Man

Lara Jorge Monteiro

Profesora Asistente

Universidad de Los Andes

Santiago, Chile

Líneas de Investigación


Etiopathology of endometriosis The role of FOXM1 in early preeclampsia-related events Biomarkers for prenatal diagnosis: intrauterine growth restriction,gestational diabetes The role and regulation of FOXM1 in chemotherapy resistance in breast cancer

Educación

  •  Brast Cancer Signalling, Transcription and Drug Resistance, IMPERIAL COLLEGE LONDON. Reino Unido, 2013
  •  Molecular Medicine, CRANFIELD UNIVERSITY. Chile, 2009
  •  Biomedical Sciences, Universidade do Algarve. Portugal, 2007

Experiencia Académica

  •   Postdoctoral Research Fellow Full Time

    UNIVERSIDAD DE LOS ANDES

    Faculty of Medicine

    Santiago, Chile

    2013 - 2018

  •   PhD student Full Time

    IMPERIAL COLLEGE LONDON

    Faculty of Medicine

    London, Reino Unido

    2009 - 2013

  •   Internship Full Time

    IMPERIAL COLLEGE LONDON

    Faculty of Medicine

    London, Chile

    2008 - 2009

  •   Investigador Adjunto Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicina

    Santiago, Chile

    2018 - 2021

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicina

    Santiago, Chile

    2022 - A la fecha

Experiencia Profesional

  •   Postdoctoral Researcher Full Time

    Universidad de los Andes

    Santiago, Chile

    2013 - 2018

  •   Investigadora Adjunta Full Time

    Universidad de los Andes

    Santiago, Chile

    2018 - A la fecha

  •   Profesor Asistente Full Time

    Universidad de los Andes

    Santiago, Chile

    2022 - A la fecha

Formación de Capital Humano


Project Management
Co-supervisor under-graduate student’s thesis (Uandes, Facultad de Odontología): “Expresión de microRNAs en fluidos orales y su asociación con el desarrollo de Diabetes Gestacional y Preeclampsia: Estudio Piloto"
Maria Fernanda Cambara de Dios

Co-supervisor PhD thesis:
María José Bendeck
"Characterization of the inflammatory phenotype of trophoblasts as a response to periodontal infection (P. gingivalis and F. nucleatum) and high glucose stimuli in vitro"

Albano J. Cáceres Verschae
"El eje IL-8/CXCR1 regula la liberación de vesículas extracelulares con un perfil protumorigénico provenientes de células de cáncer de ovario."

Postgraduate Teaching Biomedicine PhD (Universidad de los Andes)
3364 Tópicos Avanzados en Biomedicina”– Contenido Optativo: “Investigación Traslacional en Medicina Materno-Fetal”
1714 Biología Celular y Molecular en Biomedicina
1210 Avances Biotecnológicos en Medicina

Peer review of ISI Journals
Plos One: Maternal preeclampsia and androgens in the offspring around puberty: a follow-up study. Alsnes et al. 2016
Plos One: Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. Zhou et al. 2015
BioMed Research International: Update on biomarkers for the detection of endometriosis. Fassbender et al. 2015

Review Editor (added to PURE):
Frontiers Cell and Developmental Biology (desde 19.10.2020)


Premios y Distinciones

  •   FONDECYT POSTDOCTORAL 2014

    FONDECYT

    Chile, 2014

    Study the role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia

  •   PhD fellowships 2009

    MINISTRY OF SCIENCE AND TECHNOLOGY

    Portugal, 2009

    Study the role and regulation of FOXM1 in chemotherapy resistance in breast cancer

  •   Fondecyt Iniciacion

    FONDECYT

    Chile, 2018

    The role of FOXM1 in early preeclampsia-related events.

  •   First place IFPA-ECR award in IX SLIMP VIRTUAL MEETING

    IFPA

    Colombia, 2022

    First place in the IFPA-ECR award in the IX SLIMP-Latin American Society for Materno Fetal Interaction and Placenta virtual meeting (MAY 4-6, 2022)

  •   FONDECYT REGULAR

    FONDECYT

    Chile, 2023

    The potential role of menstrual mesenchymal stem cells in the etiopathology of endometriosis and its association with impaired endometrium receptivity


 

Article (32)

FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion: Potential Role in Blastocyst Implantation

Nardocci, Gino

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2024)

Identification of LOC101927355 as a Novel Biomarker for Preeclampsia

Navarro, Cristina; Nardocci, Gino

Article ISI
BIOMEDICINES  (2022)

Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of Preeclampsia

Nardocci, Gino

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2022)

Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood

Choolani, Mahesh A.; Wyneken, Ursula

Article ISI
SCIENTIFIC REPORTS  (2021)

Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle

Hoare, Anilei; Chaparro, Alejandra

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis



Article ISI
NUTRIENTS  (2021)

The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction

Ong, Judith; Nardocci, Gino

Article ISI
GENES  (2021)

Diagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use

Kusanovic, Juan P; Schepeler, Manuel; Martinez, Jaime

Article ISI SCOPUS
DIAGNOSTICS  (2020)

Diagnostic potential of peri-implant crevicular fluid microRNA-21-3p and microRNA-150-5p and extracellular vesicles in peri-implant diseases

Chaparro, Alejandra; Sanz, Antonio

Article ISI
JOURNAL OF PERIODONTOLOGY  (2020)

Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy



Article ISI SCOPUS
DIAGNOSTICS  (2020)

Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia

Venegas-Duarte, Sebastian; Hill, Charlotte; Caceres-Verschae, Albano; Zavala, Gabriela; Romero, Roberto

Article ISI SCOPUS
STEM CELLS INTERNATIONAL  (2019)

Extracellular vesicle concentration in maternal plasma as an early marker of gestational diabetes

Arias, Mario

Article ISI
REVISTA MEDICA DE CHILE  (2019)

Normality Ranges of Menstrual Fluid Volume During Reproductive Life Using Direct Quantification of Menses with Vaginal Cups

Monteiro, L. J.; Illanes, S. E.

Article ISI SCOPUS
GYNECOLOGIC AND OBSTETRIC INVESTIGATION  (2019)

Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus

Saavedra, Jose F.; Chaparro, Alejandra

Article ISI SCOPUS
PLOS ONE  (2019)

Effects of earthquake on perinatal outcomes: A Chilean register-based study



Article ISI SCOPUS
PLOS ONE  (2018)

Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia

Sanchez, Marianela; Acuña-Gallardo, Stephanie; Venegas, Pía; Herrera, Valentina; Lam, Eric W.-F.

Article ISI SCOPUS
REPRODUCTIVE SCIENCES  (2018)

Fetal programming and gestational diabetes mellitus

Monteiro, Lara J.; Norman, Jane E.; Rice, Gregory E.

Article ISI SCOPUS
PLACENTA  (2016)

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

Khongkow, P.; Gomes, A. R.; Gong, C.; Man, E. P. S.; Tsang J.W.-H.; Zhao, F.; Monteiro, L. J.; Coombes, R. C.; Medema, R. H.; Khoo, U. S.; et al.

Article SCOPUS
Oncogene  (2016)

FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer

Gong, C.; Fujino, K.; Monteiro, L. J.; Gomes, A. R.; Drost, R.; Davidson-Smith, H.; Takeda, S.; Khoo, U. S.; Jonkers, J.; Sproul, D.; et al.

Article ISI
ONCOGENE  (2015)

NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction

Dobierzewska, A; Palominos, M; Sánchez M.; Lozano, M.; Perez-Sepulveda, A; Monteiro, LJ; Burmeister, Y; Figueroa-Diesel, H; Rice, GE; Illanes, SE

Article ISI SCOPUS
Biology of Reproduction  (2015)

Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia

Perez-Sepulveda, A; Monteiro, LJ; Dobierzewska, A; Espana-Perrot, PP; Venegas-Araneda, P; Guzman-Rojas, AM; Palominos-Rivera, M; Figueroa-Diesel, H; Varas-Godoy, M.; Illanes, SE

Article ISI SCOPUS
PLOS ONE  (2015)

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

Khongkow, P.; Karunarathna, U.; Khongkow, M.; Yague, E.; Kongsema, M.; Zona, S.; Man, E. P. S.; Tsang, J. W-H; Coombes, R. C.; Wu, K-J; et al.

Article ISI
ONCOGENE  (2014)

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

Khongkow, Mattaka; Olmos, Yolanda; Gong, Chun; Gomes, Ana R.; Yaguee, Ernesto; Cavaco, Tania B.; Khongkow, Pasarat; Man, Ellen P. S.; Laohasinnarong, Sasiwan; Koo, Chuay-Yeng; et al.

Article ISI
CARCINOGENESIS  (2013)

The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

Morris, J. R.; Man, C.; Weekes, D.; Koo, C-Y; Pinto, P. H.; Varghese, V.; Kenny, L. M.

Article ISI
ONCOGENE  (2013)

Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin

Ho, Ka-Kei; McGuire, Victoria A.; Muir, Kyle W.; Maifoshie, Evie; Kelly, Douglas J.; McGovern, Ursula B.; Nebreda, Angel R.; Campbell, David G.; Arthur, J. Simon C.

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2012)

The p38 MAPK-MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment

de Olano, Natalia; Pinto, Paola H.; Aligue, Rosa

Article ISI
MOLECULAR CANCER RESEARCH  (2012)

The Transcription Factor Encyclopedia

Yusuf, Dimas; Butland, Stefanie L.; Swanson, Magdalena I.; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A.; Zhang, Xiao Yu Cindy; Dickman, Christopher T. D.; Fulton, Debra L.; Lim, Jonathan S.; et al.

Article ISI
GENOME BIOLOGY  (2012)

ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance

Millour, Julie; Horimoto, Yoshiya; Langer, Julia K.; Hajji, Nabil

Article ISI
MOLECULAR CANCER THERAPEUTICS  (2011)

iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe

Jiang, LiLi; Siu, Michelle K. Y.; Wong, Oscar G. W.; Tam, Kai-Fai; Ngan, Hextan Y. S.; Le, Xiao-Feng; Wong, Esther S. Y.; Chan, Hoi-Yan; Cheung, Annie N. Y.

Article ISI
CLINICAL CANCER RESEARCH  (2011)

Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

Chen, Jie; Wong, San Yu; Wu, Lai Han; Ng, Ting-Ting; Karadedou, Christina T.; Ip, Ying-Chi; Cheung, Yuen Nei; Sunters, Andrew; Chan, Kelvin Y. K.

Article ISI
PLOS ONE  (2010)

Definition of microRNAs That Repress Expression of the Tumor Suppressor Gene FOXO1 in Endometrial Cancer

Wang, Jun; Christian, Mark; Fusi, Luca; Dina, Roberto E.; Ghaem-Maghami, Sadaf

Article ISI
CANCER RESEARCH  (2010)

FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells

Kwok, Jimmy M. -M.; Peck, Barrie; Myatt, Stephen S.

Article ISI
MOLECULAR CANCER RESEARCH  (2010)

Proyecto (13)

DECIPHERING THE ROLE OF MITOCHONDRIAL TRANSFER IN THE PATHOPHYSIOLOGY OF PREECLAMPSIA

Nardocci, Gino A.

Proyecto
 (2024)

The potential role of menstrual mesenchymal stem cells in the etiopathology of endometriosis and its association with impaired endometrium receptivity

Patricia Luz Crawford; Manuel Donoso O.

Proyecto
 (2023)

Desarrollo de un algoritmo multiparamétrico para diagnóstico no invasivo de endometriosis



Proyecto
 (2022)

Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)



Proyecto
 (2021)

Prenatal stress: maternal astrocyte-derived extracellular vesicles as a novel stress-transfer mechanism contributing to adverse offspring neurodevelopment

Wyneken, I. U.; Nardocci, Gino

Proyecto
 (2021)

Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile

Nardocci, Gino; Arango, P

Proyecto
 (2020)

Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos.



Proyecto
 (2020)

The role of FOXM1 in early preeclampsia-related events.

Monteiro, Lara Jorge

Proyecto
 (2018)

The role of FOXM1 in early preeclampsia-related events.

FONDECYT (11181249)

Proyecto
2018-2021
Inv. Principal

The role of the aromatase pathway in 2-methoxyestradiol



Proyecto
 (2013)

THE ROLE OF THE AROMATASE PATHWAY IN 2-METHOXYESTRADIOL SYNTHESIS IN THE PATHOGENESIS OF PREECLAMPSIA

FONDECYT (3140038)

Proyecto
2013-2016
Inv. Responsable

The role and regulation of FOXM1 in chemotherapy resistance in breast cancer

Fundação para a Ciência e a Tecnologia, Portuguese Ministry of Education and Science (SFRH / BD / 47191 / 2008)

Proyecto
2009-2012
Tesista

Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia.



Proyecto
 (0)

2
Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

2
Emma Hernandez

Directora

Servicio de Anatomía Patológica

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

2
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

3
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

15
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

1
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

6
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Víctor Beltrán

Profesor Asociado

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

43
Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Valeria Ramirez

PROFESOR TITULAR

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

5
Max Monckeberg

Profesor Investigador Asistente.

Ginecología Obstetricia y Biología de la Reproducción.

Universidad de Los Andes.

Santiago, Chile

8
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

3
Reyna Peñailillo

Postdoctorado

Centro de Investigación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Gisela Canedo

Investigadora y Profesora

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

1
Charlotte Hill

Postdoctoral Fellow

CIIB

Universidad de Los Andes

Santiago, Chile

3
Pia Venegas

Asesora Técnica

Dirección de salud

Desafío Levantemos Chile

Santiago, Chile

2
Yasna Palmeiro

Research Fellow

Institute for Global Health

University College London

London, Reino Unido

1
Manuel Donoso

JEFE DE DEPARTAMENTO

Departamento de Obstetricia, Ginecología y Biología de la Reproducción

UNIVERSIDA DE LOS ANDES

SANTIAGO, Chile

1
Maria del Pilar Díaz

Profesor Jornada

Medicina

Universidad de Los Andes

Santiago, Chile

2
RAMON SERRA

JEFE DE SERVICIO

GINECOLOGIA

HOSPITAL NAVAL FFAA

PUNTA ARENAS, Chile