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Félix Ariel Urra Faúndez

Profesor asistente

University of Chile

Santiago, Chile

Líneas de Investigación


Metabolismo Celular y Bioenergética mitocondrial; plasticidad metabólica durante proliferación y migración de de células tumorales; Química-Medicinal de nuevos compuestos anti-tumorales; identificación de toxinas/venenos de serpientes y anfibios

Educación

  •  Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

  •   Profesor asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Chile

    2019 - A la fecha

Experiencia Profesional

  •   Investigador Postdoctoral Other

    Universidad de Chile, Facultad de Medicina

    Santiago, Chile

    2017 - 2019

  •   Profesor asistente Full Time

    Universidad de Chile, Facultad de Medicina

    Santiago, Chile

    2019 - A la fecha

Premios y Distinciones

  •   Beca doctoral nacional

    FONDECYT

    Chile, 2012

    Beca Doctorado Nacional Chile, para realizar mi doctorado en Farmacología durante 2012-2016.

  •   Beca Joven Investigador

    Banco Santander

    Chile, 2019

    Beca Joven Investigador Banco Santander financia estadias cortas de investigación de investigadores menores de 35 años, contratados en una institución superior. Esta estadia es en algún pais iberoamericano.


 

Article (25)

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells

Pablo Millas-Vargas, Juan; Correa, Pablo; Miranda, Dante; Pulgar, Rodrigo

Article ISI
BIOORGANIC CHEMISTRY  (2020)

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival

Cardenas, Cesar; Cruz, Pablo; Farias, Paula; Cerda, Oscar; Molgo, Jordi

Article ISI
SCIENCE SIGNALING  (2020)

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Truksa, J; Urra, FA

Article ISI
CELLS  (2020)

Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization

Vivas-Ruiz D.E.; Sandoval G.A.; Gonzalez-Kozlova E.; Zarria-Romero J.; Lazo F.; Magalhães H.P.B.; Oliveira L.S.; Alvarenga V.G.; Urra, F. A.; Yarlequé A.; et al.

Article ISI SCOPUS
International Journal of Biological Macromolecules  (2020)

Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function

Bozan, Maria Francisca; Bevilacqua, Jorge A.

Article ISI
PLOS ONE  (2020)

Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery



Article
Seminars in Cancer Biology  (2020)

Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6

Méndez, Diego; Rodríguez-Lavado, Julio; FUENTES, EDUARDO

Article ISI SCOPUS
 (2020)

The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells

Correa, Pablo

Article ISI
TOXINS  (2020)

Complex I and II are required for normal mitochondrial Ca2+ homeostasis

Rivas, José; Cruz, Pablo; Urra, Felix; Basualto-Alarcón, Carla; Sagredo, Eduardo; Ríos, Melany; Lovy, Alenka; Dong, Zhiwei; Cerda, Oscar

Article ISI SCOPUS
MITOCHONDRION  (2019)

Observations on reproduction in captivity of the endemic long-tailed snake Philodryas chamissonis (Wiegmann, 1835) (Reptilia, Squamata, Dipsadidae) from Chile

Cabeza, O; Urra, FA

Article ISI
HERPETOZOA  (2019)

Regulation of mitochondrial function as a promising target in platelet activation-related diseases

Urra, F. A.

Article ISI SCOPUS
FREE RADICAL BIOLOGY AND MEDICINE  (2019)

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta 1-integrin pathway

Urra, FA; Pena-Ahumada, B; Pulgar, R; Morales, D; Millas-Vargas, JP; Retamal E.; Pavani, M.

Article ISI SCOPUS
Scientific Reports  (2018)

The True Identity of the New World Iguanid Lizard Liolaemus chillanensis Muller and Hellmich 1932 (Iguania: Liolaemidae) and Description of a New Species in the Liolaemus elongatus Group

Urra, FA; Diaz, HA; Castro-Pastene, C; Ruiz, MS

Article ISI SCOPUS
ZOOLOGICAL STUDIES  (2018)

Phymaturus vociferator Pincheira-Donoso, 2004 (Squamata: Liolaemidae): New records and updated geographic distribution

Werning H.

Article SCOPUS
CHECK LIST  (2017)

The Mitochondrial Complex(I)ty of Cancer.

Urra, Félix A; Muñoz, Felipe; Lovy, Alenka; Cárdenas, César

Article
Frontiers in oncology  (2017)

The Paraguayan Rhinella toad venom=> Implications in the traditional medicine and proliferation of breast cancer cells.

Schmeda-Hirschmann, Guillermo; Gomez, Celeste Vega; Rojas de Arias, Antonieta; Burgos-Edwards, Alberto; Alfonso, Jorge; Rolon, Miriam; Brusquetti, Francisco; Netto, Flavia; Urra, Félix A; Cárdenas, César

Article
Journal of ethnopharmacology  (2017)

Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura=> Bufonidae).

Schmeda-Hirschmann, Guillermo; Quispe, Cristina; Arana, Gabriel Vargas; Theoduloz, Cristina; Urra, Félix A; Cárdenas, César

Article
Toxicon => official journal of the International Society on Toxinology  (2016)

Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors=> Bioenergetic Profile and Metabolic Flexibility of Cancer Cells.

Urra, Félix A; Weiss-López, Boris; Araya-Maturana, Ramiro

Article
Current pharmaceutical design  (2016)

Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaň a, Fabian; Bustos, Galdo; Urra, Félix; Smith, Natalia; Molgó, Jordi; Diehl, J Alan; Ridky, Todd W; Foskett, J Kevin.

Article
Cell Reports  (2016)

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

Cardenas C; Müller M.; McNeal A.; Lovy, A; Jaña F.; Bustos G.; Urra, F.; Smith N.; Molgó J.; Diehl J.A.; et al.

Article ISI SCOPUS
Cell Reports  (2016)

Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation.

Urra, Félix A; Córdova-Delgado, Miguel; Lapier, Michel; Orellana-Manzano, Andrea; Acevedo-Arévalo, Luis; Pessoa-Mahana, Hernán; González-Vivanco, Jaime; Martínez-Cifuentes, Maximiliano; Ramírez-Rodríguez, Oney; Millas-Vargas, Juan Pablo; Weiss-López, Boris; Pavani, Mario; Ferreira, Jorge; Araya-Maturana, Ramiro.

Article
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2016)

Identification and molecular characterization of five putative toxins from the venom gland of the snake Philodryas chamissonis (Serpentes: Dipsadidae).

Urra, Félix A; Pulgar, Rodrigo; Gutiérrez, Ricardo; Hodar, Christian; Cambiazo, Verónica; Labra, Antonieta.

Article
TOXICON  (2015)

Two new species of the Liolaemuselongatus-kriegi complex (Iguania, Liolaemidae) from Andean highlands of southern Chile.

Troncoso-Palacios, Jaime; Díaz, Hugo; Esquerré, Damien; Urra, Félix A.

Article
ZooKeys  (2015)

An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3.

Félix A. Urra; Maximiliano Martínez-Cifuentes; Mario Pavani; Michel Lapier; Fabián Jaña-Prado; Eduardo Parra; Juan Diego Maya; Hernán Pessoa-Mahana; Jorge Ferreira; Ramiro Araya-Maturana

Article
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2013)

Mitochondria: A promising target for anticancer alkaloids

Urra, F. A.; Córdova-Delgado M.; Ramírez-Rodríguez O.

Article SCOPUS
Current Topics in Medicinal Chemistry  (2013)

BookWhole (1)

Targeting mitochondrial bioenergetics of cancer cells with alkaloids: Mechanisms and anti-cancer strategies

Urra, F. A.

BookWhole SCOPUS
Alkaloids: Biosynthesis, Biological Roles and Health Benefits  (2015)

Note (1)

First record of pompilocalus sp. roig alsina, 1989 (hymenoptera: Pompilidae) preying on tachymenis chilensis coronellina (werner, 1898) (serpentes: Dipsadidae) from central Chile

Contreras F. J.M.; Urra, F. A.; Rojas-Porras N.A.

Note SCOPUS
HERPETOLOGY NOTES  (2019)

Proyecto (7)

Reprogramming mitochondrial bioenergetic adaptation with Alfa-ketoglutarate and Coenzyme Q10 to alleviate inflammation in colitis-associated macrophages



Proyecto
 (2021)

Avoiding chemotherapy-induced pro-migratory phenotype: rewiring the mitochondrial bioenergetics for new migrastatics approaches in triple-negative breast cancer cells



Proyecto
 (2020)

Red para la investigacioón del veneno de serpiente: estrategias biotecnológicas para el desarrollo de la toxicología molecular y descubrimiento de fármacos

Pulgar, Rodrigo

Proyecto
 (2019)

New mitochondria-targeted anti-tumor compounds: Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols



Proyecto
 (2018)

New mitochondria-targeted anti-tumor compounds=> Synthesis of anti-proliferative and anti-migratory phosphonium and pyridinium salts derived from acylpolyphenols

FONDECYT (1180069)

Proyecto
2018-2021
Coinvestigador(a)

Mitochondrial glutamine metabolism in metastasis of breast cancer cells: a selective dependence that offers new anti-cancer strategies



Proyecto
 (2017)

Mitochondrial glutamine metabolism in metastasis of breast cancer cells=> a selective dependence that offers new anti-cancer strategies

FONDECYT (3170813)

Proyecto
2017-2019
Inv. Responsable

Review (2)

Philodryas (Serpentes: Dipsadidae) Envenomation, A Neglected Issue in Chile

Urra, F. A.; Miranda-Calle A.B.

Review ISI SCOPUS
TOXINS  (2019)

Targeting Metastasis with Snake Toxins: Molecular Mechanisms



Review ISI SCOPUS
Toxins  (2017)

1
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

1
Oney Ramirez

Assistant Professor

Ciencias de la Salud

UNIVERSIDAD DE AYSEN

Coyhaique, Chile

2
Ramiro Araya Maturana

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

1
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

2
Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

1
Paola Murgas

Profesor Investigador Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Puerto Montt, Chile

2
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Eduardo Fuentes

Profesor Titular

Universidad de Talca

Talca, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

4
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Jorge Toledo

Investigador

Centro de Investigacion Clinica Avanzada CICA

Universidad de Chile, Hospital Clinico Universidad de Chile

Santiago, Chile

25
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
JEAN DE ANDRADE

Académico Docente

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

2
Carla Basualto

Académico, Profesor Asociado

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

3
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

3
Sebastián Fuentes

Investigador Postdoctoral

Institulo de Ciencias Biomédicas - Instituto de investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

2
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
catherin donoso

Postdoctorado

de Ciencias Exactas

Univesidad Andres Bello

Santiago, Chile

1
Dan Vivas

Director de Instituto de Investigación

Biología Celular y Genética

Universidad Nacional Mayor de San Marcos

Lima , Peru

1
Eladio Flores

Coordinator

Fundação Ezequiel Dias

Belo Horizonte, Chile