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Marcelo Enrique Farias Jofre

Assistant Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Maternal and fetal health; Preterm birth prevention; Maternal nutrition; Obesity and Diabetes in pregnancy; Perinatal infections; Molecular mechanisms of intrauterine programming; Cellular stress and infection in obstetrics and gynecology

PhD in Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
Bachelor of Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
Obstetrics and Gynecology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
Health Technology Assessment, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018
Medical Education, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019
Maternal-Fetal Immunobiology, Perinatology Research Branch (PRB), Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Hea. Estados Unidos, 2023

Adjunt Researcher Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2012 - 2015
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2015 - A la fecha

Obstetrics and Gynecology Physician Part Time

Hospital Clínico Pontificia Universidad Católica de Chile

Santiago, Chile

2011 - A la fecha
Chief, ObGyn Emergency Unit Part Time

Hospital Clínico Pontificia Universidad Católica de Chile

Santiago, Chile

2013 - 2015
Chief of Clinical Service, Obstetrics and Gynecology Part Time

Hospital Clínico Pontificia Universidad Católica de Chile

SANTIAGO, Chile

2015 - A la fecha

ESTADÍAS DE POSTDOCTORADO:
2012 Francisco Westermeier, PhD en Biología, Mención en Ciencias Fisiológicas, PUC.
2012 – 2013: Pablo Sáez, PhD en Biología, Mención en Ciencias Fisiológicas, PUC.

TESIS DE POSTGRADO:

Cecilia Baeza.
Título de Tesis: Alteración de la ruta L-arginina/óxido nítrico en niños con síndrome metabólico. Pontificia Universidad Católica de Chile.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2012.

Natalia Aybar.
Título de Tesis: Resultados obstétricos de la cirugía bariátrica en Hospital Clínico UC. Pontificia Universidad Católica de Chile.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2016.

Olimpia Buleza.
Título de Tesis: Estado nutricional de gestantes portadoras de anemia y su asociación con la antropometría neonatal.
Grado Académico: Magister en Nutrición. Pontificia Universidad Católica de Chile.
Año de obtención: 2018.

Sofía Ulloa.
Título de Tesis: Comparación de 2 curvas de evaluación nutricional de la embarazada en la predicción del crecimiento fetal.
Grado Académico: Magister en Nutrición.Pontificia Universidad Católica de Chile.
Año de obtención: 2018.

TESIS DE PREGRADO:
Luz Valdivia.
Título de Tesis: Correlación entre disfunción vascular fetoplacentaria, estado nutricional materno y diabetes gestacional
Grado: Bioquímica, Universidad de Concepción.
Año de obtención: 2017.

Andrea Saavedra.
Título de Tesis: Rol del estrés de retículo en la disfunción vascular placentaria inducida por la resistencia a la insulina en pacientes con obesidad materna.
Grado: Bioquímica. Universidad de Concepción
Año de obtención: 2016.

Matías Garcés.
Título deTesis: Obesidad Materna, su relación con el estrés del retículo endoplasmático y la resistencia a la insulina en el feto
Grado: Tecnología Médica. Universidad Pedro de Valdivia
Año de obtención: 2016.

Beca Padre Hurtado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

Year award to funding pre grade studies
Premio Mejor Investigador Junior, Facultad de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2018

Distinción anual que realiza la Facultad de Medicina para reconocer el trabajo de investigación de académicos en su etapa de consolidación inicial de la carrera.


Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal-fetal inflammation in mice Galaz J, Romero R, Arenas-Hernandez M, Farias-Jofre M, Motomura K, Liu Z, Kawahara N, Demery-Poulos C, Liu TN, Padron J, Panaitescu B, Gomez-Lopez N Article BMC PREGNANCY AND CHILDBIRTH (2022)
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women Gomez-Lopez N, Romero R, Tao L, Gershater M, Leng Y, Zou C, Farias-Jofre M, Galaz J, Miller D, Tarca AL, Arenas-Hernandez M, Bhatti G, Garcia-Flores V, Liu Z, Para R, Kanninen T, Hadaya O, Paredes C, Xu Y Article JOURNAL OF IMMUNOLOGY (2022)
Fetal and maternal NLRP3 signaling is required for preterm labor and birth Motomura, Kenichiro; Tao, Li; Garcia-Flores, Valeria; Done, Bogdan; Arenas-Hernandez, Marcia; Miller, Derek; Gutierrez-Contreras, Pedro; Aras, Siddhesh; Tarca, Adi L.; Gomez-Lopez, Nardhy Article ISI JCI INSIGHT (2022)
Machine learning-based models for gestational diabetes mellitus prediction before 24-28 weeks of pregnancy: A review Rodriguez, Andres; Araya, Juan Article ISI ARTIFICIAL INTELLIGENCE IN MEDICINE (2022)
Pregnancy imparts distinct systemic adaptive immune function Demery-Poulos, Catherine; Bhatti, Gaurav; Seyerle, Megan Article ISI AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation Farias-Jofre M, Romero R, Galaz J, Xu Y, Tao L, Demery-Poulos C, Arenas-Hernandez M, Bhatti G, Liu Z, Kawahara N, Kanninen T, Shaffer Z, Chaiworapongsa T, Theis KR, Tarca AL, Gomez-Lopez NGomez-Lopez N, Romero R, Tao L, Gershater M, Leng Y, Zou C, Farias- Article INFLAMMATION RESEARCH (2022)
The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis Gomez-Lopez N, Galaz J, Miller D, Farias-Jofre M, Liu Z, Arenas-Hernandez M, Garcia-Flores V, Shaffer Z, Greenberg JM, Theis KR, Romero R. Article REPRODUCTION (2022)
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth Gomez-Lopez N, Romero R, Galaz J, Bhatti G, Done B, Miller D, Ghita C, Motomura K, Farias-Jofre M, Jung E, Pique-Regi R, Hassan SS, Chaiworapongsa T, Tarca AL Article BIOLOGY OF REPRODUCTION (2022)
High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Maternal thyroid profile in first and second trimester of pregnancy is correlated with gestational diabetes mellitus through machine learning Araya, Juan; Rodriguez, Andres; Lagos-SanMartin, Karin; Gutierrez-Vega, Sebastian; Ortega-Contreras, Bernel; Valderrama-Gutierrez, Barbara; Gonzalez, Marcelo Article ISI PLACENTA (2021)
Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile Harris, Paul R; Serrano, Carolina; Sandoval, Mauricio; borzutzky, arturo Article ISI BMC PEDIATRICS (2020)
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function Article ISI SCOPUS NUTRIENTS (2020)
Neonates from women with pregestational maternal obesity show reduced umbilical vein endothelial response to insulin Westermeier, Francisco; Pizarro, Carolina; Toledo, Fernando; Kusanovic, Juan P; Mardones, Francisco Article ISI SCOPUS PLACENTA (2019)
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction Kerr, Bredford; Leiva, Andrea; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis Article ISI SCOPUS PLACENTA (2018)
Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium Subiabre, Mario; Silva, Luis; Toledo, Fernando; Westermeier, Francisco; Sobrevia, Luis Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Adenosine and preeclampsia Chiarello, D. I.; Vazquez, C. M. Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs Cifuentes-Zúñiga, Francisca; Figueroa, Esteban; Villanueva, Cristian; Hernández, Cherie; Alegría, René; Arroyo-Jousse, Viviana; Peñaloza, Estefania Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2017)
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion Aedo, Alejandro; Mora, Jacob; Maldonado, Jorge Article ISI SCOPUS PLACENTA (2017)
Assessment of in vivo fetal growth and placental vascular function in a novel IUGR model of progressive uterine artery occlusion in guinea pigs Herrera EA ; Alegría R ; Farias M; Díaz-López F ; Regnault TR; Casanello P ; Krause BJ Article Journal of Physiology (2016)
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus Sobrevia, Luis; Salsoso, Roco; Fuenzalida, Brbara; Barros, Eric; Toledo, Lilian; Silva, Luis; Pizarro, Carolina; Subiabre, Mario; Villalobos, Roberto; Araos, Joaqun; et al. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2016)
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses Krause, B. J.; Díaz-López, F. A. Article ISI SCOPUS JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2016)
Pregnancy outcomes and the use of two standards to assess adequacy of maternal body mass index in early gestation Mardones F ; Rosso P ; Villarroel L ; Bacallao J; Dominguez A; Passi A; Rojas I ; Farias M ; Margozzini P Article Journal of Developmental Origins of Health and Disease (2016)
CLINICAL MANAGEMENT OF BORDERLINE OVARIAN TUMORS IN DR SOTERO DEL RIO HOSPITAL: IGCS-0068 Ovarian Cancer. Puga, O; Perez, M V; Farias, M; Saez, N; Barriga, M I; Garcia, K; Saavedra, M; Fernandez, M; Rodriguez, T Article International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2015)
DYSLIPIDEMIAS IN SCHOOL-AGE CHILEAN CHILDREN: PREVALENCE AND ASSOCIATED FACTORS Yanez, SB; Gomez, PA; del Pino, LV; de Landa, AD; Valenzuela, OC; Jofre, MF; Santander, F Article ISI SCOPUS Nutricion Hospitalaria (2015)
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium. Westermeier, Francisco; Salomón, Carlos; Farías, Marcelo; Arroyo, Pablo; Fuenzalida, Bárbara; Sáez, Tamara; Salsoso, Rocío; Sanhueza, Carlos; Guzmán-Gutiérrez, Enrique; Pardo, Fabián; Leiva, Andrea; Sobrevia, Luis Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2015)
Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia. Salsoso, R; Guzmán-Gutiérrez, E; Sáez, T; Bugueño, K; Ramírez, M A; Farías, M; Pardo, F; Leiva, A; Sanhueza, C; Mate, A; Vázquez, C; Sobrevia, L Article Placenta (2015)
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children. Krause, Bernardo J; Carrasco-Wong, Ivo; Dominguez, Angélica; Arnaiz, Pilar; Farías, Marcelo; Barja, Salesa; Mardones, Francisco; Casanello, Paola Article PloS one (2015)
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA Schneider D.; Hernandez C.; Farias M.; Uauy R.; Krause, BJ; Casanello, P Article ISI SCOPUS Placenta (2015)
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses Krause BJ ; Herrera EA ; Díaz-López FA ; Farías M ; Uauy R ; Casanello P Article Journal of Developmental Origins of Health and Disease (2015)
Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children Mardones, Francisco; Arnaiz, PIlar; Pacheco, Paz; Dominguez, Angelica; Villarroel, Luis; Eriksson, Johan G.; Barja, Salesa; Farias, Marcelo; Castillo, Oscar. Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity? Sáez, Pablo J.; Villalobos-Labra, Roberto; Westermeier, Francisco; Sobrevia, Luis Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2014)
Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation Westermeier, Francisco; Sáez, Pablo J; Villalobos-Labra, Roberto; Sobrevia, Luis; Farías-Jofré Marcelo Article BioMed Research International (2014)
Ateroesclerosis subclinica y sindrome metabolic en ninos Arnaiz P.; Barjal, S; Villarroel L.; Dominguez A.; Godoy, I.; Castillo O.; Farias M.; Mardones F. Article ISI SCOPUS Nutricion Hospitalaria (2013)
BLOOD LIPIDS IN CHILEAN CHILDREN 10-14 YEARS OF AGE Barja S.; Barrios X; Arnaiz P.; Dominguez A.; Villarroel L.; Castillo O.; Farias M.; Ferreccio C.; Mardones F. Article ISI SCOPUS Nutricion Hospitalaria (2013)
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels Krause, BJ; Carrasco-Wong, I; Caniuguir, A; Carvajal, J.; Farias M.; Casanello, P Article ISI SCOPUS Placenta (2013)
Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction Role of Endothelial Nitric Oxide Synthase and Arginase II Leiva A.; de Medina, CD; Salsoso, R; Sáez T.; San Martin, S; Abarzua, F; Farias M.; Guzman-Gutierrez, E; Pardo F.; Sobrevia L. Article ISI SCOPUS ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
NUTRITIONAL STATUS, METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN FROM SANTIAGO (CHILE) Mardones F.; Arnaiz P.; Barja S.; Giadach C.; Villarroel L.; Dominguez A.; Castillo O.; Farias M. Article ISI SCOPUS Nutricion Hospitalaria (2013)
Cesárea electiva versus parto vaginal. Farías M, Oyarzún E Article Medwave (2012)
Association of carotid intima media thickness with blood pressure and HDL cholesterol in children Arnaiz P.; Villarroel L.; Barja S.; Godoy, I.; Cassis, B; Dominguez A.; Castillo O.; Farias M.; Carvajal, J.; Mardones F. Article ISI REVISTA MEDICA DE CHILE (2012)
La presión arterial es un importante marcador de ateroesclerosis subclínica en niños Pilar Arnaiz; Luis Villarroel; Salesa Barja; Iv Godoy; Berta Cassis; Ang Dom; Oscar Castillo; Marcelo Far; Jacqueline Carvajal; Ana Cristina Tinoco; et al. Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2012)
La suplementación materna con ácido docosahexaenoico (DHA) carece de beneficio clínicamente significativo Farías, Marcelo E; Poblete, José A; Carvajal, Jorge A. Article SCIELO Revista chilena de obstetricia y ginecologï¿½a (2012)
Obesity in pregnancy: why we must be concerned about maternal nutrition again. Farías M, Oyarzún E Article Medwave (2012)
Prenatal growth and metabolic syndrome components among Chilean children Mardones F.; Villarroel L.; Arnaiz P.; Barja S.; Dominguez A.; Castillo O.; Farias M.; Eriksson, JG; Pacheco P. Article ISI SCOPUS Journal of Developmental Origins of Health and Disease (2012)
[Normal plasma insulin and HOMA values among Chilean children and adolescents]. Barja, Salesa; Arnaiz, Pilar; Domínguez, Angélica; Villarroel, Luis; Cassis, Berta; Castillo, Oscar; Salomó, Gianina; Farías, Marcelo; Goycoolea, Manuela; Quiroga, Teresa; Mardones, Francisco Article Revista mÃ©dica de Chile (2011)
Combined influence of preconception body mass index and gestational weight gain on fetal growth Mardones F.; Garcia-Huidobro, T; Ralph, C.; Farias M.; Dominguez A.; Rojas, I; Urrutia, MT Article ISI REVISTA MEDICA DE CHILE (2011)
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy. Leiva, Andrea; Pardo, Fabián; Ramírez, Marco A; Farías, Marcelo; Casanello, Paola; Sobrevia, Luis Article Experimental diabetes research (2011)
Influencia combinada del índice de masa corporal pregestacional y de la ganancia de peso en el embarazo sobre el crecimiento fetal Mardones, Francisco; García-Huidobro, Trinidad; Ralph, Constanza; Farias, Marcelo; Dominguez, Angelica; Rojas, Iván; Urrutia, M. Teresa Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2011)
Insulinemia e índice HOMA en niños y adolescentes chilenos Barja, Salesa; Arnaiz, PIlar; Dominguez, Angelica; Villarroel, Luis; CASSIS, BERTA; Castillo, Oscar.; Salomó, Gianina; Farias, Marcelo; Goycoolea, Manuela; Quiroga, Teresa; et al. Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2011)
Normal plasma insulin and HOMA values among chilean children and adolescents Barja S.; Arnaiz P.; Dominguez A.; Villarroel L.; Cassis, B; Castillo O.; Salomo G.; Farias M.; Goycoolea M.; Quiroga T.; et al. Article ISI REVISTA MEDICA DE CHILE (2011)
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes Farias M.; Puebla, C; Westermeier, F; Jo, MJ; Pastor-Anglada, M; Casanello, P; Sobrevia L. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2010)
Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia. Westermeier, Francisco; Puebla, Carlos; Vega, José Luis; Farías, Marcelo; Escudero, Carlos; Casanello, Paola; Sobrevia, Luis Article Current vascular pharmacology (2009)
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia Casanello, P; Krause, B; Torres E.; Gallardo V.; GONZALEZ, M; Prieto, C; Escudero, c; Farias M.; Sobrevia L. Article ISI SCOPUS PLACENTA (2009)
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium Vega, JL; Puebla, C; Vasquez R.; Farias M.; Alarcon J.; Pastor-Anglada, M; Krause, B; Casanello, P; Sobrevia L. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2009)
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium Puebla, C; Farias M.; GONZALEZ, M; Vecchiola, A; Aguayo, C.; Krause, B; Pastor-Anglada, M; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium Vaquez, R; Farias M.; Vega, JL; Vecchiola, A; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2 Wielandt, AM; Vollrath, V; Farias M.; Chianale, J Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2006)
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium Muñoz G.; San Martín R.; Farias M.; Cea, L; Vecchiola, A; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes Farias M.; Puebla, C; Pearson, JD; Casado, JF; Pastor-Anglada, M; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium Casanello, P; Torres A.; Sanhueza, F; GONZALEZ, M; Farias M.; Gallardo V.; Pastor-Anglada, M; San Martín R.; Sobrevia L. Article ISI SCOPUS CIRCULATION RESEARCH (2005)


DIFFERENTIAL EXPRESSION OF CHOP AND GADD34 IN HUMAN FETAL ENDOTHELIUM FROM GESTATIONAL DIABETES Valdivia L.; Rojas, S.; Saavedra, A.; Gallegos D.; Cid M; Farias M.; GONZALEZ, M Abstract ISI PLACENTA (2015)
HIGH FAT DIET IN MICE INDUCES ENDOPLASMIC RETICULUM STRESS IN LIVERS OF THEIR OFFSPRING Garcés M.; Chavez, JL; Villalobos-Labra, R; Westermeier, F; Sáez PJ; Salas-Perez, F; Cautivo, K.; Busso, D.; Varas, J; Martin, SS; et al. Abstract ISI PLACENTA (2015)
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION Herrera EA; Schneider D.; Alegría R.; Figueroa, E.; Villanueva, C.; Farias M.; Casanello, P; Krause, BJ Abstract ISI PLACENTA (2015)
MATERNAL OBESITY IMPAIRS MIGRATION OF FETAL ENDOTHELIUM INVOLVING ENDOPLASMIC RETICULUM STRESS Villalobos-Labra, R; Sáez PJ; Gonzalez, I; Westermeier, F; Sobrevia L.; Casanello, P; Owen, GI; Farias-Jofre, M Abstract ISI PLACENTA (2015)
ROLE OF ENDOPLASMIC RETICULUM STRESS IN PLACENTAL VASCULAR DYSFUNCTION ASSOCIATED TO INSULIN RESISTANCE IN MATERNAL OBESITY. Saavedra, A.; Rojas, S.; Gallegos D.; Valdivia L.; Cid M; GONZALEZ, M; Farias M. Abstract ISI PLACENTA (2015)
ROLE OF PRENATAL EXPOSURE TO ENVIRONMENTAL POLLUTANTS AND MATERNAL OBESITY IN FETAL PROGRAMMING OF CHRONIC DISEASES IN MICE Salas-Perez, F; Berkowitz L.; Cautivo, K.; Rigotti, A.; Farias M.; Busso, D. Abstract ISI PLACENTA (2015)
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS Scheneider, D; Alegría R.; Herrera, E; Farias M.; Casanello, P; Krause, B Abstract ISI PLACENTA (2014)
ASSOCIATION BETWEEN PERINATAL FACTORS AND COMPONENTS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN OF PUENTE ALTO, SANTIAGO, CHILE Mardones F.; Pacheco, M; Dominguez A.; Villarroel L.; Eriksson, JG; Arnaiz P.; Barja S.; Castillo O.; Farias M. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)
ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS WITH DIFFERENT STANDARDS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE Arnai, P; Dominguez A.; Barja S.; Godoy, I.; Villarroel L.; Castillo O.; Farias M.; Mardones F. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)
HISTOPATHOLOGICAL PROGNOSTIC FACTORS IN STAGE IA-IIA CERVICAL CANCER SURGICALLY TREATED: A RETROSPECTIVE STUDY WITH FIVE YEARS FOLLOW UP. Puga O; Perez, MV; Saavedra M.; Fernandez, M.; Sierra, P; Barrena, N; Farias M.; Rodriguez, T Abstract ISI INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2013)
MATERNAL OBESITY AND NEONATAL INSULIN RESISTANCE IN THE ORIGIN OF METABOLIC SYNDROME IN CHILDHOOD Farias M.; Villalobos, R; Saez P.; Westermeier, F; Poblete, J; Mardones-Santander, F; Sobrevia L. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)
METABOLIC SYNDROME PREVALENCE IN CHILEAN CHILDREN ACCORDING TO THREE DIFFERENT CRITERIA AND ITS AGREEMENT WITH INSULIN RESISTANCE Barja S.; Arnaiz P.; Dominguez, MA; Villarroel L.; Castillo O.; Farias M.; Mardones F. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)
Metabolic Syndrome and Subclinical Atherosclerosis in Children Arnaiz P.; Villarroel L.; Godoy, I.; Barja S.; Castillo O.; Farias M.; Dominguez A.; Mardones F. Abstract ISI JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
Prenatal Growth and Metabolic Syndrome Components in Children Mardones F.; Villarroel L.; Barja S.; Arnaiz P.; Castillo O.; Farias M.; Dominguez A. Abstract ISI JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium GONZALEZ, M; Farias M.; Casanello, P; Sobrevia L. Abstract ISI FASEB JOURNAL (2008)
Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium Farias M.; Puebla, C; Vega, JL; Pastor-Anglada, M; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2008)
TGF-beta 1 inhibits adenosine transport in human fetal endothelium Vega, JL; Farias M.; Puebla, C; Casanello, P; Sobrevia L. Abstract ISI PURINERGIC SIGNALLING (2008)
Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium Vega, JL; Farias M.; Puebla, C; GONZALEZ, M; Casanello, P; Sobrevia L. Abstract PLACENTA (2008)
ALANO pathway in the feto-placental endothelium from gestational diabetes Sobrevia L.; Farias M.; Escudero, c; Casanello, P Abstract ISI PLACENTA (2007)
Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium Puebla, C; Farias M.; Vecchiola, A; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2007)
Effect of insulin on L-arginine transport through system y(+)L in human umbilical vein endothelium Varas, J; Farias M.; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2006)
Effects of insulin on the expression and activity of system y(+)L-mediated L-arginine transport in human umbilical vein endothelium Varas, J; Farias M.; Casanello, P; Sobrevia L. Abstract ISI EARLY HUMAN DEVELOPMENT (2006)
High D-glucose reduces promoter activity of human equilibrative nucleoside transporter 1 in human umbilical vein endothelium Farias M.; San Martín R.; Sobrevia L. Abstract ISI PLACENTA (2006)
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium Torres A.; San Martín R.; Farias M.; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2006)
Transcriptional repression of the equilibrative nucleoside transporter I in human umbilical vein endothelium from gestational diabetes San Martín R.; Farias M.; Sobrevia L. Abstract ISI PLACENTA (2006)
Equilibrative nucleoside transporter 1 is downregulated by activation of A(2a) adenosine receptors in human umbilical vein endothelium. Minaya, F; Farias M.; Casanello, P; Sobrevia L. Abstract PEDIATRIC RESEARCH (2005)


Nutrición materna Mardones, Francisco; Farias, Marcelo; Oyarzún, Enrique; Poblete, Andrés BookSection (2013)
Nutrición de la embarazada Mardones-Santander, Francisco; Farias, Marcelo; Pérez-Sanchez, Alfredo; Donoso, Enrique BookSection (2011)
Role of equilibrative nucleoside transporters in fetal endothelial dysfunction in gestational diabetes Sobrevia, Luis; Puebla, carlos; Farias, Marcelo; Casanello, Paola; Sobrevia, Luis; Casanello, Paola BookSection (2009)
Mecanismos moleculares asociados a la regulación del transporte y metabolismo de adenosina y L-arginina por hipoxia en endotelio fetal humano Casanello, Paola; Farias, Marcelo; Torres, Alberto; Sanhueza, Felipe; Sobrevia, Luis; Moraga, F; Pancetti F.; Vadulli, R; Jan Ryn, Z BookSection (2006)


Role of equilibrative nucleoside transporters in endothelial dysfunction: Adenosine/L-arginine/nitric oxide pathway Sobrevia L.; Farias M.; Vecchiola, A; Casanello, P ConferencePaper Acta Biomedica de l'Ateneo Parmense (2006)


Obesidad materna: severo problema de salud pública en Chile Farias, Marcelo Editorial SCIELO Revista chilena de obstetricia y ginecologï¿½a (2013)


Early origins of allergy and asthma PIA (ACT172097) Proyecto 2018-2020 Investigador(a)
Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling. FONDECYT (1180935) Proyecto 2018-2021 Coinvestigador(a)
Perfil de ácidos grasos omega-6 y omega-3 en sangre de cordón umbilical y su relación con la composición corporal en el recién nacido. SOCHINUT (Sochinut-Nestle 2016) Proyecto 2016-2017 Coinvestigador(a)
ROLE OF INSULIN RECEPTORS AND ADENOSINE RECEPTORS IN PREVENTION OF FETOPLACENTAL ENDOTHELIAL DYSFUNCTION BY INSULIN IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. FONDECYT (1150377) Proyecto 2015-2019 Coinvestigador(a)
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION FONDECYT (1130801) Proyecto 2013-2017 Coinvestigador(a)
MATERNAL OBESITY PRODUCES INSULIN RESISTANCE IN FETAL TISSUES INVOLVING ENDOPLASMIC RETICULUM STRESS FONDECYT (1121145) Proyecto 2012-2016 Inv. Responsable
Characterization of the pathophysiological mechansims, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy PIA (ACT-73) Proyecto 2011-2013 Coinvestigador(a)
ORIGEN FETAL DEL SINDROME METABOLICO EN ESCOLARES CHILENOS. PAPEL DE LA RUTA L-ARGININA/NO COMO INDICADOR DE RIESGO CARDIOVASCULAR Y DISFUNCION ENDOTELIAL. FONDECYT (1090594) Proyecto 2009-2013 Coinvestigador(a)


Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation Westermeier, Francisco; Villalobos-Labra, Roberto; Sobrevia, Luis; Farías-Jofré, Marcelo Review ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy Leiva A.; Pardo F.; Ramirez, MA; Farias M.; Casanello, P; Sobrevia L. Review ISI SCOPUS Experimental Diabetes Research (2011)
Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia Westermeier, F; Puebla, C; Vega, JL; Farias M.; Escudero, c; Casanello, P; Sobrevia L. Review CURRENT VASCULAR PHARMACOLOGY (2009)

Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

José Poblete

Jefe de Deparatmento

Departamento Obstetricia y Ginecologia

HOSPITAL CLÍNICO UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Francisco Mardones

Profesor Titular

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

Carolina Serrano

Profesor Asistente Ordinario

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Francisco Westermeier

Universidad de Chile

Santiago, Chile

Delia Chiarello

Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

Julián Varas

Director Alterno Centro de Simulación, miembro directorio Simulación UC

Departamento de Cirugía Digestiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Maria Urrutia

Profesora Investigadora

Facultad de Enfermería

Universidad Andres Bello

Santiago, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcela Cid

PROFESOR ASISTENTE

OBSTETRICIA Y PUERICULTURA

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

CATALINA PRIETO

Investigadora senior

Biología

Universidad de Chile

Santiago, Chile

ivo carrasco

Investigador

Universidad San Sebastián

Santiago, Chile

Juan Araya

Instructor

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

Loni Berkowitz

Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Caroll Hernández

Investigador Postdoctoral

Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica de Chile

Santiago , Chile

carolina iturriaga

Sub Directora Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

Mario Subiabre

Claudette Cantin

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

Sebastián Gutiérrez

Asistente de Investigación

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada

Francisca Cifuentes

Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

Lorena Carvajal

Roberto Villalobos

Académico

Facultad de Medicina

Universidad de Valparaíso

San Felipe, Chile

Jose Galaz

Assistant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcelo Enrique Farias Jofre

Líneas de Investigación

Educación

PhD in Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Bachelor of Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Obstetrics and Gynecology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011

Health Technology Assessment, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018

Medical Education, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019

Experiencia Académica

Adjunt Researcher Part Time

Assistant Professor Full Time

Experiencia Profesional

Obstetrics and Gynecology Physician Part Time

Chief, ObGyn Emergency Unit Part Time

Chief of Clinical Service, Obstetrics and Gynecology Part Time

Formación de Capital Humano

Premios y Distinciones

Beca Padre Hurtado

Premio Mejor Investigador Junior, Facultad de Medicina

Article (59)

Abstract (26)

BookSection (4)

ConferencePaper (1)

Editorial (1)

Proyecto (8)

Early origins of allergy and asthma

Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling.

Perfil de ácidos grasos omega-6 y omega-3 en sangre de cordón umbilical y su relación con la composición corporal en el recién nacido.

ROLE OF INSULIN RECEPTORS AND ADENOSINE RECEPTORS IN PREVENTION OF FETOPLACENTAL ENDOTHELIAL DYSFUNCTION BY INSULIN IN WOMEN WITH GESTATIONAL DIABETES MELLITUS.

MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION

MATERNAL OBESITY PRODUCES INSULIN RESISTANCE IN FETAL TISSUES INVOLVING ENDOPLASMIC RETICULUM STRESS

Characterization of the pathophysiological mechansims, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy

ORIGEN FETAL DEL SINDROME METABOLICO EN ESCOLARES CHILENOS. PAPEL DE LA RUTA L-ARGININA/NO COMO INDICADOR DE RIESGO CARDIOVASCULAR Y DISFUNCION ENDOTELIAL.

Review (3)