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Lara Jorge Monteiro

Profesora Asistente

Universidad de los Andes

Santiago, Chile

The role and regulation of FOXM1 in chemotherapy resistance in breast cancer. The role of FOXM1 in early preeclampsia-related events. Fetal programming and gestational diabetes mellitus. Early detection of gestational diabetes mellitus.

Brast Cancer Signalling, Transcription and Drug Resistance, IMPERIAL COLLEGE LONDON. Reino Unido, 2013
Molecular Medicine, CRANFIELD UNIVERSITY. Chile, 2009
Biomedical Sciences, Universidade do Algarve. Portugal, 2007

Postdoctoral Research Fellow Full Time

UNIVERSIDAD DE LOS ANDES

Faculty of Medicine

Santiago, Chile

2013 - 2018
PhD student Full Time

IMPERIAL COLLEGE LONDON

Faculty of Medicine

London, Reino Unido

2009 - 2013
Internship Full Time

IMPERIAL COLLEGE LONDON

Faculty of Medicine

London, Chile

2008 - 2009
Investigador Adjunto Full Time

UNIVERSIDAD DE LOS ANDES

Medicina

Santiago, Chile

2018 - 2021
Profesor Asistente Full Time

UNIVERSIDAD DE LOS ANDES

Medicina

Santiago, Chile

2022 - A la fecha

Postdoctoral Researcher Full Time

Universidad de los Andes

Santiago, Chile

2013 - 2018
Investigadora Adjunta Full Time

Universidad de los Andes

Santiago, Chile

2018 - A la fecha
Profesor Asistente Full Time

Universidad de los Andes

Santiago, Chile

2022 - A la fecha

Project Management
Co-supervisor under-graduate student’s thesis (Uandes, Facultad de Odontología): “Expresión de microRNAs en fluidos orales y su asociación con el desarrollo de Diabetes Gestacional y Preeclampsia: Estudio Piloto"
Maria Fernanda Cambara de Dios

Co-supervisor PhD thesis:
María José Bendeck
"Characterization of the inflammatory phenotype of trophoblasts as a response to periodontal infection (P. gingivalis and F. nucleatum) and high glucose stimuli in vitro"

Albano J. Cáceres Verschae
"El eje IL-8/CXCR1 regula la liberación de vesículas extracelulares con un perfil protumorigénico provenientes de células de cáncer de ovario."

Postgraduate Teaching Biomedicine PhD (Universidad de los Andes)
3364 Tópicos Avanzados en Biomedicina”– Contenido Optativo: “Investigación Traslacional en Medicina Materno-Fetal”
1714 Biología Celular y Molecular en Biomedicina
1210 Avances Biotecnológicos en Medicina

Peer review of ISI Journals
Plos One: Maternal preeclampsia and androgens in the offspring around puberty: a follow-up study. Alsnes et al. 2016
Plos One: Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. Zhou et al. 2015
BioMed Research International: Update on biomarkers for the detection of endometriosis. Fassbender et al. 2015

Review Editor (added to PURE):
Frontiers Cell and Developmental Biology (desde 19.10.2020)

FONDECYT POSTDOCTORAL 2014

FONDECYT

Chile, 2014

Study the role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia
PhD fellowships 2009

MINISTRY OF SCIENCE AND TECHNOLOGY

Portugal, 2009

Study the role and regulation of FOXM1 in chemotherapy resistance in breast cancer
Fondecyt Iniciacion

FONDECYT

Chile, 2018

The role of FOXM1 in early preeclampsia-related events.
First place IFPA-ECR award in IX SLIMP VIRTUAL MEETING

IFPA

Colombia, 2022

First place in the IFPA-ECR award in the IX SLIMP-Latin American Society for Materno Fetal Interaction and Placenta virtual meeting (MAY 4-6, 2022)


Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood Federico Batiz, Luis; Palmeiro-Silva, Yasna K.; Rice, Gregory E.; Monteiro, Lara J.; Galaburda, Albert M.; Romero, Roberto; Choolani, Mahesh A.; Wyneken, Ursula; Orellana, Pelusa; Illanes, Sebastian E. Article ISI SCIENTIFIC REPORTS (2021)
Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle Bendek, Maria Jose; Canedo-Marroquin, Gisela; Realini, Ornella; Retamal, Ignacio N.; Hernandez, Marcela; Hoare, Anilei; Busso, Dolores; Monteiro, Lara J.; Illanes, Sebastian E.; Chaparro, Alejandra Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis Serra, Ramon; Penailillo, Reyna; Monteiro, Lara J.; Mönckeberg, Max; Peña, Macarena; Moyano, Lia; Brunner, Camila; Vega, Georgina Mahesh Choolani 3 4, Sebastián E Illanes 2; Choolani, Mahesh; Illanes, Sebastián E. Article NUTRIENTS (2021)
The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction Monteiro, Lara J.; Penailillo, Reyna; Sanchez, Mario; Acuna-Gallardo, Stephanie; Monckeberg, Max; Ong, Judith; Choolani, Mahesh; Illanes, Sebastian E.; Nardocci, Gino Article ISI GENES (2021)
Diagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use Mönckeberg, Max; Arias, Valentina; Fuenzalida, Rosario; Álvarez, Santiago; Toro, Victoria; Calvo, Andrés; Kusanovic, Juan P; Monteiro, Lara J.; Schepeler, Manuel; Nien, Jyh K.; Martinez, Jaime; Illanes, Sebastián E. Article ISI SCOPUS Diagnostics (2020)
Diagnostic potential of peri-implant crevicular fluid microRNA-21-3p and microRNA-150-5p and extracellular vesicles in peri-implant diseases Chaparro, Alejandra; Atria, Pablo; Realini, Ornella; Monteiro, Lara J.; Betancur, Daniel; Acuna-Gallardo, Stephanie; Ramirez, Valeria; Bendek, Maria Jose; Pascual, Andres; Nart, Jose; Beltran, Victor; Sanz, Antonio Article ISI JOURNAL OF PERIODONTOLOGY (2020)
Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy Monteiro, Lara J.; Varas-Godoy, Manuel; Acuña-Gallardo, Stephanie; Correa, Paula; Passalacqua, Gianluca; Monckeberg, Max; Rice, Gregory E.; Illanes, Sebastián E. Article ISI SCOPUS Diagnostics (2020)
Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia Varas-Godoy, Manuel; Acuna-Gallardo, Stephanie; Venegas-Duarte, Sebastian; Hill, Charlotte; Caceres-Verschae, Albano; Realini, Ornella; Monteiro, Lara J.; Zavala, Gabriela; Khoury, Maroun; Romero, Roberto; Rice, Gregory; Illanes, Sebastian E. Article ISI SCOPUS STEM CELLS INTERNATIONAL (2019)
Extracellular vesicle concentration in maternal plasma as an early marker of gestational diabetes Arias, Mario; Monteiro, Lara J.; Acuna-Gallardo, Stephanie; Varas-Godoy, Manuel; Rice, Gregory E.; Monckeberg, Max; Diaz, Pilar; Illanes, Sebastian E. Article ISI REVISTA MEDICA DE CHILE (2019)
Normality Ranges of Menstrual Fluid Volume During Reproductive Life Using Direct Quantification of Menses with Vaginal Cups Donoso M.B.; Serra R.; Rice G.E.; Gana M.T.; Rojas C.; Khoury M.; Arraztoa J.A.; Monteiro, L. J.; AcuÃ±a S.; Illanes, S. E. Article ISI SCOPUS GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2019)
Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus Monteiro, Lara J.; Varas-Godoy, Manuel; Monckeberg, Max; Realini, Ornella; Hernandez, Marcela; Rice, Gregory; Romero, Roberto; Saavedra, Jose F.; Illanes, Sebastian E.; Chaparro, Alejandra Article ISI SCOPUS PLOS ONE (2019)
Effects of earthquake on perinatal outcomes: A Chilean register-based study Palmeiro-Silva, Yasna K.; Orellana, Pelusa; Venegas, Pia; Monteiro, Lara; Varas-Godoy, Manuel; Norwitz, Errol; Rice, Gregory; Osorio, Eduardo; Illanes, Sebastian E. Article ISI SCOPUS PLOS ONE (2018)
Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia Monteiro, Lara J.; Cubillos, Sofia; Sanchez, Marianela; Acuña-Gallardo, Stephanie; Venegas, Pía; Herrera, Valentina; Lam, Eric W.-F.; Varas-Godoy, Manuel; Illanes, Sebastián E. Article ISI SCOPUS REPRODUCTIVE SCIENCES (2018)
Fetal programming and gestational diabetes mellitus Monteiro, Lara J.; Norman, Jane E.; Rice, Gregory E.; Illanes, Sebastián E. Article ISI SCOPUS PLACENTA (2016)
Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance Khongkow, P.; Gomes, A. R.; Gong, C.; Man, E. P. S.; Tsang J.W.-H.; Zhao, F.; Monteiro, L. J.; Coombes, R. C.; Medema, R. H.; Khoo, U. S.; Lam E.W.-F. Article SCOPUS Oncogene (2016)
FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer Gong, C.; Fujino, K.; Monteiro, L. J.; Gomes, A. R.; Drost, R.; Davidson-Smith, H.; Takeda, S.; Khoo, U. S.; Jonkers, J.; Sproul, D.; Lam, E. W-F Article ISI ONCOGENE (2015)
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction Dobierzewska, A; Palominos, M; Irarrazabal, CE; Sánchez, M; Lozano, M.; Perez-Sepulveda, A; Monteiro, LJ; Burmeister, Y; Figueroa-Diesel, H; Rice, GE; Illanes, SE Article ISI SCOPUS Biology of Reproduction (2015)
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia Perez-Sepulveda, A; Monteiro, LJ; Dobierzewska, A; Espana-Perrot, PP; Venegas-Araneda, P; Guzman-Rojas, AM; Gonzalez Mi; Palominos-Rivera, M; Irarrazabal, CE; Figueroa-Diesel, H; Varas-Godoy, M; Illanes, SE Article ISI SCOPUS PLOS ONE (2015)
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance Khongkow, P.; Karunarathna, U.; Khongkow, M.; Gong, C.; Gomes, A. R.; Yague, E.; Monteiro, L. J.; Kongsema, M.; Zona, S.; Man, E. P. S.; Tsang, J. W-H; Coombes, R. C.; Wu, K-J; Khoo, U-S; Medema, R. H.; Freire, R.; Lam, E. W-F Article ISI ONCOGENE (2014)
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer Khongkow, Mattaka; Olmos, Yolanda; Gong, Chun; Gomes, Ana R.; Monteiro, Lara J.; Yaguee, Ernesto; Cavaco, Tania B.; Khongkow, Pasarat; Man, Ellen P. S.; Laohasinnarong, Sasiwan; Koo, Chuay-Yeng; Harada-Shoji, Narumi; Tsang, Janice W. -H.; Coombes, R. Charles; Schwer, Bjoern; Khoo, Ui-Soon; Lam, Eric W. -F. Article ISI CARCINOGENESIS (2013)
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment Monteiro, L. J.; Khongkow, P.; Kongsema, M.; Morris, J. R.; Man, C.; Weekes, D.; Koo, C-Y; Gomes, A. R.; Pinto, P. H.; Varghese, V.; Kenny, L. M.; Coombes, R. Charles; Freire, R.; Medema, R. H.; Lam, E. W-F Article ISI ONCOGENE (2013)
Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin Ho, Ka-Kei; McGuire, Victoria A.; Koo, Chuay-Yeng; Muir, Kyle W.; de Olano, Natalia; Maifoshie, Evie; Kelly, Douglas J.; McGovern, Ursula B.; Monteiro, Lara J.; Gomes, Ana R.; Nebreda, Angel R.; Campbell, David G.; Arthur, J. Simon C.; Lam, Eric W. -F. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The p38 MAPK-MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment de Olano, Natalia; Koo, Chuay-Yeng; Monteiro, Lara J.; Pinto, Paola H.; Gomes, Ana R.; Aligue, Rosa; Lam, Eric W. -F. Article ISI MOLECULAR CANCER RESEARCH (2012)
The Transcription Factor Encyclopedia Yusuf, Dimas; Butland, Stefanie L.; Swanson, Magdalena I.; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A.; Zhang, Xiao Yu Cindy; Dickman, Christopher T. D.; Fulton, Debra L.; Lim, Jonathan S.; Schnabl, Jake M.; Ramos, Oscar H. P.; Vasseur-Cognet, Mireille; de Leeuw, Charles N.; Simpson, Elizabeth M.; Ryffel, Gerhart U.; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda S. C.; Marco-Ferreres, Raquel; Brosens, Jan J.; Beccari, Leonardo L.; Bovolenta, Paola; Benayoun, Berenice A.; Monteiro, Lara J.; Schwenen, Helma D. C.; Grontved, Lars; Wederell, Elizabeth; Mandrup, Susanne; Veitia, Reiner A.; Chakravarthy, Harini; Hoodless, Pamela A.; Mancarelli, M. Michela; Torbett, Bruce E.; Banham, Alison H.; Reddy, Sekhar P.; Cullum, Rebecca L.; Liedtke, Michaela; Tschan, Mario P.; Vaz, Michelle; Rizzino, Angie; Zannini, Mariastella; Frietze, Seth; Farnham, Peggy J.; Eijkelenboom, Astrid; Brown, Philip J.; Laperriere, David; Leprince, Dominique; de Cristofaro, Tiziana; Prince, Kelly L.; Putker, Marrit; del Peso, Luis; Camenisch, Gieri; Wenger, Roland H.; Mikula, Michal; Rozendaal, Marieke; Mader, Sylvie; Ostrowski, Jerzy; Rhodes, Simon J.; Van Rechem, Capucine; Boulay, Gaylor; Olechnowicz, Sam W. Z.; Breslin, Mary B.; Lan, Michael S.; Nanan, Kyster K.; Wegner, Michael; Hou, Juan; Mullen, Rachel D.; Colvin, Stephanie C.; Noy, Peter John; Webb, Carol F.; Witek, Matthew E.; Ferrell, Scott; Daniel, Juliet M.; Park, Jason; Waldman, Scott A.; Peet, Daniel J.; Taggart, Michael; Jayaraman, Padma-Sheela; Karrich, Julien J.; Blom, Bianca; Vesuna, Farhad; O'Geen, Henriette; Sun, Yunfu; Gronostajski, Richard M.; Woodcroft, Mark W.; Hough, Margaret R.; Chen, Edwin; Europe-Finner, G. Nicholas; Karolczak-Bayatti, Magdalena; Bailey, Jarrod; Hankinson, Oliver; Raman, Venu; LeBrun, David P.; Biswal, Shyam; Harvey, Christopher J.; DeBruyne, Jason P.; Hogenesch, John B.; Hevner, Robert F.; Heligon, Christophe; Luo, Xin M.; Blank, Marissa Cathleen; Millen, Kathleen Joyce; Sharlin, David S.; Forrest, Douglas; Dahlman-Wright, Karin; Zhao, Chunyan; Mishima, Yuriko; Sinha, Satrajit; Chakrabarti, Rumela; Portales-Casamar, Elodie; Sladek, Frances M.; Bradley, Philip H.; Wasserman, Wyeth W. Article ISI GENOME BIOLOGY (2012)
ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance Millour, Julie; de Olano, Natalia; Horimoto, Yoshiya; Monteiro, Lara J.; Langer, Julia K.; Aligue, Rosa; Hajji, Nabil; Lam, Eric W. -F. Article ISI MOLECULAR CANCER THERAPEUTICS (2011)
iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe Jiang, LiLi; Siu, Michelle K. Y.; Wong, Oscar G. W.; Tam, Kai-Fai; Lu, Xin; Lam, Eric W-F.; Ngan, Hextan Y. S.; Le, Xiao-Feng; Wong, Esther S. Y.; Monteiro, Lara J.; Chan, Hoi-Yan; Cheung, Annie N. Y. Article ISI CLINICAL CANCER RESEARCH (2011)
Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer Chen, Jie; Gomes, Ana R.; Monteiro, Lara J.; Wong, San Yu; Wu, Lai Han; Ng, Ting-Ting; Karadedou, Christina T.; Millour, Julie; Ip, Ying-Chi; Cheung, Yuen Nei; Sunters, Andrew; Chan, Kelvin Y. K.; Lam, Eric W. -F.; Khoo, Ui-Soon Article ISI PLOS ONE (2010)
Definition of microRNAs That Repress Expression of the Tumor Suppressor Gene FOXO1 in Endometrial Cancer Myatt, Stephen S.; Wang, Jun; Monteiro, Lara J.; Christian, Mark; Ho, Ka-Kei; Fusi, Luca; Dina, Roberto E.; Brosens, Jan J.; Ghaem-Maghami, Sadaf; Lam, Eric W-F. Article ISI CANCER RESEARCH (2010)
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells Kwok, Jimmy M. -M.; Peck, Barrie; Monteiro, Lara J.; Schwenen, Helma D. C.; Millour, Julie; Coombes, R. Charles; Myatt, Stephen S.; Lam, Eric W. -F. Article ISI MOLECULAR CANCER RESEARCH (2010)


Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT) Khoury, Maroun Proyecto (2021)
Prenatal stress: maternal astrocyte-derived extracellular vesicles as a novel stress-transfer mechanism contributing to adverse offspring neurodevelopment Bátiz, Luis Federico; Monteiro, L. J.; Wyneken, I. U.; Illanes, Sebastián E.; Nardocci, Gino; Caradeux J. Proyecto (2021)
Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile Batiz, Luis Federico; Monteiro, L. J.; Illanes, S. E.; Nardocci, Gino; Avalos M.; Arango P.; Tenorio, Marcela Proyecto (2020)
Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos. Sebastián E. Illanes; Monteiro, LJ Proyecto (2020)
The role of FOXM1 in early preeclampsia-related events. Monteiro, Lara Jorge Proyecto (2018)
The role of FOXM1 in early preeclampsia-related events. FONDECYT (11181249) Proyecto 2018-2021 Inv. Principal
The role of the aromatase pathway in 2-methoxyestradiol Monteiro, Lara Jorge; Illanes, Sebastian E Proyecto (2013)
THE ROLE OF THE AROMATASE PATHWAY IN 2-METHOXYESTRADIOL SYNTHESIS IN THE PATHOGENESIS OF PREECLAMPSIA FONDECYT (3140038) Proyecto 2013-2016 Inv. Responsable
The role and regulation of FOXM1 in chemotherapy resistance in breast cancer Fundação para a Ciência e a Tecnologia, Portuguese Ministry of Education and Science (SFRH / BD / 47191 / 2008) Proyecto 2009-2012 Tesista
Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia. Illanes, SE; Monteiro, LJ; Acuña-Gallardo S; Pino-Lagos, K Proyecto (0)