Man

Jaime Andres Riquelme Melendez

Assistant Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Endothelial pharmacology; Exosomes and cardioprotection, Cell signaling in cardiac ischemia/reperfusion injury.

Educación

  •  Veterinary Medicine, UNIVERSIDAD CATOLICA DE TEMUCO. Chile, 2010
  •  Pharmacology, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Doctor of Veterinary Medicine, UNIVERSIDAD CATOLICA DE TEMUCO. Chile, 2010

Experiencia Académica

  •   Ph.D. student Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2011 - 2015

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2019 - A la fecha

  •   Postdoctoral researcher Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2016 - 2018

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2019 - A la fecha

  •   Teaching assistant Other

    Universidad Andrés Bello

    Santiago, Chile

    2018 - 2018

  •   Teaching assistant Other

    Universidad de Chile

    Santiago, Chile

    2016 - 2018

Premios y Distinciones

  •   Best work in basic sciences

    XXV Internamerican Congress of Cardiology and Cardiovascular Surgery.

    Chile, 2015

    Award for Best work in basic sciences: Riquelme JA, Westermeier F, Hall AR, Vicencio JM, Pedrozo Z, Ibacache M, Fuenzalida B, Sobrevia L, Davidson SM, Yellon DM, Sánchez G, Lavandero S. Dexmedetomidine preconditions the myocardium through an endotelial nitric oxide synthase/nitric oxide/cylic gmp dependent protein kinase.


 

Article (14)

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy
Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line
Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro
Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT(2)R and Akt-dependent mechanism
Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion
The role of PI3K alpha isoform in cardioprotection
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.
Dexmedetomidina genera óxido nítrico mediante un mecanismo independiente de la óxido nítrico sintasa inducible
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism
Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury
Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

EditorialMaterial (2)

Editorial commentary: Cardiometabolic diseases and gut microbiota-removing the veil
Heart Disease and Cancer: Are the Two Killers Colluding?

Proyecto (2)

Endothelial activation by the pro-inflammatory cytokine TNF-alfa impairs the cardioprotective effect of endothelium-derived exosomes
Papel de los exosomas provenientes de células endoteliales en el precondicionamiento miocárdico inducido por dexmedetomidina

Review (3)

Novel Therapies Targeting Cardioprotection and Regeneration
New molecular insights of insulin in diabetic cardiomyopathy
Therapeutic targeting of autophagy in myocardial infarction and heart failure
21
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

4
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

4
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

4
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Valeria Garrido

Investigador Postdoctoral

Advanced Center for Chronic Disease

Universidad de Chile

Santiago, Chile

2
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ignacio Norambuena

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Ramiro Zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Constanza Núñez

Investigadora

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile

1
Andrea Ramírez

Asistente de Investigación

Bioquímica

Universidad de Chile

Región Metropolitana, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile