Man

Gina Luisa Sanchez Vergara

Profesor Asociado

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Líneas de Investigación


Redox regulation of proteins, intracellular calcium concentration, signal transduction, cell death, apoptosis, autophagy. Molecular mechanism of cardioprotection, Ischemia Reperfusion cardiac, mechanism of degradation of proteins, mitochondrial dynam

Educación

  •  Bioquimico, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

  •   Academico Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1999 - A la fecha

Experiencia Profesional

  •   Académico Full Time

    Universidad de Chile

    Santiago, Chile

    2008 - A la fecha

Formación de Capital Humano


2005-2007
Student: Agustin Alvarado Osorio
Title: "Phosphorylation of Sarcoplasmic Reticulum Proteins by Preconditioning Tachycardia.",
Institution: UNIVERSIDAD DE CHILE, Master / Master / DEA

2008-2010
Student: Ernesto Muñoz
Title: "Activity of the Sarcoplasmic Reticulum Reticulum Calcium Pump and its Redox Modifications",
Institution: UNIVERSIDAD DE CHILE, Master

2008-2009
Student: Carolina Fernández Pérez
Title: "Participation of mitochondrial permeability transition pore (mPTP) in preconditioning by tachycardia",
Institution: UNIVERSIDAD DE CHILE, Master

2009-2012
Student: Mauricio Ibacache
Title: "Cardioprotection by dexmedetomedine in myocardial ischemia and reperfusion",
Institution: UNIVERSIDAD DE CHILE, PhD

2009-2010
Student: Julio Miranda Betancourt
Title: "S-glutathionylation of the ryanodine receptor in skeletal muscle of insulin-resistant mice.",
Institution: UNIVERSIDAD DE CHILE, Master

2012-2014
Student: Javier Pezoa
Title: "Degradation of RyR2 in rat hearts subjected to ischemia-reperfusion: role of calpains and proteosome",
Institution: UNIVERSIDAD DE CHILE, Master

2013-2017
Student: Quezada Catalán, Mauricio
Title: "Effect of ascorbic acid on the damage caused by reperfusion in an isolated heart infarct model of a rat",
Institution: UNIVERSIDAD DE CHILE, Master

2013-2015
Student: Jaime Riquelme
Title: "Role of the eNOS-nitric oxide-cGMP-dependent protein kinase pathway in the preconditioning cardiac effect of dexmedetomidine",
Institution: UNIVERSIDAD DE CHILE, PhD

2015-2016
Student: CHALMERS ESPINOZA, STEFANIE GRACE
Title: "Cardioprotective effect of n-acetylcysteine in the damage produced by ischemia, on the content of mitofusin 2, in isolated heart of rat",
Institution: UNIVERSIDAD DE CHILE, Master

2015-2017
Student: BERRIOS ZAMORA, DANIELA
Title: "Effect of the Proteasome Chymotrypsin Activity on the damage produced by ischemia in rat isolated heart",
Institution: UNIVERSIDAD ARTURO PRAT, Bachelor

2015-2018
Student: González, Jaime
Title: "Pharmacological prevention of myocardial damage due to reperfusion in acute myocardial infarction",
Institution: UNIVERSIDAD DE CHILE, PhD

2016-2017
Student: Conejeros Vasquez Carolina
Title: "Participation of Miro1 in hypertrophy in neonatal rat cardiomyocytes",
Institution: UNIVERSIDAD DE CHILE, Master

2016-2017
Student: Ahumada Cortes Xavier
Title: "Effect of the inhibition of the chymotrypsin activity of the proteasome during ischemia, in the mitochondrial structure of the rat isolated heart",
Institution: UNIVERSIDAD DE CHILE, Master

2016-2018
Student: Huechamil Iglesias Matias Ignacio
Title: " The use of iron chelators decreases diastolic dysfunction in an ex vivo model of ischemia and reperfusion due to the inhibition of titin redox status ",
Institution: UNIVERSIDAD DE CHILE, Master

2017-2018
Student: Inostroza Herrera Cristopher
Title: "Decreased myocardial damage by reperfusion in the Langendorff model by co-administration of Ascorbic Acid and Deferoxamine",
Institution: UNIVERSIDAD DE CHILE, Master

2017-2019
Student: Utreras Mendoza Yildy
Title: "" Identification of the signaling pathway of cardiac hypertrophy in C57BL / 6J mice fed a high-fat diet "",
Institution: UNIVERSIDAD DE CHILE, PhD

2018-2019
Student: Mujica Isidora
Title: "Effect of obesity produced by a high-fat diet on the cellular redox balance in the heart",
Institution: UNIVERSIDAD DE CHILE, Master

2017- 2019
Student: Gajardo, Abraham Isaac Jacob
Title: "Effect of" autonomic stress "on cardioprotection due to remote ischemic preconditioning: transferring ischemic conditioning from the laboratory to clinical practice",
Institution: UNIVERSIDAD DE CHILE, PhD


Difusión y Transferencia


Patent of Invention
INAPI
registry number 56881
Headline: Universidad de Chile
Inventors:
Sánchez Vergara, Gina; Prieto Domínguez, Juan Carlos; Florenzano Urzúa, Fernando; Gormaz Araya, Juan Guillermo; Rodrigo Salinas, Ramón; Aguayo Nayle, Rubén.
Title:
Pharmaceutical injectable antioxidant composition comprising high dose ascorbic acid, N-acetyl cysteine ??and deferoxamine; use in the prevention of damage by perfusion in patients before, during and after angioplasty, acute myocardial infarction or reperfusion in cerebrovascular accident.

Application 2014-3326
Date of application: 05-12-2014
Award date: 04-10-2018
Date of granting registration number: 03-01-2019
Effective date: 05-12-2014
Expiry date: 05-12-2034



 

Article (52)

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes
N-Methyl-d-Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre-and Postnatally to Ethanol
Autonomic imbalance in cardiac surgery: A potential determinant of the failure in remote ischemic preconditioning
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT(2)R and Akt-dependent mechanism
Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.
Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins
Exercise Preconditioning of Myocardial Infarct Size in Dogs Is Triggered by Calcium
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes
Insulin/NF kappa B protects against ischemia-induced necrotic cardiomyocyte death
Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
Modulation of cardiac ryanodine receptor activity by ROS and RNS
Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury
Nueva estrategia de preacondicionamiento no hipóxico que atenúa el efecto de la Isquemia-Reperfusión en pacientes sometidos a cirugía cardíaca con circulación extracorpórea
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex
Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation
PARTICIPACION DE CA2+ EN EL PRECONDICIONAMIENTO DEL MIOCARDIO POR EJERCICIO
Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle
Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning?
Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels
Exercise induces early and late myocardial preconditioning in dogs
Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetus
Redox regulation of calcium release in skeletal and cardiac muscle
Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs
Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia
Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia.
Study of the behavioral effects of bilateral nucleus accumbens lesions on amphetamin and apomorphine in adult cats
Tachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C

Abstract (8)

Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats
H2O2 Production and Glutathionylation of Ryanodine Receptor in Skeletal Muscle from Insulin Resistance Mice
Increased cardiac activity enhances RyR2 S-glutathionylation
Effect of tachycardia and exercise on myocardial sarcoplasmic reticulum and calcium dynamics
Role of PKC epsilon in preconditioning induced by tachycardia and exercise
Participation of the sarcoplasmic reticulum in the myocardial preconditioning by tachycardia in dogs.
Nitric oxide plays a major role in the regulation of adrenal blood now and catecholamine secretion in the llama fetus
Nitric oxide synthase (NOS) activity in the fetal llama brain submitted to hypoxaemia

BookSection (1)

Posttranslational Modifications of Cardiac Ryanodine Receptors/Calcium Release Channels by ROS and RNS. En: Systems Biology of Free Radicals and Anti-Oxidants

BookWhole (1)

Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species

ConferencePaper (1)

Non ischemic myocardial preconditioning by tachycardia and exercise

Proyecto (8)

The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-MyC dependent BIN-1 expression
Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus
Novedosa estrategia farmacológica para prevenir el daño por reperfusión en la angioplastia coronaria aplicada a pacientes con infarto agudo de miocardio
Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice
Polycystin-1 regulates L-type calcium channel
THE HIGH ROS CONTENT OF AGED RATS ALTERS RYR-MEDIATED CALCIUM-SIGNALING, IMPARTING HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY
EFFECT OF PROTEASOME INHIBITION ON THE CONTENT OF MITOFUSINS 1 AND 2 AND THE PRESERVATION OF MITOCHONDRIAL FUNCTION FOLLOWING CARDIAC ISCHEMIA-REPERFUSION
REGULACION REDOX DE PROTEINAS MITOCONDRIALES EN EL POSTCONDICIONAMIENTO CARDIACO

Review (1)

Infarto perioperatorio en cirugía no-cardíaca y dexmedetomidina
93
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

18
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

12
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

8
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

5
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

4
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

3
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

3
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

3
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

2
Victor Parra

Médico titular

ICBM, Facultad de Medicina

Instituto Nacional del Tórax y Universidad de Chile

Santiago, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

2
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

2
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

2
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Andres Chavez

Full Professor

Neuroscience

Universidad de Valparaiso

Valparaiso, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Abraham Gajardo

Médico residente UPC

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Barbara Bruna

Asistente de Investigación

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Andrea Ramírez

Asistente de Investigación

Bioquímica

Universidad de Chile

Región Metropolitana, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

1
Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

1
Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

1
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
juan duaso

Academico

Universidad Vina del Mar

Viña del Mar, Chile