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Marcelo Andrés González Ortiz

Profesor Asistente

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Mecanismos moleculares y celulares de regulación de la fisiología vascular placentaria humana, en condiciones saludables y de patologías, principalmente diabetes gestacional, preeclampsia y obesidad.

Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 2004
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2004

Profesor Asistente Full Time

UNIVERSIDAD DE CONCEPCION

Medicina

CONCEPCION, Chile

2019 - A la fecha
Profesor Asistente Full Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

CONCEPCION, Chile

2009 - 2019

Profesor Asistente Full Time

Universidad de Concepción

Concepción, Chile

2009 - A la fecha

Supervisión de Tesis

Magister en Fisiología Humana (UdeC): Pía Ávila, Lissette Cabrera, Iván Rodríguez, Tamara Ortiz, Sebastián Dubó, Victor Durán, Enzo Barrientos, Natalia Rodríguez, Víctor Lincoñir.

Magíster en Salud Sexual y Reproductiva (UdeC): María Fernanda Castillo (co-tutor).

Licenciatura en Bioquímica (UdeC): Natalia Vallejos, Emerita Basualto, Luz Valdivia, Astrid Haensgen, Andrea Saavedra, Roberto Villalobos, Carlos Palma, Cristina Valenzuela.

Licenciatura en Bioingeniería (UdeC): Pamela Careaga, David Gallegos, Rubén Grandón

Ingeniería Química (UdeC): María Soledad Parada (co-tutor).

Asignación Académica

UNIVERSIDAD DE CONCEPCION

Chile, 2019

Asignación al mérito académico (docencia, investigación, extensión) de acuerdo a lo realizado en los últimos 3 años del periodo.


Role of heme oxygenase 1 and human chorionic gonadotropin in pregnancy associated diseases Gallardo, Victoria; Gonzalez, Marcelo Article Biochimica et Biophysica Acta - Molecular Basis of Disease (2020)
The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein Rojas, Susana; Valdivia, Luz; Vallejos, Natalia; Ceballos, Karen; Rivas, Coralia; Escudero, Carlos; Toledo, Fernando; Cid, Marcela Article SCOPUS Nitric Oxide (2020)
Pharmacological inhibition of the F-1-ATPase/P2Y(1) pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation Aguayo, Claudio; Radojkovic, Claudia Article ISI SCOPUS ACTA PHYSIOLOGICA (2019)
Transport of biodegradable polymeric particles loaded with grape seed extract across Caco-2 cell monolayers Fernández K, González M Article INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2018)
Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy Villalobos-Labra, R; Silva, L; Subiabre, M; Araos, J; Salsoso, R; Fuenzalida, B; Sáez, T; Toledo, F; González, M; Quezada, C; Pardo, F; Chiarello, D; Leiva, A; Sobrevia, L=> Article JOURNAL OF DIABETES RESEARCH (2017)
Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. Troncoso, F; Acurio, J; Herlitz, K; Aguayo, C; Bertoglia, P; Guzman-Gutierrez, E; Loyola, M; Gonzalez, M; Rezgaoui, M; Desoye, G; Escudero, C. Article PLoS One (2017)
Pro-angiogenic Role of Insulin=> From Physiology to Pathology Escudero, C; Herlitz, K; Troncoso, F; Guevara, K; Acurio, J; Aguayo, C; Godoy, AS; González, M. Article Frontiers in Physiology (2017)
Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels. Dubó, S; Gallegos, D; Cabrera, L; Sobrevia, L; Zúñiga, L; González, M Article Frontiers in Physiology (2016)
Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways Cabrera L, Saavedra A, Rojas S, Cid M, Valenzuela C, Gallegos D, Careaga P, Basualto E, Haensgen A, Peña E, Rivas C, Vera JC, Gallardo V, Zúñiga L, Escudero C, Sobrevia L, Wareing M and González M Article Frontiers in Physiology (2016)
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus. Sobrevia, L; Salsoso, R; Fuenzalida, B; Barros, E; Toledo, L; Silva, L; Pizarro, C; Subiabre, M; Villalobos, R; Araos, J; Toledo, F; González, M; Gutiérrez, J; Farías, M; Chiarello, DI; Pardo, F; Leiva, A. Article Frontiers in Physiology (2016)
Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress. Cid, M; González, M Article EARLY HUMAN DEVELOPMENT (2016)
Synthesis and characterization of polyhydroxybutyrate-co-hydroxyvalerate nanoparticles for encapsulation of quercetin Lightfoot Vidal, S; Rojas, C; Bouza Padín, R; Pérez Rivera, M; Haensgen, A; González, M; Rodríguez-Llamazares, S Article JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2016)
Biología del desarrollo vascular: Mecanismos en condiciones fisiológicas y estrés de flujo Rodríguez, I; Romero, F; González, M; Ribeiro de Campo R Article International Journal of Morphology (2015)
Insulin reverses d-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells. González, M; Rojas, S; Avila, P; Cabrera, L; Villalobos, R; Palma, C; Aguayo, C; Peña, E; Gallardo, V; Guzmán-Gutiérrez, E; Sáez, T; Salsoso, R; Sanhueza, C; Pardo, F; Leiva, A; Sobrevia L Article PLoS One (2015)
Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Campos J, Schmeda-Hirschmann G, Leiva E, Guzmán L, Orrego R, Fernández P, González M, Radojkovic C, Zuñiga FA, Lamperti L, Pastene E, Aguayo C. Article FOOD CHEMISTRY (2014)
Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation. Rodríguez, I., González, M. Article Frontiers in Pharmacology (2014)
Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia. Escudero C, Bertoglia P, Hernadez M, Celis C, González M, Aguayo C, Acurio J. Article Purinergic Signalling (2013)
Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats. Escudero A, Petzold G, Moreno J, González M, Junod J, Aguayo C, Acurio J, Escudero C. Article BIOFACTORS (2013)
Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity Torres, S; Campos, V; León, C; Rodríguez-Llamazares, S; Rojas, S; González, M; Smith, C; Mondaca, M Article Journal of nanoparticles research (2012)
Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium Guzmán-Gutiérrez E; Westermeier F; Salomón C; González M; Pardo F; Leiva A; Sobrevia L Article PLoS One (2012)
L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells Díaz-Pérez F; Radojkovic C; Aguilera V; Veas C; González M; Lamperti L; Escudero C; Aguayo C Article Journal of Cardiovascular Pharmacology (2012)
Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia. Veas C; Aguilera V; Muñoz I; Gallardo V; Miguel P; González M; Lamperti L; Escudero C; Aguayo C Article The Journal of Maternal-fetal & Neonatal Medicine (2011)
Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium Westermeier, F; Salomón, C; González, M; Puebla, C; Guzmán-Gutiérrez, E; Cifuentes, F; Leiva, A; Casanello, P; Sobrevia, L Article DIABETES (2011)
Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation González M; Gallardo V; Rodríguez N; Salomón C; Westermeier F; Guzmán-Gutiérrez E; Abarzúa F; Leiva A; Casanello P; Sobrevia L Article Journal of Cellular Physiology (2011)
A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia Sobrevía, L; González, M Article Current Vascular Pharmacology (2009)
Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia Casanello, P; Krause, B; Torres, E; Gallardo, V; González, M; Prieto, C; Escudero, C; Farías, M; Sobrevia, L Article PLACENTA (2009)
High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium Puebla C; Farías M; González M; Vecchiola A; Aguayo C; Krause B; Pastor-Anglada M; Casanello P; Sobrevia L Article Journal of Cellular Physiology (2008)
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium Casanello, P; Torres, A; Sanhueza, F; González, M; Farías, M; Gallardo, V; Pastor-Anglada, M; San Martín, R; Sobrevia, L Article CIRCULATION RESEARCH (2005)
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia Aguayo, C; Casado, J; González, M; Pearson, JD; San Martín, R; Casanello, P; Pastor-Anglada, M; Sobrevia, L Article PLACENTA (2005)
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters 1 and 2, and membrane hyperpolarization in human umbilical vein endothelium González, M; Flores, C; Pearson, JD; Casanello, P; Sobrevia, L Article PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium Vásquez, G; Sanhueza, F; Vásquez, R; González, M; San Martín, R; Casanello, P; Sobrevia, L Article JOURNAL OF PHYSIOLOGY-LONDON (2004)


Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin Gonzalez, Marcelo; Preedy, Victor BookSection (2017)


PROCESO PARA OBTENER BIOLÓGICAMENTE NANOPARTÍCULAS DE SELENIO, ÚTILES EN LA SUPLEMENTACIÓN DIETARIA DE PERSONAS QUE PADECEN DEFICIENCIA DE SELENIO. Campos, Victor; Rojas, Claudio Patent (2017)


Donut-shaped starch microparticles: preparation, characterization and applications Proyecto (2019)
Caracterización de la expresión y actividad de hCATs, NADPH oxidasa y KCa en vasos sanguíneos de placenta humana proveniente de mujeres con diabetes gestacional. Proyecto (2016)
Estudio de las alteraciones eléctricas y mecánicas de membrana plasmática de células endoteliales de vena umbilical humana en respuesta a la diabetes gestacional o condiciones estresantes relacionadas con la hiperglicemia. Proyecto (2016)
Bio-obtención de nanopartículas de selenio encapsuladas en polisacáridos para su potencial uso como suplemento alimentario Proyecto (2012)
Evaluation of novel technologies for the extraction, purification and stabilization of natural proanthocyanidins: functionalized as possible phytodrug Proyecto (2012)
Regulation of expression and activity of hCAT-1 by reactive oxygen species in human endothelium exposed to insulin and high concentrations of D-glucose Proyecto (2010)