Molecular mechanisms regulating gene expression in neurons. Role of LSD1-CoREST transcriptional repressor complexes in neuronal excitability Molecular and neurochemical modifications in compulsive behaviors

Ph.D. thesis in progress:
1. Montserrat Olivares "Epigenetic regulation of the early gene Nur77 in dopaminoceptive neurons"
2. Duxan Arancibia "Evaluating the neuroprotector role of CDNF in reticular stress response in neurons"
3. Carlos Rivera "Asociation of CoREST1, CoREST2 y CoREST3 to chromatin during neuronal differentiation"

Co-tutor of in-progress Ph.D. thesis
1.- Enzo Pérez "Changes in adult dopaminergic pathways induced by CB1 agonist during adolescence”

Ph.D. thesis completed:
1.- Julián Sáez “Biochemical and Functional Properties of CoREST family proteins” 2016
2.- Angélica Escobar “Interaction between the D2 dopamine receptor and the kappa opioid receptor in a rat model of the obsessive-compulsive disorder” Co-advisor: José A Fuentealba, 2016
3.- Luis Pereira “Regulation of Nurr1 expression by miRNAs” 2015
4.- Natalia Sánchez “Nur77 expression is regulated by dopamine and glutamate in D2 receptor neurons in mice striatum” 2015
5.- Cristian Arredondo, “Post-translational modification of Nurr1 by SUMOylation, mechanisms, and effects” 2012.
6.- Andrea Gómez, “Functional interaction between the molecular chaperone Hsp70 and the transcriptional co-repressor CoREST”. 2010
7.- Danny Galleguillos, “Nurr1: Regulation of the expression of the tyrosine kinase receptor RET and function in the dopaminergic system” 2009.
8.- Andrea Vecchiola, “Regulation of Nurr1-dependent transcriptional activity by SUMO and the SUMO-E3-ligase, PIASgamma”. 2006.
9.- José A. Fuentealba, “Facilitation of dopamine release in the nucleus accumbens of rats repeatedly treated with the kappa opioid agonist U-69593”. 2005.

Co-advisor of completed Ph.D. Thesis
1.- Francisca Cornejo "Changes of the expression of scavenger receptor class A associated with aging and its participation in Alzheimer disease" 2017 Advisor: Rommy von Bernardi. 2017
2.- Paula Slater “Interaction and regulation of CRH-R2 by CRH-BP” advisor: Katia Gysling. 2016
Ongoing undergraduate thesis
1.- Gianluca Merello "Characterizing Molecular and Behavioral traits of neuroLSD1 knockout mice"
2.- Fabián Guzmán "Determining the role of CoREST2 in nuclei speckles"

Completed undergraduate thesis
1.- Diane Leighton, Biochemistry, 2017
2.- Roxana Ureta, Biochemistry. 2016
3.- Mauricio Herrera, Biochemistry, 2015
3.- Álvaro Barrios, Biochemistry and Pharmacy. 2012
4.- Mathias Saver, Biochemistry. 2011
5.- Francisca Cornejo, Biochemistry. 2011
6.- Stephanie Cortez, Biology. 2009
7.- Luis Miguel Gómez, Biochemistry. 2008
8.- Tamara Garcia, Biochemistry. 2007
9.- Marcelo Orellana, Biochemistry. 2007

Since June 2015, I am part of the expert advisory group to contribute to the design, implementation and evaluation of public policies promoted by SENDA.

2012 Organization and Participation in the Symposium “Progress and Challenges in Scientific Research on Treatment, Pharmacological Strategies and Vaccines against Drug Addiction” November, 12-14, Santiago. In preparation for the Presidencia Pro Tempore of Chile for the 1st Summit of Heads of State and Government of the CELAC.

2013 Organization and coordination of the International workshop First Joint Meeting “Alcohol and other Drugs of Abuse: from molecules to human disorders” (October, 16-19, Concepción). Sponsored by ICM, ISN y CELAC.

2015 Organization of the round Table: "Alcohol and the adolescent brain, a biopsychosocial sight" speakers: Katia Gysling (scientist, UC), Carlos Ibáñez (psychiatry and PhD, SENDA) and Paulo Egenau (psychologist and Director of Fundación Paréntesis) September 22, Coquimbo.