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GONZALO ANTONIO MARDONES COFRE

Associate Professor

Universidad San Sebastián

Valdivia, Chile

Cell & Molecular Biology; Membrane trafficking; Breast cancer; Protein trafficking; Golgi structure and function; Protein crystallography; Structural biology; Biomolecular condensates; Evolutionary cell biology

Cell & Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1995
Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Assistant Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicine

Valdivia, Chile

2010 - 2017
Associate Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicine

Valdivia, Chile

2019 - 2023
Associate Professor Part Time

Universidad San Sebastián

Medicine & Science

Santiago, Chile

2017 - 2018
Assistant Professor Part Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicine

Valdivia, Chile

2017 - 2018
Instructor Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

1998 - 1999
Associate Professor Full Time

Universidad San Sebastián

Medicine & Science

Valdivia, Chile

2023 - A la fecha

Research Fellow Full Time

National Institutes of Health

Bethesda, Estados Unidos

2008 - 2010
Postdoctoral Fellow Full Time

National Institutes of Health

Bethesda, Estados Unidos

2005 - 2008
Postdoctoral Fellow Full Time

University of Colorado Health Sciences Center

Denver, Estados Unidos

2003 - 2005
Assistant Professor Full Time

Universidad Austral de Chile

Valdivia, Chile

2010 - 2019
Associate Professor Full Time

Universidad Austral de Chile

Valdivia, Chile

2020 - 2023

2020 - Catalina Meléndez, Ph.D. Thesis student, Cell Biology & Biomedicine, Universidad San Sebastián. Efecto de GOLPH3 y su localización en el aparato de Golgi sobre la función mitocondrial y la agresividad tumoral en células de cáncer de mama. (Co-patrocinante).
2021 - 2023 Tammy Pástor, Undergraduate Thesis student, Biology, Yachay Tech University, Ecuador. "Caracterización evolutiva y funcional de la proteína GOLPH3 de mamíferos". (Tutor).
2021 - 2022 Abigail Galarza, Undergraduate Thesis student, Biotechnology, IKIAM Universidad Regional Amazónica, Ecuador. "Caracterización evolutiva y funcional de la proteína GOLPH3 de invertebrados". (Tutor).
2019 - 2021 Rodrigo Castro, Undergraduate Thesis student, Medical Technology, Universidad Austral de Chile. "Validación y caracterización de la interacción entre la oncoproteína de Golgi GOLPH3 y la GTPasa RAB2A". (Patrocinante).
2017 - 2020 Viviana Cavieres, Ph.D. Thesis student, Cell & Molecular Biology, Universidad Austral de Chile. Rol de GOLPH3 en la función de lisosomas de células tumorales. (Patrocinante).
2016 - 2019 Charlotte Luchsinger, Ph.D. Thesis student, Cell & Molecular Biology, Universidad Austral de Chile. GOLPH3 promotes the tumor phenotype favoring chemoresistance and cell migration in T98G cells of glioblastoma multiforme. (Patrocinante).
2014 - 2017 Cecilia Arriagada, Ph.D. Thesis student, Cell & Molecular Biology, Universidad Austral de Chile. Participación de GOLPH3 en la vía EGFR/mTOR y su rol en el fenotipo tumoral de células T98G de glioblastoma multiforme. (Patrocinante).
2013 - 2015 Gustavo Leal, Undergraduate Thesis student, Medical Technology, Universidad Austral de Chile. Función de la degradación de proteínas asociado a retículo endoplásmico, en control de los niveles de la proteína precursora del amiloide. (Co-patrocinante).
2013 - 2015 María José Tenorio, Undergraduate Thesis student, Medical Technology, Universidad Austral de Chile. Análisis del comportamiento de GOLPH3 en células tumorales de glándula mamaria humana mediante fluorescence recovery after photobleaching (FRAP). (Patrocinante).
2012 - 2014 Yennyfer Arancibia, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Participación de la proteína de tegumento VP11/12 del HSV-1 en la alteración del aparato de Golgi y eventos neurodegenerativos tempranos. (Co-patrocinante).
2012 - 2013 Silvia Ojeda, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Caracterización de la interacción proteína-proteína de alfa-SNAP wild type y de su mutante M105I. (Co-patrocinante).
2012 - 2014 Rodrigo Oyarzún, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Estudios funcionales de mutantes del transportador facilitativo de glucosa Glut-1. (Co-patrocinante).
2011 - 2014 Diego Acuña, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Análisis preliminar del proteoma del aparato de Golgi de células tumorales MCF-7 de glándula mamaria humana. (Tutor).
2011 - 2012 Camilo Muñoz, Undergraduate Thesis student, Medical Technology, Universidad Austral de Chile. Estudio de las consecuencias de la mutación puntual M105I en la proteína alfa-SNAP en su capacidad de interacción con membrana plasmática. (Co-patrocinante).
2010 - 2013 Esteban Corales, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Caracterización de sitios de unión para señales de destinación en la subunidad ?2 del complejo adaptador de proteínas AP-2. (Tutor).
2010 - 2013 Breyan Ross, Undergraduate Thesis student, Biochemistry, Universidad Austral de Chile. Caracterización estructural y funcional de los sitios de unión a señales de tirosina del complejo adaptador AP-1A. (Tutor).

Medalla Conmemorativa 2 de Octubre, Categoría Ciencias

Gobierno Región de Los Ríos

Chile, 2016

Distinción anual otorgada por contribución a la Región de Los Ríos, Chile, en categoría Ciencias
Honorable Mention Celldance 2007

American Society for Cell Biology

Estados Unidos, 2007

Distinction for contribution to outreach in Cell Biology in form of videomicroscopy
Postdoctoral Visiting Fellowship, John E. Fogarty International Center

NATIONAL INSTITUTE OF HEALTH

Estados Unidos, 2007

Postdoctoral fellowship
Postdoctoral Visiting Fellowship, John E. Fogarty International Center

NATIONAL INSTITUTE OF HEALTH

Estados Unidos, 2006

Postdoctoral Fellowship
Postdoctoral Visiting Fellowship, John E. Fogarty International Center

NATIONAL INSTITUTE OF HEALTH

Estados Unidos, 2008

Postdoctoral Fellowship
Travel Award

American Society for Cell Biology

Estados Unidos, 2001

Predoctoral travel award to participate in the 41st Annual Meeting of the American Society for Cell Biology, December 8-12, Washington DC, USA
Travel Award

American Society for Biochemistry and Molecular Biology

Estados Unidos, 2000

Predoctoral travel award to participate in the Annual meeting of the American Society for Biochemistry and Molecular Biology, June 4-8, Boston, MA, USA
Beca de doctorado

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 1997

Beca para estudiantes de doctorado


How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member Opazo, Juan C.; Vandewege, Michael W.; Hoffmann, Federico G.; Zavala, Kattina; Melendez, Catalina; Luchsinger, Charlotte; Cavieres, Viviana A.; Vargas-Chacoff, Luis; Morera, Francisco J.; Burgos, Patricia, V; Tapia-Rojas, Cheril; Mardones, Gonzalo A. Article ISI MOLECULAR BIOLOGY AND EVOLUTION (2023)
Identification of multiple TAR DNA Binding Protein retropseudogene lineages during the evolution of primates Opazo, Juan C.; Zavala, Kattina; Vargas-Chacoff, Luis; Morera, FJ; Mardones, Gonzalo A. Article ISI SCIENTIFIC REPORTS (2022)
Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics Aburto, Camila; Galaz, Alex; Bernier, Angelo; Yohana Sandoval, Pamela; Holtheuer-Gallardo, Sebastian; Ruminot, Ivan; Soto-Ojeda, Ignacio; Hertenstein, Helen; Aurelia Schweizer, Johanna; Schirmeier, Stefanie; Paulina Pastor, Tammy; Antonio Mardones, Gonzalo; Felipe Barros, Luis; San Martin, Alejandro Article ISI ACS SENSORS (2022)
Independent duplications of the Golgi phosphoprotein 3 oncogene in birds Opazo, Juan C.; Vandewege, MW; Gutierrez, J.; Zavala, Kattina; Vargas-Chacoff, Luis; Morera, FJ; Mardones, Gonzalo A. Article ISI SCIENTIFIC REPORTS (2021)
GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation Arriagada, Cecilia; Cavieres, Viviana A.; Luchsinger, Charlotte; Gonzalez, Alexis E.; Munoz, Vanessa C.; Cancino, Jorge; Burgos, Patricia, V; Mardones, Gonzalo A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B Cavieres, Viviana A.; Cerda-Troncoso, Cristobal; Rivera-Dictter, Andres; Castro, Rodrigo, I; Luchsinger, Charlotte; Santibanez, Natacha; Burgos, Patricia, V; Mardones, Gonzalo A. Article ISI PLOS ONE (2020)
Imaging of the Lactate/Pyruvate Ratio Using a Genetically Encoded Forster Resonance Energy Transfer Indicator Galaz, Alex; Cortes-Molina, Francisca; Arce-Molina, Robinson; Romero-Gomez, Ignacio; Antonio Mardones, Gonzalo; Barros, L. Felipe; San Martin, Alejandro Article ISI ANALYTICAL CHEMISTRY (2020)
Imaging of the Lactate/Pyruvate Ratio Using a Genetically Encoded FRET Indicator Galaz, Alex; Cortés-Molina, Francisca; Arce-Molina, Robinson; Romero-Goméz, Ignacio; Mardones, Gonzalo A.; Barros, L. Felipe; San Martín, Alejandro Article ISI Analytical Chemistry (2020)
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport Bustamante, Hianara A.; Cereceda, Karina; Gonzalez, Alexis E.; Valenzuela, Guillermo E.; Cheuquemilla, Yorka; Hernandez, Sergio; Arias-Munoz, Eloisa; Cerda-Troncoso, Cristobal; Bandau, Susanne; Soza, Andrea; Kausel, Gudrun; Kerr, Bredford; Mardones, Gonzalo A.; Cancino, Jorge; Hay, Ronald T.; Rojas-Fernandez, Alejandro; Burgos, Patricia, V Article ISI CELLS (2020)
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly Zamorano P, Koning T, Oyanadel C, Mardones GA, Ehrenfeld P, Boric MP, González A, Soza A, Sánchez FA. Article ISI SCOPUS CARCINOGENESIS (2019)
KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover Tapia, Diego; Jimenez, Tomas; Zamora, Constanza; Espinoza, Javier; Rizzo, Riccardo; Gonzalez-Cardenas, Alexis; Fuentes, Danitza; Hernandez, Sergio; Cavieres, Viviana A.; Soza, Andrea; Guzman, Fanny; Arriagada, gloria; Isabel Yuseff, Maria; Mardones, Gonzalo A.; Burgos, Patricia, V; Luini, Alberto; Gonzalez, Alfonso; Cancino, Jorge Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner. Arriagada, Cecilia; Luchsinger, Charlotte; González, Alexis E; Schwenke, Tomás; Arriagada, Gloria; Folch, Hugo; Ehrenfeld, Pamela; Burgos, Patricia V; Mardones, Gonzalo A Article PloS one (2019)
Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling Luchsinger, Charlotte; Aguilar, Marcelo; Burgos, Patricia, V; Ehrenfeld, Pamela; Mardones, Gonzalo A.; Jackson, Catherine L. Article ISI SCOPUS PLOS ONE (2018)
HIV/SIV-Nef=> Pas de trois Choreographies to Evade Immunity. daSilva, Luis L P; Mardones, Gonzalo A Article Trends in microbiology (2018)
Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein the MVB/lysosomal pathway. González, Alexis E; Muñoz, Vanessa C; Cavieres, Viviana A; Bustamante, Hianara A; Cornejo, Víctor-Hugo; Januário, Yunan C; González, Ibeth; Hetz, Claudio; daSilva, Luis L; Rojas-Fernández, Alejandro; Hay, Ronald T; Mardones, Gonzalo A; Burgos, Patricia V Article FASEB journal => official publication of the Federation of American Societies for Experimental Biology (2017)
Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the Amyloid Precursor Protein via the MVB/lysosomal pathway González, AE; Muñoz, VC; Cavieres, VA; Bustamante, HA; Cornejo, VH; Januário, YC; González, I; Hetz, C; da Silva, LL; Rojas-Fernández, A; Hay, RT; Mardones, GA; Burgos, PV Article FASEB Journal (2017)
CD4 down-regulation by HIV-1 Nef reveals distinct roles for γ1 and γ2 subunits of AP-1 complex in protein trafficking Tavares, LA; da Silva, EML; Silva-Januario, ME; Januario, YC; Carvalho, JV; Czernisz, E; Mardones, GA; da Silva, LLP Article J. Cell Sci. (2017)
CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the gamma 1 and gamma 2 subunits of the AP-1 complex in protein trafficking Tavares L.A., da Silva E.M.L.; da Silva-Januário M.E., Januário Y.C.; de Cavalho J.V., Czernisz É.S.; Mardones G.A., daSilva L.L.P. Article JOURNAL OF CELL SCIENCE (2017)
Î±-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility. Arcos, Alexis; Paola, Matilde de; Gianetti, Diego; Acuña, Diego; Velásquez, Zahady D; Miró, María Paz; Toro, Gabriela; Hinrichsen, Bryan; Muñoz, Rosa Iris; Lin, Yimo; Mardones, Gonzalo A; Ehrenfeld, Pamela; Rivera, Francisco J; Michaut, Marcela A; Batiz, Luis Federico Article Scientific reports (2017)
Distinct biochemical pools of Golgi phosphoprotein 3 in the human breast cancer cell lines MCF7 and MDA-MB-231 Tenorio M.J.; Ross B.H.; Luchsinger, C; Rivera-Dictter, A; Arriagada C.; Acuña D.; Aguilar, M; Cavieres, V; Burgos, P.V.; Ehrenfeld, P; Mardones G.A. Article ISI SCOPUS PLOS ONE (2016)
Inhibition of the Hantavirus fusion process by predicted domain III and stem peptides from glycoprotein Gc Barriga, GP; Villalón-Letelier, F; Márquez, CL; Bignon, EA; Acuña, R; Ross, BH; Monasterio, O; Mardones, GA; Vidal, SE; Tischler, ND Article PLoS Negl Trop Dis (2016)
Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. Barriga, Gonzalo P; Villalón-Letelier, Fernando; Márquez, Chantal L; Bignon, Eduardo A; Acuña, Rodrigo; Ross, Breyan H; Monasterio, Octavio; Mardones, Gonzalo A; Vidal, Simon E; Tischler, Nicole D Article PLoS neglected tropical diseases (2016)
Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. Barriga, Gonzalo P; Villalón-Letelier, Fernando; Márquez, Chantal L; Bignon, Eduardo A; Acuña, Rodrigo; Ross, Breyan H; Monasterio, Octavio; Mardones, Gonzalo A; Vidal, Simon E; Tischler, Nicole D Article PLoS neglected tropical diseases (2016)
Protein Kinase A Activity is Necessary for Fission and Fusion of Golgi to Endoplasmic Reticulum Retrograde Tubules Tenorio MJ; Luchsinger C; Mardones GA Article PLoS One (2015)
Protein kinase A activity is necessary for fission and fusion of Golgi to endoplasmic reticulum retrograde tubules. Tenorio, María J; Luchsinger, Charlotte; Mardones, Gonzalo A Article PloS one (2015)
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy Cavieres, Viviana A.; Gonzlez, Alexis; Muoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia-Rojas, Cheril; Otth, Carola.; Barrera, Mara Jos; Gonzlez, Carlos; Mardones, Gonzalo A.; Inestrosa, Nibaldo C; Burgos, Patricia, V; Lakshmana, Madepalli K. Article ISI SCOPUS PLOS ONE (2015)
Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons Mattera R; Farias GG; Mardones GA; Bonifacino JS Article PLoS Pathog (2014)
Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons. Mattera, Rafael; Farías, Ginny G; Mardones, Gonzalo A; Bonifacino, Juan S Article PLoS pathogens (2014)
Structural and functional characterization of cargo-binding sites on the mu4-subunit of adaptor protein complex 4 Ross BH; Lin Y; Corales EA; Burgos PV; Mardones GA Article PLoS One (2014)
Structural and functional characterization of cargo-binding sites on the Î¼4-subunit of adaptor protein complex 4. Ross, Breyan H; Lin, Yimo; Corales, Esteban A; Burgos, Patricia V; Mardones, Gonzalo A Article PloS one (2014)
Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex Mardones GA; Burgos PV; Lin Y; Kloer DP; Magadán JG; Hurley JH; Bonifacino JS Article J Biol Chem (2013)
Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells Bustamante HA; Rivera-Dictter A; Cavieres VA; Muñoz V; González A; Lin Y; Mardones GA; Burgos PV Article PLoS One (2013)
AGAP2 regulates retrograde transport between early endosomes and the TGN Shiba Y; Römer W; Mardones GA; Burgos PV; Lamaze C; Johannes L Article J Cell Sci (2010)
Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex Pérez-Victoria FJ; Schindler C; Magadán JG; Mardones GA; Delevoye C; Romao M; Raposo G; Bonifacino JS Article Mol Biol Cell (2010)
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex Burgos PV; Mardones GA; Rojas AL; daSilva LL; Prabhu Y; Hurley JH; Bonifacino JS Article Dev Cell (2010)
Termination of autophagy and reformation of lysosomes regulated by mTOR Yu L; McPhee CK; Zheng L; Mardones GA; Rong Y; Peng J; Mi N; Zhao Y; Liu Z; Wan F; Hailey DW; Oorschot V; Klumperman J; Baehrecke EH; Lenardo MJ Article Nature (2010)
Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes Popoff, Vincent; Mardones, Gonzalo A.; Bai, Siau-Kun; Chambon, Valerie; Tenza, Daniele; Burgos, Patricia V.; Shi, Anbing; Benaroch, Philippe; Urbe, Sylvie; Lamaze, Christophe; Grant, Barth D.; Raposo, Graca; Johannes, Ludger Article ISI TRAFFIC (2009)
The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting Mardones, Gonzalo A.; Burgos, Patricia V.; Brooks, Doug A.; Parkinson-Lawrence, Emma; Mattera, Rafael; Bonifacino, Juan S. Article ISI MOLECULAR BIOLOGY OF THE CELL (2007)
Selective plasma membrane permeabilization by freeze-thawing and immunofluorescence epitope access to determine the topology of intracellular membrane proteins Mardones, G; González A Article ISI SCOPUS JOURNAL OF IMMUNOLOGICAL METHODS (2003)
Chromogenic plate assay distinguishing bacteriolytic from bacteriostatic activity of an antibiotic agent Mardones, G; Venegas A. Article ISI SCOPUS JOURNAL OF MICROBIOLOGICAL METHODS (2000)
Hypothalamic-pituitary-adrenal axis function in patients with active rheumatoid arthritis: A controlled study using insulin hypoglycemia stress test and prolactin stimulation Gutiérrez M.A.; García, M. E.; Rodríguez, J. A.; Mardonez, G.; Jacobelli, S.; Rivero S. Article JOURNAL OF RHEUMATOLOGY (1999)


Interaction of human GOLPH3 with RAB1A and RAB1B: identification of a putative non-canonical effector Cavieres, V; Cerda, C; Rivera-Dictter, A; Castro, R; Burgos P.; Mardones, G Abstract ISI FEBS OPEN BIO (2018)
Analysis of GOLPH3 knocking-down on protein glycosylation, trafficking and function in cells T98G of glioblastoma multiforme. Momberg, CLA; Cavieres, V; Gonzalez, A; Burgos, PV; Mardones, GA Abstract ISI (2016)
Identification of novel regulators of Amyloid Precursor Protein by High Content Imaging siRNA Screening Bustamante, HA; Cheuquemilla, YI; Valenzuela, GE; Mardones, GA; Rojas-Fernandez, A; Hay, RT; Burgos, PV Abstract ISI (2016)
Defects in N-cadherin-based adherens junctions precede disruption of neural stem cells in alpha-SNAP mutant mice Miro, MP; Velasquez, ZD; Parga, C; Márquez G.; Toro, GC; Arcos A.; Munoz, C; Cavieres, V; Munoz, RI; Mardones, G; Burgos, PV; Batiz, L Abstract ISI INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2015)
Novel insights into the molecular mechanisms that mediated incorporation of the amyloid precursor protein into multivesicular bodies Cavieres, V; Bustamante, H; Gonzalez, AE; Ostrowski, M; Mardones, G; Burgos P. Abstract ISI FEBS JOURNAL (2015)
Regulation of the endolysosomal pathway by beclin-1 and its role in the proteolytic processing of the amyloid precursor protein González A; Cornejo, V; hetz C.; Mardones, G; Burgos P. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Analysis of GOLPH3 depletion in human glioblastoma multiforme T98G cells Arriagada C.; González A; Cavieres, V; Aguilar, M; Burgos P.; Mardones, G Abstract ISI FEBS JOURNAL (2014)
Depletion of Beclin-1 increases the delivery of cathepsin D and EGF receptor to lysosomes. González A; Cornejo, V; hetz C.; Mardones, G; Burgos P. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Endoplasmic reticulum-associated degradation controls the levels of amyloid precursor protein Yefi C; González A; Cavieres, V; Bustamante, H; Mardones, G; Burgos P. Abstract ISI FEBS JOURNAL (2014)
Depletion of Beclin-1 reduces the levels of carboxy terminal fragment beta of the amyloid precursor protein by a mechanism dependent on autophagosome function González A; Cornejo, V; hetz C.; Mardones, G; Burgos, PV Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
Galectin-8 increases cell proliferation activating Sonic Hedgehog and EGFR Pathways Doger, R; Oyanadel, C; Riquelme E.; Ross, B; Mardones, G; Soza A.; González A Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
APIB adaptor complex mediates basolateral sorting in a post-TGN compartment at the crossroads of the biosynthetic and recycling pathways Cancino j.; Mardones, G; Soza A.; González A Abstract MOLECULAR BIOLOGY OF THE CELL (2004)
An autoantigen contained in a cytosolic protein complex associates with the trans-Golgi network (TGN) Mardones, G; Melia R.; Jacobelli, S.; González A Abstract FASEB JOURNAL (2000)


Publisher Correction: ?-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility (Scientific Reports, (2017), 7, 1, (11765), 10.1038/s41598-017-12292-9) Arcos A.; de Paola M.; Gianetti D.; AcuÃ±a D.; VelÃ¡squez Z.D.; MirÃ³ M.P.; Toro G.; Hinrichsen B.; MuÃ±oz R.I.; Lin Y.; Mardones G.A.; Ehrenfeld P.; Rivera F.J.; Michaut M.A.; Batiz L.F. Errata SCOPUS SCIENTIFIC REPORTS (2020)


Evolution of the N-terminal region of the Golgi phosphoprotein 3 (GOLPH3) oncoprotein Opazo, Juan C.; Mardones, GA Proyecto (2021)
Partitioning of the oncoprotein GOLPH3 in biomolecular condensates by liquid-liquid phase separation: a mechanism for the phenotypic plasticity of breast cancer cells Mardones, GA; Burgos, PV; Ehrenfeld, Pamela Proyecto (2021)
The interplay between phosphorylation and ubiquitylation controls stabilization of HERPUD1 under ER stress: possible implications on TNBC aggressiveness Burgos, PV; Mardones, GA Proyecto (2021)
Selective catabolic degradation of the endoplasmic reticulum by an Atg5-independent mechanism=> identification of molecular players FONDECYT (1171649) Proyecto 2017-2020 Coinvestigador(a)
Characterization of new protein interactions of the Golgi protein GOLPH3 in cancer cell lines=> identification of new therapeutic targets FONDECYT (1161252) Proyecto 2016-2020 Inv. Responsable
Unidad de cristalización de proteínas FONDEQUIP (EQM160182) Proyecto 2016-2018 Director(a)
Microscopio Spinning-Disk FONDEQUIP (EQM150118) Proyecto 2015-2017 Subdirector(a)
Núcleo de Investigación de Excelencia CISNe=> Centro Interdisciplinario de Estudios del Sistema Nervioso Dirección de Investigación Universidad Austral de Chile (DID-UACh) Proyecto 2015-2018 Coinvestigador(a)
Vigilancia activa de hantavirus FIC Región de los Ríos (FIC15-20) Proyecto 2015-2017 Coinvestigador(a)
Desarrollo de una plataforma de análisis de interacciones moleculares para el fortalecimiento de la investigación en ciencias biomédicas y biotecnológicas en la Universidad Austral de Chile FONDEQUIP (EQM140116) Proyecto 2014-2016 Subdirector(a)
Tracking newly-synthesized APP through the secretory pathway with the RUSH system under normal and cellular stress conditions in neuronal cells PCI (C14B03) Proyecto 2014-2017 Coinvestigador(a)
Use of siRNA screening to identify ubiquitin-related pathways involved in Alzheimer's Disease PCI (20140068) Proyecto 2014-2017 Coinvestigador(a)
Golgi proteome in cancer=> identification of new therapeutic targets FONDECYT (1130710) Proyecto 2013-2016 Inv. Responsable
Protective degradation of amyloid precursor protein regulated by ER stress, ERAD, and sorting into lysosomes through MVBs and autophagosomes FONDEF (1130929) Proyecto 2013-2017 Coinvestigador(a)
Modulation of the stress sensors AMPK- and Sirtuin 1-dependent pathways during Herpes simplex virus type 1 neuronal infection FONDECYT (1120464) Proyecto 2012-2015 Coinvestigador(a)
MOLECULAR CHARACTERIZATION OF A NEW CARGO-BINDING SITE ON MU-SUBUNITS OF ADAPTOR PROTEIN COMPLEXES; IMPLICATIONS FOR PROTEIN TRAFFICKING AND CELL PHYSIOLOGY. FONDECYT (1100896) Proyecto 2010-2013 Inv. Responsable
ROLE OF THE MULTIVESICULAR BODY/LYSOSOMAL PATHWAY AND ESCRT MACHINERY IN THE TURNOVER OF THE AMYLOID PRECURSOR PROTEIN; IMPLICATIONS FOR AMYLOID-BETA GENERATION AND ALZHEIMER'S DISEASE. FONDECYT (1100027) Proyecto 2010-2013 Coinvestigador(a)
BUSQUEDA DE ELEMENTOS MOLECULARES INVOLUCRADOS EN LA MAQUINARIA EXOCITICA DE PROTEINAS FONDECYT (2990027) Proyecto 1999-2002 Inv. Responsable
ESTUDIO DE LA FUNCION DEL EJE HIPOTALAMO-HIPOFISIS-SUPRARRENAL Y DE LA PRODUCCION DE PROLACTINA POR CELULAS DEL SISTEMA INMUNE EN PACIENTES CON LUPUS ERITEMATOSO SISTEMICO Y ARTRITIS REUMATOIDEA. FONDECYT (1951217) Proyecto 1995-1996 Personal técnico y/o de apoyo


Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features Ladinsky M.S.; Mardones G.A.; Orlicky D.J.; Howell K.E.; McManaman J.L. Review ISI SCOPUS JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2019)

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Hianara Bustamante

Profesora Auxiliar

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Guillermo Valenzuela

Investigador Posdoctoral

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

CECILIA ARRIAGADA

Postdoctoral Fellow

Rutgers University

Newark, Estados Unidos

Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

ALEX GALAZ

COFOUNDER (Co-CEO)

INFOOD PROTEIN AND BIOTECHNOLOGY

VALDIVIA, Chile

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Karina Cereceda

Investigador post doctoral

Diagnóstico

Fundación Arturo López Pérez

Providencia, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Diego Tapia

Asistente de Investigación

Universidad San Sebastián

Santiago, Chile

Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

Juan Opazo

Profesor Titular

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

Ivan Ruminot

INVESTIGADOR

BIOLOGIA

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

Angelo Bernier

Tesista de Magíster

Biología

Centro de Estudios Científicos de Valdivia

Valdivia, Chile

GONZALO ANTONIO MARDONES COFRE

Líneas de Investigación

Educación

Cell & Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003

Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1995

Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

Assistant Professor Full Time

Associate Professor Full Time

Associate Professor Part Time

Assistant Professor Part Time

Instructor Part Time

Associate Professor Full Time

Experiencia Profesional

Research Fellow Full Time

Postdoctoral Fellow Full Time

Postdoctoral Fellow Full Time

Assistant Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Premios y Distinciones

Medalla Conmemorativa 2 de Octubre, Categoría Ciencias

Honorable Mention Celldance 2007

Postdoctoral Visiting Fellowship, John E. Fogarty International Center

Postdoctoral Visiting Fellowship, John E. Fogarty International Center

Postdoctoral Visiting Fellowship, John E. Fogarty International Center

Travel Award

Travel Award

Beca de doctorado

Article (41)

Abstract (13)

Errata (1)

Proyecto (19)

Selective catabolic degradation of the endoplasmic reticulum by an Atg5-independent mechanism=> identification of molecular players

Characterization of new protein interactions of the Golgi protein GOLPH3 in cancer cell lines=> identification of new therapeutic targets

Unidad de cristalización de proteínas

Microscopio Spinning-Disk

Núcleo de Investigación de Excelencia CISNe=> Centro Interdisciplinario de Estudios del Sistema Nervioso

Vigilancia activa de hantavirus

Desarrollo de una plataforma de análisis de interacciones moleculares para el fortalecimiento de la investigación en ciencias biomédicas y biotecnológicas en la Universidad Austral de Chile

Tracking newly-synthesized APP through the secretory pathway with the RUSH system under normal and cellular stress conditions in neuronal cells

Use of siRNA screening to identify ubiquitin-related pathways involved in Alzheimer's Disease

Golgi proteome in cancer=> identification of new therapeutic targets

Protective degradation of amyloid precursor protein regulated by ER stress, ERAD, and sorting into lysosomes through MVBs and autophagosomes

Modulation of the stress sensors AMPK- and Sirtuin 1-dependent pathways during Herpes simplex virus type 1 neuronal infection

MOLECULAR CHARACTERIZATION OF A NEW CARGO-BINDING SITE ON MU-SUBUNITS OF ADAPTOR PROTEIN COMPLEXES; IMPLICATIONS FOR PROTEIN TRAFFICKING AND CELL PHYSIOLOGY.

ROLE OF THE MULTIVESICULAR BODY/LYSOSOMAL PATHWAY AND ESCRT MACHINERY IN THE TURNOVER OF THE AMYLOID PRECURSOR PROTEIN; IMPLICATIONS FOR AMYLOID-BETA GENERATION AND ALZHEIMER'S DISEASE.

BUSQUEDA DE ELEMENTOS MOLECULARES INVOLUCRADOS EN LA MAQUINARIA EXOCITICA DE PROTEINAS

ESTUDIO DE LA FUNCION DEL EJE HIPOTALAMO-HIPOFISIS-SUPRARRENAL Y DE LA PRODUCCION DE PROLACTINA POR CELULAS DEL SISTEMA INMUNE EN PACIENTES CON LUPUS ERITEMATOSO SISTEMICO Y ARTRITIS REUMATOIDEA.

Review (1)