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Armando Rojas Rubio

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

Líneas de Investigación


Inflamacn; Gastric cancer; Transportadores de membrana; Vias de conexión entre Inflamación y Cancer; Regulación de expresión; Host-pathogens interactions; Helicobacter pylori; Antibiotic resistance mechanisms; RAGE/multiligand axis on physiopathology: Inflammation and  immune system; Inflammatory mediators and cancer-related inflammation; Host-pathogen interactions

Educación

  •  Genetic Toxicology, Centro Nacional de Investigaciones Científicas, La Habana. Cuba, 1988
  •  Licenciado Ciencias Biologicas, UNIVERSIDAD DE LA HABANA. Cuba, 1982

Experiencia Académica

  •   Investigador Asociado Full Time

    Centro Nacional de Investigaciones Científicas

    La Habana, Cuba

    1982 - 1990

  •   Investigador Titular, Director División de Farmacología y Toxicología Full Time

    Centro de Química Farmacética

    Chile

    1991 - 2001

  •   Profesor Titular Full Time

    Universidad Católica del Maule

    Medicina

    Talca, Chile

    2005 - A la fecha

Experiencia Profesional

  •   Profesor Titular Full Time

    Universidad Católica del Maule

    Talca, Chile

    2005 - A la fecha


 

Article (42)

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression
Adipose tissue macrophages as a therapeutic target in obesity-associated diseases
Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
Polyphenols and AGEs/RAGE axis. Trends and challenges
RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-alpha through NF-kappa beta and AP-1 in Two Cell Lines of Breast Cancer
SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?
The potential role of dietary advanced glycation endproducts in the development of chronic non-infectious diseases: a narrative review
HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
Letter to the editor: Cross-contaminated cell lines: there is no time to lose
Helicobacter pylori infection and lung cancer: New insights and future challenges
RAGE in cancer lung: The end of a long and winding road is in sight
M2 macrophages do not fly into a "RAGE"
The imperative authentication of cell lines
The imperative authentication of cell lines.
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
Tumor-associated macrophages in gastric cancer: more than bystanders in tumor microenvironment
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
Chlorogenic acid inhibits human platelet activation and thrombus formation.
Chlorogenic acid inhibits human platelet activation and thrombus formation.
Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result
Expression of RAGE in Helicobacter pylori infested gastric biopsies
iNOS Activation Regulates beta-catenin Association with Its Partners in Endothelial Cells
NOS activation regulates beta-catenin association with its partners in endothelial cells.
Statins and portal hypertension: A new pharmacological challenge
Diabetes and cancer: Looking at the multiligand/RAGE axis
Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells
High prevalence of virulence-associated genotypes in Helicobacter pylori clinical isolates in the Region del Maule, Chile
Pathophysiology of the proatherothrombotic state in the metabolic syndrome.
Pathophysiology of the proatherothrombotic state in the metabolic syndrome.
Acute and subchronic toxicological study of senna in rodents
Acute and subchronic toxicological study of senna in rodents Toxicología aguda y subcrónica de una pasta de sen en roedores
Letter to the editor [1]
Oxidative stress in tumor microenvironment - Its role in angiogenesis
The influence of cellular seeding density in the microencapsulation of hybridoma cells
Nitric oxide disrupts VE-cadherin complex in murine microvascular endothelial cells
Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells
Differential interleukin-8 response of intestinal epithelial cell line to reactogenic and nonreactogenic candidate vaccine strains of Vibrio cholerae
Effects of Phycocyanin Extract on Tumor Necrosis Factor-α and Nitrite Levels in Serum of Mice Treated with Endotoxin
Microencapsulation of an anti-VE-cadherin antibody secreting 1B5 hybridoma cells
Regulation of endothelial nitric oxide synthase expression by albumin-derived advanced glycosylation end products

BookSection (2)

AGEs clearance mechanisms
RAGE: The receptor of advanced glycation end-products

BookWhole (2)

Gastric Tumor Microenvironment
Statins and portal hypertension

ConferencePaper (1)

HMGB1-mediated RAGE activation mechanism in M2 macrophages.

Editorial (2)

RAGE at tumor microenvironment. Looking at tumor-associated macrophages
Teaching Molecular Medicine within Medical Education No time to wait

Letter (6)

Cell Line Cross-contamination: Who Wins?
Comment on "Endothelial ICAM-1 Protein Induction Is Regulated by Cytosolic Phospholipase A(2)alpha via Both NF-kappa B and CREB Transcription Factors"
Identity Crisis - Bladder cells in vascular biology
Calling attention to the use of false "endothelial'' cell lines
Stopping the use of false "endothelial" cell lines
Cell line cross-contamination in biomedical research: a call to prevent unawareness

Patent (1)

PROTEÍNA RAGE (RECEPTOR DE PRODUCTOS AVANZADOS DE LA GLICACION) COMO BIOMARCADOR DE RADIOSENSIBILIDAD TUMORAL

Proyecto (19)

ALIMENTOS INNOVADORES PARA LA PREVENCIÓN DE ENFERMEDADES RELACIONADAS CON LA INFECCIÓN POR HELICOBACTER PYLORI
DESARROLLO Y VALIDACIÓN DE UN BIOMARCADOR PREDICTIVO DE RESPUESTA A LA TERAPIA ANTITUMORAL EN TUMORES SÓLIDOS.
Transferencia examen innovador para facilitar la erradicación de H. pylori
Valorización de residuos de la agroindstria con actividad antiglicante
Valorización de residuos agroindustriales regionales como fuente de nuevos agentes antiglicantes con aplicación en la industria alimentaria y salud
Unravelling th role of RAGE axis on tumor-associated macrophages
Unravelling th role of RAGE axis on tumor-associated macrophages
The Role of RAGE in the development of Endometrial cancer
A new insight into the pathogenesis of helicobacter pylori infection: the contribution of the AGEs/RAGE axis.
A new insight into the pathogenesis of helicobacter pylori infection=> the contribution of the AGEs/RAGE axis.
Grupo de Investigación MAOLAT
Papel de los productos avanzados de la glucosilación en la activación transcripcional del receptor de andrógenos en pacientes con ovario poliquístico”
Papel de los productos avanzados de la glucosilación en la activación transcripcional del receptor de andrógenos en pacientes con ovario poliquístico”
“Inhibición de la metástasis tumoral mediante la microencapsulación de células de hibridomas secretoras de anticuerpos monoclonales anti caderina VE”
Biomarcador en Quimioterapia
Establishment and Exploitation of a European-Latin America Research Consortium towards eradication of preventable gallbladder cancer
Establishment and Exploitation of a European-Latin America Research Consortium towards eradication of preventable gallbladder cancer.
Prevención de Helicobacter pylori mediante alimentos
The Role of RAGE in the development of Endometrial cancer

Review (17)

Inhibition of RAGE Axis Signaling: A Pharmacological Challenge
Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy
Extracellular matrix glycation and receptor for advanced glycation end-products activation: a missing piece in the puzzle of the association between diabetes and cancer
Skewed Signaling through the Receptor for Advanced Glycation End-Products Alters the Proinflammatory Profile of Tumor-Associated Macrophages
Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
Lysyl oxidase isoforms in gastric cancer
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Role of multiligand/RAGE axis in platelet activation
The Emerging Role of the Receptor for Advanced Glycation End Products on Innate Immunity
The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
Fueling inflammation at tumor microenvironment: the role of multiligand/rage axis
Modulation of nitric oxide pathway by multiligands/rage axis: A crossing point on the road to microvascular complication in diabetes
Advanced glycation and ROS: A link between diabetes and heart failure
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome
Oxidative stress at the vascular wall. Mechanistic and pharmacological aspects
Advanced glycation and endothelial functions: A link towards vascular complications in diabetes
90
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

16
Ileana González

Profesor Adjunto

Ciencias Preclínicas

Universidad Católica del Maule, Escuela de Medicina..

Talca, Chile

9
Ramón Pérez

Secretario Centro Oncológico UCM y Director de Departamento de Ciencias Preclínicas, Facultad de Medicina

Facultad de Medicina

UNIVERSIDAD CATÓLICA DEL MAULE

Talca, Chile

7
Erik Morales

Profesor Auxiliar

Ciencias Preclínicas

UNIVERSIDAD CATÓLICA DEL MAULE

Talca, Chile

7
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

5
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

5
Carolina Añazco

Profesora Asociada

Universidad San Sebastián

Valdivia, Chile

3
Jordi Olloquequi

Profesor Titular

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

2
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

2
Javier Retamales

Radio Oncólogo

Medicina

Complejo Asistencial Sótero del Río

Santiago, Chile

1
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Olga Barajas

PROF. ASISTENTE/MEDICO ONCOLOGO

MEDICINA

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paz Robert

Prof. Titular

Ciencia de los Alimentos y Tecnología Química

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Monica Ahumada

medico

medicina oncologia basico clinica

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

santiago, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Pablo Báez

Investigador Postdoctoral

Centro de Informática Médica y Telemedicina

Universidad de Chile

Santiago, Chile

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
Macarena Fuentes

Profesor Asistente

Tecnología Medica

Universidad de Tarapacá

Arica, Chile

1
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

1
Bettina Müller

Jefe subrogante

Oncología Médica

Instituto Nacional del Cáncer

Santiago, Chile

1
Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile