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Julio Cesar Cardenas Matus

Associated Professor

Universidad Mayor de Chile

Santiago, Chile

Líneas de Investigación


our lab is interested in the mechanisms that regulated cellular metabolism and bioenergetic’s, with special emphasis in the functional relation between the endoplasmic reticulum and mitochondria in the context of cancer and aging

Educación

  •  Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Medical Technology, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Assitent professor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2011 - 2019

  •   Visiting Professor Other

    UNIVERSITY OF PENNSYLVANIA

    Philadelphia, Estados Unidos

    2012 - A la fecha

  •   Associate Professor Full Time

    UNIVERSIDAD MAYOR

    Facultad de Ciencias

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Assitant Professor Full Time

    University of Chile

    Santiago, Chile

    2011 - 2019

  •   Associate Professor Full Time

    Universidad Mayor

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


.2017-2018 Postdoctoral advisor: Felix Urra, FONDECYT postdoctoral grant #3170813. “Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies” Current position, Assistant Professor at University of Chile, Chile.

2014-2017 Postdoctoral advisor: Carla Basualto, FONDECYT postdoctoral grant #3150623. “Role of dysfunctional mitochondria in the muscle weakness and atrophy observed in Dermatomyositis and Polymyositis” Current position, Assistant Professor at Aysen University, Chile.

2013-2016 Postdoctoral advisor: Fabian Jana, FONDECYT postdoctoral grant #3140458. “Defining the role of mitochondrial electron transport chain complex I on the modulation of Ca2+ homeostasis: effects on cancer cell metabolism”.
Current position, Assistant Professor at Aysen University, Chile.

2017-present PhD advisor; Marioly Muller, “Role of IP3R-mediated exacerbated Ca2+ signaling in neurodegeneration and mitochondrial dysfunction in early onset of Familial Alzheimer disease”.

2017-present PhD advisor: Galdo Bustos, “Mitochondrial Ca2+ uptake of is essential to maintain mitochondrial metabolism and sustain breast cancer cell migration and invasion.

2016-present PhD advisor: Ulises Ahumada, “Endoplasmic reticulum – mitochondria coupling as regulator of cellular senescence”

2013-2016 PhD advisor: Felix Urra, “Metabolic remodeling in breast cancer: mitochondrial bioenergetics as target for the design of anti-metastatic drugs”.

2015-present Master advisor: Felipe Munoz. “Synthesis of 5,8-dihydroxi-4,4-dimetilnaftalen-1(4H)- ona-alquil TPP+ derivate; potential mitochondrial antioxidant with effects on cancer markers dependent of oxidative stress.

2014-2016 Master advisor: Melany Rios. “alpha-ketoglutarate dehydrogenase as a key regulator of metabolism in cancer cells” (University of Chile, Chile).

2015-2016 Undergraduate advisor: Santiago Sepulveda, “Mutant presenilin 1 (M146L) alter mitochondrial Ca2+ homeostasis in a model of familiar Alzheimer disease (FAD) (University of Chile, Chile).

2015-2016 Undergraduate advisor: Pablo Cruz, “Long term treatment with metformin induce changes in the cell cycle in leukemia cells. (University of Chile, Chile).

2015-2016 Undergraduate advisor: Daniela Gonzalez, “knockdown of nad-isocitrate dehydrogenase in mcf7 cells; comparative effect with InsP3R inhibition. (University of Chile, Chile).
2013-2015 Undergraduate advisor: Mery Ann Hidalgo, “Determination of autophagy levels in biopsies of patients with dysferlinophaty disease”. (University of Chile, Chile).

2014-2015 Undergraduate advisor: Natalia Smith. “Inhibition of inositol 1,4,5-trisphosphate receptor-mediated calcium release leads to decreased migration in different tumor cell lines. (University of Chile, Chile).

2013-2015 Undergraduate advisor: Sebastian Merino, “Role of MCU and MCUR1 in cancer bioenergetics” (University of Chile, Chile).

2013-2015 Undergraduate advisor: Carlos Valdes, “Modulation of cellular metabolism by InsP3R inhibition: role of sirtuin 1”. (Catholic University of Valparaiso, Chile).

2012-2013 Undergraduate advisor: Galdo Bustos “Determining the mechanism that drives cell death in the absence of InsP3R activity, by measuring apoptosis, autophagy and necrosis”. (University of Chile, Chile).

2012-2013 Undergraduate advisor: Camila Godoy “Melformin induces cell death specifically in breast tumor derived cell lines”. (University of Chile, Chile).


Premios y Distinciones

  •   Best PhD thesis award

    FUNDACION CIENCIA PARA LA VIDA

    Chile, 2005

    premio a la major tesis de doctorado del anio 2005

  •   International Travel Award

    Biophysical Society

    Estados Unidos, 2005

    trabajo en la modalidad poster premiado .

  •   Research award

    American Heart Association

    Chile, 2009

    research grant to work in atheroslcerosis


 

Article (39)

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions
CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity
In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca communication=> a dead end in cancer cells.
-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells .
Editorial=> Inter-Organelle Calcium Communication in Cancer.
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.
Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer=> A Novel Potential Target.
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells.
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells.
The Mitochondrial Complex(I)ty of Cancer.
The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells.
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura=> Bufonidae).
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival
Mitochondrial Ca 2+ signals in autophagy
Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy.
Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.
Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line
Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation
Xestospongin B, a competitive inhibitor of IP3-mediated Ca 2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells
Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells
Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase C alpha
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to inositol trisphosphate receptors

Abstract (3)

Normal distribution of Ins(1,4,5)P3 receptors is disrupted in Duchenne muscular dystrophy
Nuclear IP3 receptor isoforms regulate local Ca2+ transients and modulate CREB phosphorylation
Subcellular localisation of inositol 1,4,5-trisphosphate receptors in cultured skeletal muscle from rat and mouse
31
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

13
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

2
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

2
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Mario Sanhueza

Assistant professor

Universidad Mayor

Santiago, Chile

1
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

1
Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Ricardo Hartley

Académico

Universidad Central de Chile

Santiago, Chile

1
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Paola Murgas

Profesor Investigador Asistente

Facultad de Ciencias

Universidad Mayor de Chile

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile