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Claudette Alejandra Cantin González

Investigador Postdoctoral

Universidad San Sebastián

Santiago, Chile

Dislipidemia en el embarazo, tráfico de colesterol, fisiología fetoplacentaria, vesículas extracelulares.

Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
Doctorado en Ciencias Médicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2022

Investigador Postdoctoral Full Time

Universidad San Sebastián

Medicina y Ciencia

Santiago, Chile

2022 - A la fecha

Investigador postdoctoral Full Time

Universidad San Sebastián

Chile

2022 - A la fecha
Docente Part Time

Universidad San Sebastián

Chile

2022 - A la fecha
Docente Part Time

Universidad Finis Terrae

Chile

2022 - A la fecha

Co-tutor tesis de pregrado:
Tesis de Bioquímica
(2022-2023) Efecto de las lipoproteínas fetales de embarazos con hipercolesterolemia sobre la función de macrófagos.

2017-2018; 2023 Club cientifico Explorines para preescolares (Santiago, Chile).
2018 Taller de alimentación para parto saludable (San Felipe, Chile).

Concurso de Investigación para Pregrado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2015

Concurso de Verano para estadía corta de investigación.
Mejor presentación de póster

VI Latin American Symposium on Maternal-Fetal Interaction and Placenta (SLIMP)-XXXII Chilean Society of Physiological Sciences Annual Meeting

Chile, 2017

Mejor póster de pregrado. VI Latin American Symposium on Maternal-Fetal Interaction and Placenta (SLIMP)-XXXII Chilean Society of Physiological Sciences Annual Meeting. Puerto Varas, Chile.
Beca de Asistencia a Congreso Internacional

European Atherosclerosis Society

Holanda, 2019

Young Investigator Fellowship for European Atherosclerosis Society Congress 2019. Maastricht, The Netherlands.
Concurso USS de Atracción de Investigadores(as) Postdoctorales.

UNIVERSIDAD SAN SEBASTIAN

Chile, 2022

Concurso USS de Atracción de Investigadores(as) Postdoctorales. Vicerrectoría de Investigación y Doctorados. Universidad San Sebastián.
Premio de Excelencia en Tesis Doctoral 2022

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2022

Premio de Excelencia en Tesis Doctoral 2022, Área Biología y Ciencias de la Salud. Escuela de Graduados de la Vicerrectoría de Investigación (VRI), Pontificia Universidad Católica de Chile.
Mejor presentación de póster

V Meeting of DOHaD Latin American Regional Society-XXXIV Annual Meeting of the Chilean Society of Reproduction and Development

Chile, 2023

Mejor Presentación de Póster Postdoctoral. V Meeting of DOHaD Latin American Regional Society-XXXIV Annual Meeting of the Chilean Society of Reproduction and Development. Valdivia, Chile.


Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia Cantin, Claudette; Garchitorena, María Jesús; Escalona, Rodrigo; Carvajal, Jorge A.; Illanes, Sebastián E.; Gutierrez, Jaime; Leiva, Andrea Article Antioxidants (2022)
Effects of lipoproteins on endothelial cells and macrophages function and its possible implications on fetal adverse outcomes associated to maternal hypercholesterolemia during pregnancy Cantin, Claudette; Arenas, Gabriela; San Martin, Solange; Leiva, Andrea Article PLACENTA (2021)
High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies Contreras-Duarte, S; Cantin, C; Farias, M; Leiva, A Article Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2021)
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia Fuenzalida B.; Cantin C.; Kallol S.; Carvajal L.; PastÃ©n V.; Contreras-Duarte S.; Albrecht C.; Gutierrez J.; Leiva A. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function Contreras-Duarte S.; Carvajal L.; Garchitorena M.J.; Subiabre M.; Fuenzalida B.; Cantin C.; FarÃas M.; Leiva A. Article ISI SCOPUS Nutrients (2020)
Maternal hypercholesterolemia during pregnancy: Potential modulation of cholesterol transport through the human placenta and lipoprotein profile in maternal and neonatal circulation Cantin C.; Fuenzalida B.; Leiva A. Article ISI SCOPUS Placenta (2020)
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature Fuenzalida, B; Sobrevia, B; Cantin, C; Carvajal, L; Salsoso, R; Gutierrez, J; Contreras-Duarte, S; Sobrevia, L; Leiva, A Article ISI SCOPUS SCIENTIFIC REPORTS (2018)
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels Leiva, A.; Guzman-Gutierrez, E.; Contreras-Duarte, S.; Fuenzalida, B.; Cantin, C.; Carvajal, L.; Salsoso, R.; Gutierrez, J.; Pardo, F.; Sobrevia, L. Article ISI SCOPUS MOLECULAR ASPECTS OF MEDICINE (2017)


HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA INCREASES THE EFFLUX OF CHOLESTEROL FROM PLACENTAL TROPHOBLAST AND MICROVASCULAR ENDOTHELIAL CELLS Fuenzalida, B; Cantin, C; Carvajal, L; Contreras-Duarte, S; Pardo, F; Chiarello, DI; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA LEADS TO ENDOTHELIAL DYSFUNCTION OF THE PLACENTAL MICROVASCULATURE Fuenzalida, B; Sobrevia, B; Cantin, C; Carvajal, L; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
INCREASED MATERNAL LIPID LEVELS REDUCE THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE IN HUMAN TROPHOBLAST Cantin, C; Carvajal, L; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN PREGNANCY WORSE VASCULAR RESPONSE OF UMBILICAL VEIN RINGS FROM GESTATIONAL DIABETES MELLITUS Carvajal, L; Cantin, C; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
MODULATION OF THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE BY THE MATERNAL LIPIDS LEVEL IN HUMAN TROPHOBLAST Cantin, C; Carvajal, L; Fuenzalida, B; Contreras-Duarte, S; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
NEONATAL HIGH-DENSITY LIPOPROTEIN FROM PREGNANCIES WITH MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA IMPAIRS NITRIC OXIDE SYNTHASE ACTIVITY IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Contreras-Duarte, S; Fuenzalida, B; Cantin, C; Carvajal, L; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)
PREVALENCE OF MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN A GROUP OF CHILEAN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS Contreras-Duarte, S; Carvajal, L; Cantin, C; Fuenzalida, B; Sobrevia, L; Leiva, A Abstract ISI PLACENTA (2017)


Involvement of PCSK9 in ‘human maternal supraphysiological hypercholesterolemia’. Effects on placental cholesterol traffic and function of neonatal lipoproteins. FONDECYT (1150344) Proyecto 2015-2019 Tesista
Involvement of PCSK9 in ‘human maternal supraphysiological hypercholesterolemia’. Effects on placental cholesterol traffic and function of neonatal lipoproteins. FONDECYT (1150344) Proyecto 2015-2019 Personal técnico y/o de apoyo


Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation Contreras-Duarte, S; Carvajal, L; Fuenzalida, B; Cantin, C; Sobrevia, L; Leiva, A Review ISI CURRENT VASCULAR PHARMACOLOGY (2019)