Man

Carlos Ernesto Irarrazabal Muñoz

Full Professor

Universidad de Los Andes

Santiago, Chile

Líneas de Investigación


I am the Head of the Molecular and Integrative Physiology lab we studied Renal and Cardiovascular Physiology. Hypoxia Signaling pathways; Acute Kidney Injury; Renal Transplantation; Biomarkers, and fetal effect of uteroplacental restriction.

Educación

  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2000
  •  Biouímica, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1993

Experiencia Académica

  •   Profesor Ayudante Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1994 - 2001

  •   Profesor Auxiliar Full Time

    Universidad de los Andes

    Medicina

    Santiago, Chile

    2007 - 2011

  •   Profesor Titular Full Time

    Universidad de los Andes

    Medicina

    Santiago, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Fellow Researc Full Time

    The National Institutes of Health

    Bethesda, Estados Unidos

    2002 - 2007

  •   Ph.D. studient Full Time

    Universidad de Chile

    Santiago, Chile

    1996 - 2001

  •   Head of the Molecular and Integrative Physiology Lab Full Time

    Universidad de los Andes

    Santiago, Chile

    2010 - A la fecha

  •   Scientific Director Full Time

    Kinostics SpA

    Santiago, Chile

    2012 - 2016

Formación de Capital Humano


2019. Post-Doctoral position. “Role of extracellular nanovesicles in the cardiac ischemis” Dr. Luis Osorio
2019. Post-Doctoral position. “Role of nanovesicles extracellulars in Cerebral infarcts” Dr. Guillermo Villamizar.
2016-2018. Post-Doctoral position. “Extracellular nanovesicles in plasma are involved in ischemic response” Dr. Daniel Hevia.
2017-2018. Post-Doctoral position. “NFAT5-target gene activated by hypoxia” Dr. Rodrigo Fuentealba.
2017-2019. Magister Thesis. Universidad de Concepción. “El estrés oxidativo y la iNOS promueven una disminución de elementos asociados a cardioprotección en el corazón fetal durante el retardo de crecimiento intrauterino (RCIU)”. Lissette Puentes.
2017. Undergraduate Thesis. “NFAT 5, a través de BCl–2, Juega un Papel Protector durante la Hipoxia”. Alexander Eggers
2017. Undergraduate Thesis. “NFAT5 prevented apoptosis durante la Hipoxia”. Ma del Pilar Espinosa.
2016-2017. Post-Doctoral position. “Effect of Intrauterine Growth Restriction in fetal Cardiovascular and Renal system” Dr. Cristobal Alvarado.
2015-2016 Undergraduate Thesis, Faculty of Sciences, P. Universidad Católica. “Efecto del óxido nítrico (NO) producido por iNOS en la regulación de NFAT5 en condiciones de hipoxia e hipoxia/reoxigenación en cultivo celular”. Yair Serman.
2014. Undergraduate Thesis, Universidad Andres Bello, "Evaluación de la respuesta celular al daño inducido por hipoxia" Carla Droguett
2014. Internship in Doctoral Program, Facultad de Medicina at Universidad de los Andes. "Association of NFAT5 and S100A/B in an animal model of stroke". Diego Gaete.
2013 Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. “Effect of Intrauterine Growth Restriction in gene expression of proteins related to nitric oxide in fetal kidney”. Jorge Cifuentes.
2013. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Role of Oxidative stress on NFAT5 activation durong hypoxia and reoxygenation" Nicolás Muñoz.
2012. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Role of NFAT5 in cellular response during hypoxia and reoxygenation" Albano Caceres Verschae.
2011. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Relationchip between hif-1 alfa and TonEBP in response to hypoxia and hypertonicity. " Daniela Santapau Vignolo.


Premios y Distinciones

  •   Scientific Research in Coronary Disease Award

    Fundación Araucaria

    Chile, 2016

    Best Scientific Research in Coronary Disease Award in LIII Cardiology and Cardiovascular Surgery Congress

  •   Fogarty

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2002

    Global Health Program for Fellows and Scholars


 

Article (33)

Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells
Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis
L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice
l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice.
En el Infarto agudo al miocardio los niveles plasmáticos de microvesículas extracelulares se elevan más precozmente que el aumento de la Troponina-I
Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model
Incidence and consequences of acute kidney injury among patients admitted to critical care units
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia
Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats
Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease
Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis
Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure
The mini-PET in pediatric peritoneal dialysis: A useful tool to predict volume overload?
Urinary Exosomes as a Source of Kidney Dysfunction Biomarker in Renal Transplantation
Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses
Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
Phospholipase C-gamma 1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP
Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP
Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53

Abstract (3)

NFAT5 as a Novel Biomarker of Hypoxia: Role in Preeclampsia and Intra-Uterine Growth Restriction (IUGR)
FGF23 Is Modulated By Calcium In Children Under Chronic Peritoneal Dialysis.
Impaired growth hormone singnaling pathway in fibroblasts of children with chronic renal failure peritoneal dialysis treatment. Preliminary data

Patent (1)

Method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using NFAT5

Proyecto (11)

Desarrollo de un Test de Diagnóstico temprano de Isquemia Cardíaca Silente (ICS), no invasivo y de bajo costo, basado en la detección de Hipoxia tisular
THE PROTECTIVE ROLE OF NUCLEAR FACTOR OF ACTIVATED T-CELLS 5 (NFAT5) DURING RENAL ISCHEMIA/REPERFUSION IS DEPENDENT OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS)=> PARTICIPATION OF AQP-1
DESARROLLO DE UN PROTOTIPO DE KIT DE DIAGNÓSTICO EN ORINA PARA LA DETECCIÓN TEMPRANA DE INJURIA RENAL AGUDA (IRA) EN PACIENTES DE RIESGO
International SAE Consortium LTD. International Drug Induced Renal Injury Consortium (DIRECT) “Network” Consortium
Toll-like Receptor Mediates the Immunosuppressive to Proinflammatory Switch in Mesenchymal Stem Cells=> In vitro and in vivo Evaluation in Autoimmune Models of Multiple Sclerosis and Rheumatoid Arthritis.
Estudio de Biomarcadores de daño renal en niños con Diabetes Mellitus tipo 1
Intrauterine growth restriction induces changes in the embryonic kidney gene expression
El Retardo del Crecimiento Intrauterino (RCIU) experimental produce la activación de genes asociados con estrés.
Polimorfismos genéticos asociados a la susceptibilidad del cáncer colorrectal esporádico y su relación genotipo-fenotipo
The transcrition factor Tonicity Enhancer Binding Protein (TonEBP) has a protective role in renal ischemia-reperfusion.
DETERMINACION DE MUTACIONES EN ONCOGENES RELACIONADOS CON CANCER PULMONAR

Review (1)

Biosafety information management systems. A comparative analysis of the regulatory systems in Canada, Argentina, and Chile
34
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

6
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

5
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

5
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

4
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

4
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Flavio Carrion

Director Científico, Programa de Inmunología Traslacional. Director Doctorado en Ciencias e Innovación en Medicina. ICIM, Facultad de Medicina

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

3
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Jorge Cifuentes

Investigador

Universidad de Los Andes

Santiago, Chile

3
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

2
Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Orozimba Delgado

Profesor Asociado

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

2
Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

2
DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Lara Jorge

Investigadora Adjunta

Centro de Investigación e Innovación Biomédica

Universidad de los Andes

Santiago, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cristobal Alvarado

Coordinador Nacional de Bioquimica

Universidad San Sebastian

Chile

1
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

1
Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

1
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ioram Jacubovsky

Médico Cirujano

Servicio de Cirugía

Hospital Dr. Sótero Del Río

Santiago, Chile

1
Pia Venegas

Asesora Técnica

Enfermedades No Transmisibles

Ministerio de Salud

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
José Erpel

SUBDIRECTOR DE ESCUELA

SALUD

DUOC UC

SANTIAGO, Chile

1
Andrés Boltansky

CLINICA DÁVILA

Santiago, Chile

1
Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Fernando Verdugo

Cardiólogo

Departamento de Enfermedades Cardiovasculares

Hospital Militar de Santiago

Santiago, Chile

1
Ana Maria Vega

Investigador postdoctoral

Centro en Investigaciones Biomédicas

Universidad de Los Andes

Santiago, Chile