1-_jaime_gutierrez2.jpg_thumb90

Jaime Agustin Gutierrez Perez

Associate Professor and Researcher

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Pregnancy Syndromes, Placenta, Preeclampsia, Cell commitment and Differentiation; Trophoblast biology.

Educación

  •  Molecular and Cellular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Molecular and Cellular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Biochemist, Pontificia Universidad Católica de Chile. Chile, 2005

Experiencia Académica

  •   Associate Researcher Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Biological Sciences

    Santiago, Chile

    2010 - 2013

  •   Academic - Main Researcher Full Time

    Universidad San Sebastian

    Health Sciences

    Santiago, Chile

    2014 - A la fecha

Experiencia Profesional

  •   Researcher Other

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2005 - 2009

  •   Postdoctor Proyecto Anillos ACT-73 Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2013 - 2013

  •   Postdoctor Full Time

    University of Ottawa

    Ottawa, Canada

    2010 - 2010

  •   Postdoctor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2013

Formación de Capital Humano


David Gonzalez, PhD Molecular and Celullar Biology student training. Pontificia Universidad Católica de Chile, 2012.
Osvaldo Contreras, undergraduate training, Pontificia Universidad Católica de Chile, 2012.
Nicolas Barrera, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2014.
Alejandro Aedo, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2015.
Jacob Mora, Tesis de grado, Bioquímica, Facultad Ciencias , Universidad San Sebastian, 2016.
Leila Fernandez, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2017.
Jorge Maldonado, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2017.
Felipe Gallardo, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2018.
Cecilia Cornejo, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2018.
Denisse Moreno, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.
Karla Vega, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.
Ricardo Pincheira, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.
Yerko Espinoza, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.
Daniela Puelles, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.
Ayleen Mella, Tesis de grado, Tecnología Médica, Facultad Ciencias de la Salud, Universidad San Sebastian, 2019.


Difusión y Transferencia


Organizador Primer Simposio en Salud de la Mujer - USS: Síndromes y Patologías del Embarazo, 2016, Universidad San Sebastián, Santiago, Chile.
Co-Organizador III Meeting on Research and Innovation in Vascular Health; V Meeting on Hypertension in Pregnancy, 2019, Bío-Bío, Chile


Premios y Distinciones

  •   Award presentation

    UNIVERSIDAD DE LOS ANDES

    Chile, 2012

    Best Poster Presentation at the, "1 Congreso de Terapia Celular"

  •   Grant for assitence: Gordon Research Conferences

    Gordon Research

    Estados Unidos, 2006

    Grant for assitance

  •   Mejor Alumno Generación

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2005

    Premio por ser el mejor alumno de generación 1999, Bioquimica. Obtenida en la ceremonia de titulación.


 

Article (65)

Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia
Role of proteases in dysfunctional placental vascular remodelling in preeclampsia
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
Mechanisms of the effect of magnesium salts in preeclampsia
Adenosine and preeclampsia
Adenosine and preeclampsia.
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels.
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
Molecular implications of adenosine in obesity
Molecular implications of adenosine in obesity.
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer.
A Hypothesis for the Role of RECK in Angiogenesis
Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer?
Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer?
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
Modulation of Intracellular pH in Human Ovarian Cancer
Modulation of intracellular pH in human ovarian cancer
Nitric oxide and pH modulation in gynaecological cancer
Nitric oxide and pH modulation in gynaecological cancer.
Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy
Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia
Tetrahydrobiopterin Role in Human Umbilical Vein Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
A Hypothesis for the Role of RECK in Angiogenesis
Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction
Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction
Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears
Mesenchymal stem cell therapy fordoxorubicin cardiomyopathy: hopes andfears
RECK-Mediated beta 1-Integrin Regulation by TGF-beta 1 Is Critical for Wound Contraction in Mice
RECK-Mediated beta1-Integrin Regulation by TGF-beta1 Is Critical for Wound Contraction in Mice
RECK-Mediated beta1-Integrin Regulation by TGF-beta1 Is Critical for Wound Contraction in Mice
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells.
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy.
Human platelet activation/secretion and a membrane-associated urokinase-like activity induce the activation of the latent form of platelet transforming growth factor-beta 1 (TGF-beta 1)
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy
Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy
Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy
Role of proteoglycans in the regulation of the skeletal muscle fibrotic response
Role of skeletal muscle proteoglycans during myogenesis
Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity
Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity
A Novel Mechanism of Sequestering Fibroblast Growth Factor 2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation
A Novel Mechanism of Sequestering Fibroblast Growth Factor 2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation
Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin
Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin
Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2
Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: Role of decorin in cell response to BMP-2
Sulfation is required for bone morphogenetic protein 2-dependent Id1 induction
Sulfation is required for bone morphogenetic protein 2-dependent Id1 induction

Abstract (1)

EFFECT OF MGSO(4) ON PROTEIN EXPRESSION AND EXOSOMES RELEASE FROM HUMAN PLACENTAL MICROVASCULAR ENDOTHELIAL CELLS FROM LATE-ONSET PREECLAMPSIA

Proyecto (4)

Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling.
Role of insulin receptors and adenosine receptors in prevention if fetoplacental endothelial dysfunction by insulin in women with gestational diabetes mellitus
REDUCED RECK LEVELS IMPROVE THE MUSCLE CELL THERAPY AND DIMINISH THE FIBROSIS ASSOCIATED TO THE DYSTROPHIC MUSCLE
Mejoramiento de la formación académica y científica en biología y fisiología celular=> Función de células madres en regeneración tisular 79090027

Review (3)

Role of extracellular vesicles in glioma progression
Role of proteoglycans in the regulation of the skeletal muscle fibrotic response
Role of skeletal muscle proteoglycans during myogenesis
39
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

20
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

17
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

9
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
Delia Chiarello

Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

4
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

3
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

3
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Ana Beltrán

Profesor asociado

Educación

Universidad de Antofagasta

Antofagasta, Chile

1
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

1
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada