Profesor Asociado

Universidad Bernardo O'Higgins

Santiago, Chile

Líneas de Investigación


Mi trabajo se ha enfocado en investigar los mecanismos fisiopatológicos asociados al endotelio/vascular y los procesos regenerativos involucrados. Mecanismos asociados a: inflamación, cáncer y regeneración, entre otros.

Educación

  •  Fisiopatología, Universidad Andrés Bello. Chile, 2017
  •  Bioquímico, Universidad Andrés Bello. Chile, 2010
  •  Biología celular y molecular, Universidad Andrés Bello. Chile, 2010
  •  Bioquímica, Universidad Andrés Bello. Chile, 2008

Experiencia Académica

  •   Coordinador Académico Full Time

    Universidad Bernardo Ohiggins

    Ciencias de la Salud

    Santiago, Chile

    2018 - A la fecha

  •   Investigador- Docente Other

    Universidad Andres Bello

    Ciencias Biológicas

    Santiago, Chile

    2010 - 2012

Experiencia Profesional

  •   Co- Fundador/Director Científico Part Time

    Cellter

    santiago, Chile

    2016 - 2021


 

Article (26)

A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein

Valenzuela-Fuenzalida, J; Rodríguez-Osorio, B; Salgado-Torres, C; Nova-Baeza, P; Orellana-Donoso, M; Bruna-Mejias, A; Avila-Sepulveda, R; Becerra-Farfan, A; Rodríguez-Luengo, M; Sanchis-Gimeno, J; et al.

Article ISI
 (2024)

Systematic review and meta-analysis of right subclavian artery variants and their correlation with cervical-thoracic clinical conditions

Valenzuela-Fuenzalida, JJ; Orellana-Donoso, M; Perez-Jiménez, D; Farfán-Cabello, E; Gold-Semmler, M; Becerra-Farfan, A; Román C.; Nova-Baeza, P

Article ISI
 (2024)

Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis

Orellana-Donoso, Mathias; Milos-Brandenberg, Daniel; Benavente-Urtubia, Andoni; Guerra-Loyola, Javier; Bruna-Mejias, Alejandro; Nova-Baeza, Pablo; Becerra-Farfan, Alvaro; Sepulveda-Loyola, Walter Sepulveda; Miguel Luque-Bernal, Ricardo; Luque Bernal, Ricardo Miguel; et al.

Article ISI SCOPUS
Life  (2023)

Prevalence and Clinical Consideration of Anatomical Variants of the Splenic Artery: A Systematic Review and Meta-Analysis

Valenzuela, Juan; Martinez-Hernandez, Daniela; Perez-Jimenez, Daniela; Nova-Baeza, Pablo; Becerra-Farfan, Alvaro; Orellana-Donoso, Mathias; Mejias, Alejandro Bruna; Syed, Qareen H.; Luengo, Macarena Rodriguez; Iwanaga, Joe

Article ISI SCOPUS
APPLIED SCIENCES-BASEL  (2023)

Prevalence of the Bifid Mandibular Condyle and Its Relationship with Pathologies of the Temporomandibular Joint: A Systematic Review and Meta-Analysis

Valenzuela, Juan; Navarro, Kora lle Keller; Urbina, Pia; Trujillo-Riveros, Martin; Nova-Baeza, Pablo; Orellana-Donoso, Mathias; Luengo, Macarena Rodriguez; Beccerra Farfan, Alvaro; Sanchis-Gimeno, Juan A.

Article ISI SCOPUS
Diagnostics  (2023)

Systematic Review and Meta-Analysis: Recurrent Laryngeal Nerve Variants and Their Implication in Surgery and Neck Pathologies, Using the Anatomical Quality Assurance (AQUA) Checklist

Valenzuela, Juan; Baeza-Garrido, Vicente; Navia-Ramirez, Maria Fernanda; Cariseo-avila, Carolina; Bruna-Mejias, Alejandro; Becerra-Farfan, Alvaro; Lopez, Esteban; Obligado Donoso, Marcelo; Orellana Donoso, Mathias; Sepulveda-Loyola, Walter Sepulveda

Article ISI SCOPUS
Life  (2023)

Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction

Cortés-Rivera, Cristian; Otero, Carolina; Becerra, Alvaro; Riedel, Claudia A; Kalergis, Alexis M.; Simon, Felipe

Article ISI SCOPUS
CRITICAL CARE MEDICINE  (2019)

A comparative analysis of tellurite detoxification by members of the genus Shewanella

Becerra, A. A.

Article ISI SCOPUS
ARCHIVES OF MICROBIOLOGY  (2018)

Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries

Lillo, MA; Gaete, PS; Puebla M.; Ardiles, NM; Poblete, I; Becerra, A; Figueroa, XF

Article ISI SCOPUS
FASEB JOURNAL  (2018)

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-beta 1/ALK5/Smad pathway



Article ISI SCOPUS
LABORATORY INVESTIGATION  (2017)

Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species

Arriagada, AA; Albornoz, E; Becerra, A; Vidal, G.; Fardella C.; Michea, L.; Carrasco, N; Simon F; Bueno, SM; Riedel CA

Article ISI SCOPUS
Endocrinology  (2015)

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel

Sarmiento D.; Montorfano I.; Cerda O.; Cáceres M.; Becerra, A; Cabello-Verrugio, C; Riedel C.; Tapia, P; Varela D.; Simon F

Article ISI SCOPUS
Microvascular Research  (2015)

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-beta 1 and TGF-beta 2-dependent pathway

Montorfano, Ignacio; Becerra, Alvaro; Cerro, Roberto; Echeverria, Cesar; Sáez, Elizabeth; Morales, Maria Gabriela; Fernandez, Ricardo; Cabello-Verrugio, Claudio; Simon, Felipe

Article ISI SCOPUS
LABORATORY INVESTIGATION  (2014)

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

Berta Henriquez, Fernando J Bustos; Rodrigo Aguilar, Alvaro Becerra; Felipe Simon, Martin Montecino

Article
Molecular and Cellular Neuroscience  (2013)

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

Henriquez, B; Bustos, FJ; Aguilar, R.; Becerra, A; Simon F; Montecino, M.; van Zundert, B

Article ISI SCOPUS
MOLECULAR AND CELLULAR NEUROSCIENCE  (2013)

Lipopolysaccharide induces a Fibrotic-like phenotype in endothelial cells

César Echeverría, Ignacio Montorfano; Daniela Sarmiento, Alvaro Becerra; Felipe Nuñez-Villena, Xavier F Figueroa; Claudio Cabello?Verr ugio, Alvaro A Elorza; Claudia Riedel, Felipe Simon

Article
Journal of cellular and molecular medicine  (2013)

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

Echeverria, C; Montorfano I.; Sarmiento D.; Becerra, A; Nunez-Villena, F; Figueroa, XF; Cabello-Verrugio, C; Riedel C.; Simon F

Article ISI SCOPUS
Journal of Cellular and Molecular Medicine  (2013)

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

Jimmy Stehberg, Rodrigo Moraga-Amaro; Christian Salazar, Alvaro Becerra; Cesar Echeverría, Juan A Orellana; Geert Bultynck, Raf Ponsaerts; Luc Leybaert, Felipe Simon; Juan C Sáez, Mauricio A Retamal

Article
The FASEB Journal  (2012)

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

Stehberg, J; Moraga-Amaro, R; Salazar, C.; Becerra, A; Echeverria, C; Orellana J.A.; Bultynck G.; Ponsaerts, R; Leybaert, L; Simon F; et al.

Article ISI SCOPUS
FASEB Journal  (2012)

The paramagnetic and luminescent [Re6Se8I6](3-) cluster. Its potential use as an antitumoral and biomarker agent

Echeverria, C; Becerra, A; Nunez-Villena, F; Munoz-Castro, A; Stehberg, J; Zheng, Z.; Arratia-Perez, R; Simon F; Ramirez-Tagle, R

Article ISI SCOPUS
New Journal of Chemistry  (2012)

Fibrotic response induced by angiotensin-II requires NAD (P) H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

Claudio Cabello-Verrugio, María José Acuña; María Gabriela Morales, Alvaro Becerra; Felipe Simon, Enrique Brandan

Article
Biochemical and Biophysical Research Communications  (2011)

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

Cabello-Verrugio, C; Acuña MJ; Becerra, A; Simon F; Brandan, E.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2011)

Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death

Nunez-Villena, F; Becerra, A; Echeverria, C; Briceno, N; Porras O.; Armisen, R; Varela D.; Montorfano I.; Sarmiento D.; Simon F

Article ISI SCOPUS
Antioxidants and Redox Signaling  (2011)

Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome

Fernandez R.; Nardocci, G; Simon F; Martin, A.; Becerra, A; Rodriguez Tirado C; Maisey, KR; Acuna-Castillo, C; Cortes, PP

Article ISI SCOPUS
Respiratory Physiology and Neurobiology  (2011)

Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death

Alvaro Becerra, Cesar Echeverría; Diego Varela, Daniela Sarmiento; Ricardo Armisén, Felipe Nuñez-Villena; Mario Montecinos, Felipe Simon

Article
Cardiovascular research  (2011)

Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death

Becerra, A; Echeverria, C; Varela D.; Sarmiento D.; Armisen, R; Nunez-Villena, F; Montecinos, M; Simon F

Article ISI SCOPUS
Cardiovascular Research  (2011)

Abstract (2)

Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives

Simon F; Echeverria, C; Montorfano I.; Becerra, A; Varela D.; Hermosilla T.; Cabello-Verrugio, C; Armisen, R

Abstract ISI
CARDIOVASCULAR RESEARCH  (2014)

Polycomb-Group proteins (PcG) Ezh1 and Ezh2 differentially regulate PSD-95 gene expression in developing hippocampal neurons.

Henriquez, B; Bustos, FJ; Blanco F.; Becerra, A; Salas, C; Simon F; Montecino, M.; van Zundert, B

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

Letter (1)

Vinculando la docencia de pregrado con la investigaci�n cient�fica en carreras biom�dicas: importancia del entrenamiento del estudiantado

Manuel E. Cort�s; Vania Fuentes Bazzi; Felipe Valenzuela Vidal; �lvaro Becerra; Mart�n Lara Ortega; Jaime Za�artu Reyes; Andrea A. Alfaro-Silva

Letter SCIELO
REVISTA MEDICA DE CHILE  (2023)

Proyecto (2)

SEPSIS-INDUCED ENDOTHELIAL FIBROSIS=> ROLE OF TRPM4 AND TRPM7 ION CHANNELS AS NOVEL TARGETS FOR PREVENTION OF ENDOTHELIAL FIBROSIS DURING SEPSIS

FONDECYT (1121078)

Proyecto
2012-2016
Tesista

ROLE OF THE EARLY LPS-INDUCED ROS GENERATION IN THE ENDOTHELIAL CELL DEATH. PARTICIPATION OF THE TRPM4, A NON-SELECTIVE CATION CHANNEL AND ITS IMPLICATION IN THE SEPSIS TREATMENT

FONDECYT (11080119)

Proyecto
2008-2011
Tesista

Review (3)

Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis

Valenzuela-Fuenzalida, JJ; Núñez-Castro, CI; Morán-Durán, VB; Nova-Baeza, P; Orellana-Donoso, M; Suazo-Santibáñez, A; Becerra-Farfan, A; Oyanedel-Amaro, G; Bruna-Mejias, A; Granite, G; et al.

Review ISI
 (2025)

Hypoplastic and Congenital Absence of Coronary Arteries and Its Correlation with Clinical Implications of Cardiac Circulation: A Systematic Review and Meta-Analysis

Bruna-Mejias, Alejandro; del Villar-Valdebenito, Javiera; Roman, Camila; Alcaino-Adasme, Catalina; Sepúlveda-Loyola, Walter; Orellana-Donoso, Mathias; Nova-Baeza, Pablo; Suazo-Santibanez, Alejandra; Becerra-Farfan, Alvaro; Sanchis-Gimeno, Juan; et al.

Review ISI
JOURNAL OF CLINICAL MEDICINE  (2024)

Use of Ketamine in Patients with Multifactorial Neuropathic Pain: A Systematic Review and Meta-Analysis

Bruna-Mejias, A; Baeza V; Gamboa J.; Flores, BB; San Martin, J.; Astorga, C.; Leyton, J.; Nova-Baeza, P; Orellana-Donoso, M; Suazo-Santibáñez, A; et al.

Review ISI
 (2024)

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Alvaro Muñoz

Profesor Titular

Universidad San Sebastián

Santiago, Chile

2
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

18
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Ramiro Arratia

DIRECTOR DOCTORADO

CIENCIAS QUIMICAS

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

2
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Domingo Ruiz

Profesor Asociado

Química de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

4
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

6
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

2
Rodrigo Ramírez

Director

Direccion de Investigacion y Postgrado

Universidad de Aconcagua

Santiago, Chile

2
Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

7
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

1
Alvaro Muñoz

Full time professor

Dirección de Investigación y Postgrado

Universidad Autónoma de Chile

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

2
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

1
Carolina Rodriguez

Investigador Docente (Postdoc)

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

2
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

1
Alejandro Arriagada

Coordinador y docente

Núcleo de Ciencias Biológicas

Universidad Mayor de Chile

Santiago, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Walter Sepúlveda

PhD student

FISIOTERAPIA

UNIVERSIDADE ESTADUAL DE LONDRINA

Londrina, Brasil

27
Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

1
Sebastián Gatica

Investigador Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

1
Cristian Cortés

Académico-Investigador Auxiliar

Psicología

Universidad Católica del Maule

Talca, Chile