PDI - Resultado de Búsqueda

Javier Octavio Morales Montecinos

Profesor Asociado

Universidad de Chile

Santiago, Chile

Nanostructured materials as controlled and targeted delivery systems for biologic and conventional drugs

Pharmaceutics, UNIVERSITY OF TEXAS AT AUSTIN. Estados Unidos, 2012
Farmacia, UNIVERSIDAD DE CHILE. Chile, 2006
Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2008

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias Químicas y Farmacéuticas

Santiago, Chile

2013 - 2019
Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias Químicas y Farmacéuticas

Santiago, Chile

2019 - 2025
Profesor Titular Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias Químicas y Farmacéuticas

Santiago, Chile

2025 - A la fecha

Graduate research Assistant Full Time

The University of Texas at Austin

Austin, Estados Unidos

2008 - 2012
Profesor Part Time

Instituto Profesional de Chile

Santiago, Chile

2007 - 2008
Intern Full Time

Evonik Rohm GmbH

Darmstadt, Alemania

2011 - 2011
Miembro del comité editorial Part Time

Drug Development and Industrial Pharmacy

New York, Estados Unidos

2013 - A la fecha
Miembro del comité editorial Part Time

AAPS PharmSciTech

New York, Estados Unidos

2014 - A la fecha
Associate Editor Part Time

Drug Development and Industrial Pharmacy

New York, Estados Unidos

2018 - A la fecha
Associate Editor Part Time

Drug Development and Industrial Pharmacy

New York, Estados Unidos

2018 - A la fecha

Director de 4 investigadores postdoctorales, 15 tesis dirigidas de pregrado, 10 tesis dirigidas de magíster, 7 tesis dirigidas de doctorado.

Patentes y aplicaciones de patentes
1. J.O. Morales, M. Montenegro-Nicolini, F. Campano-Hantscheruk. Forma farmacéutica para administración bucal de dosis altamente controlada, liberación controlada y estable de biomacromolécula que comprende película polimérica como sustrato de impresión y una tinta de inyección impresa sobre dicha película polimérica que comprende nanoparticulas o suspensiones de nanopartículas con dicha biomacromolécula, y método de preparación. Application Number CL201600112, and PCT/CL2017/050001
2. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. US Application Number 14/897140 (Submitted: December 9, 2015)
3. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. Application Number WO2014065870 A1 (Published: May 1, 2014)
4. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Polymer Strip for Treatment of Oral Thermal Burns. Application/Provisional Number 61/717,082 (Submitted: Oct 22, 2012).
5. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Medicated Polymer Film Strip: Application/Provisional Number 61/719,922 (Submitted: Oct 29, 2012)

Abstract Reviewer and Publication Coordinator for the Taylor and Francis Group and and ExcipientFest 2017

Taylor and Francis Group

Estados Unidos, 2017

Selected to review and coordinate the publication in Drug Development and Industrial Pharmacy of the best abstracts at ExcipientFest 2017 in Providence, RI
Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology

UNIVERSIDAD DE CHILE

Chile, 2017

Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology for: Desarrollo de quantum dots de óxido de zinc como nanocarriers de curcumina sensibles al pH tumoral
BPS–USP PSWC2017 Congress Travel Scholarship

BPS–USP PSWC2017 Congress

Suecia, 2017

Recipient of a Congress Scholarship based on academic excellence as a Young researcher/professor. Funding to attend and present at the FIP 6th Pharmaceutical Sciences World Congress 2017 in Stockholm, Sweden
2015 ASILFA Distinguished Professional

ASILFA

Chile, 2016

Recipient of the Distinguished Professional Award from the Industrial Association of Pharmaceutical Companies (ASILFA from its Spanish translation) for outstanding work in Research & Development on Pharmaceutical Sciences. Santiago, Chile
Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics”

AAPS Annual Meeting and Exposition

Estados Unidos, 2015

Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics” and to speak on “Buccal drug delivery of biologics as an alternative delivery route” to be presented in Orlando, Florida, USA in October 2015
Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs”

AAPS National Biotechnology Conference

Chile, 2014

Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs” and to speak on “Buccal Delivery of Insulin Using Flexible Films” presented in San Diego, CA in May 2014


Application of a two-phase experiment design and optimization method to formulate ciprofloxacin-loaded bovine serum albumin nanoparticles with high-entrapment efficiency for targeting urinary tract infections Sanchez, S.V.; Jorge, E.C.; Navarro, N; Gonzalez, M.J.; Vasquez R.; Del Canto, F; Scavone, P; Arrúa, E.C.; Morales, JO Article AAPS PHARMSCITECH (2025)
Intranasal delivery of extracellular vesicles: A promising new approach for treating neurological and respiratory disorders Sanchez, Sofia, V; Otavalo, Gabriela N.; Gazeau, Florence; Silva, Amanda K. A.; Morales, Javier O. Article ISI JOURNAL OF CONTROLLED RELEASE (2025)
Exploring paediatric oral suspension development: Challenges, requirements, and formulation advancements Gaikwad, Sachin S.; Morales, Javier O.; Lande, Narayan B.; Catalan-Figueroa, Johanna; Laddha, Umesh D.; Kshirsagar, Sanjay J. Article ISI INTERNATIONAL JOURNAL OF PHARMACEUTICS (2024)
First report on the physicochemical and proteomic characterization of <i>Proteus mirabilis</i> outer membrane vesicles under urine-mimicking growth conditions: comparative analysis with <i>Escherichia coli</i> Gonzalez, Maria Jose; Navarro, Nicolas; Cruz, Erlen; Sanchez, Sofia; Morales, Javier O.; Zunino, Pablo; Robino, Luciana; Lima, Analia; Scavone, Paola Article ISI FRONTIERS IN MICROBIOLOGY (2024)
Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles-An update Nair, Varsha V.; Cabrera, Pablo; Ramirez-Lecaros, Constanza; Brayden, David J. Article ISI INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)
Gold-, silver- and magnesium-doped zinc oxide nanoparticles prevents the formation of and eradicates bacterial biofilms Cruz Jorge, Erlen; Navarro Martinez, Nicolas; Jose Gonzalez, Maria; Scavone, Paola Article ISI NANOMEDICINE (2023)
Improving Lurasidone Hydrochloride's Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-beta-cyclodextrin Caro, Nelson; Casanova, Jorge Enrique Gonzalez Article ISI PHARMACEUTICS (2023)
Nanoparticles for the potential treatment of Alzheimer's disease: A physiopathological approach Martinez, Nicolas Navarro; Hernandez, Jorge Toledo Article ISI NANOTECHNOLOGY REVIEWS (2023)
Experimental design and optimization of a novel dual-release drug delivery system with therapeutic potential against infection with Helicobacter pylori Sanchez, S.V.; Trincado, V. Article WOS ISI COLLOIDS AND SURFACES B-BIOINTERFACES (2022)
Aptamer-functionalized lipid-core micelles loaded with rhenium tricarbonyl complex Ortiz, Andrea C.; Casas, Islavo; Naranjo, Omar; Pizarro, Nancy; Garcia, Lorena Article ISI POLYHEDRON (2021)
Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems Trincado, Valeria; Gala, Rikhav P. Article ISI VACCINES (2021)
Dember photovoltaic effect as method for structural characterization of phospholipidic membranes Yablonskii, S., V; Bodnarchuk, V. V.; Geivandov, A. R.; Soto-Bustamante, E. A.; Morales, J. O. Article ISI JOURNAL OF MOLECULAR LIQUIDS (2021)
Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation Article ISI PHARMACEUTICS (2021)
Inkjet printing of small molecules, biologics, and nanoparticles W-H. Chou; A. Gamboa; Morales, J. O. Article INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)
Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy Article ISI PHARMACEUTICS (2021)
Nanoparticles as Potential Novel Therapies for Urinary Tract Infections Sanchez, Sofia, V Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)
Poloxamer 188-coated ammonium methacrylate copolymer nanocarriers as a promising strategy for overcoming gastrointestinal limitations of loperamide absorption M.A. García; P. Contreras; Fiedler J.F.; M.F. Pérez; Morales, J. O. Article MOLECULAR PHARMACEUTICS (2021)
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia Article ISI MOLECULAR PHARMACEUTICS (2021)
Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic Miguel O. Jara; Morales, J. O. Article INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)
Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids Schuessler, Nina Article ISI EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)
Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs Article ISI PHARMACEUTICS (2020)
Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters Ramirez-Sagredo, Andrea; Riveros, Ana L.; Riquelme, Jaime A.; Araya, Eyleen; Chiong, Mario; Villamizar Sarmiento, Maria Gabriela Article ISI JOURNAL OF CONTROLLED RELEASE (2020)
Poly-epsilon-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis Greatti, Vanessa Raquel; Oda, Fernando; Sorrechia, Rodrigo; Kapp, Barbara Regina; Seraphim, Carolina Manzato; Villas Boas Weckwerth, Ana Carolina; Chorilli, Marlus; Da Silva, Patricia Bento; Eloy, Josimar O.; Linhari Rodrigues Pietro, Rosemeire Cristina Article ISI ANTIBIOTICS-BASEL (2020)
Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety Sepúlveda-Rivas, Sabrina; Fritz, Hans; Valenzuela, Camila; Santiviago, Carlos; Morales, Javier Article ISI SCOPUS PHARMACEUTICS (2019)
Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis Iribarnegaray, Victoria; Navarro, Nicolas; Robino, Luciana; Zunino, Pablo; Morales, Javier; Scavone, Paola Article ISI SCOPUS NANOMEDICINE (2019)
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages Boisset C.B.; Fiedler J.L.; Morales, J. O. Article ISI SCOPUS European Journal of Pharmaceutical Sciences (2018)
Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology Landin M.; Morales, J. O. Article ISI SCOPUS Drug Delivery and Translational Research (2018)
Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches Bejarano, Julian Article ISI SCOPUS THERANOSTICS (2018)
Preparation of a novel lipid-core micelle using a low-energy emulsification method Velaga S.P.; Morales, J. O. Article ISI SCOPUS Drug Delivery and Translational Research (2018)
The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems Montenegro-Nicolini, Miguel; Reyes, Patricio E.; Jara, Miguel O.; Vuddanda, Parameswara R.; Velaga, Sitaram Article ISI SCOPUS AAPS PHARMSCITECH (2018)
Buccal delivery of small molecules and biologics=> of mucoadhesive polymers, films, and nanoparticles Morales, Javier O.; Brayden, David J. Article CURRENT OPINION IN PHARMACOLOGY (2017)
Buccal delivery of small molecules and biologics=> of mucoadhesive polymers, films, and nanoparticles. Morales, Javier O; Brayden, David J Article Current opinion in pharmacology (2017)
Buccal dosage forms: General considerations for pediatric patients Soledad Montero-Padilla; Sitaram Velaga; Javier O. Morales Article AAPS PharmSciTech (2017)
Buccal dosage forms: General considerations for pediatric patients Article AAPS PHARMSCITECH (2017)
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes Fathe, KR; Brunaugh, A; Mousavikhamene, Z; Prausnitz, MR Article ISI SCOPUS AAPS JOURNAL (2017)
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes J.O. Morales, K.R. Fathe, A. Brunaugh, S. Ferrati, S. Li, M. Montenegro-Nicolini, Z. Mousavikhamene, J.T. McConville, M.R. Prausnitz, H.D.C. Smyth Article AAPS Journal (2017)
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films Vuddanda, PR Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films P. Rao Vuddanda, M. Montenegro-Nicolini, J. O. Morales, S. Velaga Article European Journal of Pharmaceutical Sciences (2017)
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films P. Rao Vuddanda, M. Montenegro-Nicolini, J. O. Morales, S. Velaga Article European Journal of Pharmaceutical Sciences (2017)
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films P. Rao Vuddanda, M. Montenegro-Nicolini, J. O. Morales, S. Velaga Article European Journal of Pharmaceutical Sciences (2017)
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films. Vuddanda, Parameswara Rao; Montenegro-Nicolini, Miguel; Morales, Javier O; Velaga, Sitaram Article European journal of pharmaceutical sciences => official journal of the European Federation for Pharmaceutical Sciences (2017)
Formulation and Delivery of Biologics Article AAPS PHARMSCITECH (2017)
Formulation and Delivery of Biologics J.O. Morales Article AAPS PharmSciTech (2017)
Formulation and Delivery of Macromolecules. Morales, Javier O Article AAPS PharmSciTech (2017)
Inkjet printing of proteins: an experimental approach M. Montenegro-Nicolini, V. Miranda, J.O. Morales Article AAPS Journal (2017)
Inkjet printing of proteins: an experimental approach M. Montenegro-Nicolini, V. Miranda, J.O. Morales Article AAPS Journal (2017)
Inkjet Printing of Proteins: an Experimental Approach Article ISI SCOPUS AAPS JOURNAL (2017)
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics Miguel Montenegro-Nicolini; Javier O. Morales Article AAPS PharmSciTech (2017)
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics Article AAPS PHARMSCITECH (2017)
Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer Johanna Catalan-Figueroa; Sujey Palma-Florez; Gonzalo Alvarez; Hans F. Fritz; Miguel O. Jara; Javier O. Morales Article Nanomedicine (2016)
Book Review of “Remington: Essentials of Pharmaceutics” J.O. Morales Article Drug Development and Industrial Pharmacy (2015)
Nanoparticles for the Treatment of Wounds Oyarzun Ampuero, F; Vidal, A; Concha M.; Morales, J.; Orellana, S; Moreno-Villoslada, I Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Nanoparticles for the treatment of wounds Felipe Oyarzun-Ampuero; A. Vidal; Miguel Concha; Javier O. Morales; Sandra Orellana; Ignacio Moreno-Villoslada Article Current Pharmaceutical Design (2015)
Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases Javier O. Morales; Sabrina Sepúlveda-Rivas; Felipe Oyarzún-Ampuero; Sergio Lavandero; Marcelo J. Kogan Article Current Pharmaceutical Design (2015)
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases Morales, JO; Sepulveda-Rivas, S; Oyarzun Ampuero, F; Lavandero S.; Kogan, MJ Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Organic and inorganic nanoparticles for prevention and diagnosis of gastric cancer Felipe Oyarzun-Ampuero; Ariel Guerrero; Natalia Hassan; Javier O. Morales; Soledad Bollo; Alejandro Corvalán; Andrew Quest; Marcelo J. Kogan Article Current Pharmaceutical Design (2015)
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer Oyarzun Ampuero, F; Guerrero, A; Hassan-Lopez, N; Morales, JO; Bollo, S; Corvalan, A; Quest, AFG; Kogan, MJ Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Films loaded with Insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery J.O. Morales; S. Huang; R.O. Williams III; J.T. McConville Article Colloids and Surfaces B (2014)
Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery Morales, JO; Huang, SY; Williams, R.O.; McConville, JT Article ISI SCOPUS COLLOIDS AND SURFACES B-BIOINTERFACES (2014)
Lipid Nanosystems for Skin Delivery of Retinoids and Derivatives J.O. Morales; K. Valdés; J. Morales-Valenzuela; F. Oyarzun-Ampuero Article Nanomedicine (2014)
Novel strategies for the buccal delivery of macromolecules J.O. Morales; J.T. McConville Article Drug Development and Industrial Pharmacy (2014)
Preface for Buccal Drug Delivery Special Edition J.O. Morales; J.T. McConville Article Drug Development and Industrial Pharmacy (2014)
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles Joks, GM Article DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2013)
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles Javier O. Morales; Gero M. Joks; Alf Lamprecht; Alistair C. Ross; Jason T. McConville Article Drug Development and Industrial Pharmacy (2013)
Protein-coated nanoparticles embedded in films as delivery platforms Morales, JO; Ross, AC; McConville, JT Article ISI SCOPUS Journal of Pharmacy and Pharmacology (2013)
Protein-coated nanoparticles embedded in films for buccal delivery Javier O. Morales; Alistair C. Ross; Rong Su; Jason T. McConville Article Journal of Pharmacy and Pharmacology (2013)
The influence of recrystallized caffeine on water-swellable polymethacrylate mucoadhesive buccal films Javier O. Morales; Rong Su; Jason T. McConville Article AAPS PharmSciTech (2013)
The Influence of Recrystallized Caffeine on Water-Swellable Polymethacrylate Mucoadhesive Buccal Films Morales, JO; Su, R; McConville, JT Article ISI SCOPUS AAPS PHARMSCITECH (2013)
Manufacture and Characterization of Mucoadhesive Buccal Films Article EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)
Manufacture and Characterization of Mucoadhesive Buccal Films Javier O. Morales; Jason T. McConville Article European Journal of Pharmaceutics and Biopharmaceutics (2011)
Surfactants: their critical role in enhancing drug delivery to the lungs Javier O. Morales; Jay I. Peters; Robert O. Williams III Article Therapeutic Delivery (2011)
Orally Disintegrating Tablets Using Starch and Fructose Javier O. Morales; Michelle Horng; Aubrey M. Gregg; Jason T. McConville Article Pharmaceutical Technology (2010)
Characterization, phase solubility and molecular modeling of inclusion complex of 5 nitroindazole Carolina Jullian; Javier Morales-Montecinos; Gerald Zapata-Torres; Benjamin Aguilera; Jorge Rodriguez; Vicente Aran; Claudio Olea-Azar Article Bioorganic and Medicinal Chemistry (2008)
Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins Jullian C.; Morales-Montecinos, J; Zapata-Torres, G; Aguilera B.; Rodriguez J.; Aran, V; Olea Azar C. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films Vuddanda, Parameswara R.; Montenegro-Nicolini, Miguel; Morales, Javier O.; Velaga, Sitaram Article EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (0)


Buccal delivery of nanoparticles BookSection (2019)
Mechanical Particle Size Reduction Techniques McConville, JT; Watts, AB; Williams III, RO; Watts, AB; Miller, DA BookSection (2016)
Drug Delivery Systems: Oral Mucosal Mishra, M BookSection (2015)
Surface-modified nanoparticles to improve drug delivery BookSection (2014)


Preface to advances in thin film technologies in drug delivery Preface Gala R.P.; Morales, J. O. Editorial ISI SCOPUS INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)


Selected abstracts from Excipient Fest 2017 McConville, JT; Morales, JO EditorialMaterial ISI DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2018)
Preface for buccal drug delivery theme issue Morales, JO; McConville, JT EditorialMaterial ISI SCOPUS DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2014)


Forma farmacéutica para administración bucal de dosis altamente controlada, liberación controlada y estable de biomacromolécula que comprende película polimérica como sustrato de impresión y una tinta de inyección impresa sobre dicha película polimérica que comprende nanoparticulas o suspensiones de nanopartículas con dicha biomacromolécula, y método de preparación Morales, JO; Montenegro-Nicolini, M; Campano-Hantscheruk, F Patent (2020)
Bioadhesive films for local and/or systemic delivery McConville, JT; Morales, JO Patent
Composición farmacéutica que comprende un péptido o una combinación de péptidos agonistas de los receptores Mas, AT1 y AT2 Ocaranza, M.P.; Jalil, J.E.; Morales, JO; Oyarzun, F.; Soto-Bustamante, E; Gonzalez-Nilo, F Patent
Dosage form for the buccal administration of tightly controlled doses, controlled drug release, and stable biomacromolecule comprising a polymeric film as a printing substrate and an ink for printing on said film comprising nanoparticles or nanosuspensions containing said biomacromolecule, and method of manufacture Morales, JO; Montenegro-Nicolini, M; Campano-Hantscheruk, F Patent
Polymer Strip for Treatment of Oral Thermal Burns McConville, JT; Morales, JO Patent


Desarrollo de un sistema gastroretentivo nanoestructurado para el tratamiento de helicobacter pylori: enfoque in vitro e in vivo Javier O. Morales; Andrea Ortiz Proyecto (2024)
Multi-specific peptides for hypertension and heart failure powered by tailored drug delivery systems María Paz Ocaranza; Javier O. Morales; Jorge Jalil; Felipe Oyarzún; Verónica Jiménez Proyecto (2024)
A rational strategy to enhance the buccal permeation of stable peptide-loaded nanocarriers: elucidating key physicochemical properties of nanocarriers and their vehicle Javier O. Morales; Felipe Oyarzún Proyecto (2023)
A 3D-printable formulation with therapeutic potential in bone regeneration, based on Histatin-1-loaded polycaprolactone Vicente Torres; Javier O. Morales Proyecto (2022)
Implementación de nuevas tecnologías para el abordaje farmacológico del tratamiento del daño cerebral inducido por trauma e identificación de nuevos blancos farmacológicos para el diseño de nuevos fármacos Proyecto (2022)
Desarrollo y Evaluación de una Formulación Gastroretentiva con Potencial Terapéutico frente a la Infección Causada por Helicobacter Pylori Proyecto (2021)
Design of a novel administration strategy for potential extracellular vesicles therapy based on inkjet printing of films: in pursuit of a local effect and controlled release Morales, J. O.; Gazeau, F. Proyecto (2021)
Escalamiento y validación de sistema de administración bucal de insulina mediante impresión 2D Juana Castañeda; Javier O. Morales Proyecto (2021)
A Strategy Based on Aromatic-Aromatic Interactions to Develop Complexes, Nanoparticles and Massive Aggregates Showing High Encapsulation and Controlled Drug Release with Potential for Chronic Diseases Treatment Proyecto (2020)
Uso de nitroprusiato de sodio (SNP) como generador de óxido nítrico para la preservación de la calidad de la cereza exportada a mercados distantes Lorena Pizarro; Javier O. Morales Proyecto (2020)
Antibiotic nanocarriers as potential treatment for intracellular bacterial communities in urinary tract infections CSIC of Uruguay (211) Proyecto 2019-2021 Inv. Principal
Drug delivery system design for bioresponsive covalent gastric mucoadhesion and targeted delivery to Helicobacter pylori Beca Postdoctoral ACCDiS (201901) Proyecto 2019-2020 Inv. Patrocinante
Drug delivery system design for bioresponsive covalent gastric mucoadhesion and targeted delivery to Helicobacter pylori Arrúa, E.C. Proyecto (2019)
Multistrategy for the treatment of brain damage associated to traumatic brain injury through films and nanocarriers loaded with loperamide Beca Postdoctoral para Temas Estratégicos de CONICET (Argentina) (2018KB105) Proyecto 2019-2021 Inv. Patrocinante
Multistrategy for the treatment of brain damage associated to traumatic brain injury through films and nanocarriers loaded with loperamide Proyecto (2019)
Nanotransportadores de antibióticos como potencial tratamiento de las comunidades bacterianas intracelulares en la infección urinaria Robino, L Proyecto (2019)
Novel drugs and drug delivery systems for the treatment of hypertension Morales, J. O.; Ocaranza, M.P.; Jalil, J.E. Proyecto (2019)
Development of a dual acting nanocarrier for enhanced buccal permeation followed by bioresponsive cardiac targeting: formulation studies and biological proof of concept Proyecto (2018)
Development of a dual acting nanocarrier for enhanced buccal permeation followed by bioresponsive cardiac targeting=> formulation studies and biological proof of concept FONDECYT (1181689) Proyecto 2018-2022 Director(a)
Estadía para el implemento de la técnica de phage display para la identificación de secuencias peptídicas que potencien la absorción bucal de fármacos Proyecto (2018)
Incremento de valor de la tecnología de impresión de nanopartículas cargadas con fármacos biológicos en films para administración bucal de dichos fármacos Proyecto (2018)
Incremento de valor de la tecnología de impresión de nanopartículas cargadas con fármacos biológicos en films para administración bucal de dichos fármacos Proyectos en Investigación e Innovación (PII) 2018 (PII201801) Proyecto 2018-2019 Director(a)
Red Internacional para el Desarrollo de Nanocarriers de Cubierta Multiefecto que Permitan la Entrega Biosensible de Fármacos Proyecto (2018)
Red Internacional para el Desarrollo de Nanocarriers de Cubierta Multiefecto que Permitan la Entrega Biosensible de Fármacos PCI (REDI170653) Proyecto 2018-2020 Director(a)
Centre for Research in Medical Devices (CÚRAM) Pandit, A; Brayden, D Proyecto (2017)
Red DiNaC=> Identificación de nuevas dianas terapéuticas y diseño de nanoformulaciones para el tratamiento de cánceres de alta mortalidad en Chile Universidad de Chile (0667) Proyecto 2017-2019 Coinvestigador(a)
Ayuda de viaje Proyecto (2016)
Implementación de una plataforma para caracterizar nanoestructuras (tamaño, potencial zeta, concentración y fluorescencia) de interés en diversas disciplinas Proyecto (2016)
Implementación de una plataforma para caracterizar nanoestructuras (tamaño, potencial zeta, concentración y fluorescencia) de interés en diversas disciplinas FONDEQUIP (EQM160157) Proyecto 2016-2018 Coinvestigador(a)
Printing technology as a novel strategy to manufacture drug-loaded polymeric films Velaga, S Proyecto (2016)
Printing technology as a novel strategy to manufacture drug-loaded polymeric films The Swedish Foundation for International Cooperation in Research and Higher Education (STINT) (IB2015-6087) Proyecto 2016-2017 Inv. Principal
Thermosensitive microgels loaded with heat generating nanoparticles for pulsed release of anticancer nanocarriers and triggered by external magnetic fields: Formulation analysis and biological evaluation Proyecto (2016)
Thermosensitive microgels loaded with heat generating nanoparticles for pulsed release of anticancer nanocarriers and triggered by external magnetic fields=> Formulation analysis and biological evaluation FONDECYT (1161450) Proyecto 2016-2020 Coinvestigador(a)
2014 de las Becas Iberoamericana Jóvenes Profesores e Investigadores – Santander Universidades Proyecto (2015)
Beca Santander Universidades 2014 - Jóvenes Profesores e Investigadores Programa Santander Universidades Proyecto 2015-2015 Inv. Principal
Consortium on Drug Delivery of Biologics Enabled by Nanotechnology (DDBEN) application for H2020 PCI (PCI 174) Proyecto 2015-2015 Inv. Responsable
Preparation of the Consortium on Drug Delivery of Biologics Enabled by Nanotechnology (DDBEN) Proyecto (2015)
Advanced Center for Chronic Diseases (ACCDiS) FONDAP (15130011) Proyecto 2014-2019 Investigador(a)
Advanced Center for Chronic Diseases (ACCDiS) Proyecto (2014)
Plataforma Polimérica Para el Desarrollo de Soluciones Tecnológicas (POLYFORMS) Universidad de Chile (U Redes 2014-002) Proyecto 2014-2016 Coinvestigador(a)
Development of buccal films for the delivery of macromolecular drugs-loaded nanoparticles by inkjet printing FONDECYT (11130235) Proyecto 2013-2017 Inv. Responsable
Development of buccal films for the delivery of macromolecular drugs-loaded nanoparticles by inkjet printing Proyecto (2013)
Development of films for buccal administration of macromolecular drugs by inkjet printing Proyecto (2013)
Evaluación del efecto desestabilizador sobre modelos macromoleculares de fármacos del proceso de inyección de tinta y el efecto protector de la nanoencapsulación Universidad de Chile Proyecto 2013-2015 Inv. Responsable
Evaluation of the destabilizing effect of inkjet printing over macromolecular model drugs and the protective effect of nanoencapsulation Proyecto (2013)
HPLC method implementation for the quantification of a proprietary active ingredient in a controlled release dosage form Enavail LLC Proyecto 2012-2012 Investigador(a)
Beca Igualdad de Oportunidades Proyecto (2008)
Plataforma Polimérica Para el Desarrollo de Soluciones Tecnológicas (POLYFORMS) Proyecto (0)


Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer Catalan-Figueroa, J; Palma-Florez, S; Álvarez, G.; Fritz, HF; Jara MO; Morales, JO Review ISI SCOPUS NANOMEDICINE (2016)
Lipid nanoparticles for the topical delivery of retinoids and derivatives Morales, JO; Valdes K.; Morales, J.; Oyarzun Ampuero, F Review ISI SCOPUS Nanomedicine (2015)
Novel strategies for the buccal delivery of macromolecules Morales, JO; McConville, JT Review ISI SCOPUS DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2014)

Andrónico Neira

Titular Professor

Biological and Animal Science

UNIVERSIDAD DE CHILE

Santiago, Chile

Andres Vega

Director

Departamento de Química

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

SOLEDAD BOLLO

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

Ignacio Moreno

Full Professor

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Nancy Pizarro

Full professor

Ciencias Quimicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Sandra Orellana

Academico

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

Javier Morales

Académico - Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

Sebastián Miranda

Profesor Asistente

Departamento de Ciencias Químicas

UNIVERSIDAD NACIONAL ANDRES BELLO

Santiago, Chile

Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Karina Valdés

Asistente

Ciencias y Tecnología Farmacéutica

UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Toledo

Investigador

Centro de Investigacion Clinica Avanzada CICA

Universidad de Chile, Hospital Clinico Universidad de Chile

Santiago, Chile

Natalia Hassan

Coordinadora

Universidad Tecnológica Metropolitana

Santiago, Chile

Alexander Gamboa

Profesor Asistente

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

Miguel Jara

Asistente de Investigación

de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago , Chile

Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

Mario Flores

Académico Cat. III

Ciencias

Universidad Austral de Chile

Valdivia, Chile

Maria Ocaranza

Full Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

Marjorie Cepeda

Profesor asistente

Ciencias Químicas

Universidad Andrés Bello

Santiago, Chile

Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

Pablo González

Asesor Farmacéutico

Asesor Farmacéutico

Santiago, Chile

Patricio Reyes

JEFATURA DE SECCIÓN

ANAMED

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

osvaldo yañez

Académico Investigador

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Johanna Catalán

Profesor Asistente Regular

Facultad de Medicina y Ciencia

Universidad Central de Chile

Santiago, Chile

Mauricio García

Assistant Professor

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Sabrina Sepúlveda

Profesor Asistente

Medicina

Universidad Mayor de Chile

Santiago, Chile

Andrea Ramírez

Asistente de Investigación

Bioquímica

Universidad de Chile

Región Metropolitana, Chile

Wai-Houng Chou

Académico

Departamento de Ciencias Farmacéuticas

Universidad Católica del Norte

Antofagasta, Chile

María Vidal

Profesor Asociado

Anatomía, Histología y Patología

Universidad Austral de Chile

Valdivia, Chile

Andrea Ortiz

Docente

Universidad San Sebastián

Puerto Montt, Chile

Nicole Butto

Lab Manager

Polyforms

Santiago , Chile

Yvo Flores

Profesional (grado 12)

Biomédico

Instituto de Salud Pública

Santiago, Chile

Javier Octavio Morales Montecinos

Líneas de Investigación

Educación

Pharmaceutics, UNIVERSITY OF TEXAS AT AUSTIN. Estados Unidos, 2012

Farmacia, UNIVERSIDAD DE CHILE. Chile, 2006

Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

Profesor Asistente Full Time

Profesor Asociado Full Time

Profesor Titular Full Time

Experiencia Profesional

Graduate research Assistant Full Time

Profesor Part Time

Intern Full Time

Miembro del comité editorial Part Time

Miembro del comité editorial Part Time

Associate Editor Part Time

Associate Editor Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Abstract Reviewer and Publication Coordinator for the Taylor and Francis Group and and ExcipientFest 2017

Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology

BPS–USP PSWC2017 Congress Travel Scholarship

2015 ASILFA Distinguished Professional

Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics”

Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs”

Article (75)

BookSection (4)

Editorial (1)

EditorialMaterial (2)

Patent (5)

Proyecto (48)

Antibiotic nanocarriers as potential treatment for intracellular bacterial communities in urinary tract infections

Drug delivery system design for bioresponsive covalent gastric mucoadhesion and targeted delivery to Helicobacter pylori

Multistrategy for the treatment of brain damage associated to traumatic brain injury through films and nanocarriers loaded with loperamide

Development of a dual acting nanocarrier for enhanced buccal permeation followed by bioresponsive cardiac targeting=> formulation studies and biological proof of concept

Incremento de valor de la tecnología de impresión de nanopartículas cargadas con fármacos biológicos en films para administración bucal de dichos fármacos

Red Internacional para el Desarrollo de Nanocarriers de Cubierta Multiefecto que Permitan la Entrega Biosensible de Fármacos

Red DiNaC=> Identificación de nuevas dianas terapéuticas y diseño de nanoformulaciones para el tratamiento de cánceres de alta mortalidad en Chile

Implementación de una plataforma para caracterizar nanoestructuras (tamaño, potencial zeta, concentración y fluorescencia) de interés en diversas disciplinas