Man

Zully Rocío Pedrozo Cibils

Assistant professor

Universidad de Chile

SANTIAGO DE CHILE, Chile

Líneas de Investigación


My research line is focus in cardiovascular pathophysiology and signaling. We are studying the role of mechanosensors in the cardiovascular function, remodeling, regulation of channels degradation and cardiomyocytes tubulogenesis.

Educación

  •  Biochemist, revalidation. Chile, 2003
  •  Biological Science, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Chile

    2013 - A la fecha

Formación de Capital Humano


PhD THESIS STUDENTS
-Biomedical science Ph.D., Universidad de Chile. Magda Carolina Díaz. "Polycystin-1, BIN1 regulation and t-tubule ultrastructure in the cardiomycoytes". (2019-)
-Pharmacology Ph.D, Universidad de Chile. Natalia Torrealba. "HERPUD1 inhibited cardiomyocytes hypertrophy by reduction of the IP3R”. (2017).

MSc THESIS STUDENTS
-MS, Universidad de Chile. Pablo Romero. “Role of polycystin-1 in the damage during cardiac ischemia/reperfusion”. (2017).
-MS, Universidad de Chile. Cristian Espinoza. “Role of polycystin-1 in the apoptosis of the cardiomyocytes associated to the BCL-2/Nix pathway”. (2017).
-MS, Universidad de Chile. Larissa Aleman. "Study of the angiotensin enantio-retro-(1-9) in the cardiomyocytes death induced by ischemia/reperfusion”. (2018).
-MS. Universidad de Chile. Nicole Butto. "Preparation of PCL/Gelatine electro-spindle mesh enriched with carbon-based conductive materials: 3D matrix potential in cardiomyocytes culture" (2020).

Undergraduate THESIS Students
-BS, Universidad de Chile. Adriana Córdoba. “Role of polycystin-1 in the survival of the cardiomyocytes during simulated ischemia/reperfusion”. (2014)
-BS, Pontificia Universidad Católica de Chile. Gonzalo Pino. “Effect of the proteasome inhibition during cardiac ischemia/reperfusion”. (2015)
-BS, Universidad San Sebastián. Cecilia Anríquez. “Effect of the proteasome inhibition in the mitochondrial dynamic of the cardiomyocytes during ischemia/reperfusion". (2015).
-BS, Universidad San Sebastián. Paz Díaz. “Role of polycystin-1 in the expression of calcium handling proteins and excitation/contraction of the cardiomyocytes”. (2016).
-BS, Universidad Metropolitana de Ciencias de la Educación. Natalia Paredes. Role of Polycystin-1 on cardiomyocytes death during simulated ischemia/reperfusion". (2018).
-BS, Universidad San Sebastián. Raúl Flores. "Mechanical stretch induces dedifferentiation of the vascular smooth muscle cells Polycystin-1-dependent". (2018).
-BS. Universidad de Chile. Felipe Poblete. "Polycystin-1 in the regularion of c-Myc expression in cardiomyocytes". (2020).
-BS. Universidad de Chile. Daniela Mamani. "Fructose effects in fibroblast to myofibroblast differentiation and TGF-beta expression in culture". (2020)
-BS. Universidad de Chile. Alicia Calbuñir and Nicolás Palma. "Emerging Mechanosensors in Cardiomyocytes". (2020)


Difusión y Transferencia


- Explora 1000 aulas mil científicos. (2015 and 2016)
- Explora. Un día con un científico. (2018)
- Explora. Laboratorios abiertos. (2018)

COMMUNICATIONS: Since 2014, over 25 poster and oral presentation at national and international meetings.


Premios y Distinciones

  •   Recognition for ISI-WOS 2013 publication

    UNIVERSIDAD DE CHILE

    Chile, 2014

    ISI publication on the 10% superior of the Universidad de Chile

  •   Recognition for ISI-WOS

    UNIVERSIDAD DE CHILE

    Chile, 2016

    ISI publication on the 6% superior of the Universidad de Chile


 

Article (33)

Polycystin-1 mitigates damage and regulates CTGF expression through AKT activation during cardiac ischemia/reperfusion
Early left atrial dysfunction is associated with suboptimal cardiovascular health
Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes
The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion
Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
Polycystin-2-dependent control of cardiomyocyte autophagy
Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.
Dexmedetomidina genera óxido nítrico mediante un mecanismo independiente de la óxido nítrico sintasa inducible
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.
Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes.
Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury
Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.
Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
Herp depletion protects from protein aggregation by up-regulating autophagy
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Mitochondria, Myocardial Remodeling, and Cardiovascular Disease
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection
Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle

Abstract (1)

Evidence of impaired cardiac autophagic flux in patients developing post-operative atrial fibrillation

BookWhole (2)

Autophagy in the Onset of Atrial Fibrillation
Regulation of autophagy by insulin/IGF-1 signaling pathways

Proyecto (16)

Red para el estudio de enfermedades cardiopulmonares de alta letalidad (REECPAL)
The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-Myc dependent BIN1 expression
The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-Myc dependent BIN1 expression
Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice.
Importancia de la Policistina-1 del cardiomiocito en la muerte celular y la fibrosis reparativa inducida por la isquemia/reperfusión cardiaca.
POLYCYSTIN-1 REGULATES L-TYPE CALCIUM CHANNEL IN CARDIOMYOCYTES
Center for Chronic Diseases (ACCDiS)
Effect of proteasome inhibition on the content of mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia-reperfusion
Policistina-1. Un nuevo mecanosensor envuelto en la cardioprotección frente a isquemia/reperfusión vía la inhibición del Regulador de la Señalización de las Proteínas-G tipo 2
Regulación a través de policistinas de la hipertrofia de los cardiomiocitos por mecanismos dependientes de la vía m/TOR y/o calcineurina-NFAT
Center for Chronic Diseases (ACCDiS)
Effect of proteasome inhibition on the content of mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia-reperfusion
Importancia de la Policistina-1 del cardiomiocito en la muerte celular y la fibrosis reparativa inducida por la isquemia/reperfusión cardiaca.
POLYCYSTIN-1 REGULATES L-TYPE CALCIUM CHANNEL IN CARDIOMYOCYTES
Regulación a través de policistinas de la hipertrofia de los cardiomiocitos por mecanismos dependientes de la vía m/TOR y/o calcineurina-NFAT
Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice.

Review (3)

Oxidative Stress and Autophagy in Cardiovascular Homeostasis
Cardiomyocyte death: mechanisms and translational implications
Infarto perioperatorio en cirugía no-cardíaca y dexmedetomidina
39
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

19
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

17
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

8
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

7
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

6
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

4
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

4
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

4
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

3
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

3
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

3
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

2
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Ramiro Zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Paula Valenzuela

Investigadora

Aintech SpA

Santiago, Chile

1
Laura Huidobro

Académico

Ciencias Preclínicas

Universidad Católica del Maule

Talca, Chile

1
Andrea del Campo

Profesor Asistente, Investigador Principal

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Valeria Garrido

Investigador Postdoctoral

Advanced Center for Chronic Disease

Universidad de Chile

Santiago, Chile

1
CLAUDIA BAMBS

PROFESORA ASOCIADA

SALUD PÚBLICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile