Man

Lara Jorge Monteiro

Profesora Asistente

Universidad de los Andes

Santiago, Chile

Líneas de Investigación


The role and regulation of FOXM1 in chemotherapy resistance in breast cancer. The role of FOXM1 in early preeclampsia-related events. Fetal programming and gestational diabetes mellitus. Early detection of gestational diabetes mellitus.

Educación

  •  Brast Cancer Signalling, Transcription and Drug Resistance, IMPERIAL COLLEGE LONDON. Reino Unido, 2013
  •  Molecular Medicine, CRANFIELD UNIVERSITY. Chile, 2009
  •  Biomedical Sciences, Universidade do Algarve. Portugal, 2007

Experiencia Académica

  •   Postdoctoral Research Fellow Full Time

    UNIVERSIDAD DE LOS ANDES

    Faculty of Medicine

    Santiago, Chile

    2013 - 2018

  •   PhD student Full Time

    IMPERIAL COLLEGE LONDON

    Faculty of Medicine

    London, Reino Unido

    2009 - 2013

  •   Internship Full Time

    IMPERIAL COLLEGE LONDON

    Faculty of Medicine

    London, Chile

    2008 - 2009

  •   Investigador Adjunto Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicina

    Santiago, Chile

    2018 - 2021

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicina

    Santiago, Chile

    2022 - A la fecha

Experiencia Profesional

  •   Postdoctoral Researcher Full Time

    Universidad de los Andes

    Santiago, Chile

    2013 - 2018

  •   Investigadora Adjunta Full Time

    Universidad de los Andes

    Santiago, Chile

    2018 - A la fecha

  •   Profesor Asistente Full Time

    Universidad de los Andes

    Santiago, Chile

    2022 - A la fecha

Formación de Capital Humano


Project Management
Co-supervisor under-graduate student’s thesis (Uandes, Facultad de Odontología): “Expresión de microRNAs en fluidos orales y su asociación con el desarrollo de Diabetes Gestacional y Preeclampsia: Estudio Piloto"
Maria Fernanda Cambara de Dios

Co-supervisor PhD thesis:
María José Bendeck
"Characterization of the inflammatory phenotype of trophoblasts as a response to periodontal infection (P. gingivalis and F. nucleatum) and high glucose stimuli in vitro"

Albano J. Cáceres Verschae
"El eje IL-8/CXCR1 regula la liberación de vesículas extracelulares con un perfil protumorigénico provenientes de células de cáncer de ovario."

Postgraduate Teaching Biomedicine PhD (Universidad de los Andes)
3364 Tópicos Avanzados en Biomedicina”– Contenido Optativo: “Investigación Traslacional en Medicina Materno-Fetal”
1714 Biología Celular y Molecular en Biomedicina
1210 Avances Biotecnológicos en Medicina

Peer review of ISI Journals
Plos One: Maternal preeclampsia and androgens in the offspring around puberty: a follow-up study. Alsnes et al. 2016
Plos One: Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. Zhou et al. 2015
BioMed Research International: Update on biomarkers for the detection of endometriosis. Fassbender et al. 2015

Review Editor (added to PURE):
Frontiers Cell and Developmental Biology (desde 19.10.2020)


Premios y Distinciones

  •   FONDECYT POSTDOCTORAL 2014

    FONDECYT

    Chile, 2014

    Study the role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia

  •   PhD fellowships 2009

    MINISTRY OF SCIENCE AND TECHNOLOGY

    Portugal, 2009

    Study the role and regulation of FOXM1 in chemotherapy resistance in breast cancer

  •   Fondecyt Iniciacion

    FONDECYT

    Chile, 2018

    The role of FOXM1 in early preeclampsia-related events.

  •   First place IFPA-ECR award in IX SLIMP VIRTUAL MEETING

    IFPA

    Colombia, 2022

    First place in the IFPA-ECR award in the IX SLIMP-Latin American Society for Materno Fetal Interaction and Placenta virtual meeting (MAY 4-6, 2022)


 

Article (29)

Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood
Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis
The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction
Diagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use
Diagnostic potential of peri-implant crevicular fluid microRNA-21-3p and microRNA-150-5p and extracellular vesicles in peri-implant diseases
Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy
Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia
Extracellular vesicle concentration in maternal plasma as an early marker of gestational diabetes
Normality Ranges of Menstrual Fluid Volume During Reproductive Life Using Direct Quantification of Menses with Vaginal Cups
Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus
Effects of earthquake on perinatal outcomes: A Chilean register-based study
Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia
Fetal programming and gestational diabetes mellitus
Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance
FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin
The p38 MAPK-MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
The Transcription Factor Encyclopedia
ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance
iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe
Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer
Definition of microRNAs That Repress Expression of the Tumor Suppressor Gene FOXO1 in Endometrial Cancer
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells

Proyecto (10)

Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Prenatal stress: maternal astrocyte-derived extracellular vesicles as a novel stress-transfer mechanism contributing to adverse offspring neurodevelopment
Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile
Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos.
The role of FOXM1 in early preeclampsia-related events.
The role of FOXM1 in early preeclampsia-related events.
The role of the aromatase pathway in 2-methoxyestradiol
THE ROLE OF THE AROMATASE PATHWAY IN 2-METHOXYESTRADIOL SYNTHESIS IN THE PATHOGENESIS OF PREECLAMPSIA
The role and regulation of FOXM1 in chemotherapy resistance in breast cancer
Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia.
37
Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de los Andes

Santiago, Chile

12
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

6
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

3
Pia Venegas

Asesora Técnica

Enfermedades No Transmisibles

Ministerio de Salud

Santiago, Chile

2
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

2
Maroun Khoury

A/Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

1
Charlotte Hill

PhD(c)

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Yasna Palmeiro

PGTA; Student Researcher

Institute for Global Health

University College London

London, Reino Unido

1
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

1
Víctor Beltrán

Profesor Asociado

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

1
Reyna Peñailillo

Postdoctorado

Centro de Investigación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Manuel Donoso

JEFE DE DEPARTAMENTO

Departamento de Obstetricia, Ginecología y Biología de la Reproducción

UNIVERSIDA DE LOS ANDES

SANTIAGO, Chile

1
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile