Man

CORALIA ISABEL RIVAS ROCCO

Associated Professor

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Líneas de Investigación


1. Pathophysiology and Pharmacology of vitamin C 2. Antioxidants and Free Radicals in Cancer 3. Cellular and Molecular Biology of Redox Systems 4. Molecular and Structural Biology of Transports 5. Mitochondrial, Neurodegenerative Diseases

Educación

  •  BIOLOGÍA CELULAR Y MOLECULAR, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2003
  •  INMUNOLOGÍA, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1986
  •  CIENCIAS, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1977

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepcion, Chile

    2008 - A la fecha

  •   Academic Assistant Part Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Sciences

    Valdivia, Chile

    1983 - 1986

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepcion, Chile

    2004 - 2007

  •   Research Fellow Full Time

    UNIVERSITY OF COLORADO-DENVER

    Denver, Estados Unidos

    1986 - 1988

Experiencia Profesional

  •   CO-DIRECTOR LABORATORIO Full Time

    UNIVERSIDAD DE CONCEPCION

    Concepcion, Chile

    2002 - 2004

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE CONCEPCION

    Concepcion, Chile

    2004 - 2008

  •   Research Fellow Full Time

    University of Colorado Health Sciences Center

    Denver, Estados Unidos

    1986 - 1988

  •   Research Fellow Full Time

    Laboratory of Membrane Developmental Biology, Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center

    New York, Estados Unidos

    1988 - 1990

  •   Research Assistant Full Time

    Laboratory of Hematopoietic Kinetics, Program in Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center

    New York, Chile

    1990 - 1991

  •   Research Assistant Full Time

    Laboratory of Cellular and Molecular Hematology, Program in Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center

    New York, Estados Unidos

    1992 - 1996

  •   Research Associate Full Time

    Laboratory of Cellular and Molecular Hematology, Program in Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center

    New York, Estados Unidos

    1997 - 2001

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE CONCEPCION

    CONCEPCIÓN, Chile

    2008 - A la fecha

  •   Directora Sec. Graduado Facultad de Ciencias Biológicas Other

    UNIVERSIDAD DE CONCEPCION

    Concepción, Chile

    2014 - 2016

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE CONCEPCION

    CONCEPCIÓN, Chile

    2008 - A la fecha

Formación de Capital Humano


Management Thesis

Undergraduate Thesis Direction

1. Student: Kirsty Jane Mansfield Sotomayor . Title of Biochemistry , University of Concepcion . Thesis title : Characterization of the accumulation of vitamin C and reductase expression in the tumor cell line DU-145 . completed 2004

2 . Student: Michelle Maurin Marietta Meier . Title of Biochemistry , University of Concepcion . Thesis title : Characterization of the transport of vitamin C in breast cancer cells Ended 2005

3. Student: Carlos Alberto Soliz Soto. Career : Biochemistry, University of Concepcion Title Thesis: Cloning and functional characterization of glutaredoxins present in prostate tumor cells . Presentation Date : January Finalized 2007.

4 . Student: Exequiel Sobarzo Adolay Escares . Stroke: BS in Medical Technology, Title Practice , University of Concepcion . Thesis title : Characterization of ascorbic acid transporters and SVCT2 SVCT1 in prostate tissue samples . Presentation Date : Completed 2007 .

5. Student: Eduardo Andrés Peña Alarcón. Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis title : Characterization of ascorbic acid transporters in SVCT2 SVCT1 and breast tissue samples . Presentation Date : Completed 2007 .

6 . Student: Alejandra Espinoza Karena Saavedra. Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Application of In Situ Hybridization Technique for detecting vitamin C transporter SVCT2 . Presentation Date : Completed 2008 .

7 . Student: Andrea Riquelme Gizella Balogh . Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Application of the FISH technique for the detection of vitamin C transporter SVCT2 . Presentation Date : Completed 2008 .

8 . Student: Carlos Alejandro Toro Chacon. Career : Biochemistry, University of Concepcion. Thesis Title : Generation of biotechnological tools for marking structures in living cells. Presentation Date : Completed 2008 .

9. Student: Evelyn Alvarado Mariana Gonzalez . Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis title : Characterization of vitamin C transporter liver stellate cells I. Presentation Date : Completed 2009 .

10 . Student: Favio Araneda Valdes . Stroke: BS in Medical Technology , Title Practice , University of Concepcion Thesis Title : Characterization of vitamin C transporter in liver stellate cells II . Presentation Date : Completed 2009 .

11. Student: Maria Josefa Lopez Hermosilla. Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Expression of GLUT1 transporter in colon cancer progression I. Presentation Date : Completed 2009 .

12. Student : Isabel Andrea Riffo IBACA . Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Expression of GLUT1 transporter in colon cancer progression II. Presentation Date : Completed 2009 .

13. Student: Viviana Marcela Suazo Paz Muñoz . Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Implementation of the technique by vascular perfusion for histological study of expression of transporters of vitamin C in rats I. Presentation Date : Completed 2009 .

14. Student: Amnie Rose Vasquez Castro. Stroke: BS in Medical Technology , Title Practice , University of Concepcion . Thesis Title : Implementation of the technique by vascular perfusion for histological study of expression of transporters of vitamin C in rats II . Presentation Date : Completed 2009 .

15. Student: Dominique Marisel Medina Nuñez . Career : BA in Biology, University of Concepcion . Thesis Title Research Unit : TrxR1 expression and participation in the processes of accumulation and recycling of vitamin C on prostate cancer. Presentation Date : Completed 2010 .

16. Student: Francisco Javier Roa Cartes . Career : Biochemistry, University of Concepcion . Title Dissertation: Regulation of the expression of Vitamin C transporter in response to oxidative stress in breast cancer cells . Presentation Date : Completed 2011 .

17. Student: Jorge Luis Vera Becerra . Career : Biochemistry, Universidad Austral de Chile. Thesis title : Characterization of residues involved in binding the substrate exofacial conveyor SVCT2 ascorbic acid . Presentation Date : Completed 2011

18. Student: Dominique Marisel Medina Nuñez . Stroke: Biologist, University of Concepción. Seminar Title : Participation of TrxR1 in the accumulation and recycling of vitamin C on prostate cancer. Presentation Date : Completed 2011 .

19. Student: José Luis Galdames Hidalgo. Stroke: BS in Medical Technology , Title Practice, University of Concepcion. Thesis Title :Immunolocalization of Vitamin C Transporter Proteins in Colon Cancer Tissues. Presentation Date : Completed 2012

20. Student: Dominique Letic Troncoso Monsalve. Stroke: BS in Medical Technology , Title Practice, University of Concepcion . Thesis Title: Expression of SVCT2 transporter under hormonal treatment in breast cancer cell lines. Presentation Date : Completed 2012.

21. Student: Jorge Esteban Peñaranda Flores. Stroke: BS in Medical Technology, Title Practice, University of Concepcion. Thesis Title: Expression of the ascorbic acid transporter SVCT2 under hormonal treatment in breast cancer cell lines. Presentation Date : Completed 2012.

22. Student: Alejandro Eduardo Fernández Moya. Stroke: BS in Medical Technology, Title Practice, University of Concepcion. Thesis Title: Modulation of the expression of vitamin C transporters in experimental diabetes Step 1. Presentation Date : Completed 2015.

23. Student: Maríajosé C. Marchant Nahuel. Stroke: BS in Medical Technology, Title Practice, University of Concepcion. Thesis Title: Modulation of the expression of vitamin C transporters in experimental diabetes Step 2. Presentation Date : Completed 2015.

24. Student: Alonso A. Del Pino Yáñez. Stroke: BS in Medical Technology, Title Practice, University of Concepcion. Thesis Title: Modulation of the expression of vitamin C transporters in experimental diabetes Step 3. Presentation Date : Completed 2015.

Professor Undergraduate Thesis Evaluation Committee

1. Student: Paula Camila Fahrenkrog Stefania Sotomayor . Career : Biochemistry, University of Concepción . Thesis title : Characterization of ascorbic acid transporter in kidney cell lines (HEK -293 , and MDCK OK). Presentation Date : Completed 2005 .

2 . Student: Maria Elizabeth Escobar Sagredo . Career : Biochemistry, University of Concepción .
Thesis title : Accumulation of vitamin C and expression of dehydroascorbic acid reductase in human myeloid leukemia cells HL-60 . Presentation Date : Completed 2005 .

3 . Student: Marcelo Alejandro Villagrán Orellana. Career : Biochemistry, University of Concepción . Title Dissertation: Regulation of the expression of the messenger RNA sodium transporter 1 ascorbic acid ( SVCT1 ) in human rectal adenocarcinoma cells ( Caco-2 ) deficient in glutathione. Presentation Date : Completed 2006 .

4 . Student: Henny Marianne Haensgen Sáez . Career : Biochemistry, University of Concepción . Thesis title : Importance binding sites Ca2 + and Mg2 + in the transport mechanism of ascorbic acid transporter mediated SVCT2 . Presentation Date : Completed 2007 .

5 . Student: Carlos Francisco Aylwin Ramirez. Career : Biochemistry, University of Concepción . Thesis title : Identification of binding sites as nucleotide regulatory domains in SVCT2 ascorbic acid transporter . Presentation Date : Completed 2007 .

6. Student: Alejandra Andrea Muñoz Vega. Career : Biochemistry, University of Concepción . Degree thesis : Contribution and functional analysis of chimeric ascorbic acid transporters SVCT1 - SVCT2 . Presentation Date : Completed 2007 .

7 . Student: Felipe Ignacio Paredes Díaz . Career : Biochemistry, University of Concepción . Thesis Title : Development of a method for identifying bioinformatic functionally important amino - structural membrane proteins. Presentation Date : Completed 2010 .

8. Student: David Andrés Escobar Flores. Career : Biochemistry, University of Concepción . Thesis title : Molecular Analysis of the regulation of the expression of Vitamin C transporters in human cells CaCo2 . Presentation Date : Completed 2010 .

9. Student: Esteban Francis Caamaño Molina. BS in Biology, University of Concepción . Thesis title : Standardization of an in vitro model of hepatic oxidative stress induced by carbon tetrachloride . Completed 2012.

10 . Student: Paulina Andrea Saavedra Sieyes . Career: Biology, University of Concepción . Thesis Title : Expression of SMRT and NCOR corepresores in prostate cancer. Completed 2012.

11. Student: Cristina Angélica Padilla Ruiz. Career : Biochemistry, University of Concepción . Thesis title : Cloning, expression and functional characterization of SVCT3, a new member of the ascorbic acid transporter family . Presentation Date : Completed 2012 .

12. Student: Maria de Los Angeles Sepulveda Parada . Career : Biochemistry, University of Concepción . Thesis title : Analysis of the functional importance of amino acid residues binding domain transporter exofacial SVCT1 ascorbic acid . Presentation Date : Completed 2012.

13. Student: Karen Susan Sweet Alvarado. Career : Biochemistry, University of Concepción . Thesis title : Identification and functional characterization of cysteine residues with the potential regulatory SVCT2 ascorbic acid transporter . Presentation Date : Completed 2012.

14. Student: Ibeth Alejandra González Galdames . Career: Biology, University of Concepción . Thesis title : Modulation of promoter transcriptional activity mediated rat SVCT1 exogenous oxidative stress in rat hepatoma cells H4IIE . Completed 2012.

15. Student: Pamela Soledad Careaga Novoa . Career: Bioengineering , University of Concepción . Thesis Title : Effect of oxidative stress on the expression and activity of L -arginine transporter in human fetal endothelium . Completed 2012.

16. Student: Noemi Estela Candia González. Career: Biology, University of Concepción . Thesis Title : Functional activity hexose transporter GLUT4 in diabetes : Completed 2012.

17. Student: Carla Silvana Muñoz Espinoza. Major: Biology, University of Concepción . Thesis Title : Kinetic Properties ascorbic acid transporter SVCT1 : Completed 2012.

18. Student: Esteban Francis Caamaño Molina . Career: Biology, University of Concepción . Thesis title : Protective effect of glutathione in an in vitro model of carbon tetrachloride-induced hepatic oxidative stress . Completed 2013.

19. Student: Carolina Andrea Muñoz Flores . Career: Bioengineering, University of Concepción . Thesis title : Molecular tools targeting vitamin C metabolism in cancer cells through modification of SVCT2 transporter expression . Completed 2013.

20. Student: Katherine Alejandra Oporto Palma . Career: Biochemistry, University of Concepción . Thesis title : . Completed 2013.

21. Student: Natalia Cristhy Belmar Sazón . Career: Engineering in Marine Biotechnology and Aquaculture, University of Concepción . Thesis title : Molecular tools targeting vitamin C metabolism in cells Variation in the expression of estrogen receptors in androgen-independent prostate cancer . Completed 2014.

22. Student: José Mario Henriquez Toro. Career : Biochemistry, University of Concepción . Thesis Title : Role of estrogen in prostate cancer progression to androgen independence and metastasis. Date of presentation : Completed 2015.

Graduate Thesis Supervision

Magister

1. Student: Jessica Andrea Quilodrán Calderon. Magister Program in Physiology, University of Concepción . Thesis title : Expression and characterization of ascorbic acid transporters and SVCT2 SVCT1 in human prostate cancer cells . completed 2006

2 . Student: Marcell Alejandra Gatica Miranda . Program : MSc in Biochemistry and Bioinformatics, University of Concepción . Thesis title : Identification and structural and functional characterization of amino acids forming part of the binding pocket endofacial ascorbic acid on the conveyor. Co -Tutor . Presentation Date : Completed 2009 .

3 . Student: Perla Kathanina Salgado Mejias . Program : Master of Clinical Biochemistry and Immunology , University of Concepción . Thesis Title : Protective effect of cellular GSH in the defense to oxidative stress by exposure to snuff smoke in human endofaciales cells . Presentation Date : Completed 2010 .

4. Student: Claudia Solange Jaña Martínez. Program : MSc in Biochemistry and Bioinformatics, University of Concepción . Degree thesis : Cloning , expression and characterization of dehydroascorbate reductase in human tumor cells . Presentation Date : Completed 2011 .

5 . Student: Pablo Antonio Binder Saldaña. Program : Master in Biochemistry and Bioinformatics, University of Concepción . Thesis title : Functional characterization of the promoter region of dehydroascorbic acid reductase glutarredoxina 1. Presentation Date : Completed 2011 .

6 Student: Eduardo Andrés Peña Alarcón. Program : Master of Physiology, University of Concepción . Thesis title : Differential expression of Vitamin C transporters in breast cancer cells negative for the estrogen receptor . Presentation Date : Completed 2011 .

7. Student: Marilyn Denisse Vergara Valenzuela . Program : Master of Clinical Biochemistry and Immunology , University of Concepción . Thesis title : Molecular Analysis of the expression of Vitamin C transporters in colon cancer. Presentation Date : Completed 2012.

8. Student: Carla Jeno Salgado. Program in Master Human Physiology, University of Concepción . Thesis title : Role of microRNAs in gastric cancer. Presentation Date : Completed 2014.

9. Student: Manuel Rain Gajardo. Program in Master Human Physiology, University of Concepción . Thesis title : Physical exercise and colorectal cancer: Molecular Mechanism. Presentation Date : Completed 2014.

Professor Magister Thesis Evaluation Committee

1. Student: Paula Angelica Guzman Gonzalez . Program : Master of Science mention Biochemistry, University of Concepción. Thesis Title : Oxidative stress in human endothelial cells and the effect of glutathione couple vitamin C. Presentation Date : Completed 2005

2 . Student: Marcela Inés Hechenleitner Carvallo . Program : Master of Science mention Biochemistry, University of Concepción . Title : Vitamin C and glutathione in defense against acute oxidative stress in CaCo -2 cells . Presentation Date : Completed 2007 .

3. Student: Carlos Francisco Solomon Gallo. Program : MSc in Biochemistry and Bioinformatics, University of Concepción . Degree thesis : Cloning , characterization and expression of low density lipoprotein receptor -linked lectin ( LOX -1) in prostate cancer cells . Presentation Date : Completed 2008 .

4 . Student: Gloria Onate Alejandre Mardones . Program : Master of Physiology, University of Concepción . Thesis Title : Essential role of glutathione in oxidative stress defense induced snuff smoke in human endothelial cells . Presentation Date : Completed 2009 .

5 . Student: Pablo Miguel Torres Vergara. Program : Master of Pharmaceutical Sciences , University of Concepción . Thesis title : Evaluation of Influence of chitosan derivatives on intestinal permeability capreomycin models in vivo and in vitro. Date of presentation : closed in January 2010 .

6. Alumno: Paulina Carola Tálitha Fernández Garcés. Programa: Magister en Bioquímica y Bioinformática, Universidad de Concepción. Título Tesis: Efecto de adenosina sobre la movilización y angiogénesis in vitro de células progenitoras endoteliales humanas. Completed 2011.

7. Alumno: Karen Susan Sweet Alvarado. Programa: Magister en Bioquímica y Bioinformática, Universidad de Concepción. Título Tesis: Determinantes moleculares del sitio de unión de sustrato y el canal de transporte en el transportador de sodio-ascorbato SVCT2. Completed 2012.

8. Alumno: Carolina Andrea Muñoz Flores. Programa: Magister en Bioquímica y Bioinformática, Universidad de Concepción. Título Tesis: Construcción y caracterización de un modelo celular de las vías moleculares responsables de la homeostasis de vitamina C en humanos. Completed 2013

Doctorate

1. Student: Carola Andrea Muñoz Montesino . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Intracellular Transport of Vitamin C in breast cancer as a model of compartmentalization of Vitamin C. CONICYT doctoral scholarship . Co -Tutor . Presentation Date : Completed 2009 .

2 . Student: Kirsty Jane Mansfield Sotomayor . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis title : Central role dehydroascorbic acid reductases in the metabolism of vitamin C in prostate cancer cells . CONICYT doctoral scholarship . Tutor. Presentation Date : Completed 2012.

3 . Student: Henny Marianne Haensgen Sáez . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Degree thesis : Structural determinants translocation pathway substrates ascorbic acid transporter SVCT1 . CONICYT doctoral scholarship . Co -Tutor . Presentation Date : Completed 2013 .

4. Student: Carlos Francisco Aylwin Ramirez. Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Construction of a conveyor without cysteines ( cys -less ) and structural and functional characterization of the migration path of substrates in the ascorbic acid transporter SVCT2 . CONICYT doctoral scholarship . Co -Tutor . Presentation Date : Completed : 2014

5. Student: Carlos Alberto Soliz Soto. Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Metabolism of vitamin C during tumor progression in a model of co -culture of prostate cancer cells and stromal . CONICYT doctoral scholarship . Tutor. Presentation Date : Completed 2014.

6 . Student: Francisco Javier Roa Cartes. Program : PhD in Biological Sciences Cellular and Molecular Biology Area, University of Concepción . Thesis Title : Role of vitamin C transporter SVCT2 in mitochondria in human cells. Presentation Date: Completed 2016.

7. Student: Marcell Alejandra Gatica Miranda. Program : PhD in Biological Sciences Cellular and Molecular Biology Area, University of Concepción . Thesis Title : Quaternary structure of vitamin C transporter SVCT2. Co-Tutor. Presentation Date : Completed : 2016
Graduada 2016.

8. Student: Pamela Lorena Mendoza Muñoz. Program : PhD in Biological Sciences Cellular and Molecular Biology Area, University of Concepción . Thesis Title : Saturating mutational analysis of the substrate translocation pathway in the ascorbic acid transporter SVCT2. Presentation Date: Completed 2017.

9 . Student: Mauricio Gonzalez Oyarzun : Doctoral Program in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Mechanistic aspects and structural determinants of the transport cycle : ascorbic acid transporters and intracellular plasma membrane . MECESUP doctoral Fellowship . Tutor. Date of presentation : Running.

Professor PhD Thesis Evaluation Committee

1. Student: Lamperti Ivine Liliana Fernandez. Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis title : Expression and function of the receptor LOX -1 in human normal and tumor cells . Presentation Date : Completed 2009 .

2. Student: Sandra Céspedes Ivanova Ulloa . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Title : Characterization of pathogenicity islands in strains of Brucella abortus and identificacción of potential immunogens. Presentation Date : Completed 2011 .

3 . Student: Mary Elizabeth Escobar Sagredo . Program : Ph.D. in Biology , Cell Biology and Moleular area , Universidad de Concepción. Thesis title : Mutational analysis of a domain -binding EF-hand calcium vitamin C transporter SVCT1 . CONICYT doctoral scholarship . Completed 2012.

4 . Student: Paula Angelica Guzman Gonzalez. Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis title : Transcriptional regulation of vitamin C transporters SVCT2 SVCT1 and during differentiation and response to oxidative stress in human intestinal cells Caco-2 . Running.

5. Student: Andrea Alejandra Muñoz Vega. Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis title : Characterization of the promoter region of vitamin C transporter SVCT2 rat . CONICYT doctoral scholarship . Running.

6. Student: Marcell Alejandra Gatica Miranda . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Quaternary structure of vitamin C transporter SVCT2 . Running.

7 . Student: Eliana Maldonado Mafalda Villagran . Program : PhD in Biological Sciences Cellular and Molecular Biology Area , University of Concepción . Thesis Title : Early regulation of metabolism and molecular determinants of vitamin C post- partial hepatectomy in rats.
Running.

