Man

Jaime Andres Riquelme Melendez

Assistant Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Endothelial pharmacology; Exosomes and cardioprotection, Cell signaling in cardiac ischemia/reperfusion injury.

Educación

  •  Veterinary Medicine, UNIVERSIDAD CATOLICA DE TEMUCO. Chile, 2010
  •  Pharmacology, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Doctor of Veterinary Medicine, UNIVERSIDAD CATOLICA DE TEMUCO. Chile, 2010

Experiencia Académica

  •   Ph.D. student Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2011 - 2015

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2019 - A la fecha

  •   Postdoctoral researcher Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2016 - 2018

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2019 - A la fecha

  •   Teaching assistant Other

    Universidad Andrés Bello

    Santiago, Chile

    2018 - 2018

  •   Teaching assistant Other

    Universidad de Chile

    Santiago, Chile

    2016 - 2018

Premios y Distinciones

  •   Best work in basic sciences

    XXV Internamerican Congress of Cardiology and Cardiovascular Surgery.

    Chile, 2015

    Award for Best work in basic sciences: Riquelme JA, Westermeier F, Hall AR, Vicencio JM, Pedrozo Z, Ibacache M, Fuenzalida B, Sobrevia L, Davidson SM, Yellon DM, Sánchez G, Lavandero S. Dexmedetomidine preconditions the myocardium through an endotelial nitric oxide synthase/nitric oxide/cylic gmp dependent protein kinase.


 

Article (30)

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

Riquelme, Jaime A.; Villa, Monica; Chiong, Mario

Article ISI
FRONTIERS IN ENDOCRINOLOGY  (2023)

Endothelial activation impairs the function of small extracellular vesicles

Troncoso, Mayarling F.; Riquelme, Jaime A.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2023)

Methods for studying primary cilia in heart tissue after ischemia-reperfusion injury

Troncoso, Rodrigo; Riquelme, Jaime A.; Criollo, Alfredo

Article ISI
CILIA, PT B  (2023)

Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy

Riquelme, Jaime A.; Llancaqueo, Marcelo; Vergara, Cecilia

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Targeting VCAM-1: a therapeutic opportunity for vascular damage

Riquelme, Jaime A.; Muller, Marioly; Garrido, Luis; Chiong, Mario

Article ISI
EXPERT OPINION ON THERAPEUTIC TARGETS  (2023)

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Kalkhoran, Siavash Beikoghli; Hernandez-Resendiz, Sauri; Crespo-Avilan, Gustavo E.; Rosdah, Ayeshah A.; Lees, Jarmon G.; Da Costa, Joana Rodriguez Simoes; Ling, Naomi X. Y.; Holien, Jessica K.; Samangouei, Pariza; Chinda, Kroekkiat; et al.

Article ISI
CARDIOVASCULAR RESEARCH  (2022)

Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells

Quiroga, Clara; Riquelme, Jaime A.; Bustamante, Mario; Chiong, Mario

Article ISI
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2022)

The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells

Riquelme, Jaime A.

Article ISI
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY  (2022)

Communication Between Cardiomyocytes and Fibroblasts During Cardiac Ischemia/Reperfusion and Remodeling: Roles of TGF-β, CTGF, the Renin Angiotensin Axis, and Non-coding RNA Molecules

Aranguiz, Pablo; Riquelme, Jaime A.

Article ISI
FRONTIERS IN PHYSIOLOGY  (2021)

Potential Therapies to Protect the Aging Heart Against Ischemia/Reperfusion Injury

Zuniga-Cuevas, Ursula; Ramirez-Reyes, Andres; Herrera-Zelada, Nicolas; Riquelme, Jaime A.

Article ISI
FRONTIERS IN CARDIOVASCULAR MEDICINE  (2021)

Targeting the Endothelium to Achieve Cardioprotection

Riquelme, Jaime A.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2021)

Increased production of functional small extracellular vesicles in senescent endothelial cells

Riquelme, J. A.; Santiago-Fernández C.

Article ISI SCOPUS
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2020)

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury

Riquelme, J. A.; López-Crisosto C.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2020)

Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters

Ramirez-Sagredo, Andrea; Riveros, Ana L.; Riquelme, Jaime A.; Araya, Eyleen; Chiong, Mario; Villamizar Sarmiento, Maria Gabriela

Article ISI
JOURNAL OF CONTROLLED RELEASE  (2020)

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy

Villar-Fincheira, P; Hernandez-Diaz, T; Martin, AS

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion

Riquelme, J. A.; Leiva-Navarrete S.; Cayupi-Vivanco J.; Espinoza-Pérez C.; Ruz-Cortés F.

Article ISI SCOPUS
ANTIOXIDANTS  (2019)

Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line

Morales PE; Sanhueza-Olivares, F; Nunez-Soto, C; Cancino-Arenas, N; San Martin, A

Article ISI SCOPUS
PLOS ONE  (2018)

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro



Article ISI
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2018)

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

Riquelme, J. A.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2018)

High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice

Said, M; Bull, R

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism

Cordova-Casanova, A; Olmedo, I; Riquelme, JA; Barrientos, G; Gillette, TG; pedrozo, Z

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2018)

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT(2)R and Akt-dependent mechanism

Mendoza-Torres, E; Vielma, A; Sagredo, AR; Rothermel BA

Article ISI SCOPUS
PHARMACOLOGICAL RESEARCH  (2018)

Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion

Rossello, X

Article ISI SCOPUS
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2018)

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro

Davidson, SM; Riquelme, JA; Takov, K; Vicencio, JM; Boi-Doku, C; Khoo, V; Doreth, C; Radenkovic, D; Lavandero, S; Yellon, DM

Article
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2017)

The role of PI3K alpha isoform in cardioprotection

Rossello, X; He, ZH; Taferner, S; Vanhaesebroeck, B

Article ISI SCOPUS
Basic Research in Cardiology  (2017)

Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death

Sánchez, Gina

Article ISI SCOPUS
PLOS ONE  (2016)

Dexmedetomidina genera óxido nítrico mediante un mecanismo independiente de la óxido nítrico sintasa inducible

Jaime Riquelme; Francisco Westermeier; Zully Pedrozo; Lorena García; Mauricio Ibacache; Gina Sánchez; Sergio Lavandero

Article SCIELO
Revista chilena de cardiolog�a  (2016)

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism

Riquelme, JA; Westermeier, F; Hall, AR; pedrozo, Z; Ibacache M; Fuenzalida, B; Sobrevia L.; Davidson, SM; Yellon, DM; Sánchez G; et al.

Article ISI SCOPUS
PHARMACOLOGICAL RESEARCH  (2016)

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Yellon, DM; Sivaraman, V; Das D.; Boi-Doku, C; Arjun, S; Zheng Y.; Riquelme, JA; Kearney, J; Sharma V.; Multhoff, G; et al.

Article ISI SCOPUS
Journal of the American College of Cardiology  (2015)

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

Zepeda, Ramiro; Kuzmicic, Jovan; Troncoso, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo, Zully; Chiong, Mario

Article ISI
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY  (2014)

EditorialMaterial (2)

Editorial commentary: Cardiometabolic diseases and gut microbiota-removing the veil



EditorialMaterial ISI SCOPUS
TRENDS IN CARDIOVASCULAR MEDICINE  (2019)

Heart Disease and Cancer: Are the Two Killers Colluding?



EditorialMaterial ISI SCOPUS
CIRCULATION  (2018)

Proyecto (7)

Activation of ACE2 in endothelial small extracellular vesicles protect the myocardium against myocardial infarction in high fat diet fed mice

Riquelme, Jaime A.; Chiong, Mario

Proyecto
 (2023)

Endothelial activation by the pro-inflammatory cytokine TNF-alfa impairs the cardioprotective effect of endothelium-derived exosomes

FONDECYT (11181000)

Proyecto
2019-2021
Inv. Responsable

Endothelial activation by the pro-inflammatory cytokine TNF-alfa impairs the cardioprotective effect of endothelium-derived exosomes



Proyecto Initiation research grant
 (2019)

Papel de los exosomas provenientes de células endoteliales en el precondicionamiento miocárdico inducido por dexmedetomidina

Jaime Riquelme Meléndez; Mario Chiong Lay (Sponsor)

Proyecto Postdoctoral research grant
 (2016)

PAPEL DE LOS EXOSOMAS PROVENIENTES DE CÉLULAS ENDOTELIALES EN EL PRECONDICIONAMIENTO MIOCÁRDICO INDUCIDO POR DEXMEDETOMIDINA

FONDECYT (3160298)

Proyecto
2015-2018
Inv. Responsable

"EFFECT OF PROTEASOME INHIBITION ON THE CONTENT OF MITOFUSINS 1 AND 2 AND THE PRESERVATION OF MITOCHONDRIAL FUNCTION FOLLOWING CARDIAC ISCHEMIA-REPERFUSION"

FONDECYT (1130407)

Proyecto
2013-2017
Personal técnico y/o de apoyo

Advanced Center for Chronic Diseases

FONDAP (15130011)

Proyecto
2013-2018
Tesista

Review (5)

Counter-regulatory renin–angiotensin system in cardiovascular disease

Riquelme, J. A.; Jalil J.E.

Review ISI SCOPUS
 (2020)

Novel Therapies Targeting Cardioprotection and Regeneration



Review ISI SCOPUS
CURRENT PHARMACEUTICAL DESIGN  (2017)

New Molecular Insights of Insulin in Diabetic Cardiomyopathy

Westermeier, F; Riquelme, J. A.; Pavez, M.; Garrido, V; Diaz A.; Castro P.F.; Garcia, L.; Lavandero S.

Review ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2016)

Therapeutic targeting of autophagy in myocardial infarction and heart failure



Review WOS-ESCI SCOPUS
Expert Review of Cardiovascular Therapy  (2016)

Regulation of cardiac autophagy by insulin-like growth factor 1

Troncoso R.; Diaz-Elizondo, J; Espinoza, SP; Oyarzún, AP; Riquelme, JA; Garcia-Carvajal, I; Diaz-Araya, G; Garcia, L.; Hill, JA; Lavandero S.

Review ISI SCOPUS
IUBMB Life  (2013)

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

13
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

5
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

39
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

3
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Jovan Kuzmicic

Profesor Asistente

Departamento Salud

Universidad de Los Lagos

Osorno, Chile

1
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

1
Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

1
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

2
Maria Ocaranza

Full Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

8
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

1
Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ramiro Zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Paula Valenzuela

Senior Researcher

Nuevos Materiales Avanzados

Leitat Chile

Santiago, Chile

1
Constanza Núñez

Investigadora

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

2
Ignacio Norambuena

Postdoctorado

Universidad de Chile

Santiago, Chile

2
Valeria Garrido

Investigador Postdoctoral

Advanced Center for Chronic Disease

Universidad de Chile

Santiago, Chile

1
Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile

2
Andrea Ramírez

Asistente de Investigación

Bioquímica

Universidad de Chile

Región Metropolitana, Chile

1
Sebastián Leiva

Lab Manager

Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Magda Díaz

1
Sandra Espinoza

Coordinadora de campo clínico

Tecnología y Ciencias Farmacéuticas

Universidad de Chile

Santiago, Chile

1
Yvo Flores

Profesional (grado 12)

Biomédico

Instituto de Salud Pública

Santiago, Chile

2
ALEJANDRA SAN MARTIN

Professor

Medicine

Universidad Andrés Bello

Santiago, Chile

2
Fernanda Sanhueza

Bioquímica

Hospital Base San José de Osorno

Osorno, Chile

1
Jessica Díaz

Profesional especialista

Universidad Andrés Bello

Santiago, Chile