Man

Pablo A Vial Claro

Director

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

Líneas de Investigación


Hantavirus disease; Association between Genetic Markers and Diseases; Ecology and Hantavirus Disease; Vaccines; Antiviral Responses by Monocytes and T Lymphocytes; Regulation of T Lymphocyte Effector Functions by Innate Responses to Bacterial and vir

Educación

  •  Medico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1980
  •  Pediatrics, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 1984
  •  Infectious Diseases and Geographic Medicine, Center for Vaccine Development. Estados Unidos, 1987
  •  Subspecialty in Infectology and Tropical Medicine, UNIVERSITY OF MARYLAND. Estados Unidos
  •  Subspecialty in Virology, NATIONAL INSTITUTE OF HEALTH. Estados Unidos

Experiencia Académica

  •   Full Professor Full Time

    Univesidad del Desarrollo - Clínica Alemana

    Medicine

    Santiago, Chile

    2001 - A la fecha

  •   Research Assiciate Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1977 - 1980

  •   Visiting Fellow Assistant Professor Part Time

    UNIVERSITY OF MARYLAND

    Medicina

    Baltimore, Estados Unidos

    1989 - 1998

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    1989 - 1994

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    1994 - 2002

  •   Visiting Scientist Other

    UNIVERSITY OF NEW MEXICO

    Medicina

    Albuquerque, Estados Unidos

    2002 - 2002

  •   Visiting Scientist Other

    UNIVERSITY OF NEW MEXICO

    Medicina

    Albuquerque, Chile

    2011 - 2011

Experiencia Profesional

  •   Director Institute of Science and Innovation in Medicine Full Time

    Facultad de Medicina Clinica Alemana Universidad del Desarrollo

    Santiago, Chile

    2015 - A la fecha

  •   Dean Full Time

    Facultad de Medicina Clinica Alemana Universidad del Desarrollo

    Santiago, Chile

    2001 - 2015

  •   Clinical and Research Professor Full Time

    Facultad de Medicina Pontificia Universidad Católica de Chile

    Santiago, Chile

    1989 - 2001

  •   Visiting Scientist Full Time

    Center for Biologicals Evaluation and Research FDA NIH

    Bethesda, Maryland, Estados Unidos

    1988 - 1990

  •   Fellow Infectious Diseases Program Full Time

    Center for Vaccine Development Universidad de Maryland

    Baltimore, maryland, Chile

    1984 - 1988

Premios y Distinciones

  •   Award for the Best Research Work

    SOCIEDAD CHILENA DE INFECTOLOGIA

    Chile, 1989

    Award for the Best abstract presentation al the Chilean Infectious Diseases Society

  •   Award for the Best Research Work

    SOCIEDAD CHILENA DE INFECTOLOGIA

    Chile, 1990

    Award presented at the Chilean Infectious Diseases Congress

  •   Award for the Best Research Work

    Latin American Pediatric Research Society

    Chile, 1994

    Diagnosis of CMV with new Techniques

  •   Award Science and Technology in Biological Sciences

    Organization for American States

    Chile, 1995

    Award for Research Trajectory

  •   Award for the best Research Work

    Pan-American Infectious Diseases Society

    Chile, 2013

    Best Reasearch work: use of plasma immune for treatment of Hantavirus Cardio Pulmonary Syndrome

  •   Research Achievements 2012

    Sociedad Médica de Santiago

    Chile, 2013

    Best Research conducted in Chile in the field of Clinical Trials: Placebo control Trial of metilprednisolone in Hantavirus Cardio Pulmonary Syndrome

  •   Annual Award of Medical Research

    Academia Chilena de Medicina

    Chile, 2018

    Given for achivements in 18 years of research in Hantavirus infection


 

Article (89)

Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirusNeutralizing Antibodies in Patient Samples
Covid-19 in South America: clinical and epidemiological characteristics among 381 patients during the early phase of the pandemic in Santiago, Chile
Evaluation of a novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples
Modelo computacional interactivo, semi-automatizado y de código abierto aplicado a la vigilancia de virus respiratorios
Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1
A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile
Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection
Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution
Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome
Sociodemographic risk factors of hantavirus cardiopulmonary syndrome
Vacuna contra fiebre amarilla para viajeros chilenos a Brasil. Consideraciones prácticas
Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics
A non-randomized multicentre trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome caused by Andes virus
Clinical features and prognostic factors of meningococcal disease: a case series study in Chile during the 2012-2013 outbreak
Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011
High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial
Indirect Immunofluorescence Assay for the Simultaneous Detection of Antibodies against Clinically Important Old and New World Hantaviruses
DNA Vaccine-Generated Duck Polyclonal Antibodies as a Postexposure Prophylactic to Prevent Hantavirus Pulmonary Syndrome (HPS)
Etiología viral en la neumonía del adulto adquirida en la comunidad en un hospital del sur de Chile.
Viral etiology of community acquired pneumonia among adults admitted to a general hospital
Age as risk factor for death from pandemic (H1N1) 2009, Chile.
Etiology of pneumonia in Chilean HIV-infected adult patients
Hantavirosis: Caracterización clínica-epidemiológica de pacientes pediátricos en Chile.
Hantavirosis: Clinical and epidemiological characteristics of pediatric patients in Chile
Highly Differentiated, Resting Gn-Specific Memory CD8(+) T Cells Persist Years after Infection by Andes Hantavirus
Pandemic influenza A (H1N1) 2009 with neurological manifestations, a case series
Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome
Ecology, Genetic Diversity, and Phylogeographic Structure of Andes Virus in Humans and Rodents in Chile
Range expansion of Oligoryzomys longicaudatus (Rodentia, Sigmodontinae) in Patagonian Chile, and first record of Hantavirus in the region
Case report: T-cell responses during clearance of Andes virus from blood cells 2 months after severe Hantavirus Cardiopulmonary syndrome
Community acquired infections with methicillin resistant strains of Staphylococcus aureus. Report of five cases
Immunogenicity, safety, and interchangeability of two inactivated hepatitis A vaccines in Chilean children
Genetic susceptibility to Andes Hantavirus: Association between severity of disease and HLA alleles in Chilean patients
Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in Chile
Conflicts of interest in clinical practice. Ethical analysis of some relationships with the pharmaceutical industry
Incubation period of hantavirus cardiopulmonary syndrome
Neutralizing antibodies in survivors of Sin Nombre and Andes hantavirus infection
Prevalence of Bartonella henselae antibodies in Chilean children, adolescents and veterinary workers
Serological assays for the detection of human Andes hantavirus infections based on its yeast-expressed nucleocapsid protein
Addition of an arterio-venous shunt during veno-arterial extracorporeal life support in a patient with Hantavirus pulmonary syndrome
Presence of Bartonella henselae in cats, in Chile
Peridomestic small mammals associated with confirmed cases of human hantavirus disease in southcentral Chile
Age-specific prevalence of antibodies to hepatitis A in Santiago, Chile: Risk factors and shift in age of infection among children and young adults
Immunogenicity and reactogenicity of a reduced antigen content diphteriatetanus-acellular pertussis vaccine (dTpa) in 10 to 11 years old children and in adults
Seroprevalence of antibodies against hantavirus in 10 communities of the IX Region of Chile where hantavirus cardiopulmonary syndrome cases were reported
Seroprevalence of parvovirus B19 in urban Chilean children and young adults, 1990 and 1996
Complications in children with varicella in 4 hospitals in Santiago, Chile: clinical spectrum and estimation of direct costs
Efficacy of hepatitis A vaccination in children aged 12 to 24 months
Varicella complications requiring hospitalization in four hospitals in Santiago, Chile: clinical spectrum and estimation of direct costs
Refractory enteric amebiasis in pediatric patients with acute graft-versus-host disease after allogeneic bone marrow transplantation
Regional lymphadenopathy in cat-scratch disease: ultrasonographic findings
Detection of Norwalk and Mexico viruses, two human Caliciviruses in stools of Chilean children
Detection of Norwalk and Mexico viruses, two human Caliciviruses in stools of Chilean children].
Molecular epidemiology of the human immunodeficiency virus type 1 in Santiago, Chile
Antiretroviral therapy. Announcement of the Advisory Committee of the Chilean Society of Infectology on AIDS].
Hantavirus pulmonary syndrome in a Chilean patient with recent travel in Bolivia
Resistance of human immunodeficiency virus (HIV) to zidovudine. Genotypic analysis in strains isolated from Chilean patients].
Seroprevalence of Norwalk virus and Mexico virus in Chilean individuals: Assessment of independent risk factors for antibody acquisition
Time course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV
Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection after antibiotic treatment.
Efficacy of a vancomycin solution to prevent bacteremia associated with an indwelling central venous catheter in neutropenic and non-neutropenic cancer patients.
Seroprevalence of cytomegalovirus and Toxoplasma gondii in healthy subjects under 30 years old in Santiago, Chile]. Rev Med Chil. 1997 May;125(5):531-8.
Bartonella henselae infection in immunocompetent patients: cat scratch disease
Natural history of human immunodeficiency virus infection in a cohort of Chilean patients].
Neuroborreliosis in Chile. Report of a child probably infected by imported pets
T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesis
HELICOBACTER-PYLORI-ASSOCIATED GASTRODUODENAL DISEASE IN SYMPTOMATIC CHILEAN CHILDREN - DIAGNOSTIC-VALUE OF SEROLOGICAL ASSAY
Seroprevalence of Epstein Barr virus infection in a healthy population of Santiago de Chile].
Fecal lactoferrin as a marker of fecal leukocytes.
STRUCTURAL STUDIES OF THE O-ANTIGENIC POLYSACCHARIDES OF ESCHERICHIA-COLI O3 AND THE ENTEROAGGREGATIVE ESCHERICHIA-COLI STRAIN-17-2
COST-BENEFIT-ANALYSIS FOR THE USE OF HAEMOPHILUS-INFLUENZAE TYPE-B CONJUGATE VACCINE IN SANTIAGO, CHILE
SEROPREVALENCE OF HELICOBACTER-PYLORI IN CHILE - VEGETABLES MAY SERVE AS ONE ROUTE OF TRANSMISSION
STRUCTURAL STUDIES OF THE O-ANTIGENIC POLYSACCHARIDE OF AN ENTEROAGGREGATIVE ESCHERICHIA-COLI STRAIN
A SENSITIVE AND SPECIFIC DNA PROBE TO IDENTIFY ENTEROAGGREGATIVE ESCHERICHIA-COLI, A RECENTLY DISCOVERED DIARRHEAL PATHOGEN
COMPARISON OF 2 ASSAY-METHODS FOR PATTERNS OF ADHERENCE TO HEP-2 CELLS OF ESCHERICHIA-COLI FROM PATIENTS WITH DIARRHEA
DETECTION BY IMMUNE ELECTRON-MICROSCOPY OF 27-NM VIRAL PARTICLES ASSOCIATED WITH COMMUNITY-ACQUIRED DIARRHEA IN CHILDREN
Oral copper supplementation: effect on copper and zinc balance during acute gastroenteritis in infants
CHARACTERIZATION OF ENTEROADHERENT-AGGREGATIVE ESCHERICHIA-COLI, A PUTATIVE AGENT OF DIARRHEAL DISEASE
Escherichia coli that cause diarrhea
Molecular Epidemiology of Rotavirus Infection in a Room for Convalescing Newborns
MORPHOLOGICAL-STUDIES ON FIMBRIAE EXPRESSED BY VIBRIO-CHOLERAE 01
USE OF DNA PROBES AND HEP-2 CELL ADHERENCE ASSAY TO DETECT DIARRHEAGENIC ESCHERICHIA-COLI
HISTOPLASMA DUBOISII INFECTION IN A LIBERIAN GIRL
PATTERNS OF ADHERENCE OF DIARRHEAGENIC ESCHERICHIA-COLI TO HEP-2 CELLS
Evaluation of 3 laboratory methods for the serological diagnosis of rubella
Serologic screening for cytomegalovirus, rubella virus, herpes simplex virus, hepatitis B virus, and Toxoplasma gondii in two urban populations of pregnant women in Chile. Bull Pan Am Health Organ. 1986;20(1):53-61
Rapid identification of the etiological agent by the latex agglutination test in acute bacterial meningitis.
Serological study of cytomegalovirus, herpes simplex and rubella virus, hepatitis B and Toxoplasma gondii in 2 populations of pregnant women in Santiago, Chile.
Vitamin D poisoning in infants

Abstract (3)

ApOH-capture technology enhances Andes hantavirus detection allowing virus concentration from plasma and urine samples of patients with acute hantavirus cardiopulmonary syndrome
PREDICTING HANTAVIRUS RISK IN CHILE
Characterization of the hantavirus infection in Chile: Incubation period, clinical presentation and viral load in body fluids in patients with hanta cardiopulmonary syndrome (HCPS)

CaseReport (1)

Staphylococcus aureus comunitario resistente a cloxacilina: Comunicación de los primeros cinco casos descritos en Chile

Editorial (2)

Shortage of yellow fever vaccination: A travel medicine emergency for Chilean travellers
Lepra: combatimos la enfermedad no a los que la sufren

Proyecto (16)

UNDERSTANDING HOST RESPONSE TO ANDV INFECTION, IMMUNOLOGICAL AND TRANSCRIPTOMICS APPROACH
Andes virus transmission and pathogenesis in Chile
Inmunoterapia pasiva del síndrome cardiopulmonar por hantavirus (SCPH)=> protocolo de tratamiento compasivo de pacientes con infección aguda con plasma humano con altas concentraciones de anticuerpos neutralizantes
Hantavirus Ecology and Disease in Chile and Panama
IDENTIFICACION DE EPITOPES INMUNODOMINANTES INVOLUCRADOS EN LA RESPUESTA INMUNE CELULAR CONTRA HANTAVIRUS ANDES Y CARACTERIZACION DE LOS LINFOCITOS T RESPONSABLES=> BASE PARA EL DESARROLLO DE UNA VACUNA.
EXPRESION CLINICA VARIABLE DEL SINDROME CARDIOPULMONAR POR HANTAVIRUS (SCPH) Y SU ASOCIACION CON LOS ALELOS DEL SISTEMA MAYOR DE HISTOCOMPATIBILIDAD (HLA) Y DEL FACTOR DE NECROSIS TUMORAL (TNF).
ESTUDIO ETIOLOGICO DE LAS NEUMONIAS EN PACIENTES CHILENOS CON INFECCION POR VIH.
Hantavirus Ecology and Disease in Chile
ANALISIS DE LA VARIABILIDAD GENOTIPICA DEL VIRUS DE INMUNODEFICIENCIA HUMANO (VIH) Y DE LAS CONSECUENCIAS DE SU INTEGRACION EN LA ESTABILIDAD DEL GENOMA DE LOS INDIVIDUOS INFECTADOS.
DETECCION DE LA PRESENCIA DE VIRUS DE INMUNODEFICIENCIA HUMANO RESISTENTE A ZIDOVUDINA Y CARACTERIZACION DE SUS BASES GENETICAS EN PACIENTES CHILENOS.
VIRUS NORWALK Y TIPO NORWALK EN EL CONO SUR DE AMERICA
ERRADICACION DE HELICOBACTER PYLORI EN UN MEDIO DE ALTA PREVALENCIA FACTIBILIDAD Y TASAS DE REINFECCION O RECIDIVA EN PACIENTES CON ULCERA DUODENAL.
EVALUACION PROSPECTIVA DE NIVELES DE INMUNOGLOBULINAS SERICAS Y SUBCLASES DE IGG, Y DETERMINACION CUANTITATIVA Y CUALITATIVA DE LA RESPUESTA INMUNE HUMORAL EN PACIENTES CON INFECCION POR VIH.
DETERMINANTES CONDUCTUALES,SOCIOLOGICOS Y BIOLOGICOS DE LA PROGRESION DE LA INFECCION POR VIRUS DE INMUNODEFICIENCIA HUMANOS EN SUJETOS CHILENOS
HELICOBACTER PYLORI=> SEROPREVALENCIA, FACTORES DE RIESGO Y ASOCIACION CON ENFERMEDADES DIGESTIVAS EN TRES REGIONES DE CHILE
PREVALENCIA DE ANTICUERPOS ANTIHEPATITIS A POR GRUPOS ETARIOS EN 3 REGIONES DE CHILE. ESTUDIO PRELIMINAR DE PREVALENCIA DE OTROS AGENTES DE HEPATITIS VIRAL.

Review (4)

Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology
Listeria monocytogenes: Report of a rise in pregnant women and literature review
Diagnosis and treatment of new world hantavirus infections
Hantavirus infection in children
96
Pablo Vial

Director

School of Medicine

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

34
Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
KATIA ABARCA

Profesor Titular

Pediatría

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

9
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

5
Orozimba Delgado

Profesor Asociado

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

5
MARIO CALVO

Director de Instituto

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

4
Claudia Marco

Jefe de Unidad

Gerencia de Innovación y transformación Digital

Red de Salud UC CHRISTUS

Santiago, Chile

3
Thomas Weitzel

Head Travel Medicine Program

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

3
Constanza Martinez

Investigador asistente

Enfermedades infecciosas e inmunologia pediatrica

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

3
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

2
Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

2
FERNANDO TORRES

Full Professor

Instituto de Biología

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

2
Jessica Martinez

Assistant professor

Universidad del Desarrollo

Santiago, Chile

2
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

2
Ramon Palma

Full Professor

Ecología

Pontificia Universidad Católica de Chile; Facultad de Ciencias Biológicas

Santiago, Chile

2
Rene Lopez

Clinical and research fellow

Réanimation médicale

Hôpital Saint Louis

París, Francia

2
Andrea Olea

Associate Professor

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
José Montes

Médico Anestesiólogo

Clinica Alemana

Santiago, Chile

1
Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Macarena Hirmas

Regular Research Associate Professor

Center for Epidemiology and Health Policies

Universidad del Desarrollo

Santiago, Chile

1
María Matute

Regular Research Associate Professor

Centro de Epidemiologia y Politicas de Salud

Universidad del Desarrollo

Santiago, Chile

1
Grazielle Ribeiro

PhD candidate

Medicina

Universidad del Desarrollo- UDD

Santiago, Chile

1
Rafael Medina

Associate Professor

Pediatrics

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
LEONARDO CHANQUEO

Jefe Unidad Infectología & Microbiología

Medicina Interna

Hospital San Juan de Dios

Santiago, Chile

1
Tania Alfaro

Profesor asistente

Salud Pública

Universidad de Chile

Santiago, Chile

1
pamela araya

JEFE DE SECCIÓN

BIOMEDICO

INSTITUTO DE SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Juan Hormazabal

Jefe

Departamento Biomédico

Public Health Institute of Chile

Santiago, Chile

1
Paul Harris

Full Professor

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jose Munita

Profesor Asociado

Internal Medicine

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile

1
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

1
Dusan Boric

INVESTIGADOR POSDOCTORAL FONDECYT 3180237

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

1
Luis Leon

Director of Bioinformatics

R&D

Genoma Mayor SpA

Santiago, Chile

1
Rodrigo Pérez

coordinador de investigación

Paciente Critico

Clínica Alemana de Santiago

Vitacura, Chile

1
Sergio Munoz

Director

Salud Publica

Universidad de La Frontera

Temuco, Chile

1
Rodrigo Fasce

Jefe Subdepto. Enfermedades Virales

Biomédico

Instituto de Salud Pública

Santiago, Chile

1
Manuel Nájera

Instructor professor

Centro de Epidemiología y Políticas de Salud

Universidad del Desarrollo

santiago de chile, Chile