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Maria Estela Andres Coke

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Molecular mechanisms regulating gene expression in neurons. Role of LSD1-CoREST transcriptional repressor complexes in neuronal excitability Molecular and neurochemical modifications in compulsive behaviors

Educación

  •  Ph.D. in Biomedical Sciences, Universidad de Chile. Chile, 1997
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1989
  •  Postdoctoral, State University of New York at Stony Brook. Estados Unidos, 2000

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    2004 - 2019

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    1999 - 2004

  •   Visiting Professor Other

    UNIVERSITY OF WISCONSIN-MADISON

    Medicine and Public Health

    Madison, Estados Unidos

    2016 - 2016

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Ph.D. thesis in progress:
1. Montserrat Olivares "Epigenetic regulation of the early gene Nur77 in dopaminoceptive neurons"
2. Duxan Arancibia "Evaluating the neuroprotector role of CDNF in reticular stress response in neurons"
3. Carlos Rivera "Asociation of CoREST1, CoREST2 y CoREST3 to chromatin during neuronal differentiation"

Co-tutor of in-progress Ph.D. thesis
1.- Enzo Pérez "Changes in adult dopaminergic pathways induced by CB1 agonist during adolescence”

Ph.D. thesis completed:
1.- Julián Sáez “Biochemical and Functional Properties of CoREST family proteins” 2016
2.- Angélica Escobar “Interaction between the D2 dopamine receptor and the kappa opioid receptor in a rat model of the obsessive-compulsive disorder” Co-advisor: José A Fuentealba, 2016
3.- Luis Pereira “Regulation of Nurr1 expression by miRNAs” 2015
4.- Natalia Sánchez “Nur77 expression is regulated by dopamine and glutamate in D2 receptor neurons in mice striatum” 2015
5.- Cristian Arredondo, “Post-translational modification of Nurr1 by SUMOylation, mechanisms, and effects” 2012.
6.- Andrea Gómez, “Functional interaction between the molecular chaperone Hsp70 and the transcriptional co-repressor CoREST”. 2010
7.- Danny Galleguillos, “Nurr1: Regulation of the expression of the tyrosine kinase receptor RET and function in the dopaminergic system” 2009.
8.- Andrea Vecchiola, “Regulation of Nurr1-dependent transcriptional activity by SUMO and the SUMO-E3-ligase, PIASgamma”. 2006.
9.- José A. Fuentealba, “Facilitation of dopamine release in the nucleus accumbens of rats repeatedly treated with the kappa opioid agonist U-69593”. 2005.

Co-advisor of completed Ph.D. Thesis
1.- Francisca Cornejo "Changes of the expression of scavenger receptor class A associated with aging and its participation in Alzheimer disease" 2017 Advisor: Rommy von Bernardi. 2017
2.- Paula Slater “Interaction and regulation of CRH-R2 by CRH-BP” advisor: Katia Gysling. 2016
Ongoing undergraduate thesis
1.- Gianluca Merello "Characterizing Molecular and Behavioral traits of neuroLSD1 knockout mice"
2.- Fabián Guzmán "Determining the role of CoREST2 in nuclei speckles"

Completed undergraduate thesis
1.- Diane Leighton, Biochemistry, 2017
2.- Roxana Ureta, Biochemistry. 2016
3.- Mauricio Herrera, Biochemistry, 2015
3.- Álvaro Barrios, Biochemistry and Pharmacy. 2012
4.- Mathias Saver, Biochemistry. 2011
5.- Francisca Cornejo, Biochemistry. 2011
6.- Stephanie Cortez, Biology. 2009
7.- Luis Miguel Gómez, Biochemistry. 2008
8.- Tamara Garcia, Biochemistry. 2007
9.- Marcelo Orellana, Biochemistry. 2007


Difusión y Transferencia


Since June 2015, I am part of the expert advisory group to contribute to the design, implementation and evaluation of public policies promoted by SENDA.

2012 Organization and Participation in the Symposium “Progress and Challenges in Scientific Research on Treatment, Pharmacological Strategies and Vaccines against Drug Addiction” November, 12-14, Santiago. In preparation for the Presidencia Pro Tempore of Chile for the 1st Summit of Heads of State and Government of the CELAC.

2013 Organization and coordination of the International workshop First Joint Meeting “Alcohol and other Drugs of Abuse: from molecules to human disorders” (October, 16-19, Concepción). Sponsored by ICM, ISN y CELAC.

2015 Organization of the round Table: "Alcohol and the adolescent brain, a biopsychosocial sight" speakers: Katia Gysling (scientist, UC), Carlos Ibáñez (psychiatry and PhD, SENDA) and Paulo Egenau (psychologist and Director of Fundación Paréntesis) September 22, Coquimbo.


Premios y Distinciones

  •   Honor Medal "Hermann Niemayer"

    Sociedad de Bioquimica y Biologia Molecular de Chile

    Chile, 1994

    Best PhD student of PhD programs in biochemistry and related sciences in Chile.

  •   PEW fellowship

    PEW charitable trusts

    Estados Unidos, 1998

    Fellowship for postdoctoral training in USA. (10 fellowships are awarded each year for Latin American applicants)

  •   Excellence in teaching

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2014

    This prize is given by the University to the best professors every year.


 

Article (50)

Cross-talk between dopamine D1 and corticotropin releasing factor type 2 receptors leads to occlusion of their ERK1/2 signaling
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
Inhibitory Control of Basolateral Amygdalar Transmission to the Prefrontal Cortex by Local Corticotrophin Type 2 Receptor
The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death
Development of a Bicistronic Vector for the Expression of a CRISPR/Cas9-mCherry System in Fish Cell Lines
The blocking of kappa-opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization
Type 2B corticotrophin releasing factor receptor forms a heteromeric complex with dopamine D1 receptor in living cells
CDNF induces the adaptive unfolded protein response and attenuates endoplasmic reticulum stress-induced cell death
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats
PIAS gamma controls stability and facilitates SUMO-2 conjugation to CoREST family of transcriptional co-repressors
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimers disease pathophysiology
Long 3'UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats
CRF binding protein facilitates the presence of CRF type 2? receptor on the cell surface
Opposite effects of acute and chronic amphetamine on Nurr1 and NF-?B p65 in the rat ventral tegmental area
Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response
Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation
Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area
Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function
Differential Properties of Transcriptional Complexes Formed by the CoREST Family
Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32
An Amphipathic Alpha-Helix in the Prodomain of Cocaine and Amphetamine Regulated Transcript Peptide Precursor Serves as Its Sorting Signal to the Regulated Secretory Pathway
Long-term loss of dopamine release mediated by CRF-1 receptors in the rat lateral septum after repeated cocaine administration
PIAS gamma Enhanced SUMO-2 Modification of Nurr1 Activation-Function-1 Domain Limits Nurr1 Transcriptional Synergy
The effect of previous exposure to nicotine on nicotine place preference
Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons
Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis
Short communication: Effect of vitamins E and C on cortisol production by bovine adrenocortical cells in vitro
Activation of GABA-B receptors induced by systemic amphetamine abolishes dopamine release in the rat lateral septum
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain
Repeated Treatment With the kappa-Opioid Agonist U-69593 Increases K+-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex
CoREST represses the heat shock response mediated by HSF1
Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593
Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.
Intron retention as an alternative splice variant of the rat urocortin 1 gene
Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases. Stimulated dopamine extracellular levels in the rat nucleus accumbens
Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain
PIAS gamma represses the transcriptional activation induced by the nuclear receptor Nurr1
Rapid increase of Nurr1 expression in the Substantia nigra after 6-hydroxydopamine lesion in the striatum of the rat
Rest repression of neuronal genes requires components of the hSWI·SNF complex
Regulation of neuronal traits by a novel transcriptional complex.
Medullary noradrenergic neurons projecting to the bed nucleus of the stria terminalis express mRNA for the NMDA-NR1 receptor
CoREST: a functional corepressor required for regulation of neural-specific gene expression.
DIFFERENTIAL REGULATION OF DOPAMINE RELEASE BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT STRIATUM AFTER PARTIAL AND EXTREME LESIONS OF THE NIGRO-STRIATAL PATHWAY
NMDA-NR1 receptorsubunit mRNA expression in rat brain after 6-OH-dopamine induced lesions: anon-isotopic in situ hybridization study
Regulation of endogenous noradrenaline release from the bed nucleus of stria terminalis
Differential effects of haloperidol on negative symptomsin drug-naive schizophrenic patients: effects on plasma homovanillic acid
Regulation of [3H]norepinephrine release byN-methyl-D-aspartate receptors in minislices from the dentate gyrus and theCA1-CA3 area of the rat hippocampus
Studies of cholecystokinin in the rat bed nucleus of stria terminalis

Abstract (2)

Functional and molecular interaction between D2 and kappa opioid receptors: role in locomotor sensitization to quinpirole
PIAS gamma represses NURR1-dependent transciptional activity

BookSection (1)

Nicotina, la más dañina y menos temida de las adicciones

Proyecto (5)

Determining the function of LSD1-CoREST transcriptional complexes in compulsive behaviors. An opportunity to find new therapeutic targets
Nurr1/CoREST complexes controlling gene expression in dopamine neurons
Molecular and neurochemical dysfunctions in an animal model of obsessive-compulsive disorder
STUDIES ON THE MECHANISMS INVOLVED IN THE PATHOGENESIS OF COCAINE-ASSOCIATED BRAIN PERFUSION DEFECTS: THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ACTIVATION OF HEMOSTATIC SYSTEM
Nucleus Millenium in Stress and Addiction: from molecules to behavior

Review (1)

Nur transcription factors in stress and addiction
69
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

26
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

12
José Fuentealba

Associate professor

Farmacy

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

7
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

5
Andrea Gómez

Investigador Postdoctoral

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Francisca Cornejo

Postdoc

Universidad Mayor

Santiago, Chile

2
Julián Sáez

DOCENTE

UNIVERSIDAD AUTONOMA DE CHILE

TEMUCO, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

1
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Victor Martinez

PROFESRO ASOCIADO

DPTO. FOMENTO DE LA PRODUCCION ANIMAL

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marcelo Orellana

Gestor de Innovación en áreas prioritarias

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
sebastian escobar

PROFESOR ASISTENTE

CIENCIAS ANIMALES

Pontificia Universidad Católica de Chile

santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

1
Juan Maass

Asistan Professor

universidad de chile

Santiago, Chile

1
Jonathan Martínez

Profesor ayudante

UNIVERSIDAD DE VALPARAISO

Valparasiso, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Rafael Larraín

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE AGRONOMÍA E INEGNIERÍA FORESTAL

Santiago, Chile

1
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

1
Montserrat Olivares

Candidata a doctor

Biología celular y molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
CRISTIAN BRAVO

Profesional

Laboratorio Biomédico

Instituto Salud Publica

Santiago, Chile

1
Nicole Salgado

Coordinador

Facultad de Ciencias Biologicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile