Man

margarita isabel gutierrez cabrera

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Organic chemistry of heterocycles; Chemistry an biological activity of synthetic compounds; Chemistry and biological activity of natural product, Bioactivity of natural and synthetic compounds, structural elucidation

Educación

  •  Chemistry, Universidad de Talca. Chile, 2006

Experiencia Académica

  •   Proffesor Full Time

    Universidad de Talca

    Institute of Chemistry of Natural Resource

    Talca, Chile

    2007 - A la fecha

Experiencia Profesional

  •   Proffesor Full Time

    Universidad de Talca

    Talca, Chile

    2007 - A la fecha

Formación de Capital Humano


Undergraduate thesis:

Synthesis and Evaluation of acrylonitrile derivatives as acetylcholinesterase inhibitors. Ljuvica Martinic Gonzalez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2013.
Derivatives of Benzoacetonitriles as bacterial inhibitors. Maria Natalia Veliz Olivo, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica,Universidad de Talca, 2013.
Synthesis of nitrogen heterocycles and evaluation of their biological activity. Maria Magdalena Sepulveda Espinoza, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis of coumarin-quinoline hybrids as selective cholinesterase inhibitors. Rafael Latorre Oyanadel, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis of coumarin-quinolines hybrids as potential antioxidant agents. Oliver Orellana Muñoz, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis and study of biological activity of quinolin analog heterocycles. Michelle Campos Rodriguez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2015.
Synthesis, characterization and bioactivity of pyrazole and imidazole systems. Lady Valdés Salas, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2015.
Synthesis of new pyrazole compounds and their biological applications. Patricio Soto Lopez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica,Universidad de Talca, 2016.
Azorella spinosa phytochemical study. Javiera Olivares Pulgar, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis, characterization and bioactivity of ?-? unsaturated systems (chalcones). Nicol Ibarra Arellano, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis, characterization and study of biological activity of pyrazolopyrimidines. Valentina Arce Parada, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis and evaluation of the antibacterial potential of N-propargyl tetrahydroquinolines derivatives. Maximiliano Norambuena Guzman, Facultad de Ciencias de la Salud, Escuela de Tecnologia Medica, Universidad de Talca,2017.
Effect of lyophilized extracts of Aristotelia chilensis (mol.) Stuntz on the healing activity of mouse fibroblasts NIH-3T3 in vitro. Macarena Jorquera Norambuena, Carlos Segovia Vásquez, Facultad de Ciencias de la Salud, Escuela de Odontología, Universidad de Talca, 2018.

Doctoral thesis
Synthesis of 5,11 epoxieudesmanos (agarofuranos) with insecticidal and antifeedant activity. Evelyn Muñoz, Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada) .
Design, synthesis and characterization of pyrazoloquinolinic systems as cholinesterase inhibitors. Efraín Polo. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada).
Estudio de los metabolitos secundarios y proteómica de algunas especies del género Azorella Lam. (Apiaceae). Adriana Jara. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada)
Híbridos de tetrahidroquinolinas/triazoles, posible(s) moléculas(s) multidiana: diseño, síntesis, caracterización y actividad biológica. Meiby Fernandez. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (en desarrollo)

Postgraduate teaching:
2014-present: Coordinator in the obligatory “Curso de Mecanismo de Acción y ensayos biológicos”” (10 ECTS), Doctorado en Ciencias con Mención en Investigación y Desarrollo de Productos Bioactivos, Instituto de Química de Recursos Naturales, Universidad de Talca.

Undergraduate teaching:

2011-2015: Lecturer in charge of the course “ Chemistry General and Organic", Odontología, Universidad de Talca
2011-2015: Lecturer in charge of the course “ Chemistry General and Organic", Medicina, Universidad de Talca
2016-present: Lecturer in charge of the course “ Inorganic hemistry", Tecnologia Medica, Universidad de Talca
2016-present: Lecturer in charge of the course “ Chemistry", Kinesiologia, Universidad de Talca
2019-2021: Lecturer in charge of the course “ Chemistry ", Obstetricia y Puericultura, Universidad de Talca
2021: Lecturer in charge of the course “ Chemistry ", Bioquimica, Universidad de Talca

Grants

-2006: PROYECTO FIA ES-C-2005-1-A-42 Laboratorio de plantas aromáticas Instituto de Química de Recursos Naturales Universidad de Talca

-2006-2008: Fortalecimiento de la investigación en el instituto de química de recursos naturales” proyecto nº psd-16

-2007-2010: Proyecto anillo: “obtaining natural or hemisintetic products of pharmacological, agrochemical and forestry interest and their possible biotechnological development” Proyecto Nº ACT-38

2008-2010. Research program on cardiovascular disease risk factors (pifrecv).

2011-2013: Fondecyt 1120199: Chemical study of the genus Azorella. Biological activity of its metabolites.

2011-2013: Vac 600569, Universidad de Talca: Synthesis of heterocycles with biological activity.

2013-2015: Fondecyt 1130216: Research on mechanism of antiplatelet action of adenosine and other bioactive compounds from Solanum lycopersicum L.

2014-2015: Fondef Idea:Development and functional evaluation of synthetic inhibitory molecules of potassium channels TASK-3 for the treatment of solid tumors. Proyecto: CA13I10223.

2014: Fondef Idea:In vitro propagation of Rhodophiala pratensis and its use as a source of pharmacologically important alkaloids. Proyecto CA13I10272.

2015-2018 Fondecyt 1150712: Pyrazoloquinolines Derivatives: Synthesis and biological activity
2017-2020: Fondecyt 1170718Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions.
2020-2023: Fondecyt 1200531 Hybrids of Tetrahydroquinolines as Multi-Target drugs: Design, Synthesis, characterization and biological activity.


Difusión y Transferencia


Participation Science Week 2014-2019, Explora Mil Científicos Mil Aulas
Participation Scientific Fairs Explora 2015-2019
Evaluator projects Explora 2015-2019



 

Article (63)

Microwave-assisted synthesis, biological assessment, and molecular modeling of aza-heterocycles: Potential inhibitory capacity of cholinergic enzymes to Alzheimer's disease
Furanyl chalcone derivatives as efficient singlet oxygen quenchers. An experimental and DFT/MRCI study
Insecticidal and cholinesterase activity of dichloromethane extracts of Tithonia diversifolia on Atta cephalotes worker ants (Formicidae: Myrmicinae)
Tetrahydroquinoline-isoxazole/isoxazoline hybrid compounds as potential cholinesterases inhibitors: Synthesis, enzyme inhibition assays, and molecular modeling studies
Bennett acceptance ratio method to calculate the binding free energy of BACE1 inhibitors=> Theoretical model and design of new ligands of the enzyme
Crystal structure and theoretical studies of 2-bromo-N-(2,4-difluorobenzyl)benzamide; intermediate for the synthesis of phenanthridinone
Efficient synthesis and antioxidant activity of novel N-propargyl tetrahydroquinoline derivatives through the cationic Povarov reaction
Eugenol supplementation as an additive to improve the thermal stability of Hedychium coronarium Koening essential oil
Novel Coumarin-Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease
Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors
Design, facile synthesis, and evaluation of novel spiro- and pyrazolo [1,5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents
Microwave-assisted one-pot synthesis in water of carbonylpyrazolo[3,4-b] pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety
N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2-enoyl]phenyl}quinoline-3-carboxamide
Synthesis of novel 7-aryl and 7-spiropyrazolo[4 ',3 ':5,6]pyrido [2,3-d]pyrimidine derivatives and their study as AChE inhibitors
Antimicrobial and degradative bacterial dna effects of new 2-alkyl (Tetrahydroquinoline-4-yl) formamide
Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3-(pyridin-3-yl)acrylonitrile)
Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives
Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold
Monitoring and mechanisms of organophosphate resistance in San Jose scale, Diaspidiotus perniciosus (Hemiptera=> Diaspididae)
Novel N-allyl/propargyl tetrahydroquinolines=> Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors
Synthesis and in silico analysis of the quantitative structure-activity relationship of heteroaryl-acrylonitriles as AChE inhibitors
• Synthesis and in silico analysis of the quantitative structure activity relationship of heteroaryl–acrylonitriles as AChE inhibitors.
Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenus disticha and Euonymus japonicus
Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone
Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives
• Synthesis, molecular docking and design of Tetrahydroquinolines as acetylcholinesterase inhibitors
• Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents
A New Isoxazolic Compound Acts as alpha 7 Nicotinic Receptor Agonist in Human Umbilical Vein Endothelial Cells
Antioxidant activity of bioactive extracts obtained from rhizomes of cyperus digitatus roxb [Actividad antioxidante de extractos obtenidos a partir de rizomas de cyperus digitatus roxb]
Biodiesel production from an industrial residue: Alperujo
E-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles as effecient Michael acceptors for cystein: real application in biological imaging.
Effect of tomato industrial processing (different hybrids, paste, and pomace) on inhibition of platelet function in vitro, ex vivo, and in vivo.
New Diterpenes from Azorella spinosa
Synthesis of New 3-(2-Chloroquinolin-3-yl)-5-Phenylisoxazole Derivatives via Click-Chemistry Approach
Synthetic isoxazole as antiplatelet agent
Ultrasound-assisted phase-transfer catalysis in ana aqueous medium to promote the Knoevenagel reaction: Advantages over the conventional and microwave-assisted solvent-free/catalyst-free method.
Antioxidant and Antiplatelet Activities in Extracts from Green and Fully Ripe Tomato Fruits (Solanum lycopersicum) and Pomace from Industrial Tomato Processing
Crystal structure of 1,3-bis(6-methoxyquinolin-2-yl) benzene, C26H20N2O2
Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)
Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors
Synthesis of Bistetrahydroquinolines as Potential Anticholinesterasic Agents by Double Diels-Alder Reactions
A Novel Class of Selective Acetylcholinesterase Inhibitors: Synthesis and Evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3- heteroarylacrylonitriles
Antifungal Activity of Tetrahydroquinolines against Some Phytopathogenic Fungi
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum
Biological Activity of Isoflavonoids from Azorella madreporica
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity
SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES
1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one monohydrate
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables
13-EPI-NEOCLERODANES FROM BACCHARIS MARGINALIS
Quinoline-based compounds as modulators of HIV transcription through NF-kappa B and Sp1 inhibition
Synthesis of New Diversely Linked Biquinoline Derivatives by Multicomponent Imino-Diels-Alder Cycloaddition and Intramolecular Friedel-Crafts Cyclization
1-(3-Phenylisoxazol-5-yl)cyclohexane-1,2-diol
5-(1-Cyclohexen-1-yl)-3-(4-methoxyphenyl)isoxazole
Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction
Synthesis and Biotransformation of Tetrahydroquinoline by Mortierella isabelina
TRITERPENOIDS FROM Azorella trifurcata (Gaertn.) Pers AND THEIR EFFECT AGAINST THE ENZYME ACETYLCHOLINESTERASE
Inhibition of Acetylcholinesterase Activity by Dihydro-beta-agarofuran Sesquiterpenes Isolated from Chilean Celastraceae
Bioactive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile
BIOLOGICALLY ACTIVE COMPOUNDS FROM CHILEAN PROPOLIS

BiographicalItem (1)

Obituary Luis Armando Astudillo Saavedra [Calama 1960-Talca 2013], has works published, Researcher

Proyecto (7)

Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions
Pyrazoloquinolines derivatives=> synthesis and biological activity
Desarrollo y evaluacion funcional de moleculas sinteticas inhibidoras de los canales de potasio task-3 para el tratamiento de tumores solidos.
Propagacion in vitro de Rhodophiala pratensis y su uso como Fuente de alcaloides de importancia farmacologica.
Research on mechanism of antiplatelet action of adenosine and other bioactive compounds from Solanum lycopersicum L.
SÍNTESIS DE NUEVOS HÍBRIDOS MOLECULARES ENTRE SISTEMAS TETRAHIDROQUINOLÍNICOS E ISOXAZOLES/ISOXAZOLINAS COMO POSIBLES AGENTES ANTI PROTOZOARIOS Y FITOPATOGENOS
Chemical study of the genus azorella. Biological activity of its metabolites.

Review (1)

Adenosine: Synthetic methods of its derivatives and antitumor activity
57
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

9
Gabriel Vallejos

Académico

UNIVERSIDAD ASUTRAL DE CHILE

Valdivia, Chile

8
Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

7
AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

6
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

6
Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

4
YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

4
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

4
Efrain Polo

Docente

Universidad de Talca

Talca, Chile

4
Luisa Quesada

Docente e investigadora

Nutrición y Dietética

Universidad San Sebastián

Valdivia, Chile

4
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

4
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

3
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

3
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

3
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Gilda Carrasco

PROFESOR ASOCIADO

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

2
LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

2
Francisco Adasme

Asistente de Investigación

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

2
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

2
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

2
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

2
Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

2
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

2
Carlos Fernández

Investigador Postdoctoral

Universidad Austral de Chile

Valdivia, Chile

1
Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Cristian Balbontin

Investigador

Produccion Vegetal

Instituto de Investigaciones Agropecuarias

Chillán, Chile

1
Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

1
Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

1
Diógenes Hernández

Conferenciante

Instituto de química de recursos naturales

Universidad de Talca

Curico, Chile

1
Fabián Avila

INVESTIGADOR

FACULTAD DE CIENCIAS

UNIVERSIDAD MAYOR

Santiago, Chile

1
MAURICIO LOLAS

Investigador

Producción Agrícola

Universidad de Talca

Talca, Chile

1
Jose Yuri

Profesor Titular y Director del Centro de Pomáceas

Producción Agrícola

UNIVERSIDAD DE TALCA

Talca, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Luis Espinoza

Assistant Professor

Chemistry

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

1
John Amalraj

Professor Assistant

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Alexander Fernández

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
ANTONIO GALDAMEZ

ASSOCIATE PROFESSOR

CHEMISTRY

DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Cesar Retamal

Profesor Conferenciante

Departamento de Ingeniería y Gestión de la en Construcción

UNIVERSIDAD DE TALCA

Curicó, Chile

1
Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Natalia Valdés

Investigador

Universidad de Santiago de Chile

Santiago, Chile

1
Daniel Gonzalez

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

1
Horacio Poblete

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Fernando Avila

Graduate Researcher / PhD Student

Cirugía y Cancer

Imperial College London

London, Reino Unido

1
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Esteban Durán

Profesor Conferenciante

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Claudio Tenreiro

Decano

Departamento de Tecnologías Industriales

Universidad de Talca

Talca, Chile

1
Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

1
José Velázquez

Asistente de Investigación

Bioinformática

Universidad de Talca

Talca, Chile

1
Hernán Gaete

Profesor

Escuela de Ingeniería en Medioambiente

Universidad de Valparaíso

Valparaíso, Chile

1
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Eduardo Schott

Profesor Asistente

Departamento de Química Inorgánica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MAGDALENA CORTES

Académico

Universidad de Valparaíso

Valparaíso, Chile

1
Evelyn Muñoz

Docente

Ciencias Básicas

Universidad del Bío-Bío

chillan, Chile