Man

Nicole D. Tischler

Investigadora Titular

Fundación Ciencia para la Vida

Santiago, Chile

Líneas de Investigación


We focus on the molecular mechanisms that drive entry of enveloped viruses through their spike proteins and ways of inhibition. The model viruses we have been using are emerging human pathogenic hantaviruses, SARS-2 and haloarchaeal pleolipoviruses.

Educación

  •  PhD in Biotechnology, UNIVERSIDAD ANDRES BELLO. Chile, 2006
  •  Engineer in Biotechnology, Mannheim University for Applied Sciences. Alemania, 1999
  •  Technician in Phytomedicine, Berufskolleg University Hohenheim. Alemania, 1994
  •  Bioseguridad Niveles 3 y 4, AEBIOS; Spain. España, 2018
  •  Bioseguridad Niveles 3 y 4, European Comission Project. Alemania, 2014

Experiencia Académica

  •   Head (Investigadora Titular) Full Time

    FUNDACION CIENCIA PARA LA VIDA

    Santiago, Chile

    2007 - A la fecha

  •   Professor in charge of the course "Virología: principios moleculares y aplicaciones biomédicas (CS06046-1)" Other

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias

    Santiago, Chile

    2014 - A la fecha

  •   Professor of the PhD program in Biotechnology Other

    UNIVERSIDAD ANDRES BELLO

    Facultad de Ciencias Biológicas

    Santiago, Chile

    2013 - 2019

  •   Research Professor Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Investigador for I&D Full Time

    Inmuno Biological Laboratories Hamburg

    Hamburg, Alemania

    1999 - 2000

  •   Research Assistant Full Time

    Fundación Ciencia para la Vida

    Santiago, Chile

    2000 - 2002

  •   Investigadora Titular Full Time

    Fundación Ciencia para la Vida

    Santiago, Chile

    2007 - A la fecha

Formación de Capital Humano


Post-docs (2 ongoing, 1 completed)
Amelina Albornoz, Characterization of the beta3 integrin receptor in Andes hantavirus in fections in vivo. 2014-2020.
Eduardo Bignon, Structure-based characterization of the Gc fusión protein of hantaviruses. 2015-present.
Nicolás Muena, Characterization of antibody responses of COVID19 patientes against SARS-Cov-2. 2020-present

PhD thesis (5 completed, 1 ongoing)
Nicolás Cifuentes, Doctorado en Biotecnología, Universidad Andrés Bello. “Análisis funcional de la proteína de fusión Gc del virus Andes y su ensamblaje en partículas virales recombinantes”. 2006-2011.
Gonzalo Barriga, Doctorado en Biotecnología, Universidad Andrés Bello. “Entrada de hantavirus a la célula: Desarrollo de inhibidores de la proteína de fusión“. 2009-2014.
Rodrigo Acuña, Doctorado en Biotecnología, Universidad Andrés Bello. “Caracterización funcional de partículas de hantavirus Andes (VLPs) silvestres y mutantes y su uso en el estudio de la entrada viral”. 2009-2015.
María Pía García, Doctorado en Biociencias Moleculares, Universidad Andrés Bello. “Caracterización de receptores involucrados en la unión e infección de diferentes células por hantavirus Andes“. 2012-2019 (private defensa approved, public defense April 8th).
Nicolás Muena, Doctorado en Biotecnología, Universidad Andrés Bello. “Desarrollo de anticuerpos contra virus Andes (Hantaviridae) a partir de partículas semejantes a virus (VLPs) y caracterización de su actividad neutralizante y mecanismo de acción” 2014-2020.
Fabian Figueroa, Doctorado en Biotecnología, Universidad Andrés Bello, "Andes hantavirus spike assembly and priming". Since 2019.
Javier Díaz. Doctorado en Inmunología y Microbiología, Universidad San Sebastián. Molecular Virology of hantaviruses.

Master thesis (3 completed)
Simón Vidal, Magíster en Bioquímica, Universidad Andrés Bello. “Dominios de la proteína Gc del virus Andes (Hantavirus): posibles herramientas para inhibir el proceso de fusión“.2008-2009.
Ignacio Muñoz, Magister en Ciencias Naturales, Universidad de Chile. „Caracterización funcional de la región troncal de la proteína Gc del Hantavirus Andes“.2009-2011.
Ana Elola, Magister en Biotecnología, Universidad Andrés Bello, Chile. “La región troncal de la proteína Gc es requerida para la actividad de fusión y el ensamblaje de partículas de hantavirus Andes.”2012-2014.

Undergraduate thesis (9 completed, 2 ongoing)
Fernando Villalón, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Desestabilización y fusión de membranas mediante péptidos derivados de la proteína de fusión Gc del virus Andes”. 2010–2011.
Ignacio Muñoz, Ingeniería en Biotecnología Molecular, Universidad de Chile. Caracterización estructural y funcional de la región troncal de la proteína Gc del virus Andes (Hantavirus)”. 2008-2009.
Anke Roder, Bachelor of Science in Biotechnology, Hochschule Aachen, Alemania. "Role of the Andes virus Gc stem region in viral fusion activity“. 2009-2010.
Victoria Sarno, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Rol del dominio transmembrana de la proteína Gc del virus Andes (Hantavirus) en el proceso de fusión de membranas“. 2009-2012 (defense pending).
Chantal Márquez, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Caracterización del dominio transmembrana de la proteína Gc del virus Andes (Hantavirus) y su rol durante el proceso de fusión de membranas”. 2012-2014.
Natalia Salazar, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Uso de VLPs de Hantavirus para el desarrollo de estrategias terapéuticas”. 2012-2014.
Vicente Muñoz, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Rol del ectodominio de glicoproteína Gn del virus Andes (Hantavirus) en la localización y funcionalidad de Glicoproteína Gc”. 2014-2016.
Raúl Segovia, Ingeniería en Biotecnología Molecular, Universidad de Chile. “Efecto de las proteínas de hantavirus Andes sobre la tasa de apoptosis mediada por los receptores de TRAIL”. 2015-2018.
Diego Gonzalez, Magister en Biotecnología, Universidad Mayor. "Región troncal de la proteína de envoltura Gc de Andes orthohantavirus: Análisis de su rol durante la entrada y salida de la célula". 2018-2019.
Gianina Arata, Ingeniería en Biotecnología Molecular, Universidad de Chile. "Caracterización de vías autofágicas en células infectadas con Andes virus". 2020-2021.
Kevin Chou, Ingeniería en Biotecnología Molecular, Universidad de Chile. "Determinación de características moleculares de proteína de fusión viral VP4-like, mediante un sistema de expresión heterólogo en arqueas halófilas". Since 2020.
Esteban Rodríguez Rivera, Universidad San Sebastián, Carrera de Bioquímica. La espícula de phlebovirus revela una fluctuación dinámica similar a la de orthohantavirus. Since 2021.
Valeria Vásquez Sáez, Carrera de Bioquímica, Universidad de Chile, Metodología recombinante para la expresión de la proteína de superficie spike de la variante Delta de SARS-CoV-2. Since 2021
Daniela Simone Cardenas Cáceres, Carrera de Ingeniería en Biotecnología Molecular, Universidad de Chile. Clonamiento y expresión de spike de variantes de SARS-CoV-2. Since 2021.


Difusión y Transferencia


1. Participation in Cientific Societies/Committees
Since 2020 Coordinator of Group "Installations and Personnel" to define local standards for Chilean Law 21.250 about the United Nations Biological Weapons Convention (BWC).
2019 President elect (2019-2022), International Society for Hantaviruses (presidency 2022-2025)
Since 2016 Member Advisory Council, International Society for Hantaviruses
2017 - 2018 FONDECYT committee for the preparation of “Normas de Manual de Bioseguridad 2018”
Since 2008 Editorial Board member of the journal Virus Genes
Since 2008 Member of Chilean Society for Microbiology, Chilean Society for Biochemistry and Moleclar Biology, Chilean Society for Cell Biology, American Society for Virology, American Society for Microbiology, International Society for Hantaviruses

2. Activities of evaluation and revision
Since 2008 Reviewer for the following international ISI journals:
Cell, Science, Cell Reports, Cell Host Microbes, Journal of Virology, Journal of General Virology, Scientific Reports, Antiviral Research, Viruses, Archives of Virology, Virus Research, Virologica Sinica, Virology Journal, Virus Disease, Diagnostic Microbiology and Infectious Disease, Applied Microbiology and Biotechnology, Biological Research, Journal of Epidemiology and Infection.
Since 2013 Member of ANID Fellowship Evaluation Commission (Biotechnology). Programa de Formación Capital Humano Avanzado (Becas Chile), CONICYT, Chile
Since 2013 Project revisions for Deutsche Forschungsgemeinschaft (DFG), Germany; Medical Research Council UK (MRC), Newton International Fellowships of the Royal Society Great Britain, Israel Science Foundation, Israel

3. Outreach actities
Science education and practical training of students from High Schools.
Since 2018, my group participates together with "Fundación Joven" in the development of STEM education at High Schools from Ñuñoa, in our case especifically of the school Toribio Medina. We support the development of a scientific or engeneering projects for students from the 14-17 years, that includes visiting the students at school and a visit of our laboratory. We reforced their own scientific projects with education of the specific aim of our laboratory (viral infections). This later topic helped at the same time to reforze also sexual education, in order to avoid transmission of HIV that has been increasing during the last years in Chile.

Since the year 2015, our laboratory receives every year around 3 students from a High School in Santiago (Colegio Suizo de Santiago) who are interested in studying a subject of Natural Sciences. The practical training takes an entire week in our laboratory, during which the students perform experiments to amplify and isolate genes and prepare transgenic organisms, expressing viral antigens. During the entire week strong emphasis is given to teach them the goals of our studies and to guide them in finding their own interests in natural sciences in a wider context.

Television:
• Channal 24 horas, 2018."Exploradores: del atomo al cosmos: patentes de invención". Programa https://www.youtube.com/watch?v=xv8s79KHXKM
This video was prepared in order to diffuse the work of our laboratory to a broad, general audience. The video is being shown during the entire year 2017, at least 21 times. Production: Program "EUREKA" from Fundación Ciencia & Vida.
• January 22nd 2020 Noticias Chilevision, edición central, 21 hrs Virus transmission https://youtu.be/NULar07Nai0
• January 23rd 2020 Noticias TVN, edición central, 21 hrs Coronavirus transmission and international isolation of patients https://www.youtube.com/watch?v=f5K5YH6wm_E&feature=youtu.be
• January 24th 2020 24 hrs noticias, edición central, 21 hrs Coronavirus transmission https://youtu.be/f5K5YH6wm_E
• January 24th 2020 TVN 24 hrs Interview of N.Tischler about novel coronavirus https://www.youtube.com/watch?v=tuOfjxi1eo0
• February 28th 2020 Mundo Vanguardia, Canal MegaPlus: Interview N.Tischler about vaccines and treatments against SARS-Cov-2. https://www.youtube.com/watch?v=yEp01b4Cn2U&list=PLNJ7mzVqQ8UuqxlCxUisCCK4uhhhAKSel
• March 04 Noticias TVN, edición central, 21 hrs https://youtu.be/3jh_T1W8tig
• April 8th 2020 Megavision, Matinal Mucho Gusto N.Tischler about increase of coronavirus cases in Chile https://we.tl/t-op2Xz5kvf9
• April 8th 2020 Meganoticias, edición central, 21 hrs, Worries from cientists about lifting quaranteene https://www.chvnoticias.cl/noticieros-completos/chv-noticias-central-miercoles-8-de-abril-de-2020_20200408/
• April 17th 2020 Web Futuro 360 de Chilevisión y CNN Chile, Interview N.Tischler about increase of coronavirus cases in Chile https://www.chvnoticias.cl/coronavirus/virologa-advierte-hospitales-podrian-colapsar_20200417/
• April 17th 2020 Chilevisión noticias, edición central, 21 hrs Immune responses against coronavirus https://www.chvnoticias.cl/noticieros-completos/chv-noticias-central-viernes-17-de-abril-de-2020_20200417/ (MInute 38)

Newspapers/Online pages
• October 27th 2014. Redbionova
“El mundo reacciónó tarde frente al brote de ebolavirus”. Interview on behalf of the Ebola virus pandemic by Catalina Valencia.
http://www.redbionova.com/nicole-tischler-experta-virologia-molecular-mundo-reacciono-tarde-frente-al-brote-ebolavirus/
• Dicember 27th 2014. La Tercera. Tendencias. Page 14
“A propósito del Ebola: … podemos controlar la próxima epidemia”. Interview by Carolina Torrealba.
• March 21st 2016. Las Últimas Noticas. Page 26
“Científicos aplicarán la Técnica del Insecto Estéril – Golosa polilla de la uva será combatida con rayos gamma. Doctora en biotecnología explica plan para exterminar de los predios a Lobesia Botrana”. Article and interview by Ignacio Molina.
• September 26th 2016. Las Últimas Noticias. Page 26
“Aíslan a peruano que llegó de Iquitos con malaria – Nicole Tischler, ingeniera en biotecnología explica que los portadores son apartados para evitar su contacto con mosquitos”. Article and interview by Ignacio Molina.
• January 21st 2020 La Tercera, Autoridades de Salud inician campaña para prevenir contagios con virus que causa neumonía china. https://www.latercera.com/que-pasa/noticia/neumonia-campana-prevencion/981998/
• February 3rd 2020 Diario Concepción 3 de Febrero
• Feburary 28th Publimetro Coronavirus: ¿los niños están más protegidos que los mayores? https://www.publimetro.cl/cl/noticias/2020/02/28/coronavirus-los-ninos-estan-mas-protegidos-los-mayores.html
• March 02 Publimetro Coronavirus: más o menos complicado que los virus de siempre? https://www.readmetro.com/es/chile/santiago/20200302/2/#book/3
• March 10th 2020. Investigadora dio charla educativa en mercado Lo Valledor http://www.redbionova.com/investigadora-de-fundacion-ciencia-y-vida-dio-charla-educativa-en-mercado-lo-valledor/
• March 13th 2020 Las Ultimas Noticias, Variables que influyen en la propagación de los virus http://www.lun.com/Pages/NewsDetail.aspx?dt=2020-03-13&PaginaId=6&bodyid=0
• March 16th 2020 https://www.latercera.com/que-pasa/noticia/en-que-consiste-la-fase-4-del-coronavirus-en-chile/H4WBUMZ6KJFFTG52XD3YOIHIAY/
• March 17th 2020 Las Ultimas Noticias, Indirect transmission of coronavirus https://www.lun.com/Pages/NewsDetail.aspx?dt=2020-03-17&PaginaId=4&bodyid=0
• March 17th 2020 La Tercera About Epidemiological Phases 1-4 of coronavirus in Chile
• March 18th 2020 https://www.lun.com/Pages/NewsDetail.aspx?dt=2020-03-18&PaginaId=6&bodyid=0
• March 22nd El Mercurio "La actual pandemia obliga a analizar cómo mejorar la respuesta a futuros brotes" https://digital.elmercurio.com/2020/03/22/A/0Q3PDVU1
• April 2nd 2020 Interview N-Tischler in Radio Agricultura "Rompecabezas" of Pedro Carcuro about Coronavirus transmission to pets https://we.tl/t-EPTsKa0sRy• April 2nd 2020 Noticas Chilevision 21 hrs, Report on coronavirus in felinos https://we.tl/t-51bbJsSE2u
• April 2nd 2020 Las Ultimas Noticias. MIT responde las evidencias sobre dudas sobre nuevo coronavirus http://www.lun.com/Pages/NewsDetail.aspx?dt=2020-04-
• April 6th 2020 La Tercera. Transmission of coronavirus to pets http://www.latercera.com/que-pasa/noticia/tigres-y-gatos-con-coronavirus-mascotas-tambien-deberian-hacer-cuarentena/D4RRRUVRIJDRRAQRALAGQBXLCE/
• April 14th 2020 Interview at Radio Menoza about coronavirus cases in Chile, Argentina https://mdzradio.mdzol.com/article/view?slug=nicole


Premios y Distinciones

  •   Latin American Virology Scholar Award for talented virologists working in Latin America

    American Society for Virology

    Estados Unidos, 2009

    This award is given to Young Sicentists in the Virology field in order to allow them to present their work at the annual meeting of this society.

  •   Travel Award

    European Society of Virology

    Suiza, 2014

    This award was given to invite Virologists to specific meetings in Europe.

  •   PhD Fellowship

    FUNDACION INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA

    Chile, 2002

    PhD fellowship 2002-2006

  •   Fellowship

    DEUTSCHE AKADEMISCHE AUSTAUSCHDIENST

    Alemania, 1997

    Beca para realizar práctica profesional en Poytechnics Singapor

  •   Ben Barres Spotlight Award

    eLife Sciences Publications

    Reino Unido, 2019

    Ben Barres Spotlight Awards aims to provide visibility and collaboration opportunities for scientists from underrepresented groups. I have obtained this funding to make a 1-month long stay at MaxPlanck Institutes, Germany. https://elifesciences.org/inside-elife/9d33da4f/elife-latest-introducing-the-ben-barres-spotlight-awards


 

Article (29)

Halorubrum Pleomorphic Virus 6 Membrane Fusion Is Triggered by an S-Layer Component of Its Haloarchaeal Host.
Induction of SARSCoV- 2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals.
Detection of Envelope Glycoprotein Assembly from Old World Hantaviruses in the Golgi Apparatus of Living Cells
Entry of Phenuiviruses into Mammalian Host Cells
Mother-to-Child Transmission of Andes Virus through Breast Milk
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling
The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism
Cell biology of phlebovirus entry
Macromolecule Particle Picking and Segmentation of a KLH Database by Unsupervised Cryo-EM Image Processing
Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins
Protocadherin-1 is essential for cell entry by New World hantaviruses
Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation
Early Bunyavirus-Host Cell Interactions
Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc.
Mechanistic insight into bunyavirus-induced membrane fusion from structure-function analyses of the hantavirus envelope glycoprotein Gc
Acidification triggers Andes hantavirus membrane fusion and rearrangement of Gc into a stable post-fusion homotrimer.
Hantavirus Gn and Gc envelope glycoproteins=> structural key units for virus cell entry and virus assembly.
Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles
A rapid method for infectivity titration of Andes hantavirus using flow cytometry
Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis
The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.
Aromatic and polar residues spanning the candidate fusion peptide of the Andes virus Gc protein are essential for membrane fusion and infection
Development of a lentiviral vector system to study the role of the Andes virus glycoproteins
Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome
Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses
Hantavirus Gc glycoprotein=> evidence for a class II fusion protein
Human and rodent humoral immune responses to Andes virus structural proteins
Complete sequence of the genome of the human isolate of Andes virus CHI-7913=> comparative sequence and protein structure analysis

Abstract (1)

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis

ConferencePaper (2)

Invited Speaker at Gordon Research Conference Physical Virology, Mechanistic Virology and Virus-Mimetics.: The Dynamic Hantavirus Particle Surface: Molecular View of Assembly, Disassembly and Fusion
Keynote speaker “The hantavirus surface: molecular insights into glycoprotein dynamics and cell entry”.

ConferencePoster (8)

A conserved homodimeric interface of the hantavirus Gc glycoprotein directs viral particle assembly and acid-induced spike dissociation.
Hantavirus infection confers resistance to Natural Killer cell-mediated killing and activates Natural killer cells through IL-15/IL15Rα expression.
Low pH is sufficient to trigger Andes hantavirus fusion activation.
Old World hantavirus invasion of human respiratory epithelial cells.
The role of natural killer cells in hantavirus infection.
Hantavirus-cell fusion
In vivo distribution of candidate receptors for Andes hantavirus entry into susceptible cells
Low pH as trigger for Andes hantavirus fusion activation

ConferenceProceedingWhole (31)

. Identification of small-molecule viral inhibitors targeting various stages of the life-xycle of hantaviruses
A conserved homodimeric interface of the Hantavirus Gc glycoprotein directs viral particle assembly, acid-induced spike dissociation and membrane fusion.
Desarrollo de una vacuna contra hantavirus
Development of a ligand against Andes virus (Hantaviridae) and characterization of its inhibition mechanism
Dynamic fluctuation and stabilization of the hantavirus Gc pre-fusion homodimer.
Hantavirus entry into human respiratory eptithelial cells involves micropinocytosis
Hantavirus Gc homomeric dimer and trimer contacts direct spike dissociation and membrane fusion
Hantavirus pulmonary syndrome (HPS): interplay between receptors expression and pathogenesis?
Hantavirus receptors expression and distribution in a lethal pulmonary syndrome animal model
Hantavirus spike metastability: role of molecular inter-spike contacts in reversible spike association and the infection of target cells. At Colloquium: 100 Years Since The 1918 Spanish Influenza: are we prepared against the next emerging pathogen pandemic? at
Host Factor required for in vivo pathogenicity of New World Hantaviruses
La envoltura dinámica de los hantavirus: rol en el ciclo replicativo y en el diseño de estragias de intervención
Molecular Perspective of Hantavirus assembly, dissociation and membrane fusion
Seminario Internacional de Seguridad en Laboratorios. “Bioseguridad”
The hantavirus inter-spike contacts: key features during viral life cycle
Critical residue interactions in the hantavirus Gc post-fusion trimer
Development and inhibitory mechanism of a neutralizing molecule against Andes virus (Hantaviridae)
Hantavirus entry into cells: the virus-cell fusion process from a molecular perspective
Hantavirus receptors expression in a lethal pulmonary syndrome animal model
Molecular Perspective on Hantavirus-Induced Membrane Fusion and Particle Assembly
Virus-cell membrane fusion: unique features learned from hantaviruses
“Chasing RNA viruses: hosts, pathogenesis and spread”
"Mechanistic insight into hantavirus‐induced membrane fusion from structure‐guided functional analysis."
Hantavirus-cell fusion from a molecular perspective.
Hantavirus-driven membrane fusion from a molecular perspective
Inhibition of the Andes hantavirus fusion process
Mechanism of the Andes hantavirus fusion process and inhibition by Gc domain III and stem peptides
Molecular insights into the hantavirus cell fusion mechanism.
Molecular insights into Andes hantavirus cell entry and cell exit
Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles
Molecular insights into the hantavirus cell fusion mechanism

Patent (5)

Engineered spike proteins of hantaviruses and uses thereof.
Fragmentos de proteína Gc del género Hantavirus capaz de inhibir la fusión de dicho virus con una célula eucarionte, porque consiste del dominio III de Gc, o el dominio III putativo de Gc y la región troncal de la proteína Gc, composición farmacéutica que comprende el fragmento, uso de dicho fragmento.
Fragmento de la proteína Gc del género Hantavirus que inhibe la fusión de dicho virus con una célula eucarionte, el cual consiste del dominio III parcial putativo de Gc, o de la región troncal parcial putativa de Gc, composición farmacéutica que comprende el fragmento; y uso de dicho fragmento.
Hantavirus Gc fragments inhibiting the fusion of the virus with a cell.
N. Tischler, N. Cifuentes Muñoz. Partícula no replicativa de hantavirus formada por una membrana lipídica que comprende las glicoproteínas Gn/Gc de hantavirus; composición farmacéutica que comprende dicha partícula; uso para tratar, prevenir y/o diagnosticar infección por hantavirus; procedimiento de obtención de la partícula.

Proyecto (14)

Centro Científico Tecnológico de Excelencia Ciencia & Vida
Characterization of the conformational dynamics of the hantavirus Gn/Gc spikes and their stabilization for the design of next-generation vaccines.
A plasmid goes viral: Understand- ing the origin and evolution of viruses by studying a newly discovered virus-like element
High-Level Biocontainment Laboratory for Human Pathogenic Viruses and Emerging Pathogens
Integrated structural characterization of highly pathogenic bunyavirus replication machineries
Characterization of the membrane fusion mechanism of the Pleolipoviridae, enveloped viruses infecting the archaea domain of life.
Assembly of heterogeneous glycoprotein spikes of hantaviruses and their priming for cell infection
Fundación Ciencia & Vida
CHARACTERIZATION OF ANDES HANTAVIRUS CELL ENTRY AND EXIT MECHANISMS
CHARACTERIZATION OF THE BETA3 INTEGRIN RECEPTOR IN ANDES HANTAVIRUS INFECTIONS IN VIVO
Desarrollo de un antídoto profiláctico para prevenir el Síndrome Cardiopulmonar por Hantavirus
CHARACTERIZATION AND INHIBITION OF THE Gc MULTISTEP FUSION MECHANISM USED BY HANTAVIRUSES TO INFECT TARGET CELLS
Fundacion Ciencia para la Vida Proyecto Basal PFB-16
CHARACTERIZATION AND INHIBITION OF THE HANTAVIRUS Gc FUSION PROTEIN=> TOWARDS THE DEVELOPMENT OF CELL ENTRY INHIBITORS.

Review (1)

Meeting report: Eleventh International Conference on Hantaviruses
66
Nicole Tischler

Investigadora Titular

Molecular Virology Laboratory

Fundación Ciencia para la Vida

Santiago, Chile

1
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Valeria Olguín

Lab Manager

Universidad del Desarrollo

Santiago, Chile

1
Patricio Toledo

Profesor Asistente

UNIVERSIDAD ADOLFO IBANEZ

Chile

1
Miguel Carrasco

Profesor Asociado

Facultad de Ingeniería

Universidad Adolfo Ibañez

Santiago, Chile

1
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile