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Nelson Miguel Varela Figueroa

Académico

UNIVERSIDAD DE CHILE

Santiago, Chile

FARMACOGENETICA; BIOLOGIA MOLECULAR; ONCOLOGIA

Bioquímica y Biología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004
Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1999
Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - 2015
Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2015 - 2016
Académico Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2017 - A la fecha

Responsable Aseguramiento Calidad / RT-PCR para COVID1919 Part Time

Laboratorio CQF, Facultad de Medicina, Universidad de Chile

Santiago, Chile

2020 - A la fecha

Dirección de 6 tesis conducentes al grado de licenciado en el periodo 2013-2016
Actualmente dirijo 2 tesis de pregado y 1 tesis de magister, además de la co-tutoria de una tesis doctoral.


A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos Armendariz-Castillo, Isaac; Guerrero, Santiago Article ISI FRONTIERS IN PHARMACOLOGY (2021)
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19 Lopez-Cortes, Andres; Kyriakidis, Nikolaos C.; Barba-Ostria, Carlos; Leon Caceres, Angela; Guerrero, Santiago; Ortiz-Prado, Esteban; Tejera, Eduardo; Cevallos-Robalino, Domenica; Gomez-Jaramillo, Ana Maria; Simbana-Rivera, Katherine; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori Pelaez, Diana Article ISI SCIELO BIOLOGICAL RESEARCH (2021)
Pharmacogenetics-Based Preliminary Algorithm to Predict the Incidence of Infection in Patients Receiving Cytotoxic Chemotherapy for Hematological Malignancies: A Discovery Cohort Avila, Femanda; Monterrosa, Claudia; Fohner, Alison E. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients Roco, A.M.; Lavanderos, M. A.; VerÃ³n G.; Salas P.; MejÃas F.; VÃ©liz P.; Varela N.M.; Llull G. Article ISI SCOPUS (2020)
Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer Rahal, Maritza; Daniel Caceres, Dante; Abel Quinones, Luis; Miguel Varela, Nelson Article ISI BIOSCIENCE REPORTS (2020)
Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach Article WOS-ESCI CANCER INFORMATICS (2020)
IL-6-572C > G and CARD8 304T > A Genetic Polymorphisms are Associated with the Absolute Neutrophil Count in Patients with Hematological Malignancies Under Chemotherapy: An Application of Multilevel Models to a Preliminary Pharmacogenetic Study Alveal, Enzo; Soto, Tomas G.; Bustamante, Eva, I; Flores, Ivonne Article ISI PHARMACOGENOMICS PERSONALIZED MEDICINE (2020)
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population Article ISI MOLECULAR BIOLOGY REPORTS (2020)
Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients Cayun JP.; Cerro, R.; Molina-Mellico, S; Cerda, B.; Pena, K Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Study of the allelic variants CYP2C92 and CYP2C93 in the Peruvian mestizo population [Estudio de las variantes alélicas CYP2C92 y CYP2C93 en población mestiza peruana] Alvarado Á.T.; Loja B.; Miyasato J.M.; Varela N.M. Article SCOPUS Biomedica (2019)
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis. Villanueva, Francisco; Araya, Hector; Briceño, Pedro; Varela, Nelson; Stevenson, Andres; Jerez, Sofia; Tempio, Fabian; Chnaiderman, Jonas; Perez, Carola; Villarroel, Milena; Concha, Emma; Khani, Farzaneh; Thaler, Roman; Salazar-Onfray, Flavio; Stein, Gary S; van Wijnen, Andre J; Galindo, Mario Article Journal of cellular physiology (2019)
The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer Cerda, Berta Article ISI SCOPUS PHARMACOGENETICS AND GENOMICS (2019)
Farmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cáncer Roco, A; Cerda, B.; Cayun JP.; Rubilar, JC; Cerro, R.; Varela, N; Quinones, LA Article WOS-ESCI SCIELO SCOPUS REVISTA CHILENA DE PEDIATRIA (2018)
Clinical applications of pharmacogenetics Lares-Asseff, Ismael; Meneses, Francisca; Zaruma-Torres, Fausto; Escalante, Paula Article ISI REVISTA MEDICA DE CHILE (2017)
Pharmacogenomics of antiretroviral therapy in Latin America Varela N.M. Article SCOPUS Pharmacogenomics in Latin America: Challenges and Opportunities (2017)
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells Varela, N; Aranguiz, A; Lizama C.; Sepulveda, H; Antonelli M.; Thaler R.; Montecino, M.; Stein, GS; van Wijnen, AJ; Galindo, M Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene Varela, N; Quiñones, LA. Article PHARMACOLOGICAL RESEARCH (2016)
Upregulation of rat liver PPAR alpha-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol Arenas, Allan; Hernández-Rodas, María C.; Riquelme, Bárbara Article ISI SCOPUS BIOFACTORS (2016)
Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state Videla LA.; Fernández V.; Cornejo P.; Vargas, R.; Carrasco J.; Fernández J; Varela, N Article ISI SCOPUS Free Radical Biology and Medicine (2015)
Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses Varela, N; Quinones, LA; Stojanova, J; Garay, J; Caceres D.; Cespedes, S; Sasso, J.; Miranda, C. Article ISI SCOPUS Pharmacological Research (2015)
Preclinical evaluation of the Encelia canescens Lam extract: Medicinal properties useful for cancer treatment Cayun, JP; Zamorano, J; Quiñones, LA; Varela, N; Squicciarini, V; Larenas, H; Cáceres, D. Article Journal of Natural Remedies (2015)
Bioequivalence of Acenocoumarol in Chilean Volunteers: an Open, Randomized, Double-Blind, Single-Dose, 2-Period, and 2-Sequence Crossover Study for 2 Oral Formulations Sasso, J.; Carmona P.; Quinones, L; Ortiz, M; Tamayo, E; Varela, N; Caceres D.; Saavedra, I. Article ISI SCOPUS Arzneimittel-Forschung/Drug Research (2012)
Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: Comparison with caucasian and asian populations Roco, A; Quinones, L; Agundez J.A.G.; Garcia-Martin, E; Squicciarini V.; Miranda, C.; Garay, J; Farfan, N; Saavedra, I.; Caceres D.; et al. Article SCOPUS FRONTIERS IN GENETICS (2012)
Relative bioavailability of two formulations of rosuvastatin importance in clinical practice Biodisponibilidad relativa de dos formulaciones de rosuvastatina. Importancia en la práctica clínica Saavedra, I.; Quinones, L; Ortiz, M; Varela, N; Sasso, J.; Tamayo E D.C.D. Article SCOPUS Informe Medico (2012)
A comparative bioavailability study of two formulations of pregabalin in healthy chilean volunteers Saavedra, I.; Quinones, L; Sasso, J.; Tamayo, E; Catalán J; Escala, M; Varela, N; León J.; Cáceres D.D. Article SCOPUS Therapeutic Advances in Chronic Disease (2010)
Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method Saavedra, I.; Tamayo, E; Gamboa A; Sasso, J.; Varela, N; Moreno, I; Marchant, D; Caceres D.; Quinones, L Article ISI SCOPUS International Journal of Clinical Pharmacology and Therapeutics (2010)
Impaired Cell Cycle Regulation of the Osteoblast-Related Heterodimeric Transcription Factor Runx2-Cbf beta in Osteosarcoma Cells San Martin, IA; Varela, N; Gaete, M; Villegas, K.; Osorio, M; Antonelli M.; Mancilla, EE; Pereira, BP; Nathan, SS; Lian, JB; et al. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs. Luis Quiñones, Mario Rosero, Angela Roco, Ivan Moreno, Jaime Sasso, Nelson Varela, Dante Caceres Article Revista Médica de Chile (2008)
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, noalcoholic steatohepatitis obese women Varela N.M.; Orellana M.; Rodrigo R.; Poniachik, J; Csendes, A; Smok, G; Cáceres D.D. Article SCOPUS BIOLOGICAL RESEARCH (2008)
Asociación entre el sistema sanguíneo ABO y los polimorfismos genéticos de enzimas de biotransformación en relación con la susceptibilidad a cancer. Luis Quiñones, Dante Cáceres, Inés Salazar, Katherina Betta, Viviana Villela, Ángela Roco, Nelson Varela, Magdalena Orellana, e Iván Saavedra. Article Revista Chilena de Cancerología y Hematología (2007)
[Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure]. Quiñones, Luis; Lee, Kuen; Varela F, Nelson; Escala, Mario; García, Karen; Godoy, Loreto; Castro, Andrés; Soto, Jorge; Saavedra, Iván; Cáceres, Dante Article Revista mÃ©dica de Chile (2006)
Cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers Lee, K; Caceres D.; Varela, N; Csendes, A; Rios, H; Quinones, L Article ISI REVISTA MEDICA DE CHILE (2006)
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study Quinones, LA; Rojas, CR; Orellana, CE; Acevedo, C; Huidobro C.; Varela, NE Article ISI SCOPUS ASIAN JOURNAL OF ANDROLOGY (2006)
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrorne P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients Orellana M.; Rodrigo R.; Varela, N; Araya J.; Poniachik, J; Csendes, A; Smok, G; Videla LA. Article ISI SCOPUS HEPATOLOGY RESEARCH (2006)
Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: Exploring some gene-gene and gene-environment interactions Iturrieta, J; Acevedo, C; Huidobro C.; Varela, N; Quinones, L Article ISI SCOPUS EUROPEAN JOURNAL OF EPIDEMIOLOGY (2005)
Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones Galindo, M; Varela, N; Espinoza I; Toro, GC; Hellman, U; Wernstedt, C; Galanti N. Article ISI SCOPUS FEBS LETTERS (2004)
Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: (a case-only) design study Caceres D.; Iturrieta, J; Acevedo, C; Huidobro C.; Varela, N; Escala, M; Quinones, L Article ISI REVISTA MEDICA DE CHILE (2004)
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Videla LA.; Rodrigo R.; Orellana M.; Fernández V.; Tapia, G; Quinones, L; Varela, N; Contreras, J.; Lazarte, R; Csendes, A; et al. Article ISI SCOPUS CLINICAL SCIENCE (2004)
Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption Orellana M.; Varela, N; Guajardo, V; Araya J.; Rodrigo R. Article ISI SCOPUS COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY PHARMACOLOGY (2002)
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people Quinones, L; Lucas D.; Godoy, J; Caceres D.; Berthou, F; Varela, N; Lee, K; Acevedo, C; Martinez L.; Aguilera, AM; et al. Article ISI SCOPUS CANCER LETTERS (2001)
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations Article Cancer Letters (1999)


Evaluation of CYP1A1 and GSTM1 as gastric cancer susceptibility biomarkers: Influence of smoking habit and alcohol consumption Caceres D.; Lee, K; Varela, N; Csendes, A; Rios, H; Quinones, L Abstract ISI EPIDEMIOLOGY (2006)


Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through polymorphism analyses (vol 101, pg 124, 2015) Varela, N; Stojanova, J; Garay, J; Caceres D.; Cespedes, S; Sasso, J.; Miranda, C. Errata ISI SCOPUS PHARMACOLOGICAL RESEARCH (2016)


Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene Varela N.M. Letter ISI SCOPUS PHARMACOLOGICAL RESEARCH (2016)


BIOMARCADORES FARMACOGENÉTICOS DE LA TERAPIA ANTI-RETROVIRAL EN PACIENTES QUE VIVEN CON VIH=> BASES PARA UN DIAGNÓSTICO PRE-TERAPÉUTICO. Facultad de Medicina, Universidad de Chile (11-2016) Proyecto 2016-2017 Inv. Responsable
IMPROVING TESTICULAR CANCER RISK EVALUATION AND PHARMACOTHERAPY THROUGH PHARMACOGENOMICS FONDECYT (1140434) Proyecto 2014-2018 Coinvestigador(a)
ESTUDIO DE CALIDAD FARMACEUTICA PARA EL DESARROLLO DE UN EXTRACTO COMO MEDICAMENTO ANTINEOPLASICO INNOVA-CORFO (12IDL2-16208) Proyecto 2013-2015 Director(a)


The Current State of MicroRNAs as Restenosis Biomarkers Salazar, L.A. Review ISI SCOPUS (2020)
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs Quinones, L; Rosero, M; Roco, A; Moreno, I; Sasso, J.; Varela, N; Caceres D.; Saavedra, I. Review ISI REVISTA MEDICA DE CHILE (2008)
Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Quinones, L; Lee, K; Varela, N; Escala, M; García K.; GODOY, L.; Castro A.; Soto J.; Saavedra, I.; Caceres D. Review ISI REVISTA MEDICA DE CHILE (2006)

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Fernando Lanas

Profesor titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Lilian Jara

Titular Professor

Human Molecular Genetic

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

Santiago, Chile

Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

Ariel Arencibia

Profesor Titular

Centro de Biotecnología de los Recursos Naturales

UNIVERSIDAD CATÓLICA DEL MAULE

Talca, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

TOMÁS ZAMBRANO

RESEARCHER

ENVIRON SPA

SANTIAGO, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Alexander Gamboa

Profesor Asistente

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Jana Stojanova

Profesor Auxiliar

Departamento Preclinicas

Universidad de Valparaíso

Viña del Mar, Chile

Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

Carla Miranda

Encargada de estudios Clinicos y preclinicos

Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

Viviana Guajardo

Profesor Asistente

Psiquiatria

Universidad de Chile

Santiago, Chile

juan cayún

Investigador

Departamento de oncología básico-clínico

Universidad de Chile

Santiago, Chile

María Bertoglia

Profesor Asistente

Escuela de Salud Pública

Universidad de Chile

Santiago, Chile

Berta Cerda

Director

Instituto Nacional del Cáncer

Santiago, Chile

Johanna Catalán

Profesor Asistente Regular

Facultad de Medicina y Ciencia

Universidad Central de Chile

Santiago, Chile

María Lavanderos

Académica

Universidad Bernardo O'higgins

Santiago, Chile

Leslie Cerpa

Coordinación Logística del Laboratorio CQF

Departamento Oncología Básico-Clínico

Laboratorio de Carcinogénesis Química y Farmacogenética, Departamento Oncología Básico-Clínico, Fac. de Medicina, Universidad de Chile

Santiago, Chile

Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Nancy Farfán

Post-doc.

Farmacología

Universidad de Chile

Santiago, Chile

Marcia Gaete

Vivian DAfonseca da Silva

Assistant Professor and Researcher

Department of Pre-Clinical Sciences

Catholic University of Maule

Talca, Chile

Maria Hernandez

Académico. Profesor Asistente

Nutrición

Universidad de Chile

Santiago , Chile

Javier Fernández

Investigador

Fundación COANIQUEM Avances Tecnológicos

Santiago, Chile

Rocío Retamales

Consultora de análisis genómicos

Freelance

Dresden, Alemania

Ivonne Flores

Jefe Farmacia clínica

Subgerencia de servicios farmacéuticos

Fundación Arturo López Pérez

Santiago, Chile

Juan Rubilar

MARIO GALINDO

Profesor Asociado

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Nelson Miguel Varela Figueroa

Líneas de Investigación

Educación

Bioquímica y Biología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004

Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1999

Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

Académico Full Time

Académico Full Time

Académico Full Time

Experiencia Profesional

Responsable Aseguramiento Calidad / RT-PCR para COVID1919 Part Time

Formación de Capital Humano

Article (43)

Abstract (1)

Errata (1)

Letter (1)

Proyecto (3)

BIOMARCADORES FARMACOGENÉTICOS DE LA TERAPIA ANTI-RETROVIRAL EN PACIENTES QUE VIVEN CON VIH=> BASES PARA UN DIAGNÓSTICO PRE-TERAPÉUTICO.

IMPROVING TESTICULAR CANCER RISK EVALUATION AND PHARMACOTHERAPY THROUGH PHARMACOGENOMICS

ESTUDIO DE CALIDAD FARMACEUTICA PARA EL DESARROLLO DE UN EXTRACTO COMO MEDICAMENTO ANTINEOPLASICO

Review (3)