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Emma Marcela Hernandez Ríos

Directora

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

Líneas de Investigación


Local and systemic immune response to bacterial biofilms in oral diseases. Innovative therapies for oral inflammatory diseases

Educación

  •  PhD dental sciencies, UNIVERSITY OF HELSINKI. Finlandia, 2012
  •  Dental Sciences Mention Oral Pathology, UNIVERSIDAD DE CHILE. Chile, 2006
  •  SPECIALIST IN ORAL PATHOLOGY AND MEDICINE, UNIVERSIDAD DE CHILE. Chile, 2012
  •   DENTIST, UNIVERSIDAD DE CHILE. Chile, 1998
  •  Bachelor in Dentistry, UNIVERSIDAD DE CHILE. Chile, 1998
  •  Administración de empresas, Facultad de economía y negocios. Chile, 2022

Experiencia Académica

  •   Full Professor Titular Full Time

    UNIVERSIDAD DE CHILE

    ODONTOLOGIA

    SANTIAGO, Chile

    2001 - A la fecha

  •   Associate researcher Part Time

    Universidad Autónoma de Chile

    Cs. de la Salud

    Santiago, Chile

    2016 - 2019

  •   Member of the study group medicine G2-G3 National fund of scientific and technological development Part Time

    FONDECYT

    Santiago, Chile

    2016 - 2019

  •   Director of the Doctorate Program of dental sciences Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2014 - 2019

  •   Research Director Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Chile

    2012 - 2013

  •   Head of the Department of Pathology and Oral Medicine Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Chile

    2013 - 2015

  •   Director of the Service of Anatomic Páthology Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Chile

    2017 - 2019

  •   Director of Department of the Service of Anatomic Pathology Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Chile

    2022 - A la fecha

Experiencia Profesional

  •   Director of Anatomic Pathology Service Full Time

    Universidad de Chile

    Santiago, Chile

    2017 - 2019

  •   Specialist in Oral Pathology and Medicine Part Time

    Hospital Clínico Universidad de Chile

    Santiago, Chile

    2019 - A la fecha

  •   Director of Anatomic Pathology Service Full Time

    Universidad de Chile

    Chile

    2022 - A la fecha

  •   Head of the Department of Pathology and Oral Medicine Full Time

    Universidad de Chile

    Santiago, Chile

    2013 - 2015

  •   Research Director Full Time

    Universidad de Chile

    Santiago, Chile

    2012 - 2013

Formación de Capital Humano


Undergraduate thesis supervision
1. Gonzalo Orellana Zúñiga. Cytotoxicity and Effect of Alkaloids Derived from Native Trees on Inflammation Induced by Porphyromonas endodontalis in Human Macrophages. 2026. Faculty of Dentistry. Supervisors: Emma Hernández Ríos; Javier Echeverría.
2. Laura Hechavarría Ruiz. Inflammatory Profile of Peripheral Blood Monocytes in Endodontically Treated Patients with Apical Periodontitis. 2025. Faculty of Dentistry. Supervisors: Emma Hernández Ríos; Jaime Andrés Díaz Zúñiga.
3. Patricio Merino. Systemic Inflammation and Endodontic Treatment in Patients with Apical Periodontitis. 2024.
4. Gabriel I. Navia Castro. Systemic Inflammatory and Bacterial Burden in Symptomatic and Asymptomatic Apical Periodontitis. 2023. Faculty of Dentistry. Supervisors: Patricia Hernández Ríos; María José Bordagaray San Martín; Emma Hernández Ríos.
5. Daniela Rehbein Raddatz. Association Between Subgingival Load of Porphyromonas gingivalis and Low-Grade Systemic Inflammation in Individuals with Periodontitis. 2023. Faculty of Dentistry. Supervisors: María José de la Quintana Rojas; María Angélica Michea Rivera; Emma Hernández Ríos; Patricia Hernández Ríos.
6. Débora Zamorano Riquelme. Dose-Response Effect of Boldine on Cell Viability and Toxicity in Human Macrophages. 2022. Faculty of Dentistry. Supervisors: Bruce Cassels Niven; Anilei Hoare Teuche; Emma Hernández Ríos.
7. Bárbara Paola Marín Pizarro. Association Between Cotinine Levels and Size of Endodontic Apical Lesions in Smokers and Non-Smokers with Asymptomatic Apical Periodontitis. 2022. Faculty of Dentistry. Supervisors: Alejandra Fernández Moraga; Emma Hernández Ríos.
8. Almendra González Donoso. Association Between Smoking Habit, Serum Cotinine, and Periapical Lesion Size in Patients with Apical Periodontitis. 2022. Faculty of Dentistry. Supervisors: María José Bordagaray San Martín; Alejandra Fernández Moraga; Emma Hernández Ríos.
9. Catalina Montero Velásquez. Association Between Alcohol Consumption and Size of Endodontic Apical Lesions. 2021. Faculty of Dentistry. Supervisors: María José Bordagaray San Martín; Emma Hernández Ríos; Carlos Garrido Flores.
10. Diego Alfredo Morales Espinoza. Association Between Alcohol Consumption and High-Sensitivity C-Reactive Protein Levels in Serum of Individuals with Apical Periodontitis. 2021. Faculty of Dentistry. Supervisors: María José Bordagaray San Martín; Emma Hernández Ríos.
11. Florencia Inés Valdés Iturbe. Anti-Inflammatory Effect of Boldine on Human Macrophages Stimulated with Periapical Exudate from Patients with Asymptomatic Apical Periodontitis. 2021. Faculty of Dentistry. Supervisors: Bruce Cassels Niven; Alejandro Escobar Álvarez; Emma Hernández Ríos.
12. Claudia Denise Da Venezia Mujica. Association Between Periodontal Disease Severity and Cardiovascular Risk Level Determined by C-Reactive Protein in Adult Chilean Women. 2020. Faculty of Dentistry. Supervisors: Alicia Morales Chvets; Emma Hernández Ríos; Johanna Contreras Balbontín; Patricia Hernández Ríos.
13. Lynn María Barstow Melgarejo. Expression Levels of Toll-Like Receptor 4 and Interleukin-10 in Peripheral Blood Mononuclear Cells from Patients with Asymptomatic Apical Periodontitis. 2019. Faculty of Dentistry. Supervisors: Carlos Garrido Flores; Emma Hernández Ríos; Angélica María Cárdenas Gutiérrez.Alfredo Ignacio Castro Martínez. "Role of the O antigen of the lipopolysaccharide of Porphyromonas gingivalis in the profile of differentiation of macrophages". 2019. Financing: FONDECYT 1160741.
14. Francisca Quinlan Binelli, year Cardiovascular risk associated with systemic inflammation in patients with asymptomatic apical periodontitis. 2019. Financing: FONDECYT 1160741.
15. Lynn Barstow Melgarejo, Levels of expression of toll-4 receptor (TLR-4), interleukin (IL) -10 and IL-12 in peripheral blood mononuclear cells of patients with asymptomatic apical periodontitis. 2019. Financing: FONDECYT 1160741.
16. Alfredo Castro Martínez, Role of the O antigen of the lipopolysaccharide of Porphyromonas gingivalis in the profile of differentiation of macrophages. 2019. Financing: FONDECYT 1160741.
17. Catalina Schweitzer Gatica, Immunolocalization of the signaling complex of interleukin-6 in periapical lesions of endodontic origin. Student: 2019. Financing: FONDECYT 1160741.
18. Macarena Becker Pinto, Prevalence of teeth treated endodontically in a Chilean subpopulation. 2018. Financing: FONDECYT 1160741. 2018.
19. Valeska Fariña Espinosa. "Humoral immune response and endotoxemia in endodontic infection with Porphyromonas endodontalis and Porphyromonas gingivalis in Asymptomatic Apical Periodontitis. "Dept. of Pathology and Oral Medicine. University of Chile. 2015. Financing: FONDECYT 1120138.
20. Rubén Soto Galaz. "Morphological and Molecular Characterization of Mandibular Temporomal Ankylosis". Dept. of Pathology and Oral Medicine. University of Chile. Student: 2015. Financing: FIOUCH13-004.
21. Macarena Salinas Muñoz. "Levels of Tartrate-Resistant Acid Phosphatase (TRAP), Ligand Activating Receptor for the Nuclear Factor NFkB (RANKL) and Osteoprotegerin (OPG) in Symptomatic and Asymptomatic Periapical Lesions of Endodontic Origin". Dept. of Pathology and Oral Medicine. University of Chile. 2015. Financing: FONDECYT 1120138
22. Marcela Bolbarán Gómez. Myeloperoxidase (MPO) levels in Periapical Lesions of Endodontic Origin. Dept. of Pathology and Oral Medicine. University of Chile. 2014. FONDECYT financing 1120138.
23. María José Bordagaray. C-Reactive Protein in Apical Lesions of Endodontic Origin. Department of Conservative Dentistry and Pathology and Oral Medicine. University of Chile. 2013. Financing FONDECYT 1120138.
24. Germán Contreras Silva "Association between Asymptomatic Apical Periodontitis and Modifiable Risk Factors of Cardiovascular Diseases". Financing FONDECYT 1120138. 2013.
25. Josefa Belén Castro Salas. "Levels of Myeloperoxidase (MPO) in Periapical Teeth Exudate with Asymptomatic Apical Periodontitis (PAA) Measured Pre and Post-Endodontic Medications with Calcium Hydroxide". 2013. Financing FONDECYT 1120138.
26. Pilar Jerez.Tissue Localization of Matrix Metalloproteinase -12 in Periapical Lesions Consecutive to Septic Pulp Necrosis and Healthy Periapical Tissue, School of Dentistry University of Chile. Associate tutor. Year 2012. Financing FONDECYT 1090461.
27. Valentina Aranda González. Levels of Myeloperoxidase (MPO) in Crevicular Gingival Fluid (FGC) of Teeth with Asymptomatic Apical Periodontitis (PAa). Responsible tutor Year 2012. Financing FONDECYT 1090461.
28. Gianfranco Arce Salvi. Thesis Levels of Crosslinked Piridinoline of Type I Colloid Tipelactopeptide (ICTP) in Crevicular Gingival Fluid (FGC) of Teeth with Asymptomatic Apical Periodontitis (PAa). 2012. Financing FONDECYT 1090461.
29. Magdalena Infante Figueroa. Levels of Vascular Endothelial Growth Factor (VEGF-A) in Periapical Lesions Consecutive Pulp Necrosis and Periodontal Ligament. 2011Financing FONDECYT 1090461.
30. Gustavo Pérez Serrano. Year Levels of Vascular Endothelial Growth Factor (VEGF) and Interleukin-1B in Gingival Crevicular Fluid (FCG) of Teeth with Asymptomatic Apical Periodontitis (PAa) Pre and Post Endodontic Treatment (2011). 2011. Financing FONDECYT 1090461.
31. Pamela Giralt Levels of ICTP in Asymptomatic Apical Periodontitis and its Association with Periradicular Tissues. 2011. Financing FONDECYT 1090461.
32. Loreto Espinoza. Levels of Cathepsin K in Crevicular Teeth Gingival Fluid with Asymptomatic Apical Periodontitis. 2010. Financing FONDECYT 1090461.
33. Andrea González. Expression of Extracellular Matrix Metalloproteinase-13 (MMP-13) in Teeth with Asymptomatic Apical Periodontitis. 2010. Financing FONDECYT 1090461.
34. Mardones Peñailillo, Jeannette Isabel Expresión de proteína quimiótica de monocitos-3 (MCP-3/CCL7) en fluido gingival crevicular y en lesiones periapicales de dientes con periodontitis apical crónica 2009 Facultad de Odontología Garrido Flores, Carlos; Hernandez Rios, Emma; Dezerega Piwonka, Andrea.
35. Mundi Burgos, Verónica Andrea Expresión de metaloproteinasas de matriz extracelular (MMPs) -2, -13 y -14 en dientes con periodontitis apical crónica y tejido periapical sano 2009 Facultad de Odontología Dutzan Munoz, Nicolas Raul; Dezerega Piwonka, Andrea;Hernandez Rios, Emma.
36. Obregón Miano, Fabián Andrés Patrones de proteólisis en cultivos de explantes gingivales tratados con metaloproteinasa-13 provenientes de pacientes con periodontitis crónica 2008 Facultad de Odontología Hernandez Rios, Emma;Gamonal Aravena, Jorge.

Postgraduate Thesis (Master and Doctorate):
1. María José Bordagaray. Papel de Porphyromonas endodontalis en la regulación y expresión de TLR-2 y -9 y en la respuesta inflamatoria de monocitos." Programa de Doctorado en Ciencias Odontológicas Universidad de Chile. 2025. Prof. Responsable.
2. Sebastián Araneda. Rol de Porphyromonas gingivalis en la respuesta inmune innata y señalización vía receptores tipo Toll/NF-kB canónica en explantes de placenta humana. Programa de Doctorado en Ciencias Odontológicas Universidad de Chile. M Hernández –Ulrike Kemmerling. Prof. Responsable. 2025.
3. Sebastián Castro Saavedra. Efectos de boldina, laurolitsina, laurotetanina o n-metillaurotetanina en la modulación de la respuesta inmuno-inflamatoria e inhibición de la resorción ósea durante la periodontitis experimental. Doctorado en ciencias farmacéuticasfacultad de ciencias químicas y farmacéuticas, Universidad de Chile. Director de Tesis: Dr. Bruce K. Cassels Niven; Codirectores de Tesis: Dra. Marcela Hernández Ríos; Dr. Rolando Vernal Astudillo. 2025.
4. David González Efecto antiinflamatorio de boldina sobre la reprogramación M1/M2 de macrófagos humanos estimulados con Porphyromonas endodontalis inactivada por calor y exudado periapical de pacientes con Periodontitis apical asintomática (PAA) Programa de Magíster en Ciencias Odontológicas. Prof. Responsable. Finalizada 02/04/2024. Cotutor: RV; Evaluadora de tesis APL.
5. Joaquín Lucero Mora Efecto del ADN de Porphyromonas endodontalis sobre el fenotipo inflamatorio y participación de TLRs -9, -2 y -4 en macrófagos humanos Programa de Magíster en Ciencias Odontológicas 202. Prof. Responsable. Finalizada.
6. Alejandra Fernández Rol de PORPHYROMONAS ENDODONTALIS Y PORPHYROMONAS GINGIVALIS en la angiogénesis VÍA TLR2 /NF-????B en periodontitis apical asintomática y sintomática. Programa de Doctorado en Ciencias Odontológicas Universidad de Chile. Finalizada 2022. Prof. Responsable. Finalizada.
7. Veloso Matta, Pablo Polarización de macrófagos en formas clínicamente sintomáticas de periodontitis apical: rol del lipopolisacárido de especies de Porphyromonas sobre la expresión de receptores tipo Toll y su regulación epigenética Programa de Doctorado en Ciencias Odontológicas Universidad de Chile. Finalizada 2021. Prof. Responsable. Finalizada.
8. Huaman Chipana, Patricia Raquel. Inflamación sistémica e infección endodóntica por Porphyromonas endodontalis en pacientes con periodontitis apical asintomática. Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2017. Prof. Responsable. Finalizada.
9. Hernández Caldera, Arnoldo Alejandro. Efectos de la estimulación de fibroblastos de ligamento periodontal humano con IL-6 sobre la síntesis de proteína C reactiva (PCR) y citoquinas proinflamatorias. Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2015. Prof. Responsable. Finalizada.
10. Baeza Paredes, Mauricio Enrique. Marcadores de metabolismo óseo en fluido crevicular gingival como potencial herramienta diagnóstica de enfermedades inflamatorias crónicas del periodonto marginal y apical. Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2014. Prof. Responsable. Finalizada.
11. Melgar Rodríguez, Samanta Azucena Efecto de la estimulación con los distintos serotipos de Porphyromonas gingivalis y Aggregatibacter actinomycetemcomitans en la actividad de los linfocitos TCD4+ y la reabsorción ósea in vitro Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2014. Tutor asociado. Finalizada.
12. Obregón Miano, Fabián Andrés Inflamación sistémica en suero de pacientes con periodontitis apical asintomática Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2014. Prof. Responsable. Finalizada.
13. Cavalla Ruiz, Ian Franco Efecto de las metaloproteinasas de matriz extraxelular sobre los niveles de TENFa, ILß, SDF-1/CXCL12 y VEGF en fibroblastos de ligamento periodontal humano estimulados con peróxido de hidrógeno Programa de Magíster en Ciencias Odontológicas Universidad de Chile. Finalizada 2013. Prof. Responsable. Finalizada.
14. Constanza Osorio. Efecto del H2O2 sobre la actividad de la fosfatasa alcalina, los niveles de citoquinas y metaloproteinasas de matriz extracelular con actividad osteolítica en fibroblastos del ligamento periodontal humanos, Magister en Cs. Odontológicas mención Periodontología, Universidad de Chile, Facultad de Odontología. Finalizada 2013. Prof. Responsable. Finalizada.
15. Verónica Mundi. Niveles y Actividad de Metaloproteinasas de Matriz Extracelular -2, -9, -13 y ?2-macroglobulina en dientes con Periodontitis Apical Crónica. Programa Magister en Cs. Odontológicas mención Periodontología, Universidad de Chile, Finalizada 2012. Prof. Responsable. Finalizada.


Difusión y Transferencia


Invited Conferences - National:
1. Periodontal/periapical-systemic dialogue and the risk of non-communicable diseases. Annual Dental Meeting, Universidad de Talca. March 13, 2026. Talca, Chile.
2. The Oral Microbiome and Systemic Crosstalk: Insights from Apical Periodontitis. Translational Medicine Congress, Universidad de Los Andes: Science with Clinical Impact. September 26, 2025. Santiago, Chile.
3. Local and Systemic Immunoregulation in Endodontic Pathology: Therapeutic Perspectives. Research and Innovation Seminars, Universidad San Sebastián. August 28, 2025. Online format.
4. Reliable Science: Challenges in Scientific Research. International Association for Dental Research (IADR), Chile Division. October 24, 2025. Valparaíso, Chile.
5. Integrity and Transparency in Scientific Communication. Universidad Finis Terrae. August 7, 2025. Online format.
6. Apical Periodontitis: A Systemic Disease with Memory? Chilean Society of Endodontics (SECH), Scientific Lecture Series. November 19, 2025. Santiago, Chile.
7. Periodontal/periapical-systemic dialogue and the risk of non-communicable diseases.
8. Non-Plaque-Induced Gingival Lesions: The Role of General Dentists and Periodontists. XXII International Workshop on Oral Pathology and III International Conference of the Specialty in Oral and Maxillofacial Pathology. Faculty of Dentistry, Universidad de Chile. January 15, 2025. Santiago, Chile.
9. Discussion Forum on Funding, Science, and Innovation. XXXVI Annual Meeting of the IADR Chile Division. November 10, 2024. Universidad Finis Terrae. Santiago, Chile.
10. Immunobiology of Monocytes/Macrophages and Their Therapeutic Reprogramming in Apical Periodontitis. Scientific Conference of the Faculty of Dentistry: Innovation in Endodontics. November 8, 2024. Universidad de Los Andes. Santiago, Chile.
11. Mechanisms of Low-Grade Systemic Inflammation. 2nd Alumni Meeting 2024, Specialization Program in TMD and Orofacial Pain, Universidad del Desarrollo (UDD). October 25, 2024. Santiago, Chile.
12. Academic Career Pathways Lecture. Undergraduate Teaching Induction Program, Universidad de Chile, 2024 Edition. Academic Development Office, Vice-Rector’s Office for Academic Affairs, Universidad de Chile. September 26, 2024. Main Campus, Santiago, Chile.
13. Maladaptive Monocyte/Macrophage Responses in Periodontitis and Associated Non-Communicable Diseases. Chilean Association of Immunology (ASOCHIN) Seminar – International Association for Dental Research (IADR), Chile Division. September 12, 2024. Zoom platform.
14. Programming of Monocytes/Macrophages in Inflammatory Periodontal Destruction and Systemic Risk. Opening Lecture, IV Congress of the Institute of Dental Sciences, Faculty of Dentistry, Universidad de Chile (ICOD). August 1, 2024. Santiago, Chile.
15. Dentistry at the Heart: Lessons from Oral Medicine through Translational Research. II Scientific Meeting, Universidad Finis Terrae. April 19, 2024. Santiago, Chile.
16. Women’s Day Event: Dentistry and Science – Research, Development and Technology in Periodontal and Periapical Diseases. March 9, 2024. College of Dental Surgeons. Santiago, Chile.
17. Mechanisms of Periodontal-Systemic Crosstalk. Symposium on Periodontal and Regenerative Medicine, Chilean Society of Periodontology and Universidad de Los Andes. December 1–2, 2024. Santiago, Chile.
18. Apical Periodontitis, a Systemic Disease. First Clinical Research Conference, International Association for Dental Research (IADR), “Meeting of Dentistry and Science in Southern Chile.” April 14, 2023. Valdivia, Chile.
19. Healthy Periodontium for a Healthy Heart: Foundations and Clinical Considerations in Periodontitis and Endodontic Infections. UFRO Chile Dental Research Conference. November 25, 2022. Temuco, Chile.
20. Macrophage Polarization Profiles and Their Epigenetic Regulation: The Role of Lipopolysaccharide from Porphyromonas Species. II Annual ICOD Congress, “Frontier Sciences in Dentistry.” December 18, 2020. Online format.
21. Macrophage Differentiation Profiles and Their Epigenetic Regulation in Periapical Lesions of Endodontic Origin: Possible Implications for Systemic Risk. XXXI Annual Meeting of the IADR Chile Division. July 31, 2020. Online format.
22. Mechanisms of Crosstalk Between the Periapical Response and Non-Communicable Diseases. First Symposium on Oral Pathology and Research. July 24, 2020. Universidad San Sebastián. Online format.
23. Gender Challenges in Endodontic Medicine Research. XXXI Annual Meeting of the IADR Chile Division. August 30, 2019. Santiago, Chile.
24. Endodontic Infection: An Emerging Cardiovascular Risk Factor? XXX Annual Meeting of the IADR Chile Division. September 7, 2018. Santiago, Chile.
25. Endodontic Medicine: Emerging Evidence of Systemic Risk and Dental Management Considerations. VII Evidence-Based Dentistry Symposium, SOBE, National Association of Dental Students (ANACEO Chile). June 1, 2018. Austral University. Valdivia, Chile.
26. Seminar Series, Institute of Biomedical Sciences, Autonomous University of Chile. The Immunoinflammatory Response as a Link Between Endodontic Oral Infection and Cardiovascular Risk. November 23, 2017. Santiago, Chile.
27. Impact on Dental Practice of Current Research in Dental Sciences. November 3, 2017. Autonomous University. Santiago, Chile.
28. Inflammatory Response in Apical Periodontitis and Systemic Risk. Society for Oral and Maxillofacial Pathology. October 11, 2017. College of Dental Surgeons. Santiago, Chile.
29. Formation of Research Teams in the Evaluation of Periapical Inflammation as a Systemic Risk Factor. XXII CONADEO. September 11, 2017. Concepción, Chile.
30. Basic Tools in Dental Research. Research in Dentistry Seminar, Autonomous University. Temuco, Chile.
31. Periodontal Biomarkers in Oral Fluids: From Research to Dental Practice, and Panel of Experts. First Conference on Innovation and Technology Transfer in Dentistry, Universidad de La Frontera. May 19, 2017. Temuco, Chile.
32. Clinical Application of Biomarkers in Oral Fluids for the Diagnosis and Monitoring of Periodontal Diseases and Their Systemic Complications. Translational Research Session “From Science to Clinic,” XXI National Congress of Dental Students, CONADEO. August 6, 2016. Pontificia Universidad Católica de Chile. Santiago, Chile.
33. Local and Systemic Inflammation in Asymptomatic Apical Periodontitis and Its Response to Endodontic Treatment. Chilean Society of Endodontics. November 18, 2015. San Sebastián University, Bellavista Campus. Santiago, Chile.
34. Relevance of the Diagnosis and Treatment of Periapical Pathology in the Context of General Medicine. School of Medicine, Universidad del Desarrollo. August 21, 2015. Santiago, Chile.
35. Morphological Aspects and Biology of TMJ Ankylosis. Chilean Society of Oral and Maxillofacial Surgery and Traumatology. August 13, 2015. Clínica Alemana. Santiago, Chile.
36. Asymptomatic Apical Periodontitis: Local Inflammation or Systemic Response? Scientific Meeting of the Chilean Society of Endodontics. October 14, 2014. Santiago, Chile.
37. Crosstalk Between Local Host Response to Endodontic Infection and Low-Grade Systemic Inflammation in Asymptomatic Chronic Periodontitis: Prospective Study Evaluating the Effect of Conservative Endodontic Treatment. Second Research Conference in Dentistry, Faculty of Dentistry, Universidad de Chile. January 17, 2013. Santiago, Chile.
38. Host Response and Development of Biomarkers in Chronic Periodontitis. Scientific Meeting of the Chilean Society of Periodontology. October 22, 2011. Santiago, Chile.
39. Host-Derived Destruction Mediators and Their Role as Potential Biomarkers in Periodontal Pathology. First International Symposium of the Center for Odonto-Osseous Research (CIOO): Mechanisms of Regeneration, Remodeling and Odonto-Osseous Pathologies. January 19, 2011. Santiago, Chile.
40. Periapical Lesions: New Concepts and Future Perspectives. V National Conference on Oral Pathology and Medicine. Faculty of Dentistry, Universidad de Chile. January 21, 2010. Santiago, Chile.
41. Periodontal and Endodontic Pathology: Biomarkers and New Diagnostic and Therapeutic Tools. Bone Biology Symposium “Cellular and Molecular Mechanisms in Bone Pathology,” XXII Annual Meeting of the IADR Chile Division. October 23, 2009. Santiago, Chile.
42. Inflammatory Mediators and Progression of Chronic Apical Periodontitis: A Potential Contribution to Clinical Practice? Chilean Society of Oral Pathology, XXII Annual Meeting of the IADR Chile Division. October 23, 2009. Santiago, Chile.
43. Gingival Crevicular Fluid: A New Tool for the Study of Chronic Apical Periodontitis? Scientific Meeting of the Chilean Society of Endodontics. October 21, 2009. Santiago, Chile.
44. Molecular Study of Endodontic Pathology. Scientific Meeting of the Chilean Society of Endodontics. November 19, 2008. Santiago, Chile.
45. Periapical Lesions: New Methodologies Applicable to Diagnosis and Clinical Monitoring. Department of Pathology – Institute of Reference in Oral Pathology (IREPO), IV National Conference on Oral and Maxillofacial Pathology. January 2008.
46. MMPs and Tissue Destruction Profiles Associated with Chronic Periodontitis. XX Annual Meeting of the International Association for Dental Research (IADR). December 10, 2007. Faculty of Dentistry, Universidad de Chile. Santiago, Chile.

Invited Conferences - International :
1. Challenges of Dental Design in Evidence-Based Dentistry. Iberopan American Federation of Periodontology, May 8, 2023. Online modality.
2. "Oral infections and systemic diseases". Oral Gut Symposium “Mucosal immunity at the Oral-Gut axis in health or disease” Fundación Ciencia & Vida, January 14th, 2020.
3. Periapical lesion: The systemic cost of containing the endodontic infection. First international meeting of IADR, Caribbean section. October 4, 2019, Santo Domingo, Dominican Republic.
4. Preparation and publication of a scientific article: Key to success. First international meeting of IADR, Caribbean section. October 4, 2019, Santo Domingo, Dominican Republic.
5. Scientific methodology applied to dental clinical research. XIV International Conference on Science and Technology, National University of North east. September 27 Corrientes Argentina.
6. Crosstalk between local and systemic host’s inflammatory response in endodontic infection. XXIV Latin American Congress of Microbiology, November 16, 2018, Santiago Chile.
7. Apical lesions of endodontic origin: A reservoir of systemic inflammation of cardiovascular risk. XII International Congress of Dentistry National University Federico Villarreal. October 24, 2018, Lima Peru.
8. "Biological bases of endodontic medicine: Emerging evidence of cardiovascular risk" VII Congress of the Latin American Region IADR, September 1, 2018, Montevideo, Uruguay.
9. “Regulation of the periodontal inflammatory response by interleukin (IL) -6” Molecular Pathology Symposium, XIV Meeting of the Ibero-American Academy of Pathology and Oral Medicine (AIPMB), August 29, 2016 Lima Peru.
10. Differential Diagnosis of Apical Lesions of Endodontic origin, Postgraduate and Research Unit, Faculty of Dentistry, Autonomous University of Yucatán November 12, 2015 Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Mexico.
11. The Inflammatory Response in Apical Periodontitis as a Cardiovascular Risk Factor. Postgraduate and Research Unit, Faculty of Dentistry, Autonomous University of Yucatán November 11, 2015 Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Mexico.
12. Distribution of Gingival Lesions Not Induced by Plaque in Chilean Patients. Faculty of Dentistry, University of Barcelona, Master's program for Diagnostic Updating and Medical Therapeutics in Oral Medicine. June 4, 2015. Faculty of Dentistry, University of Barcelona, Barcelona, Spain.
13. Regulation of the Periodontal Inflammatory Response by Interleukin (IL)-6. Symposium on Molecular Pathology, XIV Meeting of the Ibero-American Academy of Pathology and Oral Medicine (AIPMB), Lima, Peru, August 29, 2016.
14. The Inflammatory Response in Apical Periodontitis as a Cardiovascular Risk Factor. Postgraduate and Research Unit, Faculty of Dentistry, Autonomous University of Yucatán. Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Mexico. November 11, 2015.
15. Differential Diagnosis of Apical Lesions of Endodontic Origin. Postgraduate and Research Unit, Faculty of Dentistry, Autonomous University of Yucatán. Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Mexico. November 12, 2015.
16. Distribution of Non-Plaque-Induced Gingival Lesions in Chilean Patients. Faculty of Dentistry, University of Barcelona, Master’s Program in Diagnostic and Therapeutic Updates in Oral Medicine. Faculty of Dentistry, University of Barcelona, Barcelona, Spain. June 4, 2015.
17. Dialogue between the Local and Systemic Inflammatory Response in Apical Periodontitis. XII Meeting of the Ibero-American Academy of Oral Pathology and Medicine. 1 h Santiago Chile. November 13, 2014.
18. Crosstalk between inflammatory mediators and matrix metalloproteinases in apical lesions of endodontic origin. PhD Program in Dental Sciences, Institute of Dentistry University of Helsinki, 1h. Biomedicum Helsinki, University of Helsinki, Helsinki Finland. September 3, 2014.
19. Non-plaque induced gingival lesions: Pitfalls in the AAP Classification of Periodontal Diseases. Dental Education Program (Undergraduate), Faculty of Dentistry, University of Helsinki, 1h Helsinki Finland. September 9, 2014-.
20. Bases of the Methodological Design Applied to Clinical Research in Dentistry. Pontificia Universidad Católica Madre y Maestra Santiago and Santo Tomás de Aquino Campus, 8 pm, Dominican Republic, Santiago de los Caballeros and Santo Domingo. March 24-27, 2014.
21. Biomarkers in FCG for the diagnosis and monitoring of chronic periodontitis. Pontificia Universidad Católica Madre y Maestra Santiago Campus, Santiago de los Caballeros, Dominican Republic. March 25, 2014.
22. Biomarkers in FCG for the diagnosis and monitoring of chronic periodontitis. 1 hour. Pontificia Universidad Católica Madre y Maestra Santo Tomás de Aquino Campus, Santo Domingo, Dominican Republic. March 27, 2014.
23. Panelist Round Table, International Periodontology Course, Society of Periodontology of Chile, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. March 16, 2013.
24. Proteolytic pathways involving MMP-13 and -8 in progressive chronic periodontitis Biomedicum University of Helsinki, Institute of Dentistry, Helsinki, Finlandia. 13 de mayo de 2009.


Premios y Distinciones

  •   Odontological Research Award

    COLGATE PALMOLIVE CHILE S.A

    Chile, 2012

    Award for Dental Research 2012, Colgate-Palmolive Chile, Santiago Chile. December 19, 2012.

  •   Academic Recognition Germán Valenzuela Basterrica in Research". III Conference of Internal Reflection: Good Teaching Practices "Academic Direction

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Recognition in Dental Research awarded by academic peers

  •   National Award in Dental Sciences

    International Association for Dental Research (IADR) and Chilean Academy of Sciences

    Chile, 2022

    National Award in Dental Sciences 2022 Awarded by the International Association for Dental Research (IADR), Chile Division, in collaboration with the Chilean Academy of Sciences, in its first edition (nominated every 2 years). Awarded for outstanding career, productivity, contribution to dental sciences, and the formation of researchers.

  •   Highly Cited Papers of IJMS (IF 5.6, Q1 en "Biochemistry & Molecular Biology): Matrix Metalloproteinases as Regulators of Periodontal Inflammation

    International Journal of Molecular Science

    Suiza, 2024

    Highly Cited Papers of IJMS (IF 5.6, Q1 en "Biochemistry & Molecular Biology): Matrix Metalloproteinases as Regulators of Periodontal Inflammation”, autora correspondiente

  •   Administrative Management Award

    UNIVERSIDAD DE CHILE

    Chile, 2011

    Administrative Management Award Awarded to the Deputy Director of Research, Faculty of Dentistry, University of Chile.

  •   Colgate Award – IADR Chile 2008

    International Association for Dental Research (IADR), Chilean Division

    Chile, 2009

    Colgate Award– IADR Chile 2008 For the research work titled: "Proteolytic Patterns in Chronic Periodontitis and the Role of MMP-13."

  •   First Place Award For the free topic presentation in the field of Periodontology

    2nd International Congress of Specialties

    Chile, 2008

    First Place Award For the free topic presentation in the field of Periodontology: "Characterization of Proteolytic and Peptidic Profiles in Chronic Periodontitis." At the 2nd International Congress of Specialties.

  •   Student Award: Best Research Work 4th Congress of the Institute of Dental Sciences, Faculty of Dentistry, Universidad of Chile (ICOD)

    Institute of Dental Sciences, Faculty of Dentistry, Universidad of Chile (ICOD)

    Chile, 2024

    Best Research Work Award 4th Congress of the Institute of Dental Sciences, Faculty of Dentistry, University of Chile (ICOD). Awarded to Marcelo Britos Carballo, a student in the Master’s Program in Dental Sciences, for the research titled: "Comparison of Root Canal Sampling Techniques for Microbiome Characterization in Apical Periodontitis."

  •   Student Award under Supervision: Second Place in the "Students" Category Chilean Science Stories Contest: The Legends, Merck

    MERCK

    Chile, 2024

    Student Award under Supervision: Second Place in the "Students" Category Chilean Science Stories Contest: The Legends, Merck. Awarded to Marcelo Britos Carballo for the project: "Characterization of Subgingival Bacterial Communities and Their Association with the Load of Periodontal Pathobionts in the Blood of Individuals with Periodontitis and Apical Periodontitis."

  •   Student Award under Supervision: Winner of the Scientific Program 13th IFEA World Endodontic Congress 2022 & Chilean Endodontic Society

    13 th World Endodontic Congress IFEA & Chilean Endodontic Society

    Chile, 2022

    Student Award under Supervision: Winner of the Scientific Program 13th IFEA World Endodontic Congress 2022 & Chilean Endodontic Society. Awarded to María José Bordagaray for the research: "Root Canal Treatment Reduces Serum High-Sensitivity and Monomeric C-Reactive Protein in Apical Periodontitis."

  •   Student Award under Supervision: First Place in the Research Projects Category XXXIV Annual Meeting, IADR Chile Division

    International Association for Dental Research (IADR), Chilean Division

    Chile, 2022

    Student Award under Supervision: First Place in the Research Projects Category. Awarded to David González XXXIV Annual Meeting, IADR Chile Division.

  •   Student Award under Supervision: Hatton Award XXXIII IADR Meeting, Chile Division

    International Association for Dental Research (IADR), Chilean Division

    Chile, 2021

    Student Award under Supervision: Hatton Award International Association for Dental Research 2021, XXXIII IADR Meeting, Chile Division. Awarded to PhD student Alejandra Fernández.

  •   Student Award under Supervision: David B. Scott Fellowship Award XXXIII IADR Meeting, Chile Division.

    International Association for Dental Research (IADR), Chilean Division

    Chile, 2021

    Student Award under Supervision: David B. Scott Fellowship Award XXXIII IADR Meeting, Chile Division, 2021. Awarded to undergraduate thesis student Débora Zamorano Riquelme for her project.

  •   Student Award under Supervision: Hermann Niemeyer Medal Awarded by the Chilean Society of Biochemistry and Molecular Biology

    Chilean Society of Biochemistry and Molecular Biology

    Chile, 2021

    Student Award under Supervision: Hermann Niemeyer Medal Awarded by the Chilean Society of Biochemistry and Molecular Biology. Awarded to PhD student Alejandra Fernández Moraga.

  •   Scholarship awarded by the University of Chile to staff and faculty members for the Diploma in Business Administration

    UNIVERSIDAD DE CHILE

    Chile, 2021

    Scholarship awarded by the University of Chile to staff and faculty members for the Diploma in Business Administration, Faculty of Economics and Business (FEN), 2021

  •   Scholarship for doctoral studies abroad, Becas Chile, National Agency for Research and Development (ANID)

    Agencia Nacional de Investigación y Desarrollo (ANID)

    Chile, 2012

    Scholarship for doctoral studies abroad, Becas Chile, National Agency for Research and Development (ANID), from May 2009 to January 2012.

  •   Scholarship from the University of Helsinki and Helsinki Central Hospital, Living/Working Grant for research development

    University of Helsinki and Helsinki Central Hospital

    Finlandia, 2010

    Scholarship from the University of Helsinki and Helsinki Central Hospital, Finland. Living/Working Grant for research development, awarded for the years 2009 and 2010.

  •   Initial Academic Scholarship, with a specialization in Oral Pathology. Objective: To obtain the Master’s degree.

    UNIVERSIDAD DE CHILE

    Chile, 2006

    Initial Academic Scholarship Graduate School, Faculty of Dentistry, University of Chile. Field: Dental Sciences, with a specialization in Oral Pathology. Objective: To obtain the Master’s degree. March 2000 – August 18, 2006.

  •   Milennium Nucleus Scholarship in Developmental Biology (NMBD) Awarded to develop research work for a Master’s degree in Odontogenesis

    Millennium Nucleus of Developmental Biology (NMBD)

    Chile, 2002

    Milennium Nucleus of Developmental Biology (NMBD) Scholarship Institution: NMBD Field: Developmental Biology Objective: To develop research work for a Master’s degree in Odontogenesis. March 1, 2001 – February 28, 2002.

  •   Academic Training Scholarship for Admission in the Field of Pathology

    UNIVERSIDAD DE CHILE

    Chile, 2000

    Academic Training Scholarship for Admission in the Field of Pathology Office of Academic Affairs, Faculty of Dentistry, University of Chile. March 1999 – January 2000.


 

Article (117)

Boldine and Laurolitsine Protect against Periodontitis-Associated Bone Loss via RANKL Downregulation
Subgingival Microbial Signatures Associated With Apical Periodontitis Identified by Next Generation Sequencing and Predictive Modelling
Bacterial translocation signatures and subgingival microbiome in individuals with periodontitis
Exploring the regulatory roles of MicroRNAs on NF- ΚB target genes in individuals with apical periodontitis
Odontogenic Tumors in South America - A Multicenter Study of 4399 Cases From 20 Oral Pathology Centers
Porphyromonas gingivalis Lysate Induces TLR-2/4-Dependent NF-κB Activation and Inflammatory Damage in the Human Placental Barrier
Proteomic Insights Into Gingival Crevicular Extracellular Vesicles in Periodontitis and Gestational Diabetes: An Exploratory Study
TLR-2 gene methylation in peripheral blood monocytes from apical periodontitis individuals: A cross-sectional study
TNF-alpha gene promoter's hypomethylation mediates a pro-inflammatory phenotype in peripheral blood monocytes from apical periodontitis individuals
Trueness and Passivity of Digital and Conventional Implant Impressions in Edentulous Jaws: A Prospective Clinical Study
Unveiling the association between angiogenic imbalance in the gingival crevicular fluid in maternal periodontitis and spontaneous preterm birth
Direct impact of psoriasis on gingival crevicular fluid levels of VEGF-A in periodontitis patients: a mediation analysis
Elevated serum hepatic transaminases in apical periodontitis individuals
Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature
Reduced C-reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study
Association of Periodontitis and Atopic Dermatitis with the Levels of IL-13, IL-31, and TSLP in the Gingival Crevicular Fluid
Lipopolysaccharides from Porphyromonas endodontalis and Porphyromonas gingivalis promote angiogenesis via Toll-like-receptors 2 and 4 pathways in vitro
Obesity is related to maternal periodontitis severity in pregnancy: a cross-sectional study
A universal dental adhesive containing copper nanoparticles stabilizes the hybrid layer in eroded dentin after 1 year
CpG Single-Site Methylation Regulates TLR2 Expression in Proinflammatory PBMCs From Apical Periodontitis Individuals
Editorial: The Human Microbiota in Periodontitis
Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma
Evaluation of PCR primers to identify Porphyromonas endodontalis in apical periodontitis clinical samples
Exploring the Expression of Pro-Inflammatory and Hypoxia-Related MicroRNA-20a, MicroRNA-30e, and MicroRNA-93 in Periodontitis and Gingival Mesenchymal Stem Cells under Hypoxia
Lipopolysaccharide from Porphyromonas gingivalis, but Not from Porphyromonas endodontalis, Induces Macrophage M1 Profile
MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients
Polarization Profiles of T Lymphocytes and Macrophages Responses in Periodontitis
Role of TLR9 methylation on its active transcription in apical inflammation
Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis
Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis
Anti-inflammatory effect of salt water and chlorhexidine 0.12% mouthrinse after periodontal surgery: a randomized prospective clinical study
Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels
Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance
Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia
Identification of IL-18 and Soluble Cell Adhesion Molecules in the Gingival Crevicular Fluid as Novel Biomarkers of Psoriasis
Localization of interleukin-6 signaling complex in epithelialized apical lesions of endodontic origin
Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep
Systemic and Extraradicular Bacterial Translocation in Apical Periodontitis
Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases
Epigenetic regulation of TLR2‐mediated periapical inflammation
Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis
Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis
Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis
MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites
Molecular signatures of extracellular vesicles in oral fluids of periodontitis patients
Adjunctive Effects of a Sub-Antimicrobial Dose of Doxycycline on Clinical Parameters and Potential Biomarkers of Periodontal Tissue Catabolism
Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 wild-type strain due to a decreased Th1/Th17 immune response and less osteoclast activity
Expression of Toll-like receptors 2 and 4 and its association with matrix metalloproteinases in symptomatic and asymptomatic apical periodontitis
Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis
New insights of the local immune response against both fertile and infertile hydatid cysts
Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus
Zinc oxide and copper nanoparticles addition in universal adhesive systems improve interface stability on caries-affected dentin
Comparative Study of the Minichromosome Maintenance Proteins Complex (MCM 4/5/6) in Ameloblastoma and Unicystic Ameloblastoma
Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population
Distribution of biopsied non plaque-induced gingival lesions in a Chilean population according to the classification of periodontal diseases
Echinococcus granulosus hydatid cyst location is modified by Fasciola hepatica infection in cattle
Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs
First description of Echinococcus ortleppi and cystic echinococcosis infection status in Chile
Human periodontal ligament fibroblasts synthesize C-reactive protein and Th-related cytokines in response to interleukin (IL)-6 trans-signalling
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation
Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin
Matrix Metalloproteinases as Regulators of Periodontal Inflammation
Quantification of Chemokine CCL5 in Patients with Diabetes Mellitus Type 2 and/or Chronic Periodontitis: Preliminary Study
Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases
Association of Endodontic Lesions with Coronary Artery Disease
Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up
Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study
Frequency of oral squamous cell carcinoma and oral epithelial dysplasia in oral and oropharyngeal mucosa in Chile
Actividad de metaloproteinasa de matriz extracelular-9 en fluido crevicular gingival durante la respuesta reparativa en periodontitis apical asintomática
C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6
Evaluation of Periapical Lesions of Endodontic Origin Using Cone Beam Computed Tomography
Extracellular Matrix Metalloproteinase-9 Activity in Gingival Crevicular Fluid During the Reparative Response in Asymptomatic Apical Periodontitis
H2O2 activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca2+ signals in human periodontal fibroblasts
Host response mechanisms in periodontal diseases
Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts
DL-2-Hydroxyisocaproic Acid Attenuates Inflammatory Responses in a Murine Candida albicans Biofilm Model
Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
Host-derived biomarkers of apical periodontitis in gingival crevicular fluid: a potential side-diagnostic tool
Interferon-gamma, Interleukins-6 and -4, and Factor XIII-A as Indirect Markers of the Classical and Alternative Macrophage Activation Pathways in Chronic Periodontitis
Matrix metalloproteinase-8 regulates transforming growth factor-beta 1 levels in mouse tongue wounds and fibroblasts in vitro
Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis
Serotype-dependent response of human dendritic cells stimulated with Aggregatibacter actinomycetemcomitans
Estudio de confiabilidad de la prueba de sialometría para flujo no estimulado en sujetos adultos clínicamente sanos
High Levels of CXC Ligand 12/Stromal Cell-derived Factor 1 in Apical Lesions of Endodontic Origin Associated with Mast Cell Infiltration
Interleukin-21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients
Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response
Asociación entre niveles de TNF-? en fluido crevicular gingival de dientes con periodontitis apical asintomática
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines
Inmunodetección de metaloproteinasas de matriz extracelular (MMPs)-2, -9, -13 y -14 en lesiones apicales asociadas con periodontitis apical asintomática
Levels of Interleukin-21 in Patients With Untreated Chronic Periodontitis
Oral rinse MMP-8 point-of-care immuno test identifies patients with strong periodontal inflammatory burden
Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice
Associations Between Matrix Metalloproteinase-8 and -14 and Myeloperoxidase in Gingival Crevicular Fluid From Subjects With Progressive Chronic Periodontitis: A Longitudinal Study
Chemokine Monocyte Chemoattractant Protein-3 in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods
Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis
Effect of Non-Surgical Periodontal Treatment on MMP-2 and TIMP-2 Levels in Chronic Periodontitis
Expression of CCL7 and CCR5 in periapical lesions
Expression of Colony Stimulating Factor-1 (CSF-1) and Cathepsin K in Periapical Lesions
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
MMPs in the Pathogenesis of Chronic Apical Periodontitis: Destruction or Protection of Periapical Tissues?
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade
Soluble forms of MMP-14 and CXCL12 expression in progressive chronic periodontitis
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions
Proteomic and Peptidomic Profiles in Chronic Periodontitis
MMP-13 and TIMP-1 determinations in progressive chronic periodontitis
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4(+) T lymphocytes
ICTP levels in chronic periodontitis patients and its association with disease progression
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity
Torres-Quintana MA. Matrix metalloproteinases and their role in the alteration of the osseointegration process
Ameloblastin and amelogenin expression in posnatal developing mouse molars.
Regulation of TNF-Alpha Gene Expression
Oral Mucosal Pathology in Elderly Adults. Oral Pathology Reference Institute (IREPO), Santiago, Chile

Abstract (5)

Increased gingival crevicular fluid extracellular vesicles are involved in the crosstalk between periodontitis and gestational diabetes
PORPHYROMONAS GINGIVALIS LYSATE INDUCES TISSUE DISORGANIZATION AND PROINFLAMMATORY RESPONSE IN HUMAN PLACENTAL EXPLANTS
BAT1-NFKBIL1-LTA OF MHC CLASS III IS A PREDISPOSING GENE REGION TO PERIODONTITIS
Levels of interleukin-21 in apical periodontitis and their association with disease pathogenesis and clinical symptomatology
Ameloblastin and amelogenin expression in postnatal developing mouse molars

BookSection (3)

Osteoarthritis of the Temporomandibular Joint: Clinical and Imagenological Diagnosis, Pathogenic Role of the Immuno- Inflammatory Response, and Immunotherapeutic Strategies Based on T Regulatory Lymphocytes
Chronic periodontitis: The role of immuno-inflammatory response in the pathogenesis of chronic periodontitis and development of chair-side point of care diagnostics in periodontitis and related systemic inflammation
Components of Host Response to Pathogenic Bacteria in Gingivitis, Components of Host Response to Pathogenic Bacteria in Gingivitis

ConferencePaper (87)

Clinical Application of Biomarkers in Oral Fluids for the Diagnosis and Monitoring of Periodontal Diseases and Their Systemic Complications," Translational Research Session "From Science to Clinic."
Biomarkers in GCF for Diagnosis of Superficial Sites in Periodontitis
Levels of Proinflammatory Markers and Endotoxin in Lesions of Symptomatic Apical Periodontitis
Relevance of the Diagnosis and Treatment of Periapical Pathology in the Context of General Medicine
Ameloblastoma: Description of Sociodemographic and Histological Parameters of Confirmed Cases Between 1975-2014
Dendritic cells response upon coninfection with different Aggregatibacter actinomycenetcomitans serotypes
Local and Systemic Inflammation in Asymptomatic Apical Periodontitis and Its Response to Endodontic Treatment
MMP-8, TRAP5, and OPG Biomarkers of Chronic Periodontitis in its Initial Stages
Morphological Aspects and Biology of TMJ Ankylosis
Osteogenesis and Bone Resorption in Temporomandibular Joint Ankylosis: A Morphological and Immunohistochemical Study
RANKL/OPG ratio and TRAP in Symptomatic and Asymptomatic Apical Lesions
Systemic Inflammation in Patients with Asymptomatic Apical Periodontitis Infected with Porphyromonas endodontalis
Endotoxins, Serum Antibodies, and Endothelial Dysfunction in Patients with Apical Periodontitis
Morphological Characterization of Giant Cell Granuloma
Non-Plaque Induced Gingival Lesions: 20-Year Prevalence in Chileans (IREPO, 1990-2009)
Analysis of Fertility Presentation in Cystic Echinococcosis and Fascioliasis in Slaughtered Cattle in the Metropolitan Region
Asymptomatic Apical Periodontitis: Local Inflammation or Systemic Response?
Distribution of Prevalent Non-Plaque-Induced Lesions According to the AAP Classification
H2O2 Induces MMPs through NFkB and Calcium Signaling in Periodontal Fibroblasts
Morphological Characterization of Temporomandibular Joint Ankylosis
Osteobiomarkers in Gingival Crevicular Fluid of Subjects with Inflammatory Diseases of the Marginal and Apical Periodontium
Reactive Protein is synthesized in Apical Lesions of Endodontic Origin
Systemic Inflammation, Endothelial Dysfunction, and Endotoxemia in Asymptomatic Apical Periodontitis
Analysis of Gingival Crevicular Fluid in Apical Periodontitis
Endotoxin and MMP-8 in Endodontic Apical Lesions and Apical Ligament
Aggregatibacter actinomycetencomitans and Porphyromonas gingivalis serotypes associated with chronic periodontitis
CC Chemokines and CCR Receptors in Periodontal Health or Disease
Collagenolytic MMPs and Myeloperoxidase as Biomarkers of Periodontal Diseases
Crosstalk Between Local Host Response to Endodontic Infection and Low-Grade Systemic inflammation in Asymptomatic Chronic Periodontitis: Prospective Study Evaluating tthe Effect of Conservative Endodontic Treatment
Frequency of Non-Plaque-Induced Gingival Lesions
Frequency of Non-Plaque-Induced Gingival Lesions (Santiago, Chile)
GCF biomarkers in apical and marginal periodontal chronic inflammation
H2O2 induces Inflammatory Changes in human periodontal ligament fibroblasts (PDLF)
Interleukin-6 and C-Reactive Protein in Endodontic Apical Lesions
Linfocitos Th9, Th17 y T reg en la periodonto-patogénesis
Morphologic characterization of temporomandibular joint ankylosis
MPO in Lesions of Endodontic Origin
Myeloperoxidase in Periapical Exudate of Teeth with Periapical Pathologies
Myeloperoxidase in Periapical Exudate Pre and Post Chemomechanical Endodontic Preparation
Presence and Levels in Teeth with Periapical Pathologies
SDF-1/CXCL12 in periapical lesions od endodontic origin
Soluble Adhesion Molecules in Lesions of Endodontic Origin
Synthesis of RANKL by CD4+ T Lymphocytes in Response to Different Bacterial Serotypes
Systemic Endotoxin Levels in Patients with Chronic Periodontitis
Temporomandibular Joint Ankylosis: A Clinical Study
Association between Chronic Periodontitis and Metabolic Syndrome: A Review of the Literature from the Last Decade
Characterization of MMP-8 and Bone Destruction Markers in Chronic Apical Periodontitis
Characterization of MMPs and Alpha-2-macroglobulin in asymptomatic apical periodontitis
Effect of Subantimicrobial Doses of Doxycycline as an Adjunct to Non-Surgical Periodontal Treatment
Frequency of oral squamous cell carcinoma and epitelial displasia: IREPO, University of Chile, 1990-2009
H2O2 induces MMPs via NF-kB pathway in periodontal ligament fibroblasts
MMP-12: Presence and semiquantificationin periapical exudates during endodontic therapy
Role of Mast Cells in the Etiopathogenesis of Apical Lesions
SDF-1/CXCL12 in asymptomatic apical periodontitis
Stromal Cell-Derived Factor-1, SDF-1/CXCL 12, in Lesions of Endodontic Origin
Frequency of Gingival Lesions Not Associated with Bacterial Plaque
Determination of VEGF in apical lesions and gingival crevicular fluid
Evaluation of Periodontal Response to ozone therapy in GCF
Gelatinases and Collagenases in the Pathogenesis of Periapical Lesions
H2O2 induces MMPs and NFκB signaling in periodontal ligament fibroblasts
Host Response and Development of Biomarkers in Chronic Periodontitis
Host-Derived Destruction Mediators and Their Role as Potential Biomarkers in Periodontal Pathology
MMP-12: Levels and immunolocalization in periapical lesions of endodontic origin
MMP-12: Possible Role in the Etiopathogenesis of Periapical Lesions in Teeth with Asymptomatic Apical Periodontitis
MMPs -8, -2 and -9 in endodontic periapical lesions
Oxidative Balance and Gelatinolytic Activity in Asymptomatic Apical Periodontitis
Pathogen and mast cell identification in absceced apical granulomas
Pro-oxidative status in endodontic apical lesions and gingival crevicular fluid
Role of the RUNX2 Transcription Factor as a Modulator of MMP Expression in the Migration and Invasion of Osteosarcoma Cells
SDF-1/CXCL12 in asymptomatic apical periodontitis and gingival crevicular fluid levels
TNF-α in gingival crevicular fluid of subjects with apical periodontitis
VEGF levels and oxidative stress in periodontal ligament and chronic apical periodontitis lesions
Association between MMP-8 and myeloperoxidase in progressive chronic periodontitis
Characterization of MMP-2, MMP-9, ICTP and SDF-1 in chronic apical periodontitis
H2O2 stimulates MMP gelatinolytic Activity in fibroblasts from periodontal ligament
Isolation and Characterization of Periodontal Ligament Fibroblasts
Levels of TNF-α and RANKL in Gingival Crevicular Fluid of Teeth with Chronic Apical Periodontitis
MMP-8, TIMP-1 and Myeloperoxidase as biomarkers of periodontal diseases
MMPs-13 and -13 in Teeth with Apical Lesions in Subjects with Chronic Periodontitis
Oxidative status and MMPs -2 and -9 in Apical lesions
Periapical Lesions: New Concepts and Future Perspectives
"New Study Tool in Chronic Apical Periodontitis?". Scientific Meeting of the Chilean Society of Endodontics.
Inflammatory Mediators and Progression of Chronic Apical Periodontitis: A Potential Contribution to Clinical Practice?
Periodontal and Endodontic Pathology: Biomarkers as New Diagnostic and Therapeutic Tools
Molecular Study of Endodontic Pathology
Periapical Lesions: New Methodologies Applicable to Diagnosis and Clinical Monitoring
MMPs and Tissue Destruction Profiles Associated with Chronic Periodontitis

Letter (2)

A quantitative point-of-care test for periodontal and dental peri-implant diseases
MMP activation in diagnostics of periodontitis and systemic inflammation

Proyecto (11)

Maladapted trained immunity as a mediator of cardiovascular risk in periodontitis
Núcleo lntegrativo de Exposoma y Resiliencia (ERIN) en Salud
Reprogramación de Monocitos en Inmunidad Entrenada Maladaptativa frente a Bacterias Endodónticas en Periodontitis Apical
Boldine Hydrochloride as an Immunomodulatory Bioactive Agent Targeting Macrophages in Regenerative Endodontics
The Pathogenic