Prof._nelson_varela.png_thumb90

Nelson Miguel Varela Figueroa

Académico

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


FARMACOGENETICA; BIOLOGIA MOLECULAR; ONCOLOGIA

Educación

  •  Bioquímica y Biología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1999
  •  Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

  •   Académico Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2010 - 2015

  •   Académico Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2015 - 2016

  •   Académico Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Responsable Aseguramiento Calidad / RT-PCR para COVID1919 Part Time

    Laboratorio CQF, Facultad de Medicina, Universidad de Chile

    Santiago, Chile

    2020 - A la fecha

Formación de Capital Humano


Dirección de 6 tesis conducentes al grado de licenciado en el periodo 2013-2016
Actualmente dirijo 2 tesis de pregado y 1 tesis de magister, además de la co-tutoria de una tesis doctoral.



 

Article (43)

A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori
Pharmacogenetics-Based Preliminary Algorithm to Predict the Incidence of Infection in Patients Receiving Cytotoxic Chemotherapy for Hematological Malignancies: A Discovery Cohort
As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater
Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients
Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer
Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach
IL-6-572C > G and CARD8 304T > A Genetic Polymorphisms are Associated with the Absolute Neutrophil Count in Patients with Hematological Malignancies Under Chemotherapy: An Application of Multilevel Models to a Preliminary Pharmacogenetic Study
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population
Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients
Study of the allelic variants CYP2C9*2 and CYP2C9*3 in the Peruvian mestizo population [Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en población mestiza peruana]
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis.
The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer
Pharmacogenetics, tobacco, alcohol and its effect on the risk development cancer
Clinical applications of pharmacogenetics
Pharmacogenomics of antiretroviral therapy in Latin America
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells
Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene
Upregulation of rat liver PPARα-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state
Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses
Preclinical evaluation of the Encelia canescens Lam extract: Medicinal properties useful for cancer treatment
Bioequivalence of Acenocoumarol in Chilean Volunteers: an Open, Randomized, Double-Blind, Single-Dose, 2-Period, and 2-Sequence Crossover Study for 2 Oral Formulations
Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: Comparison with caucasian and asian populations
Relative bioavailability of two formulations of rosuvastatin importance in clinical practice Biodisponibilidad relativa de dos formulaciones de rosuvastatina. Importancia en la práctica clínica
A comparative bioavailability study of two formulations of pregabalin in healthy chilean volunteers
Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method
Impaired Cell Cycle Regulation of the Osteoblast-Related Heterodimeric Transcription Factor Runx2-Cbf beta in Osteosarcoma Cells
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs.
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, noalcoholic steatohepatitis obese women
Asociación entre el sistema sanguíneo ABO y los polimorfismos genéticos de enzimas de biotransformación en relación con la susceptibilidad a cancer.
[Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure].
Cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrorne P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients
Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: Exploring some gene-gene and gene-environment interactions
Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones
Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: (a case-only) design study
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations

Abstract (1)

Evaluation of CYP1A1 and GSTM1 as gastric cancer susceptibility biomarkers: Influence of smoking habit and alcohol consumption

Errata (1)

Erratum: Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses (Pharmacological Research (2015) 101 (124-129) DOI: 10.1016/j.phrs.2015.07.020)

Letter (1)

Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene

Proyecto (3)

BIOMARCADORES FARMACOGENÉTICOS DE LA TERAPIA ANTI-RETROVIRAL EN PACIENTES QUE VIVEN CON VIH=> BASES PARA UN DIAGNÓSTICO PRE-TERAPÉUTICO.
IMPROVING TESTICULAR CANCER RISK EVALUATION AND PHARMACOTHERAPY THROUGH PHARMACOGENOMICS
ESTUDIO DE CALIDAD FARMACEUTICA PARA EL DESARROLLO DE UN EXTRACTO COMO MEDICAMENTO ANTINEOPLASICO

Review (3)

The Current State of MicroRNAs as Restenosis Biomarkers
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs
Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure
44
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

18
Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

16
DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

5
juan cayún

Investigador

Departamento de oncología básico-clínico

Universidad de Chile

Santiago, Chile

4
Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

3
María Lavanderos

Académica

Universidad Bernardo O'higgins

Santiago, Chile

2
Leslie Cerpa

Coordinación Logística del Laboratorio CQF

Departamento Oncología Básico-Clínico

Laboratorio de Carcinogénesis Química y Farmacogenética, Departamento Oncología Básico-Clínico, Fac. de Medicina, Universidad de Chile

Santiago, Chile

2
Javier Fernández

Investigador Técnico

Avances Tecnológicos Vertebral

Santiago, Chile

2
Jana Stojanova

Profesor Auxiliar

Departamento Preclinicas

Universidad de Valparaíso

Viña del Mar, Chile

2
Berta Cerda

Director

Instituto Nacional del Cáncer

Santiago, Chile

2
Carla Miranda

Encargada de estudios Clinicos y preclinicos

Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

1
Maria Hernandez

Académico. Profesor Asistente

Nutrición

Universidad de Chile

Santiago , Chile

1
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

1
Fernando Lanas

Profesor titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Vivian DAfonseca da Silva

Assistant Professor and Researcher

Department of Pre-Clinical Sciences

Catholic University of Maule

Talca, Chile

1
Viviana Guajardo

Profesor Asistente

Psiquiatria

Universidad de Chile

Santiago, Chile

1
Johanna Catalán

Académico-Investigador

Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

1
Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

1
Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Alexander Gamboa

Investigador

Ciencias de los Alimentos y Tecnología química

Universidad de Chile

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

1
Nancy Farfán

Post-doc.

Farmacología

Universidad de Chile

Santiago, Chile

1
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rocío Retamales

Docente

Facultad de Ciencias Agropecuarias

Universidad Pedro de Valdivia

Santiago, Chile