Man

PAOLA HAEGER

Associated professor

Universidad Catolica del Norte

COQUIMBO, Chile

Líneas de Investigación


Cellular and molecular mechanisms underlying complex behaviors involved in physiological or pathological conditions, such as memory formation, drug addiction. Keyword: Neurodevelopment. Alcohol. Fetal programming. Gen expression. Redox homeostasis.

Educación

  •  Doctor en Ciencias Biologicas, Pontificia Universidad Catolica de Chile. Chile, 2005
  •  Bioquímico, Universidad Austral de Chile. Chile, 1998
  •  Licenciado en Bioquimica, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1998

Experiencia Académica

  •   Associated Professor Full Time

    Universidad Catolica del Norte

    Facultad de Medicina

    Coquimbo, Chile

    2013 - A la fecha

Experiencia Profesional

  •   Posdoctorado Full Time

    Universidad de Chile. FONDAP-CEMC and Instituto de Ciencias Biomedicas

    Santiago, Chile

    2006 - 2008

  •   Posdoctorado Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2005 - 2005

  •   Posdoctorado Full Time

    Yeshiva University, Albert Einstein College of Medicine, NY, USA.

    New York, Estados Unidos

    2009 - 2013

Formación de Capital Humano


TEACHING EXPERIENCE:

GRADUATE PROGRAM
-Thesis supervision of José Cuitiño. MAGÍSTER EN CIENCIAS BIOLÓGICAS MENCIÓN NEUROCIENCIAS. Universidad de Valparaiso. Mayo 2020.
-Visitor Professor of “Calcium signaling”. Universidad de Chile, Santiago Chile. November 2007.
-Visitor Professor of “Calcium signaling”. Universidad de Chile, Santiago Chile. November 2008.
-Thesis supervision of María Mercedes Casas Alarcón. Master in Medical Sciences, Facultad de Medicina , Universidad de Chile. 2009-2011. Co-advisor with Dr. Maria Cecilia Hidalgo.

UNGRADUATE PROGRAM
-Thesis supervision Specer Alcayaga. Kinesiología. Universidad Católica de Norte. 2019
-Thesis supervision Kinesiología. Universidad Católica del Norte. 2018.
-Thesis supervision of Daniela Jara. Ingeniería en Biotecnología, Universidad Tecnológica Metropolitana. 2015
-Coordinator of Pharmacology Course for nurse students. Universidad Católica del Norte. 2013-2018
-Training in Biochemistry of Sebastian Gallardo, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 2009. Co-advisor with Dr. Maria Cecilia Hidalgo.
-Visitor Professor of Neuroscience for Biochemistry students. Lectures of Neuroanatomical bases of the Behavior: Anxiety and Learning and Memory. Universidad Nacional Andrés Bello. Santiago-Chile. October 2006, 2007, 2008..
-Training in Biology of Julián Sánchez, Facultad de Ciencias Universidad de Chile. 2009 Co–advisor with Dr. Maria Cecilia HidalgoProfessor in charge of General training course “Revelando las verdades del clonamiento” Universidad Nacional Andrés Bello. August-November 2005.
-Instructor of Pharmacology for Pharmaceutical students. P. Universidad Católica de Chile. Santiago-Chile. July-November 2005.
-Professor In charge of Cellular Biology course for Veterinary Medicine students. Universidad Nacional Andrés Bello, Santiago- Chile. March-July 2006, 2007.


Difusión y Transferencia


*2020 Organizer of "Jornada de discusión en torno a problemáticas de uso y abuso de alcohol y drogas." Coquimbo
*2019 Part of reviewer scientific committee of “Congreso Regional Explora 2019”.
*2019 Invited speaker of “II Encuentro de Investigación e Innovación con Equidad”.
Facultad de Medicina de la Universidad de Talca, Talca.
*2018 Part of reviewer scientific committee of “Congreso Regional Explora 2018”.
*2018 Invited speaker of “ Congreso Futuro 2018”. Title of presentation: Alcohol y drogas: la delgada línea entre la salud y la enfermedad”.
*2018 Invited speaker of “IV Jornada Anual de Equipos Chile Crece Contigo de Hospitales de la Región Metropolitana”.Title of presentation: Bebes Expuestos A Sustancias Por Consumo Materno De Alcohol y/o Drogas.
*2017. Invited speaker of “Seminario de Prevención del Consumo de Alcohol: Un Desafío Regional” Organizer by SENDA and Gobierno Regional de Coquimbo. Junio 7th,
*2016 Invited speaker to the conference entitled: “Alteraciones cognitivas luego de la exposición a alcohol in útero, evaluadas en modelo animal”. Facultad de Psicología, Universidad Nacional de Córdoba, Argentina. 21 Octubre 2016.
*2016 Speaker for “Explora” program. Presentation entitled: “Brain and Emotion“. For 3th grade students Colegio Arturo Prat Chacón-Coquimbo-Chile.
*2016 Speaker for “Explora” program. Presentation entitled: "From abuse drugs consumption to addiction". For 6th grade students Colegio Santa Maria del Refugio -Coquimbo-Chile.
*2016 Workshop for 5th grade students “Effect of alcohol in our organism”. This activity was inserting in the “Lanzamiento campaña regional de SENDA-Cuida tus límites”
*2015 Organizer and director of “International itinerant workshop “Consequences of ethanol consumption: Neurobiology, Prevention and Rehabilitation”. Funded by IBRO-LARC. This grant supported diverse activities for professionals working with vulnerable and addicts persons as well as with students of 5th grade of different schools in Andacollo.
*2015 Organizer and director of Workshop: “Formación de monitores preventivos de adicciones en la Universidad Católica del Norte”. Funded by “Proyecto de Interés regional, Gobierno Regional de Coquimbo. This grant supported the training of 8 students.
*2015 Speaker for “Explora” program. Presentation entitled: ¿Por qué las Mamitas embarazadas no deben beber alcohol? Audience: students of 7th grade. Escuela Gabriela Mistral, Llanquihue-Chile
*2015 Speaker for “Gobierno Regional de Coquimbo Project”. Presentation entitled:”Efecto del consumo de alcohol en nuestro cerebro”. Audience: students of 7th grade Escuela Metodista, Coquimbo-Chile
*2015 Invited teacher. Talk entitled: Why are abuse drugs the enemy of our brain? Audience: students of 2th grade at Colegio San Joaquin, La Serena-Chile.
*2015 Invited speaker for “Jornada de Neurociencia, desde la teoría a la práctica” for students and general community. Universidad Santo Tomas, Sede La Serena.
*2014-2015 Organizer of “I and II Jornadas Básicos-Clínicas” Universidad Católica del Norte. October
*2014 Invited speaker on the “Seminarios de Facultad de Medicina, Universidad Austral de Chile”, Valdivia.


Premios y Distinciones

  •   Postoctoral fellowship

    PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

    Estados Unidos, 2010

    Postdoctoral training in Dr Pablo Castillos's Laboratory

  •   Beca Chile Postdoctorado

    FONDECYT

    Chile, 2009

    2009-2013 Postdoctoral training in Pablo Castillo's laboratory at Albert Einstein College of Medicine, USA.

  •   Fondecyt Postdoctorado

    FONDECYT

    Chile, 2007

    2007-2009 “Fondecyt-Postdoctorado” – 3070035. Laboratory Dr Cecilia Hidalgo. ICBM, Universidad de Chile

  •   Beca termino tesis doctoral

    P. Universidad Catolica de Chile

    Chile, 2005

    2005 “Programa Becas Término de Tesis Doctoral”- Fondecyt 23050063


 

Article (18)

N-Methyl-d-Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre-and Postnatally to Ethanol
Pre- and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
Prenatal Ethanol Exposure Misregulates Genes Involved in Iron Homeostasis Promoting a Maladaptation of Iron Dependent Hippocampal Synaptic Transmission and Plasticity
Prenatal ethanol exposure potentiates isolation-induced ethanol consumption in young adult rats
Treatment with Melatonin Improves Cognitive Behavior and Motor Skills in a Rat Model of Liver Fibrosis
Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation
NADPH Oxidase Isoform 2 (NOX2) Is Involved in Drug Addiction Vulnerability in Progeny Developmentally Exposed to Ethanol
Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
Erratum to: Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
Ryanodine receptor-mediated calcium release stimulates gene expression in neurons
Estrogen receptors ? and ? differentially regulate the transcriptional activity of the urocortin gene
ESTROGEN RECEPTORS ALPHA AND BETA DIFFERENTIALLY REGULATE THE TRANSCRIPTIONAL ACTIVITY OF THE UROCORTIN GENE
Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.
Intron retention as an alternative splice variant of the rat urocortin 1 gene
Natural expression of immature Ucn antisense RNA in the rat brain. Evidence favoring bidirectional transcription of the Ucn gene locus
Corticotropin-releasing hormone and urocortin: redundant or distinctive functions?

Proyecto (13)

“Impacto de la pandemia COVID-19 en salud mental: Evaluación longitudinal de síntomas ansiosos, depresivos y conductas de riesgo en comunidades de las regiones de Coquimbo y de la Araucanía”.
Prenatal alcohol exposure alters the function of the glutamatergic system and ultimately results in cognitive deficits and exacerbated alcohol intake=> modulation by environmental protective and risk factor
“Formación de monitores preventivos de adicciones en la Universidad Católica del Norte”.
“International itinerant workshop “Consequences of ethanol consumption=> Neurobiology, Prevention and Rehabilitation”.
Acquisition of Confocal microscopy
EFFECT OF PRENATAL ETHANOL EXPOSURE ON NMDA RECEPTOR-MEDIATED LONG TERM PLASTICITY IN RATS=> ROLE OF REACTIVE OXYGEN SPECIES.
FONDO CONCURSABLE ASISTENCIA A CONGRESOS AÑO 2013. Vicerectoria de investigación UCN
ROLE OF ACYLPEPTIDE HYDROLASE IN SYNAPTIC FUNCTION DURING THE ONTOGENY OF SPRAGUE-DAWLEY RATS. INVOLVEMENT OF ENDOGENOUS BETA-AMYLOID PEPTIDE LEVELS AND ALFA7 NICOTINIC RECEPTORS IN THIS MECHANISM
“Cellular and molecular mechanism involved in the NMDAR dependent plasticity”
Beca Chile- Postdoctorado
“The calcium releases through Ryanodine receptor promote the spatial memory activating the PKM ζ and iron transporter expression”.
“Programa Becas Término de Tesis Doctoral”- Fondecyt
Estadía corta de investigación doctoral
19
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

6
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

4
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

3
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

2
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

1
Italo Espinoza

Lab Manager

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Andres Chavez

Full Professor

Neuroscience

Universidad de Valparaiso

Valparaiso, Chile

1
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile