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Mario Martín Chiong Lay

Profesor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


- Metabolism in cardiovascular system and disease - Signal transduction in cardiovascular system - Cell death mechanisms

Educación

  •  Doctor en Farmacología, Universidad de Chile. Chile, 2009
  •  Bioquímico, Universidad de Chile. Chile, 1986
  •  Licenciado en Bioquímica, Universidad de Chile. Chile, 1986

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2010 - A la fecha

  •   Ayudante Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Chile

    1988 - 1991

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    1991 - 1993

Experiencia Profesional

  •   Associate Professor Full Time

    Unversidad de Chile

    Santiago, Chile

    2010 - A la fecha

Formación de Capital Humano


POST-DOCTORAL FELLOWS (University of Chile)
A total of 1 completed (Raúl Vivar) and 1 ongoing (Jaime Riquelme).

Ph.D. and POST-GRADUATE STUDENTS
Director or Co-director of 2 completed (Gloria Torres; Marina García) and 3 ongoing (David Mondaca, Ignacio Norambuena, Andrea Ramirez) PhD theses
Director or Co-director of 6 completed (Pablo E. Morales, Tomas Gutierrez; Natalia Venegas, Melany Ríos, Carla Muñoz, Fernanda Sanhueza) and 1 ongoing MSc theses (Nicole Cancino)

POST-GRADUATE LECTURE COURSES (Chile)
Lecturer in 5 transversal post-graduate courses of the University of Chile (Basic Concepts in Cell Signalling; Cell Signalling in Biomedicine; Advanced Cell and Molecular Biology Course, Cell Biology and Clinical Pharmacology) per year.

UNDERGRADUATE STUDENT TRAINING IN THE LAB
Director or Co-director of 4 completed (Jonathan Hernández; Benjamín Cartes, Ignacio Norambuena, Constanza Nuñez) and 2 ongoing (Ángelo Cancino; Tomás Hernández) undergraduate theses

UNDERGRADUATE TEACHING
Coordinator and lecturer in 4 undergraduate teaching (General Physiology; Physiological and Pathological Chemistry course I; Physiological and Pathological Chemistry course II; Physiological and Pathological Chemistry advance course) every year.


Difusión y Transferencia


PATENTES DE INVENCIÓN

1. Ocaranza MP, Lavandero S, Jalil J, Michea L, Chiong M. Uso de una composición farmacéutica que contiene angiotensina-(1-9) o sus derivados, composición farmacéutica que contiene un vector que expresa la enzima ECA2 que produce angiotensina-(1-9) para elaborar medicamentos útiles para prevenir, revertir, inhibir y/o disminuir la hipertensión arterial y/o inducir vasodilatación. Prioridad CL 950-2010. Presentada en Chile, Oficina de Patentes, Ministerio de Economía Fomento y Reconstrucción. Solicitud internacional PCT/CL2012/000016. Concedida en Estados Unidos US9,511,120 (6 Diciembre 2016).

2. Ocaranza MP, Lavandero S, Jalil J, Chiong M. “Composición farmacéutica que contiene angiotensina-(1-9) o sus derivados, composición farmacéutica que contiene un vector que expresa la enzima ECA2 que produce angiotensina (1 9), usos de dichas composiciones farmacéuticas y del péptido angiotensina-(1-9) para elaborar medicamentos útiles para prevenir, revertir, inhibir y/o disminuir el remodelado cardiovascular, pulmonar, cerebral y/o renal”. Prioridad CL 3736-2008. Presentada en Chile, Oficina de Patentes, Ministerio de Economía Fomento y Reconstrucción. Presentación internacional PCT/CL2009/000029. Concedida en Estados Unidos US9132164 (15 Septiembre 2015) y en Europa EP2377544 (22 Octubre 2015).

3. Sclabos D, Toro R, Chiong M. “Solvent-free process for obtaining phospholipids and neutral enriched krill oils”. Prioridad PCT/IB2009/007269. Presentada en Patent Cooperation Treaty (PCT). Concedida en Estados Unidos US9011942 (21 Abril 2015), US9150815 (6 Octubre 2015), US8865236 (21 Octubre 2014), US8772516 (8 Julio 2014), y US8609157 (17 Diciembre 2013); Japón JP5735521 (17 Junio 2015); China CN102638998 (7 Octubre 2015) y Australia AU2009354456 (8 Mayo 2014).


Premios y Distinciones

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2010

    Award gave by the Biochemist students

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2008

    Award gave by the Biochemist students

  •   Scholarship “The British Council”,

    BRITISH COUNCIL

    Chile, 1990

    For a training in the National Institute for Biological Standards and Control in the UK

  •   Scholarship "Beca Presidente de la República"

    MINISTERIO DE EDUCACION

    Chile, 1981

    Scholarshio to study Biochemistry

  •   Colegio de Químicos Farmacéuticos Award

    COLEGIO DE QUIMICO FARMACEUTICO DE CHILE A.G.

    Chile, 1986

    Best student of Biochemstry, promotion 1986

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2011

    Award gave by the Biochemist students

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Award gave by the Biochemist students

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2014

    Award gave by the Biochemist students

  •   Mejor Docente de Pregrado de la Universidad de Chile 2014

    UNIVERSIDAD DE CHILE

    Chile, 2014

    Award gave by the "Vicerrectoría de Asuntos Estudiantiles, Universidad de Chile"

  •   Premio "Mejor Docente"

    UNIVERSIDAD DE CHILE

    Chile, 2016

    Award gave by the Biochemist students


 

Article (106)

Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats
Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension
Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology
Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators
Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
TonEBP suppresses IL-10-mediated immunomodulation
Insulin/NF kappa B protects against ischemia-induced necrotic cardiomyocyte death
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury
Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF kappa B-Opa-1 Signaling Pathway
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure
Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes
Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis
Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells
Herp depletion protects from protein aggregation by up-regulating autophagy
Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
Mayores niveles de ECA y Angiotensina II determinados genéticamente, se asocian a menor actividad del eje ECA2/angiotensina-(1-9) y mayor remodelamiento de la pared aórtica de ratas hipertensas
Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Inhibition of Cyclin-Dependent Kinase 5 but Not of Glycogen Synthase Kinase 3-beta Prevents Neurite Retraction and Tau Hyperphosphorylation Caused by Secretable Products of Human T-Cell Leukemia Virus Type I-Infected Lymphocytes
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients
Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation
The role of uric acid in heart failure
The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia cardiaca
Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Heart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
La sobreexpresión del gen de enzima convertidora de angiotensina homóloga (ECA2) revierte la hipertensión arterial y el remodelado cardíaco experimental
Menores niveles tisulares de la enzima convertidora de angiotensina I homologa (ECA-2) y angiotensina-(1-9) están asociados a mayor remodelamiento de la pared aórtica de ratas hipertensas
Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure [Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica]
Niveles aumentados de estrés oxidativo se asocian a disfunción endotelial periférica y respuesta vascular pulmonar disminuida frente a vasodilatadores en pacientes con hipertensión pulmonar
PARALLEL ACTIVATION OF CA(2+)-INDUCED SURVIVAL AND DEATH PATHWAYS IN CARDIOMYOCYTES BY SORBITOL-INDUCED HYPEROSMOTIC STRESS
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
(TTA)n Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery Disease Patients
Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II
El tratamiento con atorvastatina reduce la actividad de xantina-oxidasa unida al endotelio en pacientes con insuficiencia cardíaca crónica: ¿Un posible nuevo efecto pleiotrópico?
Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v beta 3 integrin that activates PKC alpha and RhoA
Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
Inflammation and endothelial dysfunction in patients with chronic heart failure
Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Interactions between beta(1) and beta(2) adrenergic receptor polymorphisms as risk factors for chronic heart failure
Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor
Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial function, and exercise capacity
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas
Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G beta gamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes
Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure
Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
Oxidative stress in pericardial fluid and plasma and its association with ventricular function
Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure
Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés oxidativo en pacientes con insuficiencia cardíaca crónica
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype
Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis
Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion
Persistence of oxidative stress after heart tranplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
Direct electrochemical characterization of hyperthermophilic Thermococcus celer metalloenzymes involved in hydrogen production from pyruvate
Purification and characterization of an iron-nickel hydrogenase from Thermococcus celer
VARIANTES GENETICAS DE LOS RECEPTORES ADRENERGICOS Y ENFERMEDADES CARDIOVASCULARES
Purification and characterization of ferredoxin from the hyperthermophilic Pyrococcus woesei
Optimization of the growth conditions of the extremely thermophilic microorganisms Thermococcus celer and Pyrococcus woesei
Citrus limon seedlings without functional chloroplasts are unable to induce phenylalanine ammonia-lyase in response to inoculation with Alternaria alternata
Kinetic characteristics of nucleoside mono-, di- and triphosphatase activities of the periplasmic 5'-nucleotidase of Escherichia coli
Omeprazole, a specific gastric secretion inhibitor on oxynticopeptic cells, reduces gizzard erosion in broiler chicks fed with toxic fish meals

Proyecto (43)

Autocrine/paracrine interleukin-6 and myostatin control of VSMC differentiation under exercise and resting
Autocrine/paracrine interleukin-6 and myostatin control of VSMC differentiation under exercise and resting
Shedding of vascular cell adhesion molecules predicts adverse cardiovascular events in patients submitted to cardiac surgery
Shedding of vascular cell adhesion molecules predicts adverse cardiovascular events in patients submitted to cardiac surgery
Cardiac remodeling and biological response in highly trained athletes=> study with myocardial deformation imaging and biomarkers at baseline and post-intensive acute exercise
Cardiac remodeling and biological response in highly trained athletes: study with myocardial deformation imaging and biomarkers at baseline and post-intensive acute exercise
Papel de los exosomas provenientes de células endoteliales en el precondicionamiento miocárdico inducido por dexmedetomidina
Sistema de PCR digital de última generación
PAPEL DE LOS EXOSOMAS PROVENIENTES DE CÉLULAS ENDOTELIALES EN EL PRECONDICIONAMIENTO MIOCÁRDICO INDUCIDO POR DEXMEDETOMIDINA
Comprehensive evaluation of right ventricular function, ventricular remodeling and micro RNA profiling in pulmonary artery hypertension=> Effects of a fatty acid oxidation inhibitor
Dual role of autophagy in the regulation of vascular smooth muscle cell phenotype dependent of mTOR activation
DUAL ROLE OF AUTOPHAGY IN THE REGULATION OF VASCULAR SMOOTH MUSCLE CELL PHENOTYPE DEPENDENT ON MTOR ACTIVATION
Evaluation of right ventricular function, ventricular remodeling and micro RNA profiling in patients with pulmonary artery hypertension: Effects of a fatty acid oxidation inhibitor
EVALUATION OF RIGHT VENTRICULAR FUNCTION, VENTRICULAR REMODELING AND MICRO RNA PROFILING IN PATIENTS WITH PULMONARY ARTERY HYPERTENSION=> EFFECTS OF A FATTY ACID OXIDATION INHIBITOR
Unidad de Microscopía de Dinámica Celular
Advanced Center for Chronic Diseases (ACCDiS).
Advanced Center of Chronic Diseases (ACCDiS)
Angiotensina-(1-9), un nuevo principio activo para el tratamiento de la hipertensión y del daño cardiovascular y renal secundarios=> estudio y desarrollo preclínicos
Equipo de ultracentrifugación con cuatro rotores
Plataforma de microscopía confocal para uso en investigaciones biomédicas avanzadas
Angiotensina-(1-9), un nuevo principio activo para el tratamiento de la hipertensión y del daño cardiovascular y renal secundarios: estudio y desarrollo preclínicos.
Bioenergética celular
Desarrollo de una plataforma tecnológica para análisis cuantitativos, cualitativo y de distribución subcelular de proteínas
La regulación diferencial de FOXO1 y FOXO3a por TGF-beta1, modula tanto la diferenciación como el aumento de la actividad antiapoptótica/antioxidante de fibroblastos cardiacos
Metabolic stress signaling in cancer, cardiovascular diseases and diabetes.
Metabolic stress signaling in cancer, cardiovascular diseases and diabetes.
The incretin Glucagon-Like Peptide I: Study of new metabolic mechanisms in vascular remodeling.
The incretin Glucagon-Like Peptide I=> Study of new metabolic mechanisms in vascular remodeling.
Angiotensin-(1-9): a new peptide regulator of blood pressure that decreases cardiovascular remodeling and renal injury
Angiotensin-(1-9)=> a new peptide regulator of blood pressure that decreases cardiovascular remodeling and renal injury.
Metabolismo cardiaco en la insuficiencia cardiaca crónica no isquémica y sus implicancias en el estrés oxidativo, inflamación y remodelado cardiovascular.
Metabolismo cardíaco en la insuficiencia cardíaca crónica no isquémica y sus implicancias en el estrés oxidativo, inflamación y remodelado cardiovascular.
Resistencia a insulina en la diabetes tipo II: estudio de nuevos mecanismos fisiopatológicos asociados al deterioro de la función cardiaca
Resistencia a insulina en la diabetes tipo II=> estudio de nuevos mecanismos fisiopatológicos asociados al deterioro de la función cardiaca.
Mecanismos de protección cardiovascular dependientes de la enzima convertidora de angiotensina I homóloga (ECA2) en la hipertensión arterial experimental
Mecanismos de protección cardiovascular dependientes de la enzima convertidora de angiotensina I homóloga (ECA2) en la hipertensión arterial experimental
Estrés oxidativo, inflamación y disfunción endotelial en la insuficiencia cardiaca crónica: Efectos de la inhibición de la xantino-oxidasa y 3-hidroxi-3-metilglutaril-coA reductasa.
Estrés oxidativo, inflamación y disfunción endotelial en la insuficiencia cardiaca crónica=> efectos de la inhibición de la xantino-oxidasa y 3 hidroxi 3 metilglutaril-Coa reductasa
Obtención de quitosano a partir de desechos de krill antártico y sus aplicaciones biotecnológicas
Aislamiento de los cDNA que codifican para los genes de resistencia a fitopatógenos en Citrus
Importancia de la actividad ADPásica en vegetales, animales y microorganismos
Evaluación técnico-económica para la producción de proteasas desde ciegos pilóricos de jurel, con aplicaciones en aditivos para alimentos de peces e hidrólisis de proteínas de pescado
Implementación de una plataforma para caracterizar nanoestructuras (tamaño, potencial zeta, concentración y fluorescencia) de interés en diversas disciplinas

Article (29)

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy
Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension
Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line
Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis
Increased active phase atrial contraction is related to marathon runner performance
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
Potential adverse cardiac remodelling in highly trained athletes=> still unknown clinical significance
The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content
Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.
Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation
ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.
Autophagy in cardiovascular biology.
Molecular mechanisms of autophagy in the cardiovascular system
Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).
Effects of trimetazidine in nonischemic heart failure: a randomized study.
Effects of Trimetazidine in Nonischemic Heart Failure=> A Randomized Study
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation
Organelle communication: signaling crossroads between homeostasis and disease.
Organelle communication=> Signaling crossroads between homeostasis and disease
Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.
Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure.
Influence of glucose metabolism on vascular smooth muscle cell proliferation
Angiotensina-(1-9) disminuye el remodelamiento cardiovascular hipertensivo independiente de los niveles de ECA y de angiotensina II
Autophagy as a therapeutic target in cardiovascular disease
Cardiomyocyte death: mechanisms and translational implications
Mitochondrial dynamics: a potential new therapeutic target for heart failure
Heart energy metabolism and its role in the treatment of heart failure
Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome
Uric acid, xanthine oxidase and heart failure: Unresolved issues

Review (13)

ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension
Autophagy in cardiovascular biology
Molecular Mechanisms of Autophagy in the Cardiovascular System
Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system
Influence of glucose metabolism on vascular smooth muscle cell proliferation
Autophagy as a therapeutic target in cardiovascular disease
Cardiomyocyte death: mechanisms and translational implications
Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure
Heart energy metabolism and its role in the treatment of heart failure
Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives
Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling

Abstract (11)

Angiotensin-(1-9) Prevents Cardiomyocyte Hypertrophy Through Calcium Influx Dependent Pathway
Angiotensin-(1-9) Prevents the Cardiovascular Pathological Remodeling Induced by Angiotensin II In Vivo
Evidence of impaired cardiac autophagic flux in patients developing post-operative atrial fibrillation
Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor
Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome
Extracellular endothelium-bound superoxide dismutase is a sensitive oxidative stress marker in heart failure patients
A signal transduction mechanism linking dihydropyridine receptors and phospholipase C in myotubes
Carvedilol corrects interventricular and interventricular dyssynchrony in chronic heart failure.
Apoptosis induced by hyperosmotic stress
Decrease in oxidative stress is not related to left ventricular function improvement in patients with chronic heart failure treated with carvedilol
Gene expression of profibrotic factors in isoproterenol-treated Brown-Norway and Lewis rats

Letter (3)

Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure Reply
Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome
Uric acid, xanthine oxidase and heart failure: Unresolved issues

EditorialMaterial (1)

Mechanisms of cell death: molecular insights and therapeutic perspectives

ComunicacionBreve (1)

Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
171
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

87
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

35
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

25
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

24
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

24
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

21
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

21
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

19
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

19
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

16
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

14
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

14
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

11
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

8
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

8
Andrea del Campo

Profesor Asistente, Investigador Principal

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

6
Jenny Blamey

Director

Research and Development

FUNDACIÓN CIENTÍFICA Y CULTURAL BIOCIENCIA

Santiago, Chile

6
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

5
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

4
Daniel Peña

Investigador postdoctoral

Instituto de Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

4
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Juan Carlos Quintana

Médico nuclear

Radiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

3
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

santiago, Chile

3
MARIO SIMIRGIOTIS

Associate professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

3
Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

3
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

3
Pablo Sepúlveda

Cardiólogo Intervencionista

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Roberto Ebensperger

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

2
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Carolina Nazzal

jefa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

2
Samuel Cordova

ESCUELA DE MEDICINA, PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

2
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Juan Villena

ASSOCIATE PROFESSOR

BIOMEDICAL SICIENCES

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

2
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

2
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

2
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

2
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

2
Andrés Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

1
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

1
CARLOS LAGOS

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Mario Bustamante

Docente

Universidad Mayor de Chile

Santiago, Chile

1
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
ramiro zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile

1
Rodrigo Herrera Molina

Group Leader (staff member)

Neurochemistry and Molecular Biology

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Pedro Buc

Profesor titular

Quimica y Farmacia

UNIVERSITE CATHOLIQUE DE LOUVAIN

Iquique, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Edio Maldonado

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gonzalo Martínez

Cardiólogo Intervencional

Cardiología

Hospital Clínico Universidad Católica

Santiago, Chile

1
Jorge Borquez

Académico

Química

Universidad de Antofagasta

Antofagasta, Chile

1
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Constanza Núñez

Investigadora

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
maria pando

Profesor asistente

Nutrición

Universidad de Chile

Santiago, Chile