Postdoctoral

1. Dr. Maria Valeria Bar Pantoja. 2005-2008. Postdoctoral Program School of Biological Sciences . University of Concepción . Subject to develop: realtime PCR dehydroascorbic acid reductases during differentiation , tumorigenesis and cellular response to oxidative stress. Ring Technology - ACT28 . completed 2008

2. Dr. Chethan Sampath Kumar. 2010-2013. India's foreign student and gets postulated Postdoctoral Fellowship Program Conicyt School of Biological Sciences . University of Concepción . Topic to be developed: Antioxidant defense in prostate cancer cells: molecular mechanism and pharmacological modification .


Difusión y Transferencia


2010 Biomedicine Workshop 2.0. Designing a Science Company linking strategy, TABLE III: Workshop of Cluster BíoBío Health, Genetic Engineering Workshop for Leaders of Bio-Bio Region. The workshop was attended by representatives of companies, government agencies Chile earmarked to financing R & D and regional print media. Antioxidants Laboratory, School of Biological Sciences, University of Concepción, January 27, 2010

2010
Scientists for a Day: Genetic Engineering Workshop: Southern Journal, Sunday January 31, 2010.

2010 Interview Program Conceptions of TVU, "Research in Cancer" broadcast on Thursday 9th December at 20:0 pm and rebroadcast on Sunday 12th at 20:40 hours.

2012 UdeC Scientists create transgenic mice with novel
technique. Panorama UdeC, 26 de July.


Premios y Distinciones

  •   Award: Academic Merit

    University of Concepcion

    Chile, 2006

    For exceptional performance in all of the university's academic activities related to the formation of human resources, resource management and scientific research

  •   Award: Academic Merit

    University of Concepcion

    Chile, 2008

    For exceptional performance in all of the university's academic activities related to the formation of human resources, resource management and scientific research

  •   Award: Academic Merit

    University of Concepcion

    Chile, 2011

    For exceptional performance in all of the university's academic activities related to the formation of human resources, resource management and scientific research

  •   Award: Academic Merit

    UNIVERSITY OF CONCEPCION

    Chile, 2015

    For exceptional performance in all of the university's academic activities related to the formation of human resources, resource management and scientific research.


 

Article (54)

The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein
Data on SVCT2 transporter expression and localization in cancer cell lines and tissues
GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells
Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer.
Expression and purification of the surface proteins from Andes virus
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy
Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways
Bone stroma-derived cells change coregulators recruitment to androgen receptor and decrease cell proliferation in androgen-sensitive and castration-resistant prostate cancer cells
Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells
Effectiveness of the E2-Classical Swine Fever Virus Recombinant Vaccine Produced and Formulated within Whey from Genetically Transformed Goats
Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2
Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation
Effect of a Non-methoxylated N-trimethyl Chitosan Chloride Derivative over Capreomycin Sulfate Permeability in CaCo-2 cell Monolayers
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells
Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site
Hexose Transporter GLUT1 Harbors Several Distinct Regulatory Binding Sites for Flavones and Tyrphostins
Histidine Residues in the Na+-coupled Ascorbic Acid Transporter-2 (SVCT2) Are Central Regulators of SVCT2 Function, Modulating pH Sensitivity, Transporter Kinetics, Na+ Cooperativity, Conformational Stability, and Subcellular Localization
Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol
Molecular Identification and Functional Characterization of the Vitamin C Transporters Expressed by Sertoli Cells
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2
OXIDIZED LOW DENSITY LIPOPROTEINS INDUCE APOPTOSIS IN HUMAN LYMPHOCYTES: INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASES
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Redefining the facilitated transport of mannose in human cells: Absence of a glucose-insensitive, high-affinity facilitated mannose transport system
Differential signalling for enhanced hexose uptake by interleukin (IL)-3 and IL-5 in male germ cells
Recycling of vitamin C by a bystander effect
Nicotinamide is not a substrate of the facilitative hexose transporter GLUT1
Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors
Nicotinamide is not a substrate of the facilitative hexose transporter GLUT1.
Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells.
Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer.
Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines
Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines.
Decreased insulin-like growth factor I receptor expression and function in immortalized African Pygmy T cells.
Expression of the fructose transporter GLUT5 in human breast cancer
Expression of the fructose transporter GLUT5 in human breast cancer.
Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1
Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1.
Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid.
Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid.
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells.
The alpha subunit of the human granulocyte-macrophage colony-stimulating factor receptor signals for glucose transport via a phosphorylation-independent pathway.
The colony-stimulating factors and molecular transport.
Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid.
Tumor necrosis factor-dependent production of human immunodeficiency virus 1 in chronically infected HL-60 cells.
Age-related capacity of neuroendocrine factors to differentiate T cells in vitro.
Constitutive expression of p53 protein in enriched normal human marrow blast cell populations.
Biochemical dissection of the role of the one-kilodalton carboxyl-terminal moiety of tubulin in its assembly into microtubules.
Anti-idiotypic antibodies that react with microtubule-associated proteins are present in the sera of rabbits immunized with synthetic peptides from tubulin's regulatory domain.
Antibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules.
Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule associated proteins
Fluorescent labeling of nitrocellulose-bound proteins at the nanogram level without changes in immunoreactivity
Purification, amino terminal analysis, and peptide mapping of proteins after in situ postelectrophoretic fluorescent labeling.
Heat-stable microtubule associated protein MAP-1 bind to microtubules and induces microtubule assembly
NICOTINARNIDE IS NOT A SUBSTRATE OF THE FACILITATIVE HEXOSE TRANSPORTER GLUT1

Abstract (3)

Direct inhibition of the Glut1 hexose transporter by resveratrol.
SpH-protease exists in Caco-2 cells
Vitamin C metabolism in human cancer cells

ConferencePoster (10)

Ascorbic acid transport by SVCT1 is regulated by divalent cations
Construction and functional analysis of the ascorbic acid transporter chimeras SVCT1-SVCT2
Functional analysis of the facilitative hexose transporters GLUT10 and GLUT11, and characterization of novel dehydroascorbic acid transporters
The class III hexose transporter GLUT12 transports oxidized vitamin C
Altered androgen receptor-dependent transcriptional activity in tumoral prostatic cells in the presence of bone stromal cells
Differential expression of ascorbic acid transporters in colon cancer
Expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in human tumor cells
Glutathione and vitamin C in the antioxidant defenses in endothelial cells exposed to cigarette smoke and oxidative stress
Role of cystein residues in modulating ascorbic acid transport by the SVCT1
Characterization adenosine transport in human endotelial progenitor cells

ConferenceProceedingWhole (1)

Molecular basis of antitumor therapy

Patent (2)

Receptor lox-1 inhibitor molecules and the direct effect thereof on controlling tumour progression in different types of human cancer
Secuencia De Nucleótidos Que Comprende Arn De Interferencia (ARNi) Que Regula Negativamente La Expresión Del Receptor Lox-1; Y Uso De Ella Para Bloquear El Crecimiento Y Progresión De Células Tumorales

Proyecto (27)

ABETA ASSEMBLIES PROPAGATION AND CELL DAMAGE IN ALZHEIMER DISEASE
Proyecto de Cooperación Internacional. Aβ assemblies propagation and cell damage in Alzheimer disease
Activación farmacológica del transportador de vitamina C SVCT2 para aumentar el potencial antioxidante celular y la resistencia al estrés oxidativo
Identificación de los Determinantes Estructurales de la Especificidad del transporte de ácido deshidroascórbico por GLUT1
UNRAVELLING THE MOLECULAR IDENTITY, KINETIC PROPERTIES AND FUNCTION OF INTRACELLULAR VITAMIN C TRANSPORTERS
Unravelling the molecular identity, kinetic properties and function of intracellular vitamin C transporters
Experimental validation of a family of molecules as activators of glucose transporters for use in the control of hyperglycemia characteristic of diabetes mellitus
Molecular structural biology of ascorbic acid transporter function
MOLECULAR-STRUCTURAL BIOLOGY OF ASCORBIC ACID TRANSPORTER FUNCTION
Structural-molecular biology of ascorbic acid transporter function
Validación experimental de una familia de moléculas como activadores de los transportadores de glucosa para su uso en el control de la hiperglicemia característica de la diabetes mellitus.
Identificación, desarrollo y validación de nuevas moléculas inhibidoras de los transportadores de glucosa para su aplicación en el control de la hiperglicemia característica de la diabetes mellitus, obesidad y síndrome metabólico
Identificación, desarrollo y validación de nuevas moléculas inhibidoras de los transportadores de glucosa para su aplicación en el control de la hiperglicemia característica de la diabetes mellitus, obesidad y síndrome metabólico
Antioxidants defense in prostate cancer cells: Molecular Mechanism and Pharmacological modification
Innovar en las estrategias terapéuticas para el tratamiento de la diabetes a través de un curso de acción complementario a la insulina. Desarrollo de moléculas activadoras con especificidad para sitios regulatorios de los transportadores de glucosa
Innovar en las estrategias terapéuticas para el tratamiento de la diabetes a través de un curso de acción complementario a la insulina. Desarrollo de moléculas activadoras con especificidad para sitios regulatorios de los transportadores de glucosa
Innovation in therapeutic strategies for the treatment of diabetes through a course of action complementary to insulin. Development activator molecules with specificity for regulatory sites glucose transporters
STRUCTURAL-MOLECULAR BIOLOGY OF ASCORBIC ACID TRANSPORTERS
Structural-molecular biology of ascorbic acid transporters
Valorando nuestro nanomundo=> Acción de pequeñas moléculas en salud y enfermedad, un viaje al interior de la célula en 80 milisegundos
Valuing our nanoworld: Action of small molecules in health and disease, a trip to the interior of the cell in 80 milliseconds
Tecnología. Aplicaciones biomédicas de la vitamina C=> Estudios básicos y su uso como coadjuvante en la terapia de pacientes con sepsis
Vitamina C y resistencia a estrés oxidativo=> estudios básicos y sus aplicaciones biomédicas en cáncer y prevención de enfermedades cardiovasculares
EFECTO DE ANTI-INFLAMATORIOS NO ESTEROIDALES, INHIBIDORES DE LA SINTESIS DE GLUTATION Y FITOESTROGENOS EN RELACION A LAS DEFENSAS ANTIOXIDANTES EN CELULAS TUMORALES DE PROSTATA.
Estudio piloto de factores de riesgo de ateroesclerosis (tabaco y hábitos alimentarios) y su relación con el contenido de vitamina C plasmático, en adolescentes de nivel socioeconómico bajo
VITAMINA C Y ESTRES OXIDATIVO=> MECANISMO Y FACTORES MODULADORES
PAPEL CENTRAL DE RADICALES SUPEROXIDO EN LA CAPTACION DE VITAMINA C EN CELULAS HUMANAS NORMALES Y NEOPLASICAS.

Review (2)

Therapeutic Use of Vitamin C in Cancer: Physiological Considerations
Vitamin C transporters
108
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

38
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

20
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

9
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

7
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

6
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

5
Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

4
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

4
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

4
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Marcell Gatica

Profesora asistente

Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

4
mauricio gonzalez

phd

fisiopatologia

universidad de concepción

concepcion, Chile

4
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

4
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

4
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Alexis Salas

Assistant Professor

Pharmacology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
MAFALDA MALDONADO

PROFESOR ASOCIADO

Fisopatología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

3
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Oliberto Sanchez

Associate Professor

Pharmacology

University of Concepción

Concepción, Chile

3
Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

3
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

3
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

3
Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

2
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

2
Mauricio Vargas

Head of R&D

R&D

Kura Biotech

Puerto Varas, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

2
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

1
Frank Camacho

Profesor Asistente

Farmacología

Universidad de Concepción

Concepcion, Chile

1
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

1
Jaime Madariaga

ASSOCIATE PROFESSOR

MEDICAL SPECIALTIES

UNIVERSITY OF CONCEPCION

CONCEPCION, Chile

1
Paulina Saavedra

Lab Manager / Asistente de Investigación

Fisiopatología

Universidad de Concepción

Concepción, Chile

1
Eddy González

Investigador

Fisiopatología

Universidad de Concepción

Concepción, Chile

1
CAROLINA DELGADO

Encargado de calidad Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
Marcelo González

Profesor Asistente

Obstetricia y Ginecología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Rodrigo Maldonado

Profesor Asociado

Vicerrectoria de Investigación

Universidad Mayor de Chile

Temuco, Chile

1
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Carolina Muñoz

Colaboradora Docente, Investigadora

Fisiopatologçia

Universidad de Concepción

Concepción, Chile

1
Mirna Muñoz

Profesor Asistente

Ciencias Básicas

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

1
Fredy Diaz

ASISTENTE

CIENCIAS BÁSICAS

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

1
Natalie Parra

Colaborador Académico

Farmacología

Universidad de Concepción

Concepción, Chile

1
María Starck

Colaboradora Académica

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile