Photo_eduardo_fuentes_q.jpg_thumb90

Eduardo Javier Fuentes Quinteros

Profesor Asociado

Universidad de Talca

Talca, Chile

Líneas de Investigación


Platelet function Cardiovascular diseases Natural bioactive compounds Aging

Educación

  •  Medical Technologist, UNIVERSIDAD DE TALCA. Chile, 2011
  •  PhD program in sciences research and development of bioactive products, UNIVERSIDAD DE TALCA. Chile, 2014

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE TALCA

    Facultad de Ciencias de la Salud

    Talca, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Profesor Asociado Full Time

    Universidad de Talca

    Talca, Chile

    2015 - A la fecha

Formación de Capital Humano


Dirección de memorías de pregrado (n=20) y tesis de postgrado (n=2) de la Universidad de Talca.


Difusión y Transferencia


Actividades de difusión por Explora Maule de la Universidad de Talca.


Premios y Distinciones

  •   Francisco Antonio Encina Armanet

    UNIVERSIDAD DE TALCA

    Chile, 2011

    best student in medical technology


 

Article (63)

Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype
In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15
Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6
Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study
Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products
Antiplatelet protocol: Effects of ingesting a tomato pomace extract on human platelet aggregation
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Increased platelet function during frailty
Lipid Metabolism and Signaling in Platelet Function
Methodology of generation and purification of anti-beta 2 glycoprotein I antibodies
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging
Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases
NADPH oxidase 2 (NOX2)=> A key target of oxidative stress-mediated platelet activation and thrombosis.
Nanotechnology and primary hemostasis=> Differential effects of nanoparticles on platelet responses.
Platelet mitochondrial dysfunction and mitochondria-targeted quinone-and hydroquinone-derivatives: Review on new strategy of antiplatelet activity
Adenosine A2A receptor agonists with potent antiplatelet activity.
Antiplatelet activity of drugs used in hypertension, dyslipidemia and diabetes: Additional benefit in cardiovascular diseases prevention.
Antiplatelet activity of drugs used in hypertension, dyslipidemia and diabetes: Additional benefit in cardiovascular diseases prevention.
Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles
Docking and quantitative structure-activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors
Geographic clustering of elderly people with above-norm anthropometric measurements and blood chemistry.
Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.
Impact of walkability with regard to physical activity in the prevention of diabetes
Mechanisms of endothelial dysfunction during aging=> Predisposition to thrombosis.
Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables.
Platelet oxidative stress as a novel target of cardiovascular risk in frail older people.
Effect of straight-line and road network distances to parks and markets on anthropometric measurements, biochemical markers, and a healthy lifestyle in adult people
NF-kB signaling pathway as target for antiplatelet activity.
NF-κB signaling pathway as target for antiplatelet activity.
Role of adenosine A2b receptor overexpression in tumor progression.
Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis.
Inhibitory effects of Cyperus digitatus extract on human platelet function in vitro
Primary and secondary haemostasis changes related to aging
Role of access to parks and markets with anthropometric measurements, biological markers, and a healthy lifestyle
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1 beta) and thrombus formation
A Novel Role of Eruca sativa Mill. (Rocket) Extract: Antiplatelet (NF-kappa B Inhibition) and Antithrombotic Activities
A novel role of Eruca sativa Mill. (rocket) extract: antiplatelet (NF-κB inhibition) and antithrombotic activities.
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
Effect of Tomato Industrial Processing (Different Hybrids, Paste, and Pomace) on Inhibition of Platelet Function In Vitro, Ex Vivo, and In Vivo
Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling
Protective mechanisms of adenosine 5 '-monophosphate in platelet activation and thrombus formation
Synthetic isoxazole as antiplatelet agent
Thrombus formation induced by laser in a mouse model
Antioxidant and Antiplatelet Activities in Extracts from Green and Fully Ripe Tomato Fruits (Solanum lycopersicum) and Pomace from Industrial Tomato Processing
Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)
Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae) [Determinación de la actividad antibacteriana, antioxidante, antiagregante plaquetaria e inhibición de la colinesterasa a partir de los extractos metanólicos de especies Azorella (Apiaceae)]
Effect of Tomato Industrial Processing on Phenolic Profile and Antiplatelet Activity
Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy
Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L
Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum
Evaluación de la calidad de vida en pacientes hemofílicos de Curicó, Región del Maule
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity
Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.) (Review)
El consumo de frutas y hortalizas ayuda a prevenir el daño endotelial
Actividad antioxidante, hipolipemiante y antiplaquetaria del tomate (Solanum lycopersicum L.) y el efecto de su procesamiento y almacenaje.
Anthropometric Characteristics, Physical Fitness and Lifestyles of University Students in the Maule Region of Chile.
Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste).
Mechanisms of endothelial dysfunction during aging: Predisposition to thrombosis

Abstract (2)

Inhibition of RhoA-RHO kinase pathway attenuates cocaine-induced microvascular endothelial cell dysfunction: studies under static and shear flow conditions
Mechanism of antiplatelet action induced by guanosine via increase in camp levels and its antithrombotic activity

Patent (1)

Extracto acuoso de tomasa con actividades antiagregante plaquetaria y antitrombótica, y procedimiento de obtención del mismo.

Proyecto (8)

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF MITOCHONDRIA-TARGETED HYDROQUINONE DERIVATIVES WITH ANTIPLATELET ACTIVITY
Becas Iberoamérica. Investigadores. Santander Universidades.
ADQUISICIÓN DE UN MICROSCOPIO INTRAVITAL PARA EL ESTUDIO IN VIVO DE TROMBOSIS EN MODELOS ANIMALES
Adquisición de un microscopio intravital para el estudio in vivo de trombosis en modelos animales
RESEARCH OF MECHANISMS OF ANTIPLATELET ACTION INDUCED BY GUANOSINE VIA INCREASE IN CAMP LEVELS, AND THEIR RELATION WITH ANTITHROMBOTIC ACTIVITY AND REDUCED RISK OF BLEEDING
Research of mechanisms of antiplatelet action induced by guanosine via increase in cAMP levels, and their relation with antithrombotic activity and reduced risk of bleeding
Research on Mechanisms of Antiplatelet Action of Adenosine and other Bioactive Compounds from Solanum lycopersicum L
Synthesis and Pharmacological Evaluation of Mitochondria- Targeted Hydroquinone Derivatives with Antiplatelet Activity

Review (16)

Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
Role of oxidative stress on platelet hyperreactivity during aging
Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules
Platelet miRNAs and cardiovascular diseases
Role of physical activity in cardiovascular disease prevention in older adults
Antiplatelet effects of natural bioactive compounds by multiple targets: Food and drug interactions
Mechanism of antiplatelet action of hypolipidemic, antidiabetic and antihypertensive drugs by PPAR activation PPAR agonists: New antiplatelet agents
Mechanism of the anti-platelet effect of natural bioactive compounds: Role of peroxisome proliferator-activated receptors activation
Mechanisms of endothelial cell protection by hydroxycinnamic acids
Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk
Role of multiligand/RAGE axis in platelet activation
Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome
Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products
Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis
Role of PPARs in inflammatory processes associated with metabolic syndrome
Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)
68
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

67
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

22
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

4
Diego Arauna

Investigador Postdoctorante

Universidad de Talca

Talca, Chile

4
PABLO PEREZ

Investigador Postdoctoral

Anatomía Patológica/Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

4
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

4
Gilda Carrasco

PROFESOR ASOCIADO

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

4
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

4
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

3
Gonzalo Palomo

Postdoctoral Researcher

Behavioral and Social Sciences

University of Groningen

Groningen, Holanda

3
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Carlos Mena

DECANO

GESTION FORESTAL AMBIENTAL

UNIVERSIDAD DE TALCA

Talca, Chile

3
Claudio Valenzuela

CONFERENCIANTE

ESCUELA DE MEDICINA

Universidad de Talca

Talca, Chile

3
Anibal Concha

Académico

Universidad Austral de Chile

Valdivia, Chile

3
Maria Yolanda Espinosa

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

3
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

2
Daniel Gonzalez

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

2
yony ormazábal

Académico

Ciencias Forestales

UNIVERSIDAD DE TALCA

TALCA, Chile

2
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

1
Miguel Bustamante

DIRECTOR

OTEC

RYPA CAPACITACIÓN

Talca, Chile

1
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Cecilia Albala

Director, full professor

INTA/U CHILE

Santiago, Chile

1
LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

1
Esteban Durán

Associate Professor

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

1
Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Felipe Avila

Profesor Asistente

UNIVERSIDAD DE TALCA

Talca, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Giacaman

Full Professor

Oral Rehabilitation

UNIVERSIDAD DE TALCA

Talca, Chile

1
Germán Lobos

Profesor Asociado

Economía y Finanzas

Universidad de Talca

Talca, Chile

1
John Amalraj

Professor Assistant

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Lyanne Rodríguez

Investigador Fondecyt Posdoctoral

Tecnología Médica

Universidad de Talca

Talca, Chile

1
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

1
Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

1
AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

1
Luisa Quesada

Docente e investigadora

Nutrición y Dietética

Universidad San Sebastián

Valdivia, Chile

1
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Alvaro Cerda

Académico

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
María Furrianca

PROFESOR ASOCIADO

DEPARTAMENTO DE ENFERMERÍA

Universidad de Magallanes

Punta Arenas, Chile

1
Francisco Adasme

Asistente de Investigación

Departamento de Bioinformática

Universidad de Talca

Talca, Chile