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Maria Cecilia Vial Cox

Associate Professor/Profesor Asociado

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Líneas de Investigación


Host response to infection/Respuesta a Infección Hantavirus Coronavirus Genomics/Genómica

Educación

  •  Cellular and Molecular Biology, Pontificia Universidad Católica de Chile. Chile, 2008

Experiencia Académica

  •   post doctoral fellow Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2008 - 2009

  •   Profesor Asistente Full Time

    Universidad Del Desarrollo

    Chile

    2010 - 2018

  •   Profesor Asociado Full Time

    UNIVERSIDAD DEL DESARROLLO

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Post doctoral fellow Full Time

    Pontificia Universidad Católica de Chile

    Chile

    2008 - 2009

  •   Profesor Asistente Full Time

    Universidad del Desarrollo

    Chile

    2010 - 2018

  •   Profesor Asociado Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2018 - A la fecha

Formación de Capital Humano


Undergraduate Thesis:

- Undergradute thesis tutor Daniela Budge, Francisca Velasquez (Medical Technologist UDD Sept 2017- Dec 2018) “OPTIMIZACIÓN DEL PROCESAMIENTO DE MUESTRAS DE SANGRE PARA LA OBTENCIÓN EFICIENTE DE CÉLULAS MONONUCLEARES Y ARN”
- Undergraduate thesis tutor Daniela Vidal and Gabriela Cáceres (Medical Technologist UMayor Agu 2014-Dec 2015) “ VIRUS HANTA: EFECTO DE LA INFECCIÓN POR VIRUS ANDES EN LA EXPRESIÓN GÉNICA DE CTNNA Y HSPA9 IN VITRO”

Graduate Thesis:
- Gradute Thesis tutor Grazielle Esteves Ribeiro (Doctorado Ciencias e Innovación en Medicina March 2017- ongoing)

Otras Actividades Académicas:
• Tutoring of two medicine students in a laboratory internship (PONT UDD) (May/2019-Nov/2019)
• Hemorrhagic fever class to Medicine undergrad students (October 2019)
• Professor in PhD course: Genética y Genómica Aplicadas a la Medicina de Precisión at Universidad del Desarrollo (2nd Semester, 2018)
• Professor in PhD course: Genética y Genómica Aplicadas a la Medicina de Precisión at Universidad del Desarrollo (2nd Semester, 2018)
• Professor in PhD course: Genetics and Genomics for PhD students at Universidad del Desarrollo (2nd Semester, 2017)
• Professor in undergraduate course Biología Molecular y Genética (1st semester 2017)
• Professor in undergraduate course Biología Molecular y Genética (2nd semester 2016)
• Professor in PhD course: Genetics and Genomics for PhD students at Universidad del Desarrollo (2nd Semester, 2016)
• Coordinator Professor of PhD course: Genetics and Genomics for PhD students at Universidad del Desarrollo (2nd Semester, 2014)
• Member of the PhD Comitee for the "Doctorado en Ciencias Médicas", Facultad de Medicina, Universidad del Desarrollo (dec 2014-nov 2018)
• Tutoring of two medicine students in a laboratory internship (Mar/2012-Nov/2012)
• Tutoring of an exchange student from Stanford University in a laboratory internship (10/2012-11/2012)
• COURSE Unidad de Investigación 2011, Universidad del Desarrollo, tutor of the project: Validation of a genetic test for the diagnosis of lactose intolerance in chilean pediatric population
• COURSE Unidad de Investigación 2010, Universidad del Desarrollo, tutor of the project: Osteoclast differentiation for studying Osteogenesis Imperfecta


Difusión y Transferencia


• Twitter account for information on Hantavirus for general Public @virushanta

• Instagram Account for information on Hantavirus for general Public @virushantachile

• WORKSHOP ON HANTAVIRUS RESEARCH, TRANSLATION AND PUBLIC HEALTH, Monday 11th of March Auditorium Fundación Ciencia & Vida, talk: “Understanding Hantavirus Cardiopulmonary Syndrome"

• 24 Horas (Television) Jueves 07 de Marzo del 2019 del 2019, La Mañana Informativa. Interview: Cecilia Vial, primer caso de contagio de virus Hanta en la región Metropolitana
• https://www.youtube.com/watch?v=Oq6hls7piUY

• Diario el Sur, 16 Enero 2019, Interview: Cecilia Vial, hantavirus: genetics can explain immune response to the virus

• Radio Universo, jueves 10 de enero 2019, Interview: Cecilia Vial, Investigadora Facultad de Medicina Clínica Alemana UDD, talks about Epuyen outbrake transmission and prevention of hantavirus

• 24 Horas (Television) Miércoles 09 de Enero del 2019, La Mañana Informativa. Interview: Cecilia Vial, Investigadora Facultad de Medicina Clínica Alemana UDD, talks about hantavirus transmission and prevention.
• https://www.youtube.com/watch?v=ByNTK3o30rU

• Interview a Cecilia Vial, Académica Medicina UDD, COntrafactual, 28 Diciembre 2018
• http://contrafactual.cl/2018/12/26/entrevista-a-cecilia-vial-academica-udd-la-medicina-nos-ha-tratado-por-muchos-anos-como-promedios-pero-efectivamente-como-tu-dices-somos-geneticamente-distintos-por-lo-tanto-no-siempre/

• Mini-Symposium: “Novel insights into hantavirus hosts; epidemics and infection”; 2017. Fundación Ciencia y Vida; Santiago; Chile. Talk: hantavirus quasispecies



 

Article (30)

Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirusNeutralizing Antibodies in Patient Samples
Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites
Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1
NPC1 as a Modulator of Disease Severity and Viral Entry of Sars-CoV-2
A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile
A Single-Nucleotide Polymorphism of (V3) Integrin Is Associated with the Andes Virus Infection Susceptibility
Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert
Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection
Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution
Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome
Partial microduplication in the histone acetyltransferase complex member KANSL1 is associated with congenital heart defects in 22q11.2 microdeletion syndrome patients
Partial microduplication in the histone acetyltransferase complex member KANSL1 is associated with congenital heart defects in 22q11.2 microdeletion syndrome patients
Accuracy of a genetic test for the diagnosis of hypolactasia in chilean children: Comparison with the breath test
Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics
A non-randomized multicentre trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome caused by Andes virus
Chromosomal microarrays testing in children with developmental disabilities and congenital anomalies
Genetic structure characterization of Chileans reflects historical immigration patterns
Case fatality rate and associated factors in patients with 22q11 microdeletion syndrome: a retrospective cohort study
High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial
Comparative performance of symptoms questionnaire, hydrogen test and genetic test for lactose intolerance
Diagnóstico de intolerancia a la lactosa en adultos: rendimiento comparativo de la clínica, test de hidrógeno espirado y test genético
Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway
Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity
Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin
CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy
Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation
Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2
Case fatality rate and associated factors in 22q11 microdeletion syndrome patients: A retrospective cohort study
Nonrandomized multicenter trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome by ANDV
Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Proyecto (18)

Detección de anticuerpos contra SARS-CoV-2 : IgG mediante ELISA y neutralizantes en una plataforma de Bioseguridad tipo 2.
Mecanismos inmunológicos protectores y biomarcadores de respuesta inmune en COVID19: Identificación de dianas terapéuticas para la recomendación de terapias inmunomoduladoras de uso precoz.
Unraveling the differences between mild and severe hantavirus infected patients: delineating mechanisms to propose novel therapeutic approaches.
Collaborative network on immunopathogenesis of Hantavirus Infection
PROMETHEUS=> A PLATFORM FOR RAPID DEVELOPMENT OF HUMAN ANTIBODY-BASED THERAPEUTICS AND PROPHYLACTICS AGAINST EMERGING VIRAL THREATS
Ecology and Evolutionary Epidemiology of Andes Hantavirus and its Associated Rodent Reservoir
Understanding host response to ANDV infection, immunological and transcriptomics approach
Understanding Host Response to ANDV infection, immunological and transcriptomics approach
VIRAL QUASISPECIES, ORAL HOST IMMUNE AND CONSTITUTIVE FACTORS IN ANDES VIRUS INFECTED CASES AND EXPOSED SUBJECTS=> ROLE IN INFECTION AND TRANSMISSION.
Anomalías congénitas y trastornos del desarrollo=> Evaluación de costo-efectividad de las nuevas herramientas diagnósticas
EXPLORANDO LA SENSIBILIDAD AL ESTRES EN INFANTES=> UN ESTUDIO GENETICO, PSICOBIOLOGICO Y VINCULAR
GENETIC MODIFIERS OF THE CARDIOVASCULAR PHENOTYPE OF CHROMOSOME 22Q11 MICRODELETION SYNDROME=> NEXT-GENERATION SEQUENCING OF CANDIDATE REGIONS IDENTIFIED BY GENOME-WIDE ASSOCIATION ANALYSIS
GENETIC VARIANTS RELATED TO PRESENCE OF BLADDER UROTHELIAL CARCINOMA IN A HIGH-RISK, ARSENIC-EXPOSED POPULATION IN NORTHERN CHILE (ANTOFAGASTA)=> A GENOME-WIDE ASSOCIATION STUDY.
Host Genetic Factors and Severity of Andes hantavirus Infection=> a Genome Wide Association Study
Andes VIrus Transmission and Pathogenesis in Chile
GENETIC MODIFIERS OF THE 22Q11 MICRODELETION SYNDROME=> A GENOME-WIDE ASSOCIATION STUDY
Center of Aging and regeneration (CARE)
center for cellular regulation and pathology FONDAP

Review (2)

Meeting report: Eleventh International Conference on Hantaviruses
Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy
37
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

11
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

8
Pablo Vial

Director

School of Medicine

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

8
Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Constanza Martinez

Investigador asistente

Enfermedades infecciosas e inmunologia pediatrica

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

3
MARIO CALVO

Director de Instituto

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

3
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

3
Orozimba Delgado

Profesor Asociado

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

3
Guillermo Lay-Son

PROFESOR ASISTENTE

CENTRO DE GENÉTICA Y GENÓMICA

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

2
FERNANDO TORRES

Full Professor

Instituto de Biología

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

2
Mario Fernandez

Associate Professor

Urology

CLÍNICA ALEMANA DE SANTIAGO

Santiago, Chile

2
Luis Leon

Director of Bioinformatics

R&D

Genoma Mayor SpA

Santiago, Chile

2
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

2
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

2
Rene Lopez

Clinical and research fellow

Réanimation médicale

Hôpital Saint Louis

París, Francia

1
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Claudia Marco

Jefe de Unidad

Gerencia de Innovación y transformación Digital

Red de Salud UC CHRISTUS

Santiago, Chile

1
Yalda Lucero

Profesor Asistente

Programa de Microbiología y Micología; Departamento de Pediatría y Cirugía infantil;

DIVISIÓN NORTE, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE, DEPARTAMENTO DE PEDIATRÍA Y CIRUGÍA INFANTIL-HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

1
Jessica Martinez

Assistant professor

Universidad del Desarrollo

Santiago, Chile

1
Felipe Martinez

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ramon Palma

Full Professor

Ecología

Pontificia Universidad Católica de Chile; Facultad de Ciencias Biológicas

Santiago, Chile

1
Nicole Tischler

Investigadora Titular

Molecular Virology Laboratory

Fundación Ciencia para la Vida

Santiago, Chile

1
Grazielle Ribeiro

PhD candidate

Medicina

Universidad del Desarrollo- UDD

Santiago, Chile

1
Rodrigo Pérez

coordinador de investigación

Paciente Critico

Clínica Alemana de Santiago

Vitacura, Chile

1
Dusan Boric

INVESTIGADOR POSDOCTORAL FONDECYT 3180237

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

1
Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Pablo Cañón

Académico Regular

Escuela de Agronomía

Universidad Mayor de Chile

Santiago, Chile