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Lorena Paz Carvajal Rios

Autofagia y ox-LDL en el desarrollo placentario

Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2023

Profesor instructor Other

Universidad San Sebastián

Medicina y Ciencia

Santiago, Chile

2021 - A la fecha

Personal técnico de laboratorio Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2016 - 2017


Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro Contreras-Duarte, Susana; Escalona-Rivano, Rodrigo; Cantin, Claudette; Valdivia, Pascuala; Zapata, David; Carvajal, Lorena; Brito, Roberto; Cerda, Alvaro; Illanes, Sebastian; Gutierrez, Jaime; Leiva, Andrea Article ISI VASCULAR PHARMACOLOGY (2023)
Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells Carvajal, Lorena; Gutierrez, Jaime; Morselli, Eugenia; Leiva, Andrea Article ISI FRONTIERS IN ONCOLOGY (2021)
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia Fuenzalida B.; Cantin C.; Kallol S.; Carvajal L.; PastÃ©n V.; Contreras-Duarte S.; Albrecht C.; Gutierrez J.; Leiva A. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function Contreras-Duarte S.; Carvajal L.; Garchitorena M.J.; Subiabre M.; Fuenzalida B.; Cantin C.; FarÃas M.; Leiva A. Article ISI SCOPUS Nutrients (2020)
Eleveted maternal lipid level increases cholesterol efflux to hdl in human trophoblast but not in placental microvascular endothelial cells Fuenzalida B., Cantin C.; Carvajal L., Contreras-Duarte S.; Sobrevia L., Leiva A. Article Placenta (2017)
Increased maternal lipid levels reduce the placental HDL and LDL cholesterol uptake in human trophoblast Cantin C., Carvajal L.; Fuenzalida B., Contraras-Duarte S.; Sobrevia L., Leiva A. Article Placenta (2017)
Maternal supraphysiological dyslipidemia in pregnancy worse vascular response of umbilical vein rings from gestational diabetes mellitus. Carvajal L., Cantin C.; Fuenzalida B., Contreras-Duarte S.; Sobrevia L., Leiva L. Article Placenta (2017)
Modulation of the placental HDL and LDL cholesterol uptake by the maternal lipids level in human trophoblast Cantin C., Carvajal L.; Fuenzalida B., Contreras-Duarte S.; Sobrevia L., Leiva A. Article Placenta (2017)
Neonatal high-density lipoprotein from pregnancies with maternal supraphysiological hypercholesterolemia impairs nitric oxide synthase activity in human umbilical vein endothelial cells Contreras-Duarte S., Fuenzalida B.; Cantin C., Carvajal L.; Sobrevia L., Leiva A. Article Placenta (2017)
Prevalence of maternal supraphysiological dyslipidemia in a group of Chilean pregnant women with gestational diabetes mellitus Contreras-Duarte S., Carvajal L.; Cantin C., Fuenzalida B.; Sobrevia L., Leiva A. Article Placenta (2017)
Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice=> Chronotropic and negative inotropic effect, a nifedipine-like action Fredi Cifuentes, Adrián Paredes; Javier Palacios, Fernanda Muñoz; Lorena Carvajal, Chukwuemeka R. Nwokocha Article Journal of ethnopharmacology (2016)


PREECLAMPSIA IS ASSOCIATED WITH AN IMBALANCE IN THE PROTEIN EXPRESSION OF LDLR AND SR-BI, TOTAL CHOLESTEROL LEVELS AND AUTOPHAGY MARKERS IN THE HUMAN PLACENTA Carvajal, L; Cantin, C; Fuenzalida, B; Contreras-Duarte, S; Gutierrez, J; Morselli E.; Leiva, A Abstract ISI PLACENTA (2018)


Involvement of PCSK9 in "human maternal supraphysiological hypercholesterolemia". Effects on placental cholesterol traffic and function of neonatal lipoproteins FONDECYT (1150344) Proyecto 2015-2018 Tesista

Lorena Carvajal

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Claudette Cantin

Investigador Postdoctoral

Universidad San Sebastián

Santiago, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Lorena Paz Carvajal Rios

Líneas de Investigación

Educación

Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2023

Experiencia Académica

Profesor instructor Other

Experiencia Profesional

Personal técnico de laboratorio Full Time

Article (11)

Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function

Eleveted maternal lipid level increases cholesterol efflux to hdl in human trophoblast but not in placental microvascular endothelial cells

Increased maternal lipid levels reduce the placental HDL and LDL cholesterol uptake in human trophoblast

Maternal supraphysiological dyslipidemia in pregnancy worse vascular response of umbilical vein rings from gestational diabetes mellitus.

Modulation of the placental HDL and LDL cholesterol uptake by the maternal lipids level in human trophoblast

Neonatal high-density lipoprotein from pregnancies with maternal supraphysiological hypercholesterolemia impairs nitric oxide synthase activity in human umbilical vein endothelial cells

Prevalence of maternal supraphysiological dyslipidemia in a group of Chilean pregnant women with gestational diabetes mellitus

Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice=> Chronotropic and negative inotropic effect, a nifedipine-like action

Abstract (1)

PREECLAMPSIA IS ASSOCIATED WITH AN IMBALANCE IN THE PROTEIN EXPRESSION OF LDLR AND SR-BI, TOTAL CHOLESTEROL LEVELS AND AUTOPHAGY MARKERS IN THE HUMAN PLACENTA

Proyecto (1)

Involvement of PCSK9 in "human maternal supraphysiological hypercholesterolemia". Effects on placental cholesterol traffic and function of neonatal lipoproteins

Lorena Carvajal

Andrea Leiva

Claudette Cantin

Susana Contreras

Jaime Gutierrez

Marcelo Farias

Mario Subiabre