Man

Andrea Morena Soza Gajardo

Profesor Asociado

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


We are interesting to understand how interaction between carbohydrate binding proteins and glycoproteins at the cell surface modulate different cellular processes relevant to the immune system, auto immunity and cancer.

Educación

  •  Biologia Celular y Molecular, HUMBOLDT UNIVERSITAT ZU BERLIN. Alemania, 1998
  •  Bioquímico, Humboldt Universität zu Berlin. Alemania, 1993

Experiencia Académica

  •   Postdoc Full Time

    HUMBOLDT UNIVERSITAT ZU BERLIN

    Medicine

    Berlin, Alemania

    1998 - 1999

  •   Profesor Asistente Adjunto Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2006 - 2016

  •   Profesor Asociado Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Santiago, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Profesor Asistente Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2006 - 2016

  •   Profesor Asociado Full Time

    Universidad San Sebastián

    Santiago, Chile

    2016 - A la fecha

Formación de Capital Humano


Undergraduate Thesis Mentoring:

1) Lucas Vicuña. “Galectin-8 binds to LFA-1 integrin and activates the ERK pathway in peripheral blood mononuclear cells.” Undergraduate Biochemistry thesis. Faculty of Biological Sciences. Pontificia Universidad Católica de Chile. (2005 – 2007)
2) Evelin Pardo. “Anti-galectin-8 autoantibodies present in patients with systemic lupus erythematosus.” Undergraduate Biochemistry thesis. Faculty of Biological Sciences. Pontificia Universidad Católica de Chile. ( 2009)
3) Claudia Oyanadel. “Antibodies against the mu subunits of adaptor complexes and against galectin-8 in the study of cell polarity.” Undergraduate Biochemistry thesis. Faculty of Biological Sciences. Pontificia Universidad Católica de Chile. ( 2009)
4) Felipe Garay. “Function of galectin-8 in drug resistance of ovarian cancer.” Undergraduate Biochemistry thesis. Faculty of Biological Sciences. Pontificia Universidad Católica de Chile. (2012 – 2013)
5) Cristobal Curkovic. “The role of galectin-8 in the immune system and autoimmune diseases” Thesis to obtain a Masters in Biotechnology, Faculty of Engineering in Biotechnology, Universidad Andres Bello. (2012 – 2013)
6) Christopher Holmes. “Galectin-8 interacts with cell-surface carbohydrates and enhances proteasome activity in a EGFR and FAK dependent process”. (Undergraduate Biochemistry Thesis). Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile. (2013-2014)
7) Felipe Padilla. “Efecto de galectina 8 sobre la actividad y composición del proteasoma en células del sistema inmune y en células epiteliales”. (Undergraduate Biochemistry Thesis). Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile.( 2015-2016)
8) Adely de la Peña: Práctica profesional, P. Universidad Católica de Chile/ Universidad San Sebastián (2018)

PhD Thesis Mentoring (C0-mentoring)

1) Claudia Cárcamo. “Función de la galectina-8 en linfocitos T y en autoinmunidad”. (PhD Thesis in Sciences, mention in Cell and Molecular Biology). Facultad Ciencias Biológicas. Pontificia Universidad Católica de Chile. (1998-2004).
2) Remziye Doger. “Determinants of differential functions of galectin-8 on T cells and tumoral cells: Interplay of galectine-8 isoforms, integrin and growth factor signaling pathways”. (PhD Thesis in Sciences, mention in Cell and Molecular Biology). Facultad Ciencias Biológicas. Pontificia Universidad Católica de Chile. 2009-2014.
3) Jorge Ibañez.“ROL DEL PROTEOSOMA 26S EN LA FORMACIÓN Y FUNCIÓN DE LA SINAPSIS INMUNE DE LOS LINFOCITOS B”.(PhD Thesis in Sciences, mention in Cell and Molecular Biology). Facultad Ciencias Biológicas. Pontificia Universidad Católica de Chile. (2016-2019)


Difusión y Transferencia


PATENTES
1) Inventores: Alfonso González, Andrea Soza y Claudia Metz
“Inhibidores de fosfohidrolasa de ácido fosfatídico (PAP), incluyendo D-propranolol y análogos, solos o en combinación con desipramina, para bloquear cánceres dependientes del EGFR, sus variantes oncogénicas y otros miembros de su familia ErbB/HER”.
Oficina de Patentes de Chile, Nº0273-2011; 08/02/2011
Patent Cooperation Treaty Nº PCT/ CL2012/000005 , 9/02/2012
Fases Nacionales: 06/08/2103: México (MX/a/2013/009091); USA (13/984,012); Canadá (2826785); Brasil (BR 11 2013 020125 8); Europa (12717035.5
EPO-Patente Europea); Rusia (2013/137960); India (1692/MUMNP/2013); China (2,0128E+12).
Patente Aprobada en USA. Mayo, 2016. Nº patente: US9345710 B2. “Inhibitors of phosphatidic acid phosphohydrolase (PAP) enzymes for the treatment of cancers that depend on members of the ErbB/HER tyrosine kinase receptor family”.
2) Inventores: Alfonso González, Andrea Soza, Evelyn Pardo, Claudia Cárcamo, and Reinaldo Uribe
Título: “A method and a kit to predict prognosis in patients with relapsing remitting multiple sclerosis and poor prognosis: A decision making tool for prescription of treatment”.
US provisional application number62/067554 filed on October 23, 2014. PCT/IB2015/058172 y Fases nacionales: Europe: Patent file Nº 15852024.7 Date: 23-05-2017; EEUU, Nº: 15/521152; Date: 21-04-2017; CANADA, Nº: 2,965,593, Date 24-04-2017 CHILE: 1010-2017; Date: 24-04-2017.



 

Article (29)

Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts
Galectins in the Brain: Advances in Neuroinflammation, Neuroprotection and Therapeutic Opportunities
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport
Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies
KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells
Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse
Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin-Darby canine kidney cells
Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis
KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence
Galectin-8 promotes migration and proliferation and prevents apoptosis in U87 glioblastoma cells
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer
Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients
Galectin-8 Promotes Cytoskeletal Rearrangement in Trabecular Meshwork Cells through Activation of Rho Signaling
Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation
Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation
Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta 1i), MECL1 (beta 2i) and LMP7 (beta 5i)
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells
Antibodies against galectin-8 in patients with systemic lupus erythematosus
Galectin-8 binds specific ?1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
Galectin-8 binds specific beta 1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
SORTING COMPETITION WITH MEMBRANE-PERMEABLE PEPTIDES IN INTACT EPITHELIAL CELLS REVEALED DISCRIMINATION OF TRANSMEMBRANE PROTEINS NOT ONLY AT THE TRANS-GOLGI NETWORK BUT ALSO AT PRE GOLGI STAGES
Sorting competition with membrane-permeable peptides in intact epithelial cells revealed discrimination of transmembrane proteins not only at the trans-Golgi network but also at pre-Golgi stages
Overexpression of the proteasome subunits LMP2, LMP2, and MECL-1, but not PA28?/?, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope

Abstract (8)

Galectin-8 induces apoptotic signaling through a link between phospholipase D, PKA and ERK pathways in Jurkat cells
Silencing of M1B in MDCK and FRT epithelial cells
APIB adaptor complex mediates basolateral sorting in a post-TGN compartment at the crossroads of the biosynthetic and recycling pathways
Autoantibodies against galectin-8 block adhesion and lamellipodia formation induced by galectin-8 in Jurkat cells
Cytosolic determinants for trafficking of a model GPI-protein to the cell surface
Silencing of m1B in MDCK and FRT epithelial cells redistributes LDL and transferrin receptors from basolateral to apical membrane.
Brefeldin A-induced tubules from trans-Golgi network accumulate by PKA inhibitors
Chimeric temperature-sensitive reporter proteins and cell-permeable peptides to disclose diversity on ER-to-Golgi and TGN-to-basolateral cell surface transport

Proyecto (11)

PKA-Mediated Regulation of EGFR Endocytic Traffikinig=> Molecular Mechanisms and Function
REGULATION OF IMMUNE SYNAPSES THROUGH CELL POLARITY=> IMPACT ON B CELL RESPONSES
REGULATION OF IMMUNE SYNAPSES THROUGH CELL POLARITY=> IMPACT ON B CELL RESPONSES
GAL-8 AS A NOVEL REGULATOR OF PROTEOSOMAL FUNCTION IN AUTOIMMUNITY AND CANCER
Proyecto Fondef Generación y desarrollo de nuevos fármacos para el tratamiento de cánceres dependientes del EGFR.
Function of Galectin-8 in the immune system and autoinmune diseases
Novel endocytic control of EGFR function through phosphatidic acid/PKA signaling.
Centro de Regeneración y Envejecimiento.
Función de la Gal-8 y los autoanticuerpos anti-Gal-8 en linfocitos T y su relación con autoinmunidad.
Identification and Characterization of cell surface Autoantibodies associated to the systemic lupus erythematosus.
Estudio de los mecanismos de reconocimiento de señales de destinación basolateral en células polarizadas
39
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

10
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

5
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

4
Jorge Cancino

Assistant Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

4
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

4
CLAUDIA CARCAMO

Profesor Asistente

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

3
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

3
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

3
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

2
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

1
Gloria Arriagada

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Hianara Bustamante

Profesor Adjunto Ad-Honorem

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Guillermo Valenzuela

Investigador Posdoctoral

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

1
Karina Cereceda

Investigador post doctoral

Diagnóstico

Fundación Arturo López Pérez

Providencia, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile