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Fabián Josué Segovia Miranda

Associate professor

Universidad de Concepción

Concepción, Chile

Líneas de Investigación


Cell and tissue architecture, deep tissue imaging, 3D tissue reconstructions, liver, regeneration, non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma.

Educación

  •  Bachelor in Medical Technology, UNIVERSIDAD DE TALCA. Chile, 2006
  •  Master in Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  PhD in Biological Sciences specializing in Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Postdoctoral fellow, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
  •  Postdoctoral fellow, MAX-PLANCK INSTITUT FUR MOLEKULARE ZELLBIOLOGIE UN GENETIK (MPI-CBG). Alemania, 2019

Experiencia Académica

  •   Professor of Hematology Laboratory Other

    UNIVERSIDAD DE TALCA

    Faculty of Health Sciences

    Talca, Chile

    2006 - 2007

  •   Assistant professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepción, Chile

    2019 - A la fecha

  •   Associate professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepción, Chile

    2024 - A la fecha

Experiencia Profesional

  •   Tecnólogo Médico Laboratorio de Parasitología Full Time

    Servicio de Laboratorios Clínicos de la Pontificia Universidad Católica de Chile

    Santiago, Chile

    2006 - 2006

Formación de Capital Humano


GRADUATE THESIS ADVISOR
• 2023 – current: Dilan Martinez. Doctorado en Ciencias Biológicas Area Biología Celular y Molecular, Universidad de Concepción.
• 2023 – current: Cristian Perez. Doctorado en Ciencias Biológicas Area Biología Celular y Molecular, Universidad de Concepción.

UNDERGRADUATE THESIS ADVISOR
• 2023: Isidora Sovino. Bioingeniería, Universidad de Concepción.
• 2023: Valentina Maldonado. Bioingeniería, Universidad de Concepción.
• 2022: Boris Vega. Ingeniería civil biomédica, Universidad de Concepción.
• 2022: Dilan Martinez. Bioingeniería, Universidad de Concepción.
• 2021: Rodrigo Yañez. Biología, Universidad de Concepción.


Premios y Distinciones

  •   Henri Nestlé Award

    NESTLE CHILE S.A.

    Chile, 2009

    Thirdly by the research article (Biol Trace Elem Res 125: 109-119, 2008).

  •   CONICYT scholarship

    CONICYT

    Chile, 2007

    CONICYT scholarship for doctoral studies in Chile

  •   Best graduated

    UNIVERSIDAD DE TALCA

    Chile, 2006

    Best graduated. Bachelor of Medical Technology

  •   Cuadro de Honor

    UNIVERSIDAD DE TALCA

    Chile, 2003

    Given to the best student of the entire undergraduate Medical Technology program.


 

Article (18)

Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
Quantification of nematic cell polarity in three-dimensional tissues
Liquid-crystal organization of liver tissue
PREDICTION OF MULTIPLE 3D TISSUE STRUCTURES BASED ON SINGLE-MARKER IMAGES USING CONVOLUTIONAL NEURAL NETWORKS
Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression
Content-aware image restoration: pushing the limits of fluorescence microscopy
Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis
AUTOMATIC RECOGNITION AND CHARACTERIZATION OF DIFFERENT NON-PARENCHYMAL CELLS IN LIVER TISSUE
A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture
Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice
Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model
Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome
Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome
Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile
Heme iron uptake by Caco-2 cells is a saturable, temperature sensitive and modulated by extracellular pH and potassium

Abstract (1)

Anti-P Autoantibodies Enhance Cytosolic Calcium and Neurotransmission in Hippocampal Neurons by Cross-Reacting with Cell Surface NSPA

Review (1)

An insight into the pathophysiology of thrombosis in antiphospholipid syndrome
20
Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

5
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

4
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

4
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
CLAUDIA CARCAMO

Profesor Asociado

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

1
Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Fernando Pizarro

Profesor Titular

INTA-UNIVERSIDAD DE CHILE

Santiago, Chile

1
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile