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Guillermo Schmeda Hirschmann

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Natural Products Chemistry; Biological activity of naturally occurring compounds and semisynthetic derivatives; Ethnopharmacology; Biodiversity; Food Chemistry

Educación

  •  Bioquímico, Universidad Nacional de Asuncion, Paraguay. Paraguay, 1978
  •  Organic Chemistry, TECHNISCHE UNIVERSITAT BERLIN. Alemania, 1984

Experiencia Académica

  •   Profesor Investigador Full Time

    Universidad Nacional de Asunción, Paraguay

    Facultad de Ciencias Químicas

    Asunción (San Lorenzo), Paraguay

    1981 - 1989

  •   Asesor Científico Part Time

    Universidad Nacional de Asunción, Paraguay

    Facultad de Ciencias Veterinarias

    Asunción (San Lorenzo), Paraguay

    1987 - 1989

  •   Profesor Titular Full Time

    Universidad de Talca

    Talca, Chile

    1989 - A la fecha

Experiencia Profesional

  •   Microbiólogo Full Time

    Cervecería Paraguaya S.A.

    Asunción, Paraguay

    1978 - A la fecha

Formación de Capital Humano


Dirección de Tesis de Doctorado finalizadas: 8
Co-dirección de Tesis de Doctorado finalizadas: 4
Dirección de Tesis de Doctorado y Magister 2014-2017: Doctorado: 1 finalizada, dos en ejecución; Magister: dos completadas (una como Director, otra como co-Director).
Los doctorandos que se encuentran realizando sus Tesis, así como los nuevos alumnos de Doctorado que iniciarán actividades este año, investigan distintos aspectos de la relación entre composición, identidad de componentes y bioactividad en alimentos sudamericanos. La investigación incluye chemical profiling, identificación de compuestos bioactivos, mecanismos de acción de extractos y compuestos en distintos modelos biológicos in vitro y en cultivos de células humanas.

COLABORACIONES en PUBLICACIONES RECIENTES

Thomas Efferth, Abteilungsleiter, Johannes Gutenberg-Universität, Institut für Pharmazie, D-55128 Mainz, Alemania

Camille Oger, Thierry Durand, Institut des Biomolécules Max Mousseron, IBMM, UMR 5247, University of Montpellier, CNRS, ENSCM, Montpellier, France

Ángel Gil-Izquierdo, Raúl Domínguez-Perles, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), University Campus of Espinardo, Edif. 25, 30100, Murcia, Spain

Luis Bustamante, Claudia Mardones, Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, Chile

Katherine Márquez, David Contreras, Biotechnology Centre and Chemical Sciences Faculty, University of Concepcion, Concepcion, Chile

Ana Ladio, Laboratorio Ecotono, INIBIOMA (CONICET), Universidad Nacional del Comahue, Bariloche, Río Negro, Argentina

Jaume Bastida, Grup de Productes Naturals, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain

Laura Edith Alché, Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428BGA Buenos Aires, Argentina

María Inés Isla (F. Cattaneo, M.S. Costamagna, I.C. Zampini, J. Sayago, M.R. Alberto, V. Chamorro, A. Pazos), INQUINOA (CONICET), 4000 S.M. de Tucumán, Tucumán, Argentina, Fundación Miguel Lillo, 4000 S.M. de Tucumán, Tucumán, Argentina

Felix A. Urra, Cesar Cardenas, Programa de Anatomía y Biología del Desarrollo, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, Universidad de Chile and Geroscience Center for Brain Health and Metabolism, Santiago, Chile

Nibaldo C. Inestrosa, Juan M. Zolezzi, Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile


Premios y Distinciones

  •   AvH Stipendium

    ALEXANDER VON HUMBOLDT FOUNDATION

    Alemania, 1996

    Research on microbial metabolites and biotechnology, Kaiserslautern. Germany


 

Article (314)

Iridoids and polyphenols from chilean Gaultheria spp. berries decrease the glucose uptake in Caco-2 cells after simulated gastrointestinal digestion
Phenolic Composition and alpha-Glucosidase Inhibition of Leaves from Chilean Bean Landraces
The use of medicinal plants by Paraguayan migrants in the Atlantic Forest of Misiones, Argentina, is based on Guarani tradition, colonial and current plant knowledge
Antiglycating Effect of Phenolics from the Chilean Currant Ribes cucullatum under Thermal Treatment
Improving Fruit Quality, Bioactive Compounds, and Storage Life of Date Palm (Phoenix dactylifera L., cv. Barhi) Using Natural Elicitors
Phenolic composition, antioxidant capacity and α-glucosidase inhibitory activity of raw and boiled Chilean Araucaria araucana kernels
Seasonal Variation of Plant Defense Inductor Ellagitannins in Strawberry Leaves under Field Conditions for Phytosanitary Technological Applications
Synergistic Effect of Preharvest Spray Application of Natural Elicitors on Storage Life and Bioactive Compounds of Date Palm (Phoenix dactylifera L., cv. Khesab)
Cyclic dipeptides from the Chilean hazelnut cotyledons (Gevuina avellana Mol., Proteaceae).
Effects of gastrointestinal digested polyphenolic enriched extracts of Chilean currants (Ribes magellanicum and Ribes punctatum) on in vitro fecal microbiota
Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion
Iridoids and Amino Acid Derivatives from the Paraguayan Crude Drug Adenocalymma marginatum (ysypo hu)
Isolation and characterization of secondary metabolites from Gaultheria tenuifolia berries.
Phenolics from the Bolivian highlands food plant Ombrophytum subterraneum (Aspl.) B. Hansen (Balanophoraceae): Antioxidant and α-glucosidase inhibitory activity
Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids
The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells
Fabiana imbricata Ruiz et Pav. (Solanaceae), a review of an important Patagonian medicinal plant.
An efficient cyclization of Lapachol to new benzo[h]chromene hybrid compounds: Tandem vs one-pot esterification-click (CuAAC) study.
Andean Prumnopitys Andina (Podocarpacae) Fruit Extracts: Characterization of Secondary Metabolites and Potential Cytoprotective Effect
Anti-inflammatory effect of polyphenols from Chilean currants (Ribes magellanicum and R. punctatum) after in vitro gastrointestinal digestion on Caco-2 cells.
Antioxidant activity and isolation of polyphenols and new iridoids from Chilean Gaultheria phillyreifolia and G. poeppigii berries
Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms
Effect of simulated gastrointestinal digestion on polyphenols and bioactivity of the native Chilean red strawberry (Fragaria chiloensis ssp. chiloensis f. patagonica)
Male sexual enhancers from the Peruvian Amazon.
Patagonian berries as native food and medicine.
Phenolic, oxylipin and fatty acid profiles of the Chilean hazelnut (Gevuina avellana): Antioxidant activity and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
Polyphenol Composition and (Bio)Activity of Berberis Species and Wild Strawberry from the Argentinean Patagonia
Tetraglochin andina Ciald.: a medicinal plant from the Argentinean highlands with potential use in vaginal candidiasis.
Argentinean Larrea dry extracts with potential use in vaginal candidiasis.
Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion
Cholinesterase inhibition activity, alkaloid profiling and molecular docking of Chilean Rhodophiala (Amaryllidaceae).
Colonic fermentation of polyphenols from Chilean currants (Ribes spp.) and its effect on antioxidant capacity and metabolic syndrome-associated enzymes
Effect of polyphenols from wild Chilean currants (Ribes spp.) on the activity of intracellular antioxidant enzymes in human gastric AGS cells.
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations
Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: in vitro and in silico studies.
Neuroprotective effects of ferruginol, jatrophone, and junicedric acid against amyloid-β injury in hippocampal neurons.
Polyphenolic profile and antioxidant activity of meristem and leaves from "chagual" (Puya chilensis Mol.), a salad from central Chile
Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry.
The major chromophore arising from glucose degradation and oxidative stress occurrence during lens proteins glycation induced by glucose.
Antiprotozoal Activity of Triazole Derivatives of Dehydroabietic Acid and Oleanolic Acid
Chemical and functional characterization of seed, pulp and skin powder from chilto (Solanum betaceum), an Argentine native fruit. Phenolic fractions affect key enzymes involved in metabolic syndrome and oxidative stress
Chemical and functional characterization of skin, pulp and seed powder from the Argentine native fruit Mistol (Ziziphus mistol). Effects of phenolic fractions on key enzymes involved in metabolic syndrome and oxidative stress.
Cytoprotective effect mediated by polyphenols from Chilean native berries against free radical-induced damage on AGS cells.
Inhibition of of pro-inflammatory enzymes by medicinal plants from the Argentinean highlands (Puna)
Isovitexin as marker and bioactive compound in the antinociceptive activity of the Brazilian crude drug extracts of Echinodorus scaber and E. grandiflorus.
Qualitative and quantitative changes in polyphenol composition and bioactivity of Ribes magellanicum and R. punctatum after in vitro gastrointestinal digestion
The native fruit Geoffroea decorticans from the arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome associated enzymes.
The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells
Antibacterial and leishmanicidal activity of Bolivian propolis.
Antifungal activities of extracts produced by liquid fermentation of Chilean Stereum species against Botrytis cinerea (grey mould agent).
Antioxidant activity and phenolic profiles of the wild currant Ribes magellanicum from Chilean and Argentinean Patagonia.
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae)
Biological activities of polyphenols-enriched propolis from Argentina arid regions.
Chemical profiling and antioxidant activity of Bolivian propolis
Fast high resolution Orbitrap MS fingerprinting of the resin of H. taltalense Phil. from the Atacama Desert.
Flour from Prosopis alba cotyledons: A natural source of nutrient and bioactive phytochemicals
Fruit characteristics and cuticle triterpenes as related to postharvest quality of highbush blueberries
New homoisoflavanes, a new alkaloid and spirostane steroids from the roots of Herreria montevidensis Klotzsch ex Griseb. (Herreriaceae).
Phenolics from the Patagonian currants Ribes spp.: isolation, characterization and cytoprotective effect in AGS cells.
Polyphenol rich fraction from Geoffroea decorticans fruits flour affects key enzymes involved in metabolic syndrome, oxidative stress and inflammatory process.
The Chilean wild raspberry (Rubus geoides Sm.) increases intracellular GSH content and protects against H2O2 and methylglyoxal-induced damage in AGS cells
Anti-inflammatory activity of Copao (Eulychnia acida Phil., Cactaceae) fruits.
Antibacterial activity, antioxidant effect and chemical composition of propolis from Región del Maule, central Chile.
Chilean Prosopis mesocarp flour: phenolic profiling and antioxidant activity.
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma.
Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway.
Phenolic profiling of the South American “Baylahuen” tea (Haplopappus spp., Asteraceae) by HPLC-DAD-ESI-MS.
Phytophthora austrocedri elicitates changes in diterpene profile of Austrocedrus chilensis.
Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic acid and carnosol derivatives.
Topical anti-inflammatory activity of new hybrid molecules of terpenes and synthetic drugs.
Anti-inflammatory activity of animal oils from the Peruvian Amazon.
Antioxidant activity and characterization of constituents in copao fruits (Eulychnia acida Phil., Cactaceae) by HPLC-DAD-MS/MSn
Antioxidant activity and characterization of constituents in Copao fruits (Eulychnia acida Phil., Cactaceae) by HPLC-DAD-MS/MSn.
Antioxidant effect and characterization of South American Prosopis pods syrup.
Antioxidant effect and characterization of South American Prosopis pods syrup.
Antiproliferative activity and new argininyl bufadienolide esters from the “Cururú” toad Rhinella (Bufo) schneideri.
Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells
Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells.
Lemon Grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidized low-density lipoprotein.
Polyphenolic compounds and anthocyanin content of Prosopis nigra and Prosopis alba pods flour and their antioxidant and anti-inflammatory capacity.
Seasonal Variation and Resin Composition in the Andean Tree Austrocedrus chilensis
Seasonal variation and resin composition in the Andean tree Austrocedrus chilensis.
Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid.
Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid.
1,2,3-Triazole-Substituted Oleanolic Acid Derivatives: Synthesis and Antiproliferative Activity
1,2,3-triazole-substituted oleanolic acid derivatives: synthesis and antiproliferative activity.
Antioxidant capacity, polyphenolic content and tandem HPLC-DAD-ESI/MS profiling of phenolic compounds from the South American berries Luma apiculata and L. chequen
Antioxidant capacity, polyphenolic content and tandem HPLC-DAD-ESI/MS profiling of phenolic compounds from the South American berries Luma apiculata and Luma chequén.
Bioactive coumarins and HPLC-PDA-ESI-ToF-MS metabolic profiling of edible queule fruits (Gomortega keule), an endangered endemic Chilean species
Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects
Diterpenylquinone Hybrids: Synthesis and Assessment of Gastroprotective Mechanisms of Action in Human Cells
Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells.
HIGH SPEED CENTRIFUGAL COUNTERCURRENT CHROMATOGRAPHY (HSCCC) ISOLATION AND IDENTIFICATION BY LC-MSn ANALYSIS OF THE POLAR PHENOLICS FROM VASCONCELLEA QUERCIFOLIA
In vivo antimalarial activity of Keetia leucantha twigs extracts and in vitro antiplasmodial effect of their constituents
Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera
The Passiflora tripartita (banana passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS.
Antimicrobial phenylpropanoids from the Argentinean highland plant Parastrephia lucida (Meyen) Cabrera
Direct characterisation of phenolic antioxidants in infusions from four Mapuche medicinal plants by liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionisation tandem mass spectrometry (HPLC-ESI-MS)
Direct characterization of phenolic antioxidants in infusions from four medicinal Mapuche plants by liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionization tandem mass spectrometry (HPLC-ESI-MS).
New gastroprotective labdeneamides from (4S,9R,10R) methyl 18-carboxi-labda-8,13(E)-diene-15-oate.
New gastroprotective labdeneamides from (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate.
Phenolic Constituents of the Chilean Herbal Tea Fabiana imbricata R. et P.
Potential Gastroprotective Effect of Novel Cyperenoic Acid/Quinone Derivatives in Human Cell Cultures
VCD absolute configuration and complete 1H NMR characterization of rosmaridiphenol diacetate.
VCD absolute configuration and complete 1H NMR characterization of rosmaridiphenol diacetate.
Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models.
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables
Diterpenes from the resin of Austrocedrus chilensis. A GC-MS and 1HNMR analysis.
Gastroprotective Effect and Cytotoxicity of Carnosic Acid Derivatives
Gastroprotective Effect and Cytotoxicity of Labdeneamides with Amino Acids
Resin diterpenes from Austrocedrus chilensis.
Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
Argentinean Propolis from Zuccagnia punctata Cav. (Caesalpinieae) Exudates: Phytochemical Characterization and Antifungal Activity
Determination of phenolic composition and antioxidant activity in fruits, rhizomes and leaves of the white strawberry (Fragaria chiloensis spp chiloensis form chiloensis) using HPLC-DAD-electrospray tandem mass spectrometry and free radical quenching techniques.
Determination of phenolic composition and antioxidant activity in fruits, rhizomes and leaves of the white strawberry (Fragaria chiloensis spp. chiloensis form chiloensis) using HPLC-DAD-ESI-MS and free radical quenching techniques
Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionization tandem mass spectrometry (HPLC-MSn).
Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry
Gastroprotective Effect of Carnosic Acid gamma-Lactone Derivatives
Gastroprotective effect of carnosic acid γ-lactone derivatives.
Synthesis, Gastroprotective Effect and Cytotoxicity of New Amino Acid Diterpene Monoamides and Diamides
The Corrected Structure of Rosmaridiphenol, a Bioactive Diterpene from Rosmarinus officinalis
The corrected structure of rosmaridiphenol, a bioactive diterpene from Rosmarinus officinalis L.
Antimicrobial activity of extracts, essential oil and metabolites obtained from Tagetes mendocina
Antimicrobial and antioxidant compound from the infusion and polar extract of Baccharis incarum (Wedd.) Perkins.
ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives.
Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives.
Comparison of phenolic composition and antioxidant properties of two native Chilean and one domestic strawberry genotypes.
Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean lamiaceae Sphacele chamaedryodes (Balbis) Briq.
Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean Lamiaceae Sphacele chamaedryoides (Balbis) Briq.
Identification of phenolic compounds from the fruits of the mountain papaya Vasconcellea pubescens A. DC grown in Chile by liquid chromatography-uv detection–mass spectrometry.
Main flavonoids, DPPH activity and metal content allow determining the geographical origin of propolis from the Province of San Juan (Argentina).
Main Flavonoids, DPPH Activity, and Metal Content Allow Determination of the Geographical Origin of Propolis from the Province of San Juan (Argentina)
Transcript profiling suggests transcriptional repression of the flavonoid pathway in the white-fruited Chilean strawberry, Fragaria chiloensis (L.) Mill.
Transcript profiling suggests transcriptional repression of the flavonoid pathway in the white-fruited Chilean strawberry, Fragaria chiloensis (L.) Mill.
A new antifungal and antiprotozoal depside from the Andean lichen Protousnea poepigii.
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii
Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells.
Free radical scavengers from the Mexican herbal tea “poleo” (Hedeoma drummondii).
Free radical scavengers from the Mexican herbal tea “poleo” (Hedeoma drummondii).
Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls.
New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells.
Studies on quinones. Part 43: synthesis and cytotoxic avaluation of polyoxyethylene-containing 1,4-naphthoquinones
Biotransformation of jatrophone by Aspergillus niger ATCC 16404
Biotransformation of jatrophone by Aspergillus niger ATCC 16404.
Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures.
Free radical scavengers from Cymbopogon citratus (DC.) stapf plants cultivated in bioreactors by the temporary immersion (TIS) principle
Free radical scavenging activity and phenolic content in achenes and thalamus from Fragaria chiloensis ssp chiloensis, F vesca and F. x ananassa cv. Chandler
Free radical scavenging activity and phenolic content in achenes and thalamus from Fragaria chiloensis ssp. chiloensis, F. vesca and F. x ananassa cv. Chandler.
Free radical scavenging activity and secondary metabolites from in vitro cultures of Sanicula graveolens
Free radical scavenging activity and secondary metabolites from in vitro cultures of Sanicula graveolens.
Gastroprotective and cytotoxic effect of semisynthetic ferruginol derivatives.
Gastroprotective effect and cytotoxicity of diterpenes from the Paraguayan crude drug “yagua rova” (Jatropha isabelii).
Gastroprotective effect and cytotoxicity of labdenamides.
Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives.
Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug yagua rova" (Jatropha isabelli)"
4-Methyl-1-hepten-3-one, the defensive compound from Agathemera elegans (Philippi) (Phasmatidae), Insecta
Gastroprotective activity and cytotoxic effect of cyperenoic acid derivatives
Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models.
Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: In vitro-in vivo relationships
Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: in vitro-in vivo relationships.
Gastroprotective effect and cytotoxicity of cyperenoic acid derivatives.
Studies on Quinones. Part 40. Synthesis and cytotoxicity evaluation of anthraquinone epoxides and isomerization products.
Studies on quinones. Part 40: Synthesis and cytotoxicity evaluation of anthraquinone epoxides and isomerization products
Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones
Synthesis and cytotoxic activity of isoquinoline-containing polycyclic quinones.
Antimicrobial butyrolactone I derivatives from the ecuadorian soil fungus Aspergillus terreus thorn. Var terreus
Bioactive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile
E-cinnamic acid derivatives and phenolics from Chilean strawberry fruits, Fragaria chiloensis ssp chiloensis
Free radical scavengers and antioxidants from Cymbopogon citratus (DC.) Stapf.
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice.
Gastroprotective activity of sesquiterpene derivatives from Fabiana imbricata
Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives
Gastroprotective and ulcer-healing effect of new solidagenone derivatives in human cell cultures
Gastroprotective effect and cytotoxicity of natural and semisynthetic labdane diterpenes from Araucaria araucana resin
Gastroprotective effect and cytotoxicity of natural and semisynthetic labdane diterpenes from Araucaria araucana.
Gastroprotective effect of the Mapuche crude drug Araucaria araucana resin and its main constituents
Metabolites from Microsphaeropsis olivacea (Bonord.) Hohn, an endophytic fungus of Pilgerodendron uviferum (D. Don) Florin.
Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum
Proximate composition and free radical scavenging activity of edible fruits from the Argentinian Yungas
Secondary metabolite content in rhizomes, callus cultures and in vitro regenerated plantlets of Solidago chilensis
Secondary metabolite content in rhizomes, cell, callus cultures and in vitro regenerated plantlets of Solidago chilensis.
Secondary metabolites from endophytic fungi isolated from the Chilean gimnosperm Prumnopitys andina (Lleuque)
Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina (Lleuque)
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
Traditional medicine and gastroprotective crude drugs.
1 beta,7 beta-Dihydroxydehydroabietic acid, a new biotransformation product of dehydroabietic acid by Aspergillus niger
1,7-Dihydroxydehydroabietic acid, a new biotransformation product of dehydroabietic acid by Aspergillus niger.
Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi
Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi.
Bioguided isolation and identification of the non-volatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste.
Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste
Biotransformation of solidagenone by Alternaria alternata, Aspergillus niger and Curvularia lunata cultures
Biotransformation of Solidagenone by Alternaria alternata, Aspergillus niger and Curvularia lunata cultures.
Free radical scavengers and antioxidants from Baccharis grisebachii.
Free radical scavengers and antioxidants from Baccharis grisebachii
Free radical scavengers and antioxidants from Tagetes mendocina
Free radical scavengers and antioxidants from Tagetes mendocina.
Secondary metabolite content in Fabiana imbricata plants and in vitro cultures
Secondary metabolite content in Fabiana imbricata plants and in vitro cultures.
Antimicrobial activity of the Argentinian medicinal plant Baccharis grisebachii (Asteraceae).
Bioactive alkyl phenols and embelin from Oxalis erythrorhiza
Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity
Free radical scavengers and antioxidants from Peumus boldus Mol. (“Boldo”).
Naphtoquinone derivatives and lignans from the Paraguayan crude drug "Tayï pytá" (Tabebuia heptaphylla).
Oleanolic acid promotes healing of acetic acid-induced chronic gastric ulcers in rats.
Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica
Free radical scavengers, antiinflammatory and analgesic activity of Acaena magellanica.
Gastroprotective activity of oleanolic acid derivatives on experimentally induced gastric lesions in mice.
Gastroprotective activity of solidagenone on experimentally induced gastric lesions in rats.
Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice
Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice.
Saponins from Cariniana rubra (Lecythidaceae).
Alkaline substances used with coca (Erythroxylum coca Lam., Erythroxylaceae) leaf insalivation in northwestern Argentina.
Cryptofolione derivatives from Cryptocarya alba.
Immunomodulatory activity of Chilean Cyttaria species in mice with L5178Y lymphoma
Immunomodulatory activity of Chilean Cyttaria species in mice with L5178Y lymphoma.
Inhibitory activity of xanthine-oxidase and superoxide scavenger properties of Inga verna subsp. affinis. Its morphological and micrographic characteristics
A DNA binding compound from Prosopis tamarugo pods.
A DNA BINDING COMPOUND FROM PROSOPIS TAMARUGO PODS
Acetophenone derivatives from a Chilean isolate of Trichoderma longibrachiatum.
Acetophenone derivatives from Chilean isolate of Trichoderma pseudokoningii Rifai
Activity of Amaryllidaceae alkaloids on the blood pressure of normotensive rats.
Activity of Solidagenone and their semisynthetic derivatives on the glucocorticoid-mediated signal transduction.
Biologically active alkaloids and a free radical scavenger from Prosopis species
Biologically active alkaloids and a free radical scavenger from Prosopis species.
BIOLOGICALLY ACTIVE COMPOUNDS FROM CHILEAN PROPOLIS
Biologically active compounds from Chilean propolis.
DNA binding activity of Amaryllidaceae alkaloids
DNA binding activity of Amaryllidaceae alkaloids.
Free radical scavenging activity of Lafoensia pacari
Free radical scavenging activity of Lafoensia pacari.
Proximate composition and biological activity of Chilean Prosopis species
Proximate composition and biological activity of Chilean Prosopis species.
Schmeda-Hirschmann, G., Rodriguez, J. A., Loyola, J. I., Astudillo, L., Bastida, J., Viladomat, F., Codina, C.
Biological activity and food analysis of Cyttaria spp. (Discomycetes).
DNA BINDING ALKALOIDS FROM LOBELIA BRIDGESII HOOK ET ARN AND LOBELIA TUPA L
DNA binding alkaloids from Lobelia bridgesii Hook et Arn.and Lobelia tupa L.
DNA binding alkaloids from Prosopis alba.
Free radical scavengers from Mutisia friesiana (Asteraceae) and Sanicula graveolens (Apiaceae).
Proximate composition and biological activity of food plants gathered by Chilean amerindians.
Etnobotánica Ayoreo. Contribución al estudio de la flora y vegetación del Chaco. XI.
Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii.
Biological activity and xanthine oxidase inhibitors from Scirpus californicus (C. A. Mey.) Steud.
Secoisotetrandrine from Laurelia sempervirens.
Xanthine oxidase inhibitory activity of flavonoids and tannins from Hexachlamys edulis (Myrtaceae).
Biological activity of medicinal plants of Ica (Perú).
Effect of Fabiana imbricata constituents on Rhopalosiphum padi and Heliothis zea.
Flavonoids from Calycorectes, Campomanesia, Eugenia, and Hexachlamys species (Myrtaceae).
Madia sativa, a potential oil crop of central Chile.
(24S) 3ß hydroxy ergost 5 en 6 one and other sterines from Cyttaria johowii Espinosa.
Hypoglycaemic activity of Geranium core core, Oxalis rosea and Plantago major extract in rats.
Hypotensive and diuretic effect of Equisetum bogotense and Fuchsia magellanica extract in rats and micropropagation of E. bogotense.
Hypotensive effect of Laurelia sempervirens (Monimiaceae) on normotensive rats.
Plant resources used by the Ayoreo of the Paraguayan Chaco.
Rutin and scopoletin content and micropropagation of Fabiana imbricata.
Sesquiterpenes from Fabiana imbricata.
Tree ash as an Ayoreo salt source in the Paraguayan Chaco.
ß Glucuronidase inhibition and diuretic activity of Fabiana imbricata (Solanaceae).
Antiviral activity of Chilean medicinal plant extracts.
Magic and medicinal plants of the Ayoreos of the Chaco Boreal (Paraguay).
Prevalence of Chagas' disease in Ayoreo communities of the Paraguayan Chaco.
Two new 17 progesterone transformation products from Nocardia DSM 43298.
A screening method for natural products on Triatomine bugs
Diterpenes and a lignan from Jatropha grossidentata.
Feeding deterrency and insecticidal effects of plant extracts on Lutzomyia longipalpis.
Hypoglycaemic activity of Hexachlamys edulis ("Yvahai") extract in rats.
Hypotensic effect and enzyme inhibitory activity of Mapuche medicinal plant extracts.
Xanthine oxidase inhibitory activity of Chilean Myrtaceae.
A survey of medicinal plants of Minas Gerais, Brazil.
Paraguayan medicinal Compositae.
Indigo from Eupatorium laeve.
A labdan diterpene from Solidago chilensis roots.
Ethnobotanical observations on Paraguayan Myrtaceae I.
Eugenia uniflora leaf extract and lipid metabolism in Cebus apella monkeys.
Pyrrolizidine alkaloids from Senecio deferens.
Rhamnofolane derivatives from Jatropha grossidentata.
The effects of Melia azederach fruits on Triatoma infestans bugs.
Xanthine oxidase inhibitory activity of Paraguayan Myrtaceae.
A magic use of Crotalaria incana pods.
Beyerene derivatives and other terpenoids from Stevia aristata.
Further eudesmane derivatives from Verbesina species
Germacra 1, 10Z, 4E dien 12,8 a olides from Mikania micrantha.
Preliminary pharmacological studies on Eugenia uniflora leaves: Xanthine oxidase inhibitory activity.
Pyrrolizidine alkaloid content in some Senecio grisebachii populations.
Pyrrolizidine alkaloids from Senecio brasiliensis populations.
A myrtenylfuroheliangolide from Calea rupicola.
Balansolide and other sesquiterpene lactones from Bejaranoa balansae.
Dimeric guajanolide and other constituents from Gochnatia species.
Further sesquiterpenelactones from Elephantopus mollis and Centratherum punctatum.
Hirsutinolide, glaucolide and new type of sesquiterpene lactones from Vernonia species.
Melampolides and germacranolides from Stevia amambayensis.
Retrorsin from a Paraguayan herbal tea.
The constituents of Ambrosia tenuifolia and Pectis odorata.
A new type of pyrrolizidine alkaloid from Senecio grisebachii Baker var. grisebachii.
Clerodane and labdane diterpenoids from Baccharis species.
Eremophilane derivatives and other constituents from Senecio species.
Further sesquiterpene lactones from Calea and Viguiera species.
Isodaucane derivatives, norsesquiterpenes and clerodanes from Chromolaena laevigata.
New vernolepin derivatives from Vernonia glabra and glaucolides from Vernonia scorpioides.
Further 6, 12 cis germacranolides and eudesmanolides from Montanoa species.
Germacranolides from Gochnatia vernonioides.
Heliangolide, Trachyloban und Villanovan Derivate aus Viguiera Arten.
Neue Melampolide aus Acanthospermum australe.
New chromolaenin derivatives from Chromolaena christieana.
New heliangolides and germacranolides from Disynaphia multicrenulata.
Nor ent Labdan Derivate aus Austroeupatorium inulaefolium.
The constituents from Achyrocline satureioides D.C.
Decathieleanolide, ein dimeres Guajanolid aus Decachaeta thieleana.
The flavonoids from Eupatorium laeve D.C.
Arylated analogues of cypronazole: fungicidal efect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations
Phenolics from the Patagonian currants Ribes spp.: Isolation, characterization and cytoprotective effect in human AGS cells

BookSection (5)

Chilean White Strawberry: Phenolic Profiling of its Different Parts
Ethnopharmacology as a basis for medicinal chemistry studies: combining natural products and semisynthesis for gastroprotective agents
Chemistry of the Chilean strawberry (Fragaria chiloensis spp. chiloensis).
.Comparison of secondary plant metabolite production in cell suspensions, callus culture and temporary immersion system.
Bioactive products from South American plants.

Patent (1)

Usos de especie de Cittaria (Diguenes), para estimular la respuesta inmune del organismo, procedimiento para preparar los extractos solubles de Cittaria

Proyecto (44)

A metabolomic approach on the health promoting effect of phenolics and saponins from Chilean beans and squash
Cape Horn International Center for Global Change Studies and Biocultural Conservation (CHIC)
Multidisciplinary studies on bioactive compounds from the Chilean Phaseolus vulgaris L. landraces and their potential effects in the prevention of non-communicable chronic diseases
Espectrómetro de Resonancia Magnética Nuclear de 500 MHz para potenciar investigaciones interdisciplinarias en química orgánica, caracterización de compuestos bioactivos y metabolómica en Chile y la Región del Maule.
Phenolic metabolome of Chilean native nuts and seeds: antioxidant activity and inhibitory effect on key enzymes associated with metabolic syndrome
Phenolic metabolome of Chilean native nuts and seeds=> antioxidant activity and inhibitory effect on key enzymes associated with metabolic syndrome
LA BIODIVERSIDAD IBEROAMERICANA COMO FUENTE DE RECURSOS NATURALES PARA SU EXPLOTACION SOSTENIBLE (BIFRENES)
METABOLOMICS OF CHILEAN NATIVE FRUITS
Metabolomics of Chilean native fruits
Novel hybrid terpene-naphthoquinone gastroprotective compounds: synthesis and assessment of action mechanisms using human cell culture models
NOVEL HYBRID TERPENE-NAPHTHOQUINONE GASTROPROTECTIVE COMPOUNDS=> SYNTHESIS AND ASSESSMENT OF ACTION MECHANISMS USING HUMAN CELL CULTURE MODELS.
Semisynthesis of new gastroprotective labdane diterpenes: structure-activity relationships
SEMISYNTHESIS OF NEW GASTROPROTECTIVE LABDANE DITERPENES=> STRUCTURE-ACTIVITY RELATIONSHIPS.
Fortalecimiento innovativo de la investigación en productos bioactivos (FIPROBIO).
Estudio del mecanismo gastroprotector de diterpenos naturales y hemisinteticos derivados del ferruginol y carnosol, utilizando modelos animales y cultivo de celulas epiteliales gastricas humanas
ESTUDIO DEL MECANISMO GASTROPROTECTOR DE DITERPENOS NATURALES Y HEMISINTETICOS DERIVADOS DEL FERRUGINOL Y CARNOSOL, UTILIZANDO MODELOS ANIMALES Y CULTIVO DE CELULAS EPITELIALES GASTRICAS HUMANAS.
ACTIVIDAD ANTIULCEROGENICA DE PRODUCTOS DE HEMISINTESIS Y BIOTRANSFORMACIONES DEL ACIDO ABIETICO, DEHIDROABIETICO Y ACIDO IMBRICATOLICO.
Antioxidants, antifungic and antiparasitary compounds from Protousnea poepigii, Tagetes mendocina, Usnea florida and Zucccagnia punctata.
Antiulcerogenic activity of hemisynthesis and biotransformation products from abietic-, dehydroabietic- and imbricatolic acid.
ESTUDIO DE LA ACTIVIDAD GASTROPROTECTORA DEL ACIDO OLEANOLICO, SOLIDAGENONA Y DERIVADOS DE HEMISINTESIS Y BIOTRANSFORMACIONES, UTILIZANDO MODELOS BASADOS EN EL CULTIVO DE CELULAS EPITELIALES GASTRICAS.
Geographic variation in mistletoe seed dispersal in southern South America (Argentina & Chile).
Mechanism of the gastroprotective activity of oleanolic acid, solidagenone and their hemisynthesis and biotransformation products on epitelial gastric cells in culture.
Free radical scavengers and enzyme inhibitors from South American medicinal and aromatic plants
Programa de Investigación en Productos Naturales Bioactivos
Biotransformaciones de acido oleanolico y solidagenona y su actividad antiulcerogenica. Biotransformations of oleanolic acid and solidagenone and its antiulcerogenic activity
Biotransformations of oleanolic acid and solidagenone and its antiulcerogenic activity
Actividad biológica y química del género Prosopis en Argentina y Chile
Adaptación de Azadirachta indica y Melia azederach (Meliaceae) al secano costero de la VII Región
New trends and know-how transfer in the search for bioactive compounds
Plantas alimenticias y medicinales de Amerindios chilenos=> química y actividad biológica.
Plantas alimenticias y medicinales de Amerindios chilenos: química y actividad biológica
Antiviral and antiprotozoal compounds from South American crude drugs
Metabolitos secundarios biológicamente activos de plantas Sudamericanas
The active constituents of Hexachlamys edulis (Myrtaceae), an hypoglycaemiating South American crude drug
Química, actividad biológica y micropropagación de plantas medicinales Mapuches.
Ayoreo ethnobotany
Plant antivirals
Química, actividad biológica y micropropagación de plantas medicinales Mapuches
Química, actividad biológica y etnobotánica de las Mirtáceas de la VII Región, Maule
Chemistry of Paraguayan medicinal Myrtaceae
Natural Products as alternative in controlling Chagas' disease
Natural Products as alternative in controlling Chagas' disease vectors
Alexander von Humboldt Fellowship
Evaluación de Productos Naturales sobre Rhodnius neglectus y Tripanosoma cruzi, vector y causante de la enfermedad de Chagas

Review (1)

Bioactive Constituents from South American Prosopis and their Use and Toxicity
296
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

6
Samanta Thomas

Profesor Titular

Facultad de Farmacia

Universidad de Valparaíso

Valparaíso, Chile

5
Cristina Quispe

ACADEMICO

FACULTAD DE CIENCIAS DE LA SALUD

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

5
Maria Theoduloz

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

3
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

2
Alberto Burgos

Asistente de Investigación

Departamento de investigación

Universidad Nacional de Asunción

San Lorenzo, Paraguay

2
Felipe Avila

Profesor Asistente

UNIVERSIDAD DE TALCA

Talca, Chile

2
MARIANO PERTINO

Profesor conferenciante

UNIVERSIDAD DE TALCA, INSTITUTO DE QUÍMICA DE RECURSOS NATURALES

TALCA, Chile

2
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

2
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

2
Daniel Droguett

Profesor Conferenciante

Estomatología

Universidad de Talca

Talca, Chile

2
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
MARIO SIMIRGIOTIS

Associate professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jose Yuri

Profesor Titular y Director del Centro de Pomáceas

Producción Agrícola

UNIVERSIDAD DE TALCA

Talca, Chile

1
JEAN DE ANDRADE

Académico Investigador

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Ivanna Bravo

Doctora

Kinesiología

Laboratorio de Kinesiología de análisis del movimiento humano

Talca, Chile

1
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
MAURICIO LOLAS

Investigador

Producción Agrícola

Universidad de Talca

Talca, Chile

1
Gustavo Lobos

Associate Professor

Horticulture

FACULTDAD DE CIENCIAS AGRARIAS, UNIVERSIDAD DE TALCA

Talca, Chile

1
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Gilda Carrasco

PROFESOR ASOCIADO

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

1
CLAUDIA MOGGIA

PROFESOR ASOCIADO

HORTICULTURA

UNIVERSITY OF TALCA

Talca, Chile

1
Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

1
Peter Caligari

Science Advisor

CGNA

Temuco, Chile