Man

Ana Maria Sandino Garcia

Profesor Titular

Universidad de Santiago de Chile

Santiago, Chile

Líneas de Investigación


Estudio de patologías infecciosas, especialmente producidas por virus, tanto en salud humana como veterinaria. Abarcando la identificación del patógeno, su comportamiento molecular, celular e inmunológico y el desarrollo de herramientas de control.

Educación

  •  Ciencias c/m Biología, UNIVERSIDAD DE CHILE. Chile, 1990
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1984

Experiencia Académica

  •   Instructor Part Time

    UNIVERSIDAD DE CHILE

    INTA

    santiago, Chile

    1988 - 1992

  •   profesor asistente Full Time

    UNIVERSIDAD DE CHILE

    INTA

    santiago, Chile

    1992 - 1995

  •   Profesor asociado Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    santiago, Chile

    1995 - 2005

  •   Profesor titular Part Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    santiago, Chile

    2005 - A la fecha

Experiencia Profesional

  •   Director Científico y cofundadora Part Time

    Diagnotec

    Santiago, Chile

    1997 - 2011

  •   Director Científico y cofundadora Part Time

    ActivaQ

    Santiago, Chile

    2011 - A la fecha

  •   Pasantía Estudiante de Doctorado Other

    Universidad de Rutgers de New Yersey, Departamento de Bioquímica.

    New Jersey, Estados Unidos

    1989 - 1989

  •   Pasantía Estudiante de Doctorado Other

    Universidad de Miami, Departamento de Microbiología e Inmunología.

    Miami, Estados Unidos

    1989 - 1989

  •   Estadía Postdoctoral Other

    Centre Hospitalier Regional et Universitaire de Dijon. Hospital du Bocage. Laboratorio de Virología

    Dijon, Francia

    1992 - 1992

  •   Pasantía Profesor Other

    Norwegian School of Veterinary, Department of Food Safety and Infection Biology

    Oslo, Noruega

    2002 - 2002

Premios y Distinciones

  •   Rey Baldouino

    Fundación Internacional para la Ciencia

    Suecia, 1995

    Reconocimiento a investigación de calidad en países subdesarrollados.

  •   100 mujeres Líderes de Chile, categoría ciencias

    Mercurio y Mujeres Empresarias

    Chile, 2020

    Aporte en el diagnóstico del virus SARS CoV-2

  •   Mujer destacada 2021

    Embajada de Israel

    Chile, 2021

    Reconocimiento al aporte en el control de la pandemia por COVID-19


 

Article (58)

Analysis by real-time PCR of five transport and conservation mediums of nasopharyngeal swab samples to COVID-19 diagnosis in Santiago of Chile
EVALUATION OF THE IMMUNE RESPONSE INDUCED BY CORONAVAC 28-DAY SCHEDULE VACCINATION IN A HEALTHY POPULATION GROUP
FIRST IDENTIFICATION OF REINFECTION BY A GENETICALLY DIFFERENT VARIANT OF SARS-COV-2 IN A HOMELESS PERSON FROM THE METROPOLITAN AREA OF SANTIAGO , CHILE
Sleeping With the Enemy? The Current Knowledge of Piscine Orthoreovirus (PRV) Immune Response Elicited to Counteract Infection
ANALYSIS OF FOUR DIFFERENT TRANSPORT AND PRESERVATION MEDIUM KITS FOR SARS-COV-2 DIAGNOSIS FROM NASOPHARYNGEAL SWAB BY REAL-TIME PCR: ADAPTING TO THE CONSTANTLY INCREASING DEMAND OF SAMPLING PROCESSING AND STOCK-OUTS DURING THE PANDEMIC
Lactococcus lactis Expressing Type I Interferon From Atlantic Salmon Enhances the Innate Antiviral Immune Response In Vivo and In Vitro
Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals
The Analysis of Live-Attenuated Piscirickettsia salmonis Vaccine Reveals the Short-Term Upregulation of Innate and Adaptive Immune Genes in Atlantic Salmon (Salmo salar): An In Situ Open-Sea Cages Study
Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected by Piscirickettsia salmonis
Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
The Atlantic salmon interleukin 4/13 receptor family: Structure, tissue distribution and modulation of gene expression
Non-lysosomal Activation in Macrophages of Atlantic Salmon (Salmo salar) After Infection With Piscirickettsia salmonis
Detection of piscine orthoreovirus in farmed rainbow trout from Chile
Effect of yeast (Xanthophyllomyces dendrorhous) and plant (Saint Johns wort, lemon balm, and rosemary) extract based functional diets on antioxidant and immune status of Atlantic salmon (Salmo salar) subjected to crowding stress
Study of RNA-A Initiation Translation of The Infectious Pancreatic Necrosis Virus
beta-1,3/1,6-Glucan-supplemented diets antagonize immune inhibitory effects of hypoxia and enhance the immune response to a model vaccine
Isolation and characterization of salmonid CD4+ T cells
Development of a nanoparticle-based oral vaccine for Atlantic salmon against ISAV using an alphavirus replicon as adjuvant
Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV)
Evaluation of the bactericidal activity of secondary metabolites isolated from Heliotropium genus against Piscirickettsia salmonis
Ribavirin stimulates the immune response of Atlantic salmon
Induction of anti-inflammatory cytokine expression by IPNV in persistent infection
Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines
Antiviral activity in vitro and in vivo of natural flavonoids isolated from Heliotropium sinuatum against infectious salmon anemia virus (ISAV)
Evaluation of the immune response against immature viral particles of infectious pancreatic necrosis virus (IPNV): A new model to develop an attenuated vaccine
IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence
Simultaneous detection of the IPN and ISA viruses in outbreaks of clinical disease and mortality in farmed Atlantic salmon, Salmo salar L., in Chile
Inhibitory effect of a nucleotide analog on infectious salmon anemia virus infection
Bioinformatic Analysis of the Genome of Infectious Salmon Anemia Virus Associated with Outbreaks with High Mortality in Chile
Inhibitory effect of aromatic geranyl derivatives isolated from Heliotropium filifolium on infectious pancreatic necrosis virus replication
Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
Inhibition of virion-associated IPNV RNA polymerase, VP1, by radiolabeled nucleotide analogs
Genome assembly and particle maturation of the birnavirus infectious pancreatic necrosis virus
Effect of a nucleotide-enriched diet on the immune system, plasma cortisol levels and resistance to infectious pancreatic necrosis (IPN) in juvenile rainbow trout (Oncorhynchus mykiss)
Electrophoretic analysis of ITS from Piscirickettsia salmonis Chilean isolates
tRNA genes were found in Piscirickettsia salmonis 16S-23S rDNA spacer region (ITS)
In vivo effect of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-carboxamide) on experimental infected rainbow trout (Oncorhynchus mykiss) and coho salmon (Onchorhynchus kisutch) fry with infectious pancreatic necrosis virus
Inhibitory effects of EICAR on infectious pancreatic necrosis virus replication
Detection of the infectious hematopoietic necrosis virus directly from infected fish tissues by dot blot hybridization with a non-radioactive probe
Inhibitors of infectious pancreatic necrosis virus (IPNV) replication
FIRST ISOLATION OF PISCIRICKETTSIA-SALMONIS FROM COHO SALMON, ONCORHYNCHUS-KISUTCH (WALBAUM), AND RAINBOW-TROUT, ONCORHYNCHUS-MYKISS (WALBAUM), DURING THE FRESH-WATER STAGE OF THEIR LIFE-CYCLE
A DETECTION METHOD FOR INFECTIOUS PANCREATIC NECROSIS VIRUS (IPNV) BASED ON REVERSE TRANSCRIPTION (RT)-POLYMERASE CHAIN-REACTION (PCR)
INHIBITION OF IN-VITRO RECONSTITUTION OF ROTAVIRUS TRANSCRIPTIONALLY ACTIVE PARTICLES BY ANTI-VP6 MONOCLONAL-ANTIBODIES
POLYACRYLAMIDE-GEL ELECTROPHORESIS OF VIRAL GENOMIC RNA AS A DIAGNOSTIC METHOD FOR INFECTIOUS PANCREATIC NECROSIS VIRUS DETECTION
Structure of rotavirus particle: Interaction of the inner capsid protein VP6 with the core polypeptide VP3
FUNCTION OF ROTAVIRUS VP3 POLYPEPTIDE IN VIRAL MORPHOGENESIS
IN-VITRO RECONSTITUTION OF ROTAVIRUS TRANSCRIPTIONAL ACTIVITY USING VIRAL CORES AND RECOMBINANT BACULOVIRUS-EXPRESSED VP-6
RESPIRATORY SYNCYTIAL VIRUS DETECTION BY DOT BLOT HYBRIDIZATION WITH A NONRADIOACTIVE SYNTHETIC OLIGODEOXYNUCLEOTIDE PROBE
ROTAVIRUS DETECTION BY DOT BLOT HYBRIDIZATION ASSAY USING A NONRADIOACTIVE SYNTHETIC OLIGODEOXYNUCLEOTIDE PROBE
CHARACTERIZATION OF ROTAVIRUS ELECTROPHEROTYPES EXCRETED BY SYMPTOMATIC AND ASYMPTOMATIC INFANTS
CHARACTERIZATION OF ROTAVIRUS GUANYLYLTRANSFERASE ACTIVITY ASSOCIATED WITH POLYPEPTIDE VP3
Effect of nucleotide analogues on rotavirus transcription and replication
PHOTOAFFINITY-LABELING OF ROTAVIRUS VP1 WITH 8-AZIDO-ATP - IDENTIFICATION OF THE VIRAL-RNA POLYMERASE
FECAL EXCRETION OF ROTAVIRUS AND OTHER ENTEROPATHOGENS IN NEWBORNS OF THE HIGH AND LOW SOCIO-ECONOMIC STRATUM IN SANTIAGO, CHILE
Involvement of structural and nonstructural polypeptides on human rotavirus RNA synthesis
In vitro transcription catalized by human pararotavirus
ROLE OF THE INNER PROTEIN CAPSID ON INVITRO HUMAN ROTAVIRUS TRANSCRIPTION
Estudio comparativo de dos métodos en el diagnóstico de rotavirus en lactantes con diarrea aguda y asintomáticos.

Abstract (4)

Antioxidant and immunostimulant evaluation of functional feed in Atlantic salmon under overcrowding stress
Evaluation of the immune and antioxidants response in Atlantic salmon fed with diets supplemented with yeast extract
ImmuneTrack (R) I and ImmuneTrack (R) A, kits for innate and adaptive immune response evaluation in salmonids
The adjuvants have a key role improving the protection and immune response induced by recombinant protein vaccine against infectious salmon anemia virus ISAV in Atlantic salmon

BookSection (2)

Fish Cytokines and Immune Response
Capítulo Virus de la Necrosis Pancreática Infecciosa

Patent (5)

Antiparasitic formulation of spores and/or protein for the treatment of parasites of the caligidae family in fish
VACUNA ORAL CONTRA EL VIRUS DE LA ANEMIA INFECCIOSA DEL SALMON (ISAV) QUE COMPRENDE NANOPARTÍCULAS DE QUITOSÁN CARGADAS CON VIRINA DEL ISAV Y NANOPARTICULAS DE QUITOSÁN CARGADAS CON ADYUVANTE QUE CONSISTE EN UN ADN QUE CODIFICA LA REPLICASA/TRANSCRIPTASA DE UN ALFAVIRUS DE SALMÓN (REPLICÓN)
uso de 1-beta-D- ribofuranosil-1H-1,2,4-triazol-3-carboxamida para el tratamiento de la anemia infecciosa del salmón ocasionada por el virus de la anemia infecciosa del salmón o virus ISA, en salmónidos.
Method for increasing the survival of aquatic and other animals exposed to an aquatic virus, Birnavirus or other RNA virus and composition for such methods
Neomycin for increasing the survival of aquatic animals exposed to IPNV

Proyecto (13)

PLEIOTROPIC EFFECTS OF IL-4/13 ACTING ON THE ADAPTIVE IMMUNE RESPONSES OF SALMONIDS
INITIATION OF TRANSLATION OF THE MESSENGER RNAS OF THE INFECTIOUS PANCREATIC NECROSIS VIRUS.
EVALUATION OF NATURAL PRODUCTS WITH POTENTIAL ANTIBACTERIAL ACTIVITY AGAINST PISCIRICKETTSIA SALMONIS=> A HEALTH CHALLENGE FOR THE SALMON INDUSTRY
Uso de nanopartículas encapsuladoras de antígenos como plataforma de producción de vacunas en salmónidos.
ESTUDIO DEL MECANISMO DE TRADUCCION DE LAS PROTEINAS DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA
ESTUDIO DE LA REPLICACION DEL GENOMA Y SU RELACION CON LA MORFOGENESIS DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA
ANALISIS DE LA REGION ESPACIADORA 16S-23S DEL LOCUS RRN DE DISTINTOS AISLADOS DE PISCIRIKETTSIA SALMONIS Y SU CORRELACION CON LA PATOGENICIDAD
ESTUDIO DE LA TRANSCRIPCION Y REPLICACION DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA.
REORDENAMIENTO GENETICO DE ROTAVIRUS
DESARROLLO DE METODOS DE DIAGNOSTICO DE VIRUS ASOCIADOS A PATOLOGIAS DE PECES EN CULTIVO
ESTUDIO DE LOS MECANISMOS DE REPLICACION, TRANSCRIPCION Y EXPRESION DEL GENOMIO DE ROTAVIRUS.
DESARROLLO DE SONDAS MOLECULARES NO RADIACTIVAS PARA EL DIAGNOSTICO RAPIDO DE VIRUS Y BACTERIAS PATOGENICAS.
EXPRESION GENICA DE ROTAVIRUS=> CARACTERISTICAS DEL CICLO INFECTIVO.

Review (1)

Infectious salmon anemia virus-Genetics and pathogenesis
70
Ana Sandino

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

13
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

11
Eugenio Spencer

DIRECTOR-INVESTIGADOR

BIOLOGIA

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

10
Felipe Reyes

Associate profesor - Head of UAB Fish transcriptomics platform

Universitat Autònoma de Barcelona

Barcelona, España

5
Mario Tello

Académico

Biología

Universidad de Santiago de Chile

Santiago, Chile

5
Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

4
Eva Vallejos

Investigador Postdoctoral

Centro de Biotecnología Acuícola

Universidad de Santiago de Chile

Santiago, Chile

4
Brenda Modak

Directora Departamento de Ciencias del Ambiente

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

4
Beatriz Valenzuela

Asistente de investigación/Profesor por Hora

Departamento de ciencias del ambiente

Universidad de Santiago de Chile

Santiago, Chile

3
Luis Cottet

Investigador

Ciencias

Universidad Santo Tomas

Santiago, Chile

3
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Jaime Rivas

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

2
Sarita Soto

Asistente de Investigación

Facultad de Odontología

Universidad de Chile

Santiago, Chile

2
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

2
Deborah Vargas

Investigadir

Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Natalia Valdés

Investigador

Universidad de Santiago de Chile

Santiago, Chile

2
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Claudia Reinoso

Docente de planta

Ciencias Básicas

Universidad Santo Tomás

Santiago, Chile

1
Víctor Cifuentes

Prof. Titular

Departamento de Ciencias Ecológicas

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE.

Santiago, Chile

1
Ana Farias

académico

Instituto de Acuicultura

UNIVERSIDAD AUSTRAL DE CHILE

Puerto Montt, Chile

1
Alvaro Sequeida

Investigador Post-Doctoral

ICOD

Universidad de Chile

Santiago, Chile

1
Sergio Guajardo

Postdoctoral researcher

Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Eduardo Olivares

Director area biomedicina

Diagnóstico molecular

Bioingentech

santiago, Chile

1
Andres Castillo

Investigador

Laboratorio Biomédico

Instituto de Salud Pública

Santiago, Chile

1
Mick Parra

Asistente de investigacion

Facultad Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Daniela Toro

Profesor Asistente

facultad de ciencias de la salud

Universidad Autonoma de Chile

Santiago, Chile

1
Ruben Vidal

Profesor Asociado

Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
ADRIÁN HERNÁNDEZ

Profesor Asociado

Departamento de Ciencias Agropecuarias y Acuícolas

UNIVERSIDAD CATÓLICA DE TEMUCO, FACULTAD DE RECURSOS NATURALES

Temuco, Chile

1
Dante Miranda

Director de Extensión

Bioquímica y Biología Molecular

Universidad de Chile, Faculatd de Ciencias Químicas y Farmacéuticas

Santiago, Chile

1
Víctor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

1
Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Camila Solís

Docente Hora / Investigador Lab. Inmunología en Peces

Biología

Universidad Andrés Bello

Santiago, Chile

1
SEBASTIAN REYES

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor de Chile

Santiago, Chile

1
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile