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Julio Cesar Cardenas Matus

Associated Professor

Universidad Mayor de Chile

Santiago, Chile

our lab is interested in the mechanisms that regulated cellular metabolism and bioenergetic’s, with special emphasis in the functional relation between the endoplasmic reticulum and mitochondria in the context of cancer and aging

Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2005
Medical Technology, UNIVERSIDAD DE CHILE. Chile, 2000

Assitent professor Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2011 - 2019
Visiting Professor Other

UNIVERSITY OF PENNSYLVANIA

Philadelphia, Estados Unidos

2012 - A la fecha
Associate Professor Full Time

UNIVERSIDAD MAYOR

Facultad de Ciencias

Santiago, Chile

2019 - A la fecha

Assitant Professor Full Time

University of Chile

Santiago, Chile

2011 - 2019
Associate Professor Full Time

Universidad Mayor

Santiago, Chile

2019 - A la fecha

.2017-2018 Postdoctoral advisor: Felix Urra, FONDECYT postdoctoral grant #3170813. “Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies” Current position, Assistant Professor at University of Chile, Chile.

2014-2017 Postdoctoral advisor: Carla Basualto, FONDECYT postdoctoral grant #3150623. “Role of dysfunctional mitochondria in the muscle weakness and atrophy observed in Dermatomyositis and Polymyositis” Current position, Assistant Professor at Aysen University, Chile.

2013-2016 Postdoctoral advisor: Fabian Jana, FONDECYT postdoctoral grant #3140458. “Defining the role of mitochondrial electron transport chain complex I on the modulation of Ca2+ homeostasis: effects on cancer cell metabolism”.
Current position, Assistant Professor at Aysen University, Chile.

2017-present PhD advisor; Marioly Muller, “Role of IP3R-mediated exacerbated Ca2+ signaling in neurodegeneration and mitochondrial dysfunction in early onset of Familial Alzheimer disease”.

2017-present PhD advisor: Galdo Bustos, “Mitochondrial Ca2+ uptake of is essential to maintain mitochondrial metabolism and sustain breast cancer cell migration and invasion.

2016-present PhD advisor: Ulises Ahumada, “Endoplasmic reticulum – mitochondria coupling as regulator of cellular senescence”

2013-2016 PhD advisor: Felix Urra, “Metabolic remodeling in breast cancer: mitochondrial bioenergetics as target for the design of anti-metastatic drugs”.

2015-present Master advisor: Felipe Munoz. “Synthesis of 5,8-dihydroxi-4,4-dimetilnaftalen-1(4H)- ona-alquil TPP+ derivate; potential mitochondrial antioxidant with effects on cancer markers dependent of oxidative stress.

2014-2016 Master advisor: Melany Rios. “alpha-ketoglutarate dehydrogenase as a key regulator of metabolism in cancer cells” (University of Chile, Chile).

2015-2016 Undergraduate advisor: Santiago Sepulveda, “Mutant presenilin 1 (M146L) alter mitochondrial Ca2+ homeostasis in a model of familiar Alzheimer disease (FAD) (University of Chile, Chile).

2015-2016 Undergraduate advisor: Pablo Cruz, “Long term treatment with metformin induce changes in the cell cycle in leukemia cells. (University of Chile, Chile).

2015-2016 Undergraduate advisor: Daniela Gonzalez, “knockdown of nad-isocitrate dehydrogenase in mcf7 cells; comparative effect with InsP3R inhibition. (University of Chile, Chile).
2013-2015 Undergraduate advisor: Mery Ann Hidalgo, “Determination of autophagy levels in biopsies of patients with dysferlinophaty disease”. (University of Chile, Chile).

2014-2015 Undergraduate advisor: Natalia Smith. “Inhibition of inositol 1,4,5-trisphosphate receptor-mediated calcium release leads to decreased migration in different tumor cell lines. (University of Chile, Chile).

2013-2015 Undergraduate advisor: Sebastian Merino, “Role of MCU and MCUR1 in cancer bioenergetics” (University of Chile, Chile).

2013-2015 Undergraduate advisor: Carlos Valdes, “Modulation of cellular metabolism by InsP3R inhibition: role of sirtuin 1”. (Catholic University of Valparaiso, Chile).

2012-2013 Undergraduate advisor: Galdo Bustos “Determining the mechanism that drives cell death in the absence of InsP3R activity, by measuring apoptosis, autophagy and necrosis”. (University of Chile, Chile).

2012-2013 Undergraduate advisor: Camila Godoy “Melformin induces cell death specifically in breast tumor derived cell lines”. (University of Chile, Chile).

Best PhD thesis award

FUNDACION CIENCIA PARA LA VIDA

Chile, 2005

premio a la major tesis de doctorado del anio 2005
International Travel Award

Biophysical Society

Estados Unidos, 2005

trabajo en la modalidad poster premiado .
Research award

American Heart Association

Chile, 2009

research grant to work in atheroslcerosis


The IP3R inhibitor desmethylxestospongin B reduces tumor cell migration , invasion and metastasis by impairing lysosome acidification and β1-integrin recycling Puebla, Andrea; Casanova-Canelo, Cesar; Smith-Cortinez, Natalia; Farias, Paula; Molgo, Jordi; Torres, Vicente A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2025)
17-β-estradiol and phytoestrogens elicit NO production and vasodilatation through PI3K, PKA and EGF receptors pathways, evidencing functional selectivity Catalan-Salas, Vicente; Sagredo, Pablo; Melgarejo, Williams; Valdes, Daniel; Huidobro-Toro, J. Pablo Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2024)
Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells Cereceda, Lucas; Hidalgo, Yessia Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice Acuna-Catalan, Diego; Shah, Samah; Wehrfritz, Cameron; Nomura, Mitsunori; Acevedo, Alejandro; Olmos, Cristina; Quiroz, Gabriel; Bons, Joanna; Ampuero, Estibaliz; Wyneken, Ursula; et al. Article ISI CELL REPORTS MEDICINE (2024)
Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism Morgado-Caceres, Pablo; Kangme-Encalada, Matias; de Arbina, Amaia Lopez; Hidalgo, Yessia Article ISI Scientific Reports (2024)
Novel Inositol 1,4,5-Trisphosphate Receptor Inhibitor Antagonizes Hepatic Stellate Cell Activation: A Potential Drug to Treat Liver Fibrosis Heegsma, Janette Article ISI CELLS (2024)
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation Veliz-Valverde, Felipe; Quiroz, Gabriel; Iqbal, Somya; Eaton, Samantha L.; Bernales, Sebastian; Cerpa, Waldo; Court, Felipe A. Article ISI AGING CELL (2023)
Sustained IP3-linked Ca<SUP>2+</SUP> signaling promotes progression of triple negative breast cancer cells by regulating fatty acid metabolism De Mario, Agnese; Audano, Matteo; Romani, Patrizia; Pedretti, Silvia; Cardenas, Cesar; Dupont, Sirio; Mammucari, Cristina; Mitro, Nico Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging Hung, Mei-Li Diaz; Vidal, Rene; Fuentealba, Matias; Miedema, Tim; Sabusap, Carleen M.; Adamson, Stuart; Vitangcol, Kaitlyn; Zhang, Xu; Nakamura, Tomohiro; Sardi, Sergio Pablo; et al. Article ISI EMBO JOURNAL (2022)
A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington's disease Ordonez, Jose Luis; Rivas, Alexis; Pihan, Philippe; Ahumada, Ulises; Barriga, Andres; Seguel, Ivette; Cardenas, Cesar Article ISI PLOS ONE (2021)
Ca2+ transfer to mitochondria: a spark of life in unexpected conditions Cardenas, Julio Cesar Article ISI Molecular and Cellular Oncology (2021)
CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity Farias, Paula; Vargas, Leonardo; Simon, Valeska; Cardenas, Cesar; Rosemblatt, Mario; Bono, Maria Rosa; Sauma, Daniela Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence Alberto Lopez-Dominguez, Jose; Rodriguez-Lopez, Sandra; Desprez, Pierre-Yves; Konovalenko, Maria; Laberge, Remi-Martin; Cardenas, Cesar; Manuel Villalba, Jose; Campisi, Judith Article ISI AGING-US (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abildgaard, Marie H.; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E.; Adolph, Timon E.; et al. Article ISI AUTOPHAGY (2021)
In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes Puebla-Huerta, Andrea; Cardenas, Cesar Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells Cruz, Pablo; Molgo, Jordi; Sauma, Daniela; Cardenas, Cesar Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Keeping zombies alive: The ER-mitochondria Ca<SUP>2+</SUP> transfer in cellular senescence Cuevas-Espinoza, Victor Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival Podunavac, Masa; Mailyan, Artur K.; Jackson, Jeffrey J.; Farias, Paula; Molgo, Jordi; Cardenas, Cesar Article ISI ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival Cardenas, Cesar; Cruz, Pablo; Farias, Paula; Cerda, Oscar; Molgo, Jordi Article ISI SCIENCE SIGNALING (2020)
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria Farias, Paula; Molgo, Jordi; Cardenas, Cesar Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function Bozan, Maria Francisca; Bevilacqua, Jorge A. Article ISI PLOS ONE (2020)
SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells Krabbendam I.E.; Honrath B.; Bothof L.; Huerta, H.; PeÃ±aranda Fajardo N.M.; Dekker F.; Culmsee C.; CÃ©sar CÃ¡rdenas J.; Kruyt F. Article ISI SCOPUS (2020)
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep Castillo, R. L.; Reyes, R. V.; Llanos, A. J.; Herrera, E. A. Article ISI SCOPUS REDOX BIOLOGY (2019)
Complex I and II are required for normal mitochondrial Ca2+ homeostasis Rivas, José; Cruz, Pablo; Urra, Felix; Basualto-Alarcón, Carla; Sagredo, Eduardo; Ríos, Melany; Lovy, Alenka; Dong, Zhiwei; Cerda, Oscar Article ISI SCOPUS MITOCHONDRION (2019)
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca communication=> a dead end in cancer cells. Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka; Pardo, Evelyn; Molg?, Jordi; Cárdenas, César Article Autophagy (2019)
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Durand, Sylvere; Mortenson, David E.; Hazari, Younis; Sassano, Maria L.; Pihan, Philippe; van Vliet, Alexander R.; Gonzalez-Quiroz, Matias; Kerkhofs, Martijn; Kaufman, Randal J.; Luke Wiseman, R.; et al. Article ISI SCOPUS Nature Cell Biology (2019)
-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells . Flores-Santibáñez, Felipe; Cuadra, Bárbara; Fernández, Dominique; Rosemblatt, Mariana V; Núñez, Sarah; Cruz, Pablo; Gálvez-Cancino, Felipe; Cárdenas, J César; Lladser, Alvaro; Rosemblatt, Mario; Bono, María Rosa; Sauma, Daniela Article Frontiers in immunology (2018)
Editorial=> Inter-Organelle Calcium Communication in Cancer. Cardenas, Cesar; Pinton, Paolo; Bultynck, Geert Article Frontiers in oncology (2018)
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/Î²1-integrin pathway. Urra, Félix A; Muñoz, Felipe; Córdova-Delgado, Miguel; Ramírez, María Paz; Peña-Ahumada, Bárbara; Rios, Melany; Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Pulgar, Rodrigo; Morales, Danna; Varela, Diego; Millas-Vargas, Juan Pablo; Retamal, Evelyn; Ramírez-Rodríguez, Oney; Pessoa-Mahana, Hernán; Pavani, Mario; Ferreira, Jorge; Cárdenas, César; Araya-Maturana, Ramiro Article Scientific reports (2018)
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging Mueller, Marioly; Sanhueza, Mario; Court, Felipe A.; Cardenas, Cesar Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Miller, Russell A; Shi, Yuji; Lu, Wenyun; Pirman, David A; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas, César; Wan, Min; Foskett, J Kevin; Park, Junyoung O; Zhang, Yiyi; Holland, William L; Rabinowitz, Joshua D; Birnbaum, Morris J Article Nature medicine (2018)
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression. Erices, Rafaela; Cubillos, Sofía; Aravena, Raúl; Santoro, Felice; Marquez, Monica; Orellana, Renan; Ramírez, Carolina; González, Pamela; Fuenzalida, Patricia; Bravo, María Loreto; Oliva, Bárbara; Kato, Sumie; Ibañez, Carolina; Brañes, Jorge; Bravo, Erasmo; Alonso, Catalina; García, Karen; Arab, Clemente; Torres, Vicente A; Godoy, Alejandro S; Pereira, Jaime; Bustos, Galdo; Cardenas, Julio Cesar; Cuello, Mauricio A; Owen, Gareth I Article Oncotarget (2017)
Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer=> A Novel Potential Target. Bustos, Galdo; Cruz, Pablo; Lovy, Alenka; Cárdenas, César Article Frontiers in oncology (2017)
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. Cataldo, Luis Rodrigo; Mizgier, María L; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos, Paola; Busso, Dolores; Olmos, Pablo; Galgani, José E; Santos, José L; Cortés, Víctor A Article PloS one (2017)
The Mitochondrial Complex(I)ty of Cancer. Urra, Félix A; Muñoz, Felipe; Lovy, Alenka; Cárdenas, César Article Frontiers in oncology (2017)
The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann, Guillermo; Gomez, Celeste Vega; Rojas de Arias, Antonieta; Burgos-Edwards, Alberto; Alfonso, Jorge; Rolon, Miriam; Brusquetti, Francisco; Netto, Flavia; Urra, Félix A; Cárdenas, César Article Journal of ethnopharmacology (2017)
The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann, Guillermo; Gomez, Celeste Vega; Rojas de Arias, Antonieta; Burgos-Edwards, Alberto; Alfonso, Jorge; Rolon, Miriam; Brusquetti, Francisco; Netto, Flavia; Urra, Félix A; Cárdenas, César Article Journal of ethnopharmacology (2017)
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease Herrera A.; Muñoz P; Paris, I; Mora S.; Inzunza, J; Hultenby K.; Cardenas C; Jaña F; Gysling, K; Abarca, J; et al. Article ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura=> Bufonidae). Schmeda-Hirschmann, Guillermo; Quispe, Cristina; Arana, Gabriel Vargas; Theoduloz, Cristina; Urra, Félix A; Cárdenas, César Article Toxicon => official journal of the International Society on Toxinology (2016)
InsP(3)R, the calcium whisperer: Maintaining mitochondrial function in cancer Foskett, J. Kevin; Cardenas, Cesar Article WOS-ESCI Molecular and Cellular Oncology (2016)
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria Cardenas C; Müller M.; McNeal A.; Lovy, A; JaÃ±a F.; Bustos G.; Urra, F.; Smith N.; Molgó J.; Diehl J.A.; et al. Article ISI SCOPUS Cell Reports (2016)
LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation Doonan, PJ; Zhang, XQ; Cardenas C; Shanmughapriya, S; Rajan, S; Vallem, S; Chen, XW; Foskett, JK; Cheung, JY; Houser, SR; et al. Article ISI SCOPUS FASEB JOURNAL (2014)
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism Mallilankaraman K.; Cardenas C; Doonan, PJ; Irrinki, KM; Golenar, T; Csordas, G; Madireddi, P; Yang, J.; Miller, R; Kolesar, JE; et al. Article ISI Nature Cell Biology (2012)
MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival Mallilankaraman K.; Doonan P.; Cardenas C; Chandramoorthy H.C.; Miller, R; Hoffman N.E.; Gandhirajan R.K.; Molgó J.; Birnbaum M.J.; Rothberg B.S.; et al. Article ISI SCOPUS Cell (2012)
Mitochondrial Ca2+ signals in autophagy Cardenas C Article ISI SCOPUS Cell Calcium (2012)
Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells Cardenas C; Juretic, N; Garcia, IE; Figueroa, R.; Hartley, R; Taratuto, AL; Gejman, R; Riveros, N.; Molgó J.; Jaimovich E. Article ISI SCOPUS FASEB Journal (2010)
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Article CELL (2010)
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy Cardenas C; Escobar M.; Garcia, A.; Osorio-Reich, M; Hartel, S; Foskett, JK; Franzini-Armstrong, C Article ISI SCOPUS Journal of Structural Biology (2010)
Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Müller M, Cárdenas C, Mei L, Cheung KH, Foskett JK. Article Proc Natl Acad Sci U S A (2009)
Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line Kusnier, C; Cardenas C; Hidalgo J.; Jaimovich E. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2006)
Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation Cardenas C; Molgó J.; Colasante, C; Mignery, GA; Jaimovich E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2005)
Xestospongin B, a competitive inhibitor of IP3-mediated Ca 2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells Jaimovich E.; Liberona J.L.; Cardenas C; Estrada, M; Mattei, C; Barbier, J; Molgó J.; Debitus, C; Laurent, D Article FEBS LETTERS (2005)
Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase C alpha Cardenas C; Jaimovich E.; Pérez, F; Buchuk, D; Quest, AFG Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes Ibarra, C; Estrada, M; CARRASCO L.; Chiong M.; Cardenas C; Diaz-Araya, G; Jaimovich E.; Lavandero S. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to inositol trisphosphate receptors Estrada, M; Cardenas C; Mignery, GA; Allen, PD; Jaimovich E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)


Normal distribution of Ins(1,4,5)P3 receptors is disrupted in Duchenne muscular dystrophy Cardenas C; Figueroa, R.; Taratuto, AL; Molgó J.; Jaimovich E. Abstract ISI NEUROMUSCULAR DISORDERS (2006)
Nuclear IP3 receptor isoforms regulate local Ca2+ transients and modulate CREB phosphorylation Cardenas C; Molgó J.; Colassante, CO; Mignery, G; Jaimovich E. Abstract BIOPHYSICAL JOURNAL (2005)
Subcellular localisation of inositol 1,4,5-trisphosphate receptors in cultured skeletal muscle from rat and mouse Cardenas C; Powell, JA; Adams, D.; Mignery, G; Jaimovich E. Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Balancing energy and protein homeostasis at ER-mitochondria contact sites Review ISI SCIENCE SIGNALING (2022)
Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration Gudenschwager, Camila; Chavez, Isadora; Cardenas, Cesar Review ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
The ER-mitochondria Ca<SUP>2+</SUP> signaling in cancer progression: Fueling the monster Cardena, J. Cesar Review ISI INTER-ORGANELLAR CA2+ SIGNALING IN HEALTH AND DISEASE - PT B (2021)

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Maria Magdalena Sanhueza

Profesora Asociada

Biología

Universidad de Chile

Santiago, Chile

Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

René Vidal

Profesor Asociado

Universidad Mayor

Santiago, Chile

Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Paola Murgas

Profesor Investigador Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Puerto Montt, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Flavio Salazar

Profesor Titular

Oncología Básico Clínica

Universidad de Chile

SANTIAGO, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Mario Sanhueza

Regional Director of Research

Universidad Mayor

Temuco, Chile

Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Ricardo Hartley

Investigador

Instituto de Investigación y Postgrado

Universidad Central de Chile

Santiago, Chile

Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

José Ordóñez

Académico

Medicina y Ciencia

Universidad San Sebastián

Concepción, Chile

Alejandro Gonzalez

Profesor Asociado

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Carla Basualto

Académico, Profesor Asociado

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Gabriela Martinez

Profesor Asociado

Filosofía y educación

Universidad Metropolitana de Ciencias de la Educación

santiago, Chile

Yessia Hidalgo

Researcher

Centro de Investigación e Innovación Biomédica

Corporación IMPACT

Santiago, Chile

Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

Reinaldo Figueroa

Instructor Adjunto

Facultad de Medicina y Ciencias de la Salud

Universidad Mayor de Chile

Santiago, Chile

Marioly Muller

Académico

Tecnología Médica

Universidad de Chile

Santiago, Chile

Elizabeth Rivas

Academico

Medicina

Universidad de Atacama

Copiapo, Chile

Julio Cesar Cardenas Matus

Líneas de Investigación

Educación

Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2005

Medical Technology, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

Assitent professor Full Time

Visiting Professor Other

Associate Professor Full Time

Experiencia Profesional

Assitant Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Premios y Distinciones

Best PhD thesis award

International Travel Award

Research award

Article (55)

Abstract (3)

Review (3)