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Félix Ariel Urra Faúndez

Profesor asistente

University of Chile

Santiago, Chile

Líneas de Investigación


Metabolismo Celular y Bioenergética mitocondrial; plasticidad metabólica durante proliferación y migración de de células tumorales; Química-Medicinal de nuevos compuestos anti-tumorales; identificación de toxinas/venenos de serpientes y anfibios

Educación

  •  Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

  •   Profesor asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Chile

    2019 - A la fecha

Experiencia Profesional

  •   Investigador Postdoctoral Other

    Universidad de Chile, Facultad de Medicina

    Santiago, Chile

    2017 - 2019

  •   Profesor asistente Full Time

    Universidad de Chile, Facultad de Medicina

    Santiago, Chile

    2019 - A la fecha

Premios y Distinciones

  •   Beca doctoral nacional

    FONDECYT

    Chile, 2012

    Beca Doctorado Nacional Chile, para realizar mi doctorado en Farmacología durante 2012-2016.

  •   Beca Joven Investigador

    Banco Santander

    Chile, 2019

    Beca Joven Investigador Banco Santander financia estadias cortas de investigación de investigadores menores de 35 años, contratados en una institución superior. Esta estadia es en algún pais iberoamericano.


 

Article (25)

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells
Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization
Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function
Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6
The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells
Complex I and II are required for normal mitochondrial Ca2+ homeostasis
Observations on reproduction in captivity of the endemic long-tailed snake Philodryas chamissonis (Wiegmann, 1835) (Reptilia, Squamata, Dipsadidae) from Chile
Regulation of mitochondrial function as a promising target in platelet activation-related diseases
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta 1-integrin pathway
The True Identity of the New World Iguanid Lizard Liolaemus chillanensis Muller and Hellmich 1932 (Iguania: Liolaemidae) and Description of a New Species in the Liolaemus elongatus Group
Phymaturus vociferator Pincheira-Donoso, 2004 (Squamata: Liolaemidae): New records and updated geographic distribution
The Mitochondrial Complex(I)ty of Cancer.
The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells.
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura=> Bufonidae).
Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors=> Bioenergetic Profile and Metabolic Flexibility of Cancer Cells.
Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation.
Identification and molecular characterization of five putative toxins from the venom gland of the snake Philodryas chamissonis (Serpentes: Dipsadidae).
Two new species of the Liolaemuselongatus-kriegi complex (Iguania, Liolaemidae) from Andean highlands of southern Chile.
An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3.
Mitochondria: A promising target for anticancer alkaloids

BookWhole (1)

Targeting mitochondrial bioenergetics of cancer cells with alkaloids: Mechanisms and anti-cancer strategies

Note (1)

First record of pompilocalus sp. roig alsina, 1989 (hymenoptera: Pompilidae) preying on tachymenis chilensis coronellina (werner, 1898) (serpentes: Dipsadidae) from central Chile

Proyecto (7)

Reprogramming mitochondrial bioenergetic adaptation with Alfa-ketoglutarate and Coenzyme Q10 to alleviate inflammation in colitis-associated macrophages
Avoiding chemotherapy-induced pro-migratory phenotype: rewiring the mitochondrial bioenergetics for new migrastatics approaches in triple-negative breast cancer cells
Red para la investigacioón del veneno de serpiente: estrategias biotecnológicas para el desarrollo de la toxicología molecular y descubrimiento de fármacos
New mitochondria-targeted anti-tumor compounds: Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols
New mitochondria-targeted anti-tumor compounds=> Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols
Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies
Mitochondrial glutamine metabolism in metastasis of breast cancer cells=> a selective dependence that offers new anti-cancer strategies

Review (2)

Philodryas (Serpentes: Dipsadidae) Envenomation, A Neglected Issue in Chile
Targeting Metastasis with Snake Toxins: Molecular Mechanisms
25
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

3
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

3
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

2
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

2
Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

2
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

2
Sebastián Fuentes

Estudiante postgrado

Farmacología

Universidad de Chile

Santiago, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Dan Vivas

Director de Instituto de Investigación

Biología Celular y Genética

Universidad Nacional Mayor de San Marcos

Lima , Peru

1
Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Jorge Toledo

Investigador

Departamento de Anatomia y Biologia del Desarrollo

Universidad de Chile; Biomedical Neuroscience Institute (BNI)

Santiago, Chile

1
Eladio Flores

Coordinator

Fundação Ezequiel Dias

Belo Horizonte, Chile

1
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

1
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

1
JEAN DE ANDRADE

Académico Investigador

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Carla Basualto

Jefe de Departamento - Académico

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Paola Murgas

Profesor Investigador Asistente

Facultad de Ciencias

Universidad Austral de Chile

Valdivia , Chile

1
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Oney Ramirez

Assistant Professor

Ciencias de la Salud

UNIVERSIDAD DE AYSEN

Coyhaique, Chile

1
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

1
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile