Man

Brigitte Adriana Johanna van Zundert Mathyssen

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Líneas de Investigación


neuronal plasticity; learning and memory; neurodegeneration; amyotrophic lateral sclerosis (ALS); Frontotemporal dementia (FTD)

Educación

  •  Molecular and Cell Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2002
  •  Biochemistry, Hogeschool West-Brabant. Holanda, 1993
  •  Master in Science, University of Utrecht. Chile, 1996

Experiencia Académica

  •   postdoctoral fellow Full Time

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Biology

    Boston, Estados Unidos

    2002 - 2005

  •   postdoctoral fellow Full Time

    HARVARD UNIVERSITY

    Boston, Chile

    2002 - 2005

  •   Assistent Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepcion, Chile

    2005 - 2009

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Concepcion, Chile

    2010 - 2010

  •   Full Professor Full Time

    Universidad Andres Bello

    Biological Sciences

    Santiago, Chile

    2015 - A la fecha

  •   Associate Professor Full Time

    Universidad Andres Bello

    Biological sciences

    Santiago, Chile

    2010 - 2015

Experiencia Profesional

  •   Associate Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2010 - 2015

  •   Associate Professor Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2010 - 2010

  •   Assistent Professor Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2005 - 2010

  •   Full Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2015 - A la fecha

  •   Full Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2015 - A la fecha

Formación de Capital Humano


DIRECTION OF POSTDOCTORAL FELLOWS: Supervising in last 5 years (2012-current): 6.
1. Berta Henríquez (PhD from UDEC); Postdoc co-directed with Dr. Montecino (2011-2013). Project “Expression of plasticity genes regulating dendritogenesis by epigenetic mechanisms: participation of covalent histone H3 modifications and polycomb proteins” has been financed by Postdoctoral Project FONDECYT N° 3110138.
2. Estibaliz Ampuero (PhD from UChile); Postdoc (2012-2014). Project “Participation of NMDARs and extracellular matrix components in the reactivation of dendritogenesis and synaptogenesis in mature hippocampal neurons” has been financed by Postdoctoral Project FONDECYT N° 3130582
3. Agnieszka Dyrda (PhD from U. de Rennes, France); Postdoc (2012-2015). Project “Role of PolyP in the pathogenesis and death of motoneuron death in ALS” has been financed by the RING/Anillo grant (BvZ).
4. Mario Sanchez (PhD from UChile); Postdoc co-directed with Dr. Montecino (2015-2018). Project “Epigenetic regulation of memory formation and maintenance” is being financed by Postdoctoral Project FONDECYT N° 316022.
5. Claudio Capelli (PhD from UChile); Postdoc (2016). Project “Identification of epi-drugs to increase the expression of the gene C9orf72 in FTD” is being financed by ATA grant (to BvZ).
6. Christian Arredondo (PhD from PUC-Chile); Postdoc (2015-2017). Project “Identification of the toxic factor(s) released by ALS astrocytes” is being financed by ATA grant (to BvZ).

PhD THESIS STUDENTS: Supervising in last 5 years (2012-current): 5.
1. Eveling Inostroza: “Role of the association of NR2B containing NMDARs with RasGRF1 and CaMKII in neuronal plasticity in vitro”, PhD Program in Biological Sciences, UDEC (Terminated, 2014).
2. Fernando Bustos (co-tutor Dr. Montecino): “Role of anchoring protein PSD95 in the regulation of the dendritic architecture: define epigenetic mechanisms controlling the expression of PSD95 during brain development”, PhD Program in Biological Sciences, UDEC (Terminated, 2014).
3. David Gonzalez (co-tutor Dr. Brandan at PUC): “Role of the pro-fibrotic factors and extracellular matrix components in the progression of ALS”, PhD Program in Cellular and Molecular Biological Sciences (in Thesis since 2013).
4. Sebastian Abarzua (co-tutor Dr. Montecino): “Altered chromatin remodeling and changes in gene expression in ALS astrocytes”, PhD Program in Molecular Biosciences (in Thesis since 2016).
5. Pablo Martínez: “Identification of the toxic factor released from skeletal muscles in ALS and its role in pathogenesis in motoneuron degeneration” PhD Program in Molecular Biosciences (in Thesis since 2016).

MASTER THESIS STUDENTS: Supervising in last 5 years (2012-current): 11.
1. Elsa Fritz: “Analysis of the mechanisms underlying cell death and hyperexcitability in diverse ALS models”. Master Program in Science, UDEC. (Terminated, 2014)
2. Matias Campos: “Role of NR1NR2B NMDARs and CaMKII in the dendritic arborization in hippocampal neurons in vitro”. Master Program in Science, UNAB. (Terminated, 2014)
3. David González: “Role of the NR2A/PSD-95 and NR2B/SAP102 complexes in dendritogenesis and neuronal plasticity in the developing and mature brain”. Master in Science, UNAB. (Terminated, 2015)
4. Paulina Nuñez (co-tutor Dr. Stehberg): “Effect of the binding of Runx1 to the promoter of the P2X3 receptor on inflammatory pain”. Master Program in Science, UNAB. (Terminated, 2015)
5. Sebastián Abarzúa: “Generation of superoxide in structural plasticity through the NR2B-NMDAR/ RasGRF1/NOX2 signaling pathway in neurons in vitro”. Master Program in Science, UNAB. (Terminated, 2015)
6. Nicole Cortes: “Role of intracellular calcium in the production of ROS in diverse models of ALS and FTD in vitro”. Master in Science, UNAB. (Terminated, 2017)
7. Patricia Valentina Jorquera (co-tutor Dr. Varela-Nallar): “Role of PSD-95 in the formation of glutamatergic synapses of newborn neurons in the adult brain”. Master Program in Science, UNAB (Terminated, 2017)
8. Ivan Diaz: “Role of ROS in epigenetic changes in ALS astrocytes in vivo”. Master in Science, UNAB. (Ongoing since 2016)
9. Paula Cubillos: “Stability of epigenetic changes in vitro induced by epigenome editing tools”. Master in Science, UNAB. (Ongoing since 2016)
10. Esteban Quezada (co-tutor Dr. Montecino): “Identifying of beneficial epidrugs in an ALS/FTD model in vitro”. Master in Science, UNAB. (Ongoing since 2016)
11. Patricio Garcia: “Set-up of a high-throughput screening for drug discovery in diverse models of ALS and FTD in vitro”. Master in Science, UNAB. (Ongoing since 2017)

UNDERGRADUATE THESIS STUDENTS: Supervising in last 5 years (2012-current): 3.
1. Martin Oude Alink “Transfection and Perfection: Regulating de origins of pain perception”. Bachelor Program in Medicine. U. of Groningen, the Netherlands (Terminated, 2013).
2. Nur Jury: “Altered PSD95 expression by epigenetic mechanisms: effect on the neuronal architecture en hippocampal neurons in vivo”. Bachelor Program in Biochemistry, PUCV (Terminated, 2016).
3. Claudio Salas: “Long-term memory consolidation in a conditioned fear model; role of PSD95”. Bachelor Program in Biotechnology, UNAB (Terminated, 2016).

INTERNATIONAL STUDENTS AND POSTDOCS:
BvZ is coordinator of an international program called International Research Staff Exchange Scheme (IRES) “EULAMDIMA” between U. of Groningen (the Netherlands), U. of Heidelberg (Germany), UNAM (Mexico), and UNAB (Chile), that involves the training and recipocal exchange of 23 students, young scientists, and PIs from and to Chile for 4 years (2012-2016).


Premios y Distinciones

  •   The most outstanding young scientists 2010

    Chilean Society for Biology

    Chile, 2010

    Awarded by the "Chilean Society for Biology" and "Grupo BIOS S.A."

  •   The best Doctoral Thesis 2004

    Chilean Foundation for Cell Biology

    Chile, 2004

    Awarded by the "Chilean Foundation for Cell Biology"

  •   Postdoctoral fellowship “Pierre de Bourknecht ALS Research Fund”

    International Pierre de Bourknecht ALS Research Fund

    Estados Unidos, 2003

    Awared while being a Postdoctoral fellowship at MIT and Harvard/MGH (2003-2005).


 

Article (35)

ALS skeletal muscle shows enhanced TGF-beta signaling, fibrosis and induction of fibro/adipogenic progenitor markers
Chronic infusion of SOD1(G93A) astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats
Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons
Silencing strategies for therapy of SOD1-mediated ALS
ALS-linked protein disulfide isomerase variants cause motor dysfunction
Dissecting the role of redox signaling in neuronal development
Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus
Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B
Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress
PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors
A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex
Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons
Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability
Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBP ss factors
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis
Runx1 and C/EBP ss transcription factors directly up-regulate P2X3 gene transcription
1 alpha,25-Dihydroxy Vitamin D-3 Induces Nuclear Matrix Association of the 1 alpha,25-Dihydroxy Vitamin D-3 Receptor in Osteoblasts Independently of Its Ability to Bind DNA
Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1
Synaptic Drive at Developing Synapses: Transient Upregulation of Kainate Receptors
Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons
Changes on the properties of glycine receptors during neuronal development
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons
Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal.
Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons
Effects of chronic ethanol treatment on gamma-aminobutyric acid(A) and glycine receptors in mouse glycinergic spinal neurons
Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF-2) in vitro and in vivo.

Proyecto (8)

Epigenetic changes in the pathogenesis of dementia: contribution of environmental stressors
Identification of the neurotoxic factor secreted by diverse ALS astrocyte models and elucidation of its primary molecular target on motoneurons
Astrocyte-to-neuron communication in plasticity, learning and memory
Role of PSD95 in NMDAR-mediated refinement of the neuronal structure and consolidation of fear memories
A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models
EULAMDIMA
Research ring in oxidative stress in de nervous system; physiological and pathological aspects
Reactivation of dendritic arbor development and plasticity in developing and adult brain: Role of NMDA receptors, CaMKII and PSD95
45
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

6
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

5
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

5
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

4
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

3
Juan Tapia

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

2
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

2
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

2
Nicole Cortés

Coordinadora de Estudios Clínicos

Laboratorio de Biología Celular, Molecular y Neurociencias, Corporación Centro Internacional de Biomedicina, ICC

Santiago, Chile

2
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

2
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

2
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Magdalena Cuevas

Profesor Asistente

Departamento de Fisiología

Universidad de Concepción

Concepción, Chile

1
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Melissa Calegaro

Investigadora Principal

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
David González

Investigador postdoctoral

Institut des Neurosciences de Montpellier (INM)

Montpellier, Francia

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Daniel Bórquez

Profesor asociado

Facultad de Medicina

Universidad Diego Portales

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Rodolfo Madrid

Full Professor

Departamento de Biología

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Pamela Urrutia

Investigador

Biología

Universidad de Chile

Santiago, Chile

1
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

1
Mauricio Sáez

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor

Santiago, Chile

1
Gloria Arriagada

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

1
Matias Campos

Business Developer

Fundación LEITAT Chile

Santiago, Chile