Man

Marcelo Enrique Farias Jofre

Assistant Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Líneas de Investigación


Maternal and fetal health; Maternal nutrition; Obesity and Diabetes in pregnancy; Perinatal infections; Molecular mechanisms of intrauterine programming; Cellular stress and infection in obstetrics and gynecology

Educación

  •  PhD in Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Bachelor of Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
  •  Obstetrics and Gynecology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
  •  Health Technology Assessment, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018
  •  Medical Education, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019

Experiencia Académica

  •   Adjunt Researcher Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2012 - 2015

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Obstetrics and Gynecology Physician Part Time

    Hospital Clínico Pontificia Universidad Católica de Chile

    Santiago, Chile

    2011 - A la fecha

  •   Chief, ObGyn Emergency Unit Part Time

    Hospital Clínico Pontificia Universidad Católica de Chile

    Santiago, Chile

    2013 - 2015

  •   Chief of Clinical Service, Obstetrics and Gynecology Part Time

    Hospital Clínico Pontificia Universidad Católica de Chile

    SANTIAGO, Chile

    2015 - A la fecha

Formación de Capital Humano


ESTADÍAS DE POSTDOCTORADO:
2012 Francisco Westermeier, PhD en Biología, Mención en Ciencias Fisiológicas, PUC.
2012 – 2013: Pablo Sáez, PhD en Biología, Mención en Ciencias Fisiológicas, PUC.

TESIS DE POSTGRADO:

Cecilia Baeza.
Título de Tesis: Alteración de la ruta L-arginina/óxido nítrico en niños con síndrome metabólico. Pontificia Universidad Católica de Chile.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2012.

Natalia Aybar.
Título de Tesis: Resultados obstétricos de la cirugía bariátrica en Hospital Clínico UC. Pontificia Universidad Católica de Chile.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2016.

Olimpia Buleza.
Título de Tesis: Estado nutricional de gestantes portadoras de anemia y su asociación con la antropometría neonatal.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2018.

Sofía Ulloa.
Título de Tesis: Comparación de 2 curvas de evaluación nutricional de la embarazada en la predicción del crecimiento fetal.
Grado Académico: Magister en Nutrición.Pontificia Universidad Católica de Chile.
Año de obtención: 2018.

TESIS DE PREGRADO:
Luz Valdivia.
Título de Tesis: Correlación entre disfunción vascular fetoplacentaria, estado nutricional materno y diabetes gestacional
Grado: Bioquímica, Universidad de Concepción.
Año de obtención: 2017.

Andrea Saavedra.
Título de Tesis: Rol del estrés de retículo en la disfunción vascular placentaria inducida por la resistencia a la insulina en pacientes con obesidad materna.
Grado: Bioquímica. Universidad de Concepción
Año de obtención: 2016.

Matías Garcés.
Título deTesis: Obesidad Materna, su relación con el estrés del retículo endoplasmático y la resistencia a la insulina en el feto
Grado: Tecnología Médica. Universidad Pedro de Valdivia
Año de obtención: 2016.


Premios y Distinciones

  •   Beca Padre Hurtado

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    Year award to funding pre grade studies

  •   Premio Mejor Investigador Junior, Facultad de Medicina

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2018

    Distinción anual que realiza la Facultad de Medicina para reconocer el trabajo de investigación de académicos en su etapa de consolidación inicial de la carrera.


 

Article (49)

Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile
Gestational diabetes mellitus treatment schemes modify maternal plasma cholesterol levels dependent to women´s weight: Possible impact on feto-placental vascular function
Neonates from women with pregestational maternal obesity show reduced umbilical vein endothelial response to insulin
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction
Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium
Adenosine and preeclampsia
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion
Assessment of in vivo fetal growth and placental vascular function in a novel IUGR model of progressive uterine artery occlusion in guinea pigs
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses
Pregnancy outcomes and the use of two standards to assess adequacy of maternal body mass index in early gestation
CLINICAL MANAGEMENT OF BORDERLINE OVARIAN TUMORS IN DR SOTERO DEL RIO HOSPITAL: IGCS-0068 Ovarian Cancer.
DYSLIPIDEMIAS IN SCHOOL-AGE CHILEAN CHILDREN: PREVALENCE AND ASSOCIATED FACTORS
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium.
Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia.
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children.
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses
Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children
Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity?
Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation
Ateroesclerosis subclinica y sindrome metabolic en ninos
BLOOD LIPIDS IN CHILEAN CHILDREN 10-14 YEARS OF AGE
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels
Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction Role of Endothelial Nitric Oxide Synthase and Arginase II
NUTRITIONAL STATUS, METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN FROM SANTIAGO (CHILE)
Cesárea electiva versus parto vaginal.
Association of carotid intima media thickness with blood pressure and HDL cholesterol in children
La presión arterial es un importante marcador de ateroesclerosis subclínica en niños
La suplementación materna con ácido docosahexaenoico (DHA) carece de beneficio clínicamente significativo
Obesity in pregnancy: why we must be concerned about maternal nutrition again.
Prenatal growth and metabolic syndrome components among Chilean children
[Normal plasma insulin and HOMA values among Chilean children and adolescents].
Combined influence of preconception body mass index and gestational weight gain on fetal growth
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy.
Influencia combinada del índice de masa corporal pregestacional y de la ganancia de peso en el embarazo sobre el crecimiento fetal
Insulinemia e índice HOMA en niños y adolescentes chilenos
Normal plasma insulin and HOMA values among chilean children and adolescents
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes
Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia.
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium

Abstract (26)

DIFFERENTIAL EXPRESSION OF CHOP AND GADD34 IN HUMAN FETAL ENDOTHELIUM FROM GESTATIONAL DIABETES
HIGH FAT DIET IN MICE INDUCES ENDOPLASMIC RETICULUM STRESS IN LIVERS OF THEIR OFFSPRING
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION
MATERNAL OBESITY IMPAIRS MIGRATION OF FETAL ENDOTHELIUM INVOLVING ENDOPLASMIC RETICULUM STRESS
ROLE OF ENDOPLASMIC RETICULUM STRESS IN PLACENTAL VASCULAR DYSFUNCTION ASSOCIATED TO INSULIN RESISTANCE IN MATERNAL OBESITY.
ROLE OF PRENATAL EXPOSURE TO ENVIRONMENTAL POLLUTANTS AND MATERNAL OBESITY IN FETAL PROGRAMMING OF CHRONIC DISEASES IN MICE
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS
ASSOCIATION BETWEEN PERINATAL FACTORS AND COMPONENTS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN OF PUENTE ALTO, SANTIAGO, CHILE
ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS WITH DIFFERENT STANDARDS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE
HISTOPATHOLOGICAL PROGNOSTIC FACTORS IN STAGE IA-IIA CERVICAL CANCER SURGICALLY TREATED: A RETROSPECTIVE STUDY WITH FIVE YEARS FOLLOW UP.
MATERNAL OBESITY AND NEONATAL INSULIN RESISTANCE IN THE ORIGIN OF METABOLIC SYNDROME IN CHILDHOOD
METABOLIC SYNDROME PREVALENCE IN CHILEAN CHILDREN ACCORDING TO THREE DIFFERENT CRITERIA AND ITS AGREEMENT WITH INSULIN RESISTANCE
Metabolic Syndrome and Subclinical Atherosclerosis in Children
Prenatal Growth and Metabolic Syndrome Components in Children
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium
Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium
TGF-beta 1 inhibits adenosine transport in human fetal endothelium
Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium
ALANO pathway in the feto-placental endothelium from gestational diabetes
Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium
Effect of insulin on L-arginine transport through system y(+)L in human umbilical vein endothelium
Effects of insulin on the expression and activity of system y(+)L-mediated L-arginine transport in human umbilical vein endothelium
High D-glucose reduces promoter activity of human equilibrative nucleoside transporter 1 in human umbilical vein endothelium
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium
Transcriptional repression of the equilibrative nucleoside transporter I in human umbilical vein endothelium from gestational diabetes
Equilibrative nucleoside transporter 1 is downregulated by activation of A(2a) adenosine receptors in human umbilical vein endothelium.

BookSection (4)

Nutrición materna
Nutrición de la embarazada
Role of equilibrative nucleoside transporters in fetal endothelial dysfunction in gestational diabetes
Mecanismos moleculares asociados a la regulación del transporte y metabolismo de adenosina y L-arginina por hipoxia en endotelio fetal humano

ConferencePaper (1)

Role of equilibrative nucleoside transporters in endothelial dysfunction: Adenosine/L-arginine/nitric oxide pathway

Editorial (1)

Obesidad materna: severo problema de salud pública en Chile

Proyecto (8)

Early origins of allergy and asthma
Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling.
Perfil de ácidos grasos omega-6 y omega-3 en sangre de cordón umbilical y su relación con la composición corporal en el recién nacido.
ROLE OF INSULIN RECEPTORS AND ADENOSINE RECEPTORS IN PREVENTION OF FETOPLACENTAL ENDOTHELIAL DYSFUNCTION BY INSULIN IN WOMEN WITH GESTATIONAL DIABETES MELLITUS.
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION
MATERNAL OBESITY PRODUCES INSULIN RESISTANCE IN FETAL TISSUES INVOLVING ENDOPLASMIC RETICULUM STRESS
Characterization of the pathophysiological mechansims, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy
ORIGEN FETAL DEL SINDROME METABOLICO EN ESCOLARES CHILENOS. PAPEL DE LA RUTA L-ARGININA/NO COMO INDICADOR DE RIESGO CARDIOVASCULAR Y DISFUNCION ENDOTELIAL.

Review (3)

Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia
84
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

34
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

29
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

14
Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

14
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

12
Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

10
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

8
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

8
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

7
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

7
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

5
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

4
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

4
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

3
Francisco Mardones

Profesor Titular

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

3
Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

2
Marcela Cid

PROFESOR ASISTENTE

OBSTETRICIA Y PUERICULTURA

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

2
Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Julián Varas

Coordinador Médico Centro de Simulación, miembro directorio Simulación UC

Departamento de Cirugía Digestiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Maria Urrutia

Profesora Investigadora

Facultad de Enfermería

Universidad Andres Bello

Santiago, Chile

2
José Poblete

Jefe de Deparatmento

Departamento Obstetricia y Ginecologia

HOSPITAL CLÍNICO UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

2
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

2
Delia Chiarello

Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Francisco Westermeier

Universidad de Chile

Santiago, Chile

1
Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Marco Ramirez

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

1
Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile

1
ivo carrasco

encargado investigación

Universidad de Valparaíso

Valparaíso, Chile

1
Loni Berkowitz

Profesor Asistente - Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
carolina iturriaga

Sub Directora Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

1
Carolina Serrano

Profesor Asistente Adjunto

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

1
Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Caroll Hernández

Investigador Postdoctoral

Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica de Chile

Santiago , Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada