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Pablo Ricardo Moya Vera

Full Professor

Universidad de Valparaiso

Valparaiso, Chile

Líneas de Investigación


Behavioral Neuroscience Psychiatric Genetics Molecular Pharmacology

Educación

  •  Biomedical Sciences, Universidad de Chile. Chile, 2005
  •  Bioquimico, Universidad de Santiago de Chile. Chile, 1999

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    NATIONAL INSTITUTE OF HEALTH

    Bethesda, Estados Unidos

    2006 - 2013

  •   Profesor Adjunto Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Chile

    2013 - 2018

  •   Profesor Titular Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Chile

    2018 - A la fecha

  •   Profesor Titular Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaiso, Chile

    2018 - A la fecha

Experiencia Profesional

  •   POSTDOCTORATE Full Time

    NATIONAL INSTITUTE OF MENTAL HEALTH

    BETHESDA, Estados Unidos

    2006 - 2013

  •   RESEARCH FELLOW Full Time

    NATIONAL INSTITUTE OF HEALTH

    BETHESDA, Chile

    2011 - 2013

Formación de Capital Humano


Estadías Estudiantes Internacionales
2019 Joselyn Cortes, Doctorado en Psicología, Universidad da Coruña, España
2018-2019 Nicole Steinbach, Bachillerato Biología, LMU Universität München, Alemania

Postdoc
2016-2019 Dr. Jose Casanova (actualmente postdoc en École Normale Supérieure, CNRS, Francia)
2018-2019 Dr Angélica Escobar (actualmente Prof Asistente, Universidad de Valparaiso, Chile)

PhD
2021 Nicolás Ardiles. Doctorado en Neurosciencia, Universidad de Valparaíso, Chile
2020 Cristopher Reyes. Doctorado en Neurosciencia, Universidad de Valparaíso, Chile

Master
2019 Luis Manriquez. Magister in Neurosciencias, Universidad de Valparaíso, Chile.
2019 Tito Castillo. Magister in Neurosciencias, Universidad de Valparaíso, Chile.
2018 Ricardo Illesca. Magister in Neurosciencias, Universidad de Valparaíso, Chile.
2017 Marisol Cisternas. Magister en Biotechnologia Universidad Andres Bello, Chile.
2017 Claudia Delgado. Magister en Ciencias Medicas, Universidad de Valparaíso, Chile.
2017 Julio Riquelme. Magister in Ciencias m/Neurología Celular, Universidad de Valparaíso, Chile.

Undergraduate
2022 Francisca Marín. Bioquímica. P. Universidad Católica de Valparaíso, Chile.
2020 Mahly Villagran. Química y Farmacia, Universidad de Valparaíso, Chile.
2018 Luciana Rodriguez. Nutrición y Dietética, Universidad de Valparaíso, Chile.
2017 Francisca Henriquez. Bioquímica, P. Universidad Católica de Valparaíso, Chile.
2017 Carlos Catalan. Ingeniería Bioinformática, Universidad de Talca, Chile


Difusión y Transferencia


Conferencias y presentaciones orales en los últimos 10 años

2019 “OCD relevant behaviors and synaptic alterations in a mouse model with increased neuronal glutamate transporter EAAT3 expression”, Oral presentation at 4th Biennial Conference “Brain in Flux: Genetic, Physiologic, and Therapeutic Perspectives on Transporters in the Nervous System”, Saint Paulin-Quebec, Canada.
2017 “OCD Genetics: from association studies to functional studies”, Conference at the Symposium Task Force in Psychiatric Genomics, LXXII Society of Neurology and Psychiatry Meeting, Viña del Mar, Chile.
2017 “Glutamate Transporter EAAT3 as a novel target in Obsessive-Compulsive Disorder”, Seminar Series on Neuromedicine, Biomedical Neurosciences Institute BNI, Santiago, Chile.
2016 “Transgenic Mouse Overexpressing Eaat3 (Neuronal Glutamate Transporter): A Novel Genetic Model of Obsessive-Compulsive Disorder” Oral presentation at XXIV World Congress of Psychiatric Genetics, Jerusalem, Israel.
2016 “Polymorphisms in ABCB1 and ABCC2 genes in patients with Drug-Resistant Epilepsy at Van Buren Hospital in Valparaíso, Chile”. Oral presentation at the 2nd International Conference on Epilepsy and Treatment, Rome, Italy.
2014 “Common and rare gain-of-function alleles of the serotonin transporter gene, SLC6A4, associated with Tourette disorder” Oral presentation at The International Society for Serotonin Research Meeting, Arabella, South Africa.
2012 “Rare and common gain-of-function alleles of the serotonin transporter gene, SLC6A4, associated with Tourette disorder”, en sesión: “Neuropsychiatric Disorders”; 62 Annual Meeting of American Society of Human Genetics (ASHG), San Francisco, CA, USA. (Ab. # 261)
2012 “Regulación de la expresión del transportador de serotonina: variantes humanas y su rol en neuropsiquiatría”, in symposium “Neurofarmacología de transportadores de monoaminas: del modelamiento molecular a la conducta”; XXXIV reunión de la Sociedad de Farmacología de Chile, Pucón, Chile.
2012 "Functional variants in the serotonin transporter gene (SLC6A4) associated with Tourette syndrome", in nanosymposium: “ADHD, SLI, Dyslexia and Other Specific Disorders of Neurobehavior”; reunion anual de la Society for Neuroscience, New Orleans, LA, USA. (Abstract # 122.06)

Reviewer

Ad-hoc: Molecular Psychiatry, Journal of Neurochemistry, Frontiers in Psychiatry, Frontiers in Pharmacology, ACS Chemical Neuroscience, Neural Plasticity, Neurochemical Research, Pharmacogenomics and Personalized Medicine.

Grant reviewer: the International OCD Foundation (2021); Fondecyt Regular grupos de estudio Biologia 3 y Medicina G1 (2015-2021); FONDEF (2014-2015).

Outreach and press

https://diariotalca.cl/cuatro-universidades-investigaran-el-maltrato-infantil-en-el-maule/
https://www.tvn.cl/ntv/nochesnerd/ultimoscapitulos/noches-nerd-capitulo-8-neurociencia-4989342
https://www.cronicadigital.cl/2021/08/20/universidad-de-valparaiso-es-la-unica-institucion-de-la-v-region-autorizada-para-secuenciar-el-coronavirus-y-detectar-nuevas-variantes/
https://images.lun.com/Pages/NewsDetail.aspx?dt=2021-04-15&PaginaId=2&bodyid=0
https://www.lun.com/Pages/NewsDetail.aspx?dt=2021-03-13&PaginaId=13&bodyid=0
https://youtu.be/N6ll-oyO270
https://youtu.be/M52eOBNFma0
https://youtu.be/zowTsDfJVQY
https://youtu.be/jEG_GDqvXmk
https://www.lun.com/Pages/NewsDetail.aspx?dt=2020-07-24&PaginaId=8&bodyid=0
https://www.youtube.com/watch?v=m-XTd-iNUlw
https://www.mercuriovalpo.cl/impresa/2019/09/03/full/cuerpo-principal/8/


Premios y Distinciones

  •   Fellows Award for Research Excellence (FARE),

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2008

    NIH travel award for outstanding research projects ($1,000)

  •   The Serotonin Club Travel Award

    The Serotonin Club (now International Society for Serotonin Research)

    Chile, 2004

    Travel award for attendance and presentation at the Serotonin Satellite Meeting, 4th Congress of the Federation of European Pharmacological Societies (EPHAR), Porto, Portugal (£1,000 grant)

  •   NIDA travel award

    International Society for Serotonin Research

    Chile, 2014

    Travel Award to attend and present at the 11th International Society for Serotonin Research, Hermanus, South Africa, July 2014.


 

Article (36)

Polymorphisms in schizophrenia-related genes are potential predictors of antipsychotic treatment resistance and refractoriness.
Altered Grooming Syntax and Amphetamine-Induced Dopamine Release in EAAT3 Overexpressing Mice.
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders
ABC transporters and drug resistance in epilepsy: biological plausibility pharmacogenetics and precision medicine
History of child abuse among patients with bipolar disorders
Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats
Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine
The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder
3D similarities between the binding sites of monoaminergic target proteins
Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats
Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner.
Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice
Connecting Synaptic Activity with Plasticity-Related Gene Expression: From Molecular Mechanisms to Neurological Disorders.
Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats
Improving amphetamine therapeutic selectivity=> N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction.
Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive - compulsive disorder as an example of overlapping clinical and genetic heterogeneity
Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder
Meta-analysis of association between obsessive-compulsive disorder and the 3 ' region of neuronal glutamate transporter gene SLC1A1
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells
Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans
Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo
In a Model of Batten Disease, Palmitoyl Protein Thioesterase-1 Deficiency Is Associated with Brown Adipose Tissue and Thermoregulation Abnormalities
A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study
Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G x G and G x E differences in health and disease
Lentivirally mediated GSK-3 beta silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice
Increased gene expression of diacylglycerol kinase eta in bipolar disorder
A Haplotype Containing Quantitative Trait Loci for SLC1A1 Gene Expression and Its Association With Obsessive-Compulsive Disorder
A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)(2A) and 5-HT2C receptors
Pharmacological identification of P2X(1), P2X(4) and P2X(7) nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors

Editorial (1)

Connecting synaptic activity with plasticity-related gene expression: From molecular mechanisms to neurological disorders

Proyecto (6)

Molecular and Functional Evaluation of a Mouse Model of Obsessive-Compulsive Disorder with Increased EAAT3 Expression
Centro Interdisciplinario de Neurociencia de Valparaíso CINV
EVALUACIÓN DE BIOMARCADORES GENÉTICOS EN PACIENTES CON EPILEPSIA RESISTENTE A FÁRMACOS DEL POLICLÍNICO DE NEUROLOGÍA DEL HOSPITAL CARLOS VAN BUREN
NEONATAL PROGRAMMING=> SEX HORMONES EXCESS DISRUPTS MIDBRAIN DOPAMINE FUNCTION IN THE ADULTHOOD.
GENERATION AND FUNCTIONAL CHARACTERIZATION OF MICE WITH ALTERED EXPRESSION OF EAAT3=>A MODEL FOR OBSESSIVE-COMPULSIVE DISORDER.
Nucleo Milenio en Biologia de Enfermedades Neuropsiquiátricas NU-MIND
35
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

7
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

4
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

3
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Andres Chavez

Full Professor

Neuroscience

Universidad de Valparaiso

Valparaiso, Chile

1
Jonathan Martínez

Profesor ayudante

UNIVERSIDAD DE VALPARAISO

Valparasiso, Chile

1
Alvaro Cavieres

Profesor

Departamento de Psiquiatría

Universidad de Valparaíso

Valparaíso, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Pablo Fuentealba

Assistant Professor

Psychiatry

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

1
Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

1
Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Carolina Campos

Associate Professor

School of Chemistry and Pharmacy

Universidad de Valparaiso

Valparaíso, Chile

1
Maria Bustamante

Profesora Asistente

Facultad de Medicina

Universidad de Chile

Santiago , Chile

1
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Oscar Urrejola

Subdirector de Investigación

Dirección Médica Nacional

Teletón

Santiago, Chile