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Félix Ariel Urra Faúndez

Profesor asistente

University of Chile

Santiago, Chile

Metabolismo Celular y Bioenergética mitocondrial; plasticidad metabólica durante proliferación y migración de de células tumorales; Química-Medicinal de nuevos compuestos anti-tumorales; identificación de toxinas/venenos de serpientes y anfibios

Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016

Profesor asistente Full Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Chile

2019 - A la fecha

Investigador Postdoctoral Other

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2017 - 2019
Profesor asistente Full Time

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2019 - A la fecha

Beca doctoral nacional

FONDECYT

Chile, 2012

Beca Doctorado Nacional Chile, para realizar mi doctorado en Farmacología durante 2012-2016.
Beca Joven Investigador

Banco Santander

Chile, 2019

Beca Joven Investigador Banco Santander financia estadias cortas de investigación de investigadores menores de 35 años, contratados en una institución superior. Esta estadia es en algún pais iberoamericano.


An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells Donoso-Bustamante, Viviana; Borrego, Edgar A.; Schiaffino-Bustamante, Yareli; Gutierrez, Denisse A.; Pablo Millas-Vargas, Juan; Fuentes-Retamal, Sebastian; Correa, Pablo; Carrillo, Ileana; Aguilera, Renato J.; Miranda, Dante; Chavez-Baez, Ignacio; Pulgar, Rodrigo.; Urra, Felix A.; Varela-Ramirez, Armando; Araya-Maturana, Ramiro Article ISI BIOORGANIC CHEMISTRY (2020)
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival Cardenas, Cesar; Lovy, Alenka; Silva-Pavez, Eduardo; Urra, Felix; Mizzoni, Craig; Ahumada-Castro, Ulises; Bustos, Galdo; Jana, Fabian; Cruz, Pablo; Farias, Paula; Mendoza, Elizabeth; Huerta, Hernan; Murgas, Paola; Hunter, Martin; Rios, Melany; Cerda, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgo, Jordi; Foskett, J. Kevin Article ISI SCIENCE SIGNALING (2020)
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells Fuentes-Retamal, S; Sandoval-Acuna, C; Peredo-Silva, L; Guzman-Rivera, D; Pavani, M; Torrealba, N; Truksa, J; Castro-Castillo, V; Catalan, M; Kemmerling, U; Urra, FA; Ferreira, J Article ISI CELLS (2020)
Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization Vivas-Ruiz D.E.; Sandoval G.A.; Gonzalez-Kozlova E.; Zarria-Romero J.; Lazo F.; RodrÃguez E.; MagalhÃ£es H.P.B.; ChÃ¡vez-Olortegui C.; Oliveira L.S.; Alvarenga V.G.; Urra F.A.; Toledo J.; YarlequÃ© A.; Eble J.A.; Sanchez E.F. Article ISI SCOPUS International Journal of Biological Macromolecules (2020)
Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function Basualto-Alarcon, Carla; Urra, Felix A.; Bozan, Maria Francisca; Jana, Fabian; Trangulao, Alejandra; Bevilacqua, Jorge A.; Cardenas, J. Cesar Article ISI PLOS ONE (2020)
Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery Urra, Félix A.; Araya-Maturana, Ramiro Article Seminars in Cancer Biology (2020)
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6 Méndez, Diego; Urra, Félix A.; Millas-Vargas, Juan Pablo; Alarcón, Marcelo; Rodríguez-Lavado, Julio; Palomo, Iván; Trostchansky, Andrés; Araya-Maturana, Ramiro; Fuentes, Eduardo Article ISI SCOPUS (2020)
The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells Schmeda-Hirschmann, Guillermo; de Andrade, Jean Paulo; Soto-Vasquez, Marilu Roxana; Alvarado-Garcia, Paul Alan Arkin; Palominos, Charlotte; Fuentes-Retamal, Sebastian; Mellado, Mathias; Correa, Pablo; Urra, Felix A. Article ISI TOXINS (2020)
Complex I and II are required for normal mitochondrial Ca2+ homeostasis Jaña, Fabian; Bustos, Galdo; Rivas, José; Cruz, Pablo; Urra, Felix; Basualto-Alarcón, Carla; Sagredo, Eduardo; Ríos, Melany; Lovy, Alenka; Dong, Zhiwei; Cerda, Oscar; Madesh, Muniswamy; Cárdenas, César Article ISI SCOPUS MITOCHONDRION (2019)
Observations on reproduction in captivity of the endemic long-tailed snake Philodryas chamissonis (Wiegmann, 1835) (Reptilia, Squamata, Dipsadidae) from Chile Cabeza, O; Vargas, E; Ibarra, C; Urra, FA Article ISI HERPETOZOA (2019)
Regulation of mitochondrial function as a promising target in platelet activation-related diseases Fuentes E.; Araya-Maturana R.; Urra F.A. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2019)
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta 1-integrin pathway Urra, FA; Munoz, F; Cordova-Delgado, M; Ramirez, MP; Pena-Ahumada, B; Rios, M; Cruz, P; Ahumada-Castro, u; Bustos, G; Silva-Pavez, E; Pulgar, R; Morales, D; Varela, D; Millas-Vargas, JP; Retamal E.; Ramirez-Rodriguez, O; Pessoa-Mahana, H; Pavani, M.; Ferreira, J; Cardenas, C; Araya-Maturana, R Article ISI SCOPUS Scientific Reports (2018)
The True Identity of the New World Iguanid Lizard Liolaemus chillanensis Muller and Hellmich 1932 (Iguania: Liolaemidae) and Description of a New Species in the Liolaemus elongatus Group Troncoso-Palacios, J; Esquerre, D; Urra, FA; Diaz, HA; Castro-Pastene, C; Ruiz, MS Article ISI SCOPUS ZOOLOGICAL STUDIES (2018)
Phymaturus vociferator Pincheira-Donoso, 2004 (Squamata: Liolaemidae): New records and updated geographic distribution Urra F.A.; Díaz H.A.; Werning H.; Eisenberg T.; Troncoso-Palacios J. Article SCOPUS Check List (2017)
The Mitochondrial Complex(I)ty of Cancer. Urra, Félix A; Muñoz, Felipe; Lovy, Alenka; Cárdenas, César Article Frontiers in oncology (2017)
The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann, Guillermo; Gomez, Celeste Vega; Rojas de Arias, Antonieta; Burgos-Edwards, Alberto; Alfonso, Jorge; Rolon, Miriam; Brusquetti, Francisco; Netto, Flavia; Urra, Félix A; Cárdenas, César Article Journal of ethnopharmacology (2017)
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura=> Bufonidae). Schmeda-Hirschmann, Guillermo; Quispe, Cristina; Arana, Gabriel Vargas; Theoduloz, Cristina; Urra, Félix A; Cárdenas, César Article Toxicon => official journal of the International Society on Toxinology (2016)
Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors=> Bioenergetic Profile and Metabolic Flexibility of Cancer Cells. Urra, Félix A; Weiss-López, Boris; Araya-Maturana, Ramiro Article Current pharmaceutical design (2016)
Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaň a, Fabian; Bustos, Galdo; Urra, Félix; Smith, Natalia; Molgó, Jordi; Diehl, J Alan; Ridky, Todd W; Foskett, J Kevin. Article Cell Reports (2016)
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria Cárdenas C; Müller M.; McNeal A.; Lovy, A; JaÃ±a F.; Bustos G.; Urra, F.; Smith N.; Molgó J.; Diehl J.A.; Ridky T.W.; Foskett J.K. Article ISI SCOPUS CELL REPORTS (2016)
Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Urra, Félix A; Córdova-Delgado, Miguel; Lapier, Michel; Orellana-Manzano, Andrea; Acevedo-Arévalo, Luis; Pessoa-Mahana, Hernán; González-Vivanco, Jaime; Martínez-Cifuentes, Maximiliano; Ramírez-Rodríguez, Oney; Millas-Vargas, Juan Pablo; Weiss-López, Boris; Pavani, Mario; Ferreira, Jorge; Araya-Maturana, Ramiro. Article TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Identification and molecular characterization of five putative toxins from the venom gland of the snake Philodryas chamissonis (Serpentes: Dipsadidae). Urra, Félix A; Pulgar, Rodrigo; Gutiérrez, Ricardo; Hodar, Christian; Cambiazo, Verónica; Labra, Antonieta. Article TOXICON (2015)
Two new species of the Liolaemuselongatus-kriegi complex (Iguania, Liolaemidae) from Andean highlands of southern Chile. Troncoso-Palacios, Jaime; Díaz, Hugo; Esquerré, Damien; Urra, Félix A. Article ZooKeys (2015)
An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3. Félix A. Urra; Maximiliano Martínez-Cifuentes; Mario Pavani; Michel Lapier; Fabián Jaña-Prado; Eduardo Parra; Juan Diego Maya; Hernán Pessoa-Mahana; Jorge Ferreira; Ramiro Araya-Maturana Article TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Mitochondria: A promising target for anticancer alkaloids Urra F.A.; CÃ³rdova-Delgado M.; Pessoa-Mahana, H; RamÃrez-RodrÃguez O.; Weiss-LÃ³pez B.; Ferreira J.; Araya-Maturana, R Article SCOPUS Current Topics in Medicinal Chemistry (2013)


Targeting mitochondrial bioenergetics of cancer cells with alkaloids: Mechanisms and anti-cancer strategies Urra F.A.; Araya-Maturana, R BookWhole SCOPUS Alkaloids: Biosynthesis, Biological Roles and Health Benefits (2015)


First record of pompilocalus sp. roig alsina, 1989 (hymenoptera: Pompilidae) preying on tachymenis chilensis coronellina (werner, 1898) (serpentes: Dipsadidae) from central Chile Contreras F. J.M.; Urra F.A.; Rojas-Porras N.A. Note SCOPUS HERPETOLOGY NOTES (2019)


Reprogramming mitochondrial bioenergetic adaptation with Alfa-ketoglutarate and Coenzyme Q10 to alleviate inflammation in colitis-associated macrophages Dubois-Camacho, Karen Proyecto (2021)
Avoiding chemotherapy-induced pro-migratory phenotype: rewiring the mitochondrial bioenergetics for new migrastatics approaches in triple-negative breast cancer cells Urra, Felix A. Proyecto (2020)
Red para la investigacioón del veneno de serpiente: estrategias biotecnológicas para el desarrollo de la toxicología molecular y descubrimiento de fármacos Urra, Felix A.; Pulgar, Rodrigo. Proyecto (2019)
New mitochondria-targeted anti-tumor compounds: Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols Araya-Maturana, Ramiro; Urra, Felix A. Proyecto (2018)
New mitochondria-targeted anti-tumor compounds=> Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols FONDECYT (1180069) Proyecto 2018-2021 Coinvestigador(a)
Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies Urra, Felix A.; Cárdenas, Julio C Proyecto (2017)
Mitochondrial glutamine metabolism in metastasis of breast cancer cells=> a selective dependence that offers new anti-cancer strategies FONDECYT (3170813) Proyecto 2017-2019 Inv. Responsable


Philodryas (Serpentes: Dipsadidae) Envenomation, A Neglected Issue in Chile Urra F.A.; Miranda-Calle A.B.; Araya-Maturana R. Review ISI SCOPUS TOXINS (2019)
Targeting Metastasis with Snake Toxins: Molecular Mechanisms Urra, FA; Araya-Maturana, R Review ISI SCOPUS Toxins (2017)

Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Carla Basualto

Jefe de Departamento - Académico

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

Sebastián Fuentes

Estudiante postgrado

Farmacología

Universidad de Chile

Santiago, Chile

Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Jorge Toledo

Investigador

Departamento de Anatomia y Biologia del Desarrollo

Universidad de Chile; Biomedical Neuroscience Institute (BNI)

Santiago, Chile

Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Dan Vivas

Director de Instituto de Investigación

Biología Celular y Genética

Universidad Nacional Mayor de San Marcos

Lima , Peru

Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

Eladio Flores

Coordinator

Fundação Ezequiel Dias

Belo Horizonte, Chile

Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

JEAN DE ANDRADE

Académico Investigador

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

Paola Murgas

Profesor Investigador Asistente

Facultad de Ciencias

Universidad Austral de Chile

Valdivia , Chile

Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

Oney Ramirez

Assistant Professor

Ciencias de la Salud

UNIVERSIDAD DE AYSEN

Coyhaique, Chile

Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

Félix Ariel Urra Faúndez

Líneas de Investigación

Educación

Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

Profesor asistente Full Time

Experiencia Profesional

Investigador Postdoctoral Other

Profesor asistente Full Time

Premios y Distinciones

Beca doctoral nacional

Beca Joven Investigador

Article (25)

BookWhole (1)

Note (1)

Proyecto (7)

New mitochondria-targeted anti-tumor compounds=> Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols

Mitochondrial glutamine metabolism in metastasis of breast cancer cells=> a selective dependence that offers new anti-cancer strategies

Review (2)