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Ivan Marcelo Ruminot Moraga

Profesor asociado

Universidad San Sebastián

VALDIVIA, Chile

Metabolismo energético cerebral; Interacción neurona-astrocito Mecanismos de regulación de pH y su relación con el metabolsmo celular Rol del glicogeno en la energización celular Rol de los astrocitos en la dinámica energética posterior a la isquemia

DOCTORADO EN CIENCIAS MENCION BIOLOGÍA CELULAR Y MOLECULAR, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2012
LICENCIATURA EN BIOQUÍMICA, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005
BIOQUÍMICO, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Profesor Asistente Part Time

UNIVERSIDAD SANTO TOMAS

2009 - 2012
Postdoctoral fellow Full Time

UNIVERSITY OF KAISERSLAUTERN

Kaiserslautern, Alemania

2012 - 2015
INVESTIGADOR POSTDOCTORAL Full Time

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

2015 - 2018
INVESTIGADOR Full Time

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIIVIA, Chile

2018 - A la fecha
Profesor asociado Full Time

Universidad San Sebastián

Ciencias de la rehabilitación y calidad de vida

Valdivia, Chile

2022 - A la fecha

Asistente de investigación

Centro de Estudios Científicos

Chile

2005 - 2007

Jana Schmälzle, Bachelor in Science, TU Kaiserslautern, Germany
Dominik Appel, Master in Science, TU Kaiserslautern, Germany
Belén Leyton, Tecnología Médica, Universidad Austral de Chile, Valdivia
Hector Oyarzún, Tecnología Médica, Universidad Austral de Chile, Valdivia
Pablo Castro, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Matias Ditzel, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Paloma Soto, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Sebastián Holtheuer, Escuela de Bioquímica, Universidad Austral de Chile, Valdivia
Scarleth Quiroz, Escuela de Tecnología Médica, Universidad San Sebastián, Valdivia
Millaray Madrid, Escuela de Tecnología Médica, Universidad San Sebastián, Valdivia
Valentina Nicoreo, Escuela de Tecnología Médica, Universidad San Sebastián, Valdivia

Participación continua en el programa de difusión científica "Científicos por un mes", dirigido a estudiantes secundarios quienes desarrollan un proyecto científico en los laboratorios del Centro de Estudios Científicos.


Acute stimulation of glucose metabolism by H2O2 sustains the NADPH steady-state under oxidative stress Aburto C.; Ruminot, I; San Martin A. Article ISI SCOPUS Redox Biology (2025)
APOE genotype-dependent differences in human astrocytic energy metabolism Budny, V; Bodenmann, C; Zürcher, KJ; Krüger, M; de Leeuw, SM; Weber, RZ; Rust, R; Ravotto, L; Ruminot, I; Barros L.F.; et al. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2025)
Dietary Fiber Modulates the Release of Gut Bacterial Products Preventing Cognitive Decline in an Alzheimer's Mouse Model Cuervo-Zanatta, D; Syeda, T; Sánchez-Valle, V; Irene-Fierro, M; Torres-Aguilar, P; Torres-Ramos, MA; Shibayama-Salas, M; Silva-Olivares, A; Noriega, LG; Torres N.; et al. Article ISI SCOPUS Cellular and Molecular Neurobiology (2023)
Enlightening brain energy metabolism Barros L.F.; Ruminot, I; Sandoval P.Y.; San Martin A. Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2023)
CO2 signaling mediates neurovascular coupling in the cerebral cortex Hosford P.S.; Wells J.A.; Nizari S.; Christie I.N.; Theparambil S.M.; Castro P.A.; Hadjihambi A.; Barros L.F.; Ruminot, I; Lythgoe M.F.; et al. Article SCOPUS NATURE COMMUNICATIONS (2022)
Inhibition of the sodium-dependent HCO 3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Philp A.R.; Villanueva, Sandra; Ruminot, Ivan; Carrasco, Cristian; Gray, Michael A.; Flores, Carlos A. Article ISI SCOPUS eLife (2022)
Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics Aburto, Camila; Bernier, Angelo; Yohana Sandoval, Pamela; Holtheuer-Gallardo, Sebastian; Ruminot, Ivan; Soto-Ojeda, Ignacio; Hertenstein, Helen; Aurelia Schweizer, Johanna; Paulina Pastor, Tammy; Felipe Barros, Luis Article ISI SCOPUS ACS Sensors (2022)
Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur Barros L.F.; Ruminot, I; San MartÃƒÂn A.; Lerchundi R.; FernÃƒÂ¡ndez-Moncada I.; Baeza-Lehnert F. Article ISI SCOPUS Neurochemical Research (2021)
Bidirectional astrocytic GLUT1 activation by elevated extracellular K+ Castro, Pablo; Epp, Robert; Ruminot, Ivan Article ISI SCOPUS GLIA (2021)
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle Hosford, Patrick S.; Ruminot, Ivan; Kopach, Olga; Reynolds, James R.; Rusakov, Dmitri A.; Gourine, Alexander, V Article ISI SCOPUS NATURE COMMUNICATIONS (2020)
Fluid Brain Glycolysis: Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate Ruminot, Ivan; Rauseo, Daniela; Valdivia, Sharin Article ISI SCOPUS Neurochemical Research (2020)
GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells Inostroza, Eveling; Venegas, Camila; Ruminot, Ivan; Maldonado, Mafalda; RIVAS, Coralia I.; Carlos Vera, Juan; Mardones, Lorena Article ISI SCOPUS JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue Ruminot, I; Schmalzle, J; Deitmer JW Article ISI SCOPUS JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)
Proton Fall or Bicarbonate Rise GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION Theparambil, Shefeeq M.; Weber, Tobias; Schmälzle, Jana Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes Sotelo-Hitschfeld, T; Niemeyer M.I.; Machler, P; Ruminot, I; Lerchundi R.; Wyss M.T.; Stobart J.; Fernández-Moncada, I; Valdebenito R.; Garrido-Gerter, P; et al. Article ISI SCOPUS Journal of Neuroscience (2015)
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function Jamali, S; Klier, M; Ames, S; Barros L.F.; McKenna, R; Deitmer JW; Becker, HM Article ISI SCOPUS Scientific Reports (2015)
Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859 Heidtmann, Hella; Ruminot, Ivan; Becker, Holger M. Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
The role of membrane acid/base transporters and carbonic anhydrases for cellular pH and metabolic processes Ruminot, Ivan Article ISI FRONTIERS IN NEUROSCIENCE (2015)
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices Jakoby, P; Schmidt E.; Ruminot, I; Gutiérrez, R.; Barros L.F.; Deitmer JW Article ISI CEREBRAL CORTEX (2014)
The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes Ruminot, Ivan; Schneider, Hans-Peter Article ISI JOURNAL OF NEUROSCIENCE (2014)
A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells San Martin A.; Ceballo, S; Ruminot, I; Lerchundi R.; Frommer W.B.; Barros L.F. Article ISI SCOPUS PLOS ONE (2013)
Small is fast: astrocytic glucose and lactate metabolism at cellular resolution Barros L.F.; San Martin A.; Sotelo-Hitschfeld, T; Lerchundi R.; Fernández-Moncada, I; Ruminot, I; Gutiérrez, R.; Valdebenito R.; Ceballo, S; Alegria, K; et al. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate bittner cx; Valdebenito R.; Ruminot, I; Loaiza A.; Larenas V; Sotelo-Hitschfeld, T; Moldenhauer, H; San Martin A.; Gutiérrez, R.; Zambrano M.; et al. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2011)
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+ Ruminot, I; Gutiérrez, R.; Peña-Münzenmayer, G; Añazco, C; Sotelo-Hitschfeld, T; Lerchundi R.; Niemeyer M.I.; Shull, GE; Barros L.F. Article ISI SCOPUS Journal of Neuroscience (2011)
Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes Barros L.F.; bittner cx; Loaiza A.; Ruminot, I; Larenas V; Moldenhauer, H; Oyarzun C.; Álvarez, M. Article ISI SCOPUS Journal of Neurochemistry (2009)
Preferential Transport and Metabolism of Glucose in Bergmann Glia over Purkinje Cells: A Multiphoton Study of Cerebellar Slices Barros L.F.; Courjaret, R; Jakoby, P; Loaiza A.; Lohr, C; Deitmer JW Article ISI SCOPUS GLIA (2009)
Na+-Ca2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured Astrocytes Ruminot, I; Loaiza A.; Barros L.F. Article ISI SCOPUS GLIA (2008)
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload Castro J.; Ruminot, I; Flores, CM; Hermosilla T.; Verdugo, E; Venegas F.; Hartel S.; Michea L.; Barros L.F. Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2006)


Imaging dynamics of energy metabolites in hippocampal astrocytes during neuronal activity Ruminot, I; Schmalzle, J; Heidtmann, H; Barros L.F.; Deitmer JW Abstract ISI GLIA (2015)
Non-catalytic enhancement of H+-coupled lactate transport by carbonic anhydrase IX in MCF-7 breast cancer cells Jamali, S; Barros F.; Deitmer JW; Becker, HM Abstract ISI ACTA PHYSIOLOGICA (2015)
EXPRESSION OF GLUCOSE TRANSPORTER 8 IS ASSOCIATED WITH LACTOSE SYNTHESIS IN MAMMARY GLAND OF MICE. Villagran M.; Munoz, M.; Muñoz, K; Ruminot, I; Venegas C.; del Pozo, R; Mardones L. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
K+ AND GLUTAMATE TRIGGER THE RELEASE OF LACTATE FROM ASTROCYTES WITHIN SECONDS, AS DETECTED BY A LACTATE SNIFFER CELL Hitschfeld, TS; Ruminot, I; San Martin A.; Barros L.F. Abstract ISI GLIA (2013)
Single-cell real-time energy metabolism observed with FRET biosensors Barros L.F.; Ruminot, I; Gutiérrez, R.; San Martin A.; Sotelo-Hitschfeld, T; Lerchundi R.; Valdebenito R.; Fernández-Moncada, I; Baeza-Lehnert F. Abstract ISI JOURNAL OF NEUROSCIENCE RESEARCH (2013)
PEEKING INTO THE EARLY NEUROMETABOLIC RESPONSE Ruminot, I; bittner cx; Gutiérrez, R.; Valdebenito R.; Añazco, C; Peña-Münzenmayer, G; Sotelo-Hitschfeld, T; Lerchundi R.; San Martin A.; Niemeyer M.I.; et al. Abstract ISI GLIA (2011)
DIFFERENTIAL TRANSPORT AND METABOLISM OF FLUORESCENT GLUCOSE IN CEREBELLAR SLICES Jakoby, P; Courjaret, R; Loaiza A.; Lohr, C; Barros L.F.; Deitmer JW Abstract ISI GLIA (2009)


Embracing the Modern Biochemistry of Brain Metabolism Bolaños, JP; Alberini, CM; Almeida A.; Barros L.F.; Bonvento, G; Bouzier-Sore, AK; Dringen, R; Hardingham, GE; Hirrlinger, J; Magistretti, PJ; et al. EditorialMaterial ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2025)


Astrocytic metabolism after ischemic stress Proyecto (2019)
Synergic metabolic signaling by noradrenaline and K+ in astrocytes Proyecto Development of an optical method to estimate acute glycogen mobilization in single astrocytes. Investigate the impact of fast glycogen mobilization on glucose consumption in astrocytes stimulated with noradrenaline and increases of extracellular K+. (2019)


Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer's disease Budny, V; Ruminot, I; Wybitul, M; Treyer, V; Barros L.F.; Tackenberg, C Review ISI SCOPUS Translational Psychiatry (2025)
Metabolic Recruitment in Brain Tissue Barros L.F.; Ruminot, I; Sotelo-Hitschfeld, T; Lerchundi R.; Fernández-Moncada, I Review ISI SCOPUS Annual Review of Physiology (2023)
Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis Theparambil S.M.; Noor S.I. Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2019)
Glucose and lactate supply to the synapse Barros L.F.; Deitmer JW Review ISI SCOPUS Brain Research Reviews (2010)

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Mirna Muñoz

Profesor Asistente

Ciencias Básicas

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Alejandro San Martin

Senior Reseacher

Biología

CENTRO DE ESTUDIOS CIENTIFICOS

Valdivia, Chile

Carolina Añazco

Associate Professor

Nutrition and Dietetics

Universidad San Sebastián

Valdivia, Chile

ESTEBAN PARRA

Médico Staff

Hospital Las Higueras

Concepción, Chile

Ivan Ruminot

Profesor asociado

Universidad San Sebastián

VALDIVIA, Chile

MAFALDA MALDONADO

PROFESOR ASOCIADO

Fisopatología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

Pamela Sandoval

Postdoctoral Researcher

Biología

Centro de Estudios Científicos -CECs-

Valdivia, Chile

Reginald del Pozo

Profesor Asociado

Ciencias Básicas

Universidad Catolica de la Santisima Concepcion

Concepción, Chile

MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

Sharin Valdivia

Profesor asistente

Departamento de Ciencias Biológicas y Químicas

Universidad San Sebastián

Concepción, Chile

ALEX GALAZ

COFOUNDER (Co-CEO)

INFOOD PROTEIN AND BIOTECHNOLOGY

VALDIVIA, Chile

Angelo Bernier

Tesista de Magíster

Biología

Centro de Estudios Científicos de Valdivia

Valdivia, Chile

Carla Bittner

Profesor Asociado

Departamento de Salud

Universidad de Los Lagos

Puerto Montt, Chile

Camila Aburto

PhD(c)

Biología

Centro de estudios Científicos

Valdivia, Chile

Ivan Marcelo Ruminot Moraga

Líneas de Investigación

Educación

DOCTORADO EN CIENCIAS MENCION BIOLOGÍA CELULAR Y MOLECULAR, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2012

LICENCIATURA EN BIOQUÍMICA, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

BIOQUÍMICO, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Experiencia Académica

Profesor Asistente Part Time

Postdoctoral fellow Full Time

INVESTIGADOR POSTDOCTORAL Full Time

INVESTIGADOR Full Time

Profesor asociado Full Time

Experiencia Profesional

Asistente de investigación

Formación de Capital Humano

Difusión y Transferencia

Article (28)

Abstract (7)

EditorialMaterial (1)

Proyecto (2)

Review (4)