Man

Javier Octavio Morales Montecinos

Profesor Asociado

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Nanostructured materials as controlled and targeted delivery systems for biologic and conventional drugs

Educación

  •  Pharmaceutics, UNIVERSITY OF TEXAS AT AUSTIN. Estados Unidos, 2012
  •  Farmacia, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2013 - 2019

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Graduate research Assistant Full Time

    The University of Texas at Austin

    Austin, Estados Unidos

    2008 - 2012

  •   Profesor Part Time

    Instituto Profesional de Chile

    Santiago, Chile

    2007 - 2008

  •   Intern Full Time

    Evonik Rohm GmbH

    Darmstadt, Alemania

    2011 - 2011

  •   Miembro del comité editorial Part Time

    Drug Development and Industrial Pharmacy

    New York, Estados Unidos

    2013 - A la fecha

  •   Miembro del comité editorial Part Time

    AAPS PharmSciTech

    New York, Estados Unidos

    2014 - A la fecha

  •   Associate Editor Part Time

    Drug Development and Industrial Pharmacy

    New York, Estados Unidos

    2018 - A la fecha

  •   Associate Editor Part Time

    Drug Development and Industrial Pharmacy

    New York, Estados Unidos

    2018 - A la fecha

Formación de Capital Humano


Director de 2 investigadores postdoctorales, 9 tesis dirigidas de pregrado, 3 tesis dirigidas de magíster, 6 tesis dirigidas de doctorado, 12 cursos de postgrado, 6 Unidades de Investigación de postgrado, 5 Actividades de titulación de postgrado, 38 Cursos de pregrado, 15 Unidades de Investigación de pregrado, 22 Actividades de titulación de pregrado, 3 Cursos nuevos de pregrado, 1 Curso innovado de pregrado, 2 Curso nuevo de postgrado.


Difusión y Transferencia


Patentes y aplicaciones de patentes
1. J.O. Morales, M. Montenegro-Nicolini, F. Campano-Hantscheruk. Forma farmacéutica para administración bucal de dosis altamente controlada, liberación controlada y estable de biomacromolécula que comprende película polimérica como sustrato de impresión y una tinta de inyección impresa sobre dicha película polimérica que comprende nanoparticulas o suspensiones de nanopartículas con dicha biomacromolécula, y método de preparación. Application Number CL201600112, and PCT/CL2017/050001
2. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. US Application Number 14/897140 (Submitted: December 9, 2015)
3. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. Application Number WO2014065870 A1 (Published: May 1, 2014)
4. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Polymer Strip for Treatment of Oral Thermal Burns. Application/Provisional Number 61/717,082 (Submitted: Oct 22, 2012).
5. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Medicated Polymer Film Strip: Application/Provisional Number 61/719,922 (Submitted: Oct 29, 2012)


Premios y Distinciones

  •   Abstract Reviewer and Publication Coordinator for the Taylor and Francis Group and and ExcipientFest 2017

    Taylor and Francis Group

    Estados Unidos, 2017

    Selected to review and coordinate the publication in Drug Development and Industrial Pharmacy of the best abstracts at ExcipientFest 2017 in Providence, RI

  •   Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology

    UNIVERSIDAD DE CHILE

    Chile, 2017

    Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology for: Desarrollo de quantum dots de óxido de zinc como nanocarriers de curcumina sensibles al pH tumoral

  •   BPS–USP PSWC2017 Congress Travel Scholarship

    BPS–USP PSWC2017 Congress

    Suecia, 2017

    Recipient of a Congress Scholarship based on academic excellence as a Young researcher/professor. Funding to attend and present at the FIP 6th Pharmaceutical Sciences World Congress 2017 in Stockholm, Sweden

  •   2015 ASILFA Distinguished Professional

    ASILFA

    Chile, 2016

    Recipient of the Distinguished Professional Award from the Industrial Association of Pharmaceutical Companies (ASILFA from its Spanish translation) for outstanding work in Research & Development on Pharmaceutical Sciences. Santiago, Chile

  •   Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics”

    AAPS Annual Meeting and Exposition

    Estados Unidos, 2015

    Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics” and to speak on “Buccal drug delivery of biologics as an alternative delivery route” to be presented in Orlando, Florida, USA in October 2015

  •   Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs”

    AAPS National Biotechnology Conference

    Chile, 2014

    Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs” and to speak on “Buccal Delivery of Insulin Using Flexible Films” presented in San Diego, CA in May 2014


 

Article (67)

Experimental design and optimization of a novel dual-release drug delivery system with therapeutic potential against infection with Helicobacter pylori
Aptamer-functionalized lipid-core micelles loaded with rhenium tricarbonyl complex
Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems
Dember photovoltaic effect as method for structural characterization of phospholipidic membranes
Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation
Inkjet printing of small molecules, biologics, and nanoparticles
Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy
Nanoparticles as Potential Novel Therapies for Urinary Tract Infections
Poloxamer 188-coated ammonium methacrylate copolymer nanocarriers as a promising strategy for overcoming gastrointestinal limitations of loperamide absorption
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic
Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids
Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs
Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters
Poly-epsilon-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis
Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety
Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology
Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
Preparation of a novel lipid-core micelle using a low-energy emulsification method
The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems
Buccal delivery of small molecules and biologics=> of mucoadhesive polymers, films, and nanoparticles
Buccal delivery of small molecules and biologics=> of mucoadhesive polymers, films, and nanoparticles.
Buccal dosage forms: General considerations for pediatric patients
Buccal dosage forms: General considerations for pediatric patients
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films.
Formulation and Delivery of Biologics
Formulation and Delivery of Biologics
Formulation and Delivery of Macromolecules.
Inkjet Printing of Proteins: an Experimental Approach
Inkjet printing of proteins: an experimental approach
Inkjet printing of proteins: an experimental approach
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics
Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
Book Review of “Remington: Essentials of Pharmaceutics”
Nanoparticles for the treatment of wounds
Nanoparticles for the Treatment of Wounds
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases
Organic and inorganic nanoparticles for prevention and diagnosis of gastric cancer
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
Films loaded with Insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery
Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery
Lipid Nanosystems for Skin Delivery of Retinoids and Derivatives
Novel strategies for the buccal delivery of macromolecules
Preface for Buccal Drug Delivery Special Edition
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles
Protein-coated nanoparticles embedded in films as delivery platforms
Protein-coated nanoparticles embedded in films for buccal delivery
The influence of recrystallized caffeine on water-swellable polymethacrylate mucoadhesive buccal films
The Influence of Recrystallized Caffeine on Water-Swellable Polymethacrylate Mucoadhesive Buccal Films
Manufacture and Characterization of Mucoadhesive Buccal Films
Manufacture and Characterization of Mucoadhesive Buccal Films
Surfactants: their critical role in enhancing drug delivery to the lungs
Orally Disintegrating Tablets Using Starch and Fructose
Characterization, phase solubility and molecular modeling of inclusion complex of 5 nitroindazole
Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films

BookSection (4)

Buccal delivery of nanoparticles
Mechanical Particle Size Reduction Techniques
Drug Delivery Systems: Oral Mucosal
Surface-modified nanoparticles to improve drug delivery

Editorial (1)

Preface to advances in thin film technologies in drug delivery Preface

EditorialMaterial (2)

Selected abstracts from Excipient Fest 2017
Preface for buccal drug delivery theme issue

Patent (4)

Bioadhesive films for local and/or systemic delivery
Dosage form for the buccal administration of tightly controlled doses, controlled drug release, and stable biomacromolecule comprising a polymeric film as a printing substrate and an ink for printing on said film comprising nanoparticles or nanosuspensions containing said biomacromolecule, and method of manufacture
Forma farmacéutica para administración bucal de dosis altamente controlada, liberación controlada y estable de biomacromolécula que comprende película polimérica como sustrato de impresión y una tinta de inyección impresa sobre dicha película polimérica que comprende nanoparticulas o suspensiones de nanopartículas con dicha biomacromolécula, y método de preparación
Polymer Strip for Treatment of Oral Thermal Burns

Proyecto (25)

Implementación de nuevas tecnologías para el abordaje farmacológico del tratamiento del daño cerebral inducido por trauma e identificación de nuevos blancos farmacológicos para el diseño de nuevos fármacos
Desarrollo y Evaluación de una Formulación Gastroretentiva con Potencial Terapéutico frente a la Infección Causada por Helicobacter Pylori
Design of a novel administration strategy for potential extracellular vesicles therapy based on inkjet printing of films: in pursuit of a local effect and controlled release
A Strategy Based on Aromatic-Aromatic Interactions to Develop Complexes, Nanoparticles and Massive Aggregates Showing High Encapsulation and Controlled Drug Release with Potential for Chronic Diseases Treatment
Drug delivery system design for bioresponsive covalent gastric mucoadhesion and targeted delivery to Helicobacter pylori
Multistrategy for the treatment of brain damage associated to traumatic brain injury through films and nanocarriers loaded with loperamide
Nanotransportadores de antibióticos como potencial tratamiento de las comunidades bacterianas intracelulares en la infección urinaria
Novel drugs and drug delivery systems for the treatment of hypertension
Development of a dual acting nanocarrier for enhanced buccal permeation followed by bioresponsive cardiac targeting: formulation studies and biological proof of concept
Estadía para el implemento de la técnica de phage display para la identificación de secuencias peptídicas que potencien la absorción bucal de fármacos
Incremento de valor de la tecnología de impresión de nanopartículas cargadas con fármacos biológicos en films para administración bucal de dichos fármacos
Red Internacional para el Desarrollo de Nanocarriers de Cubierta Multiefecto que Permitan la Entrega Biosensible de Fármacos
Centre for Research in Medical Devices (CÚRAM)
Ayuda de viaje
Implementación de una plataforma para caracterizar nanoestructuras (tamaño, potencial zeta, concentración y fluorescencia) de interés en diversas disciplinas
Printing technology as a novel strategy to manufacture drug-loaded polymeric films
Thermosensitive microgels loaded with heat generating nanoparticles for pulsed release of anticancer nanocarriers and triggered by external magnetic fields: Formulation analysis and biological evaluation
2014 de las Becas Iberoamericana Jóvenes Profesores e Investigadores – Santander Universidades
Preparation of the Consortium on Drug Delivery of Biologics Enabled by Nanotechnology (DDBEN)
Advanced Center for Chronic Diseases (ACCDiS)
Development of buccal films for the delivery of macromolecular drugs-loaded nanoparticles by inkjet printing
Development of films for buccal administration of macromolecular drugs by inkjet printing
Evaluation of the destabilizing effect of inkjet printing over macromolecular model drugs and the protective effect of nanoencapsulation
Beca Igualdad de Oportunidades
Plataforma Polimérica Para el Desarrollo de Soluciones Tecnológicas (POLYFORMS)

Review (3)

Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
Lipid nanoparticles for the topical delivery of retinoids and derivatives
Novel strategies for the buccal delivery of macromolecules
76
Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

4
Johanna Catalán

Académico-Investigador

Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

2
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

2
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Sabrina Sepúlveda

Profesor Asistente

Medicina

Universidad Mayor de Chile

Santiago, Chile

1
Karina Valdés

Asistente

Ciencias y Tecnología Farmacéutica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Nancy Pizarro

Associate professor

Ciencias Quimicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Marjorie Cepeda

Profesor asistente

Ciencias Químicas

Universidad Andrés Bello

Santiago, Chile

1
Ignacio Moreno

Full Professor

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Andrónico Neira

Titular Professor

Biological and Animal Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

1
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mario Flores

Académico cat. III

Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Patricio Reyes

JEFATURA DE SECCIÓN

ANAMED

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

1
osvaldo yañez

Post Doctorado

Departamento de Ciencias y Tecnología Farmacéutica

Universidad de Chile

Santiago, Chile

1
Natalia Hassan

Coordinadora

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Andrea Ramírez

Asistente de Investigación

Bioquímica

Universidad de Chile

Región Metropolitana, Chile

1
Miguel Jara

Asistente de Investigación

de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago , Chile

1
Sandra Orellana

Academico

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
SOLEDAD BOLLO

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Javier Morales

Académico - Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

1
CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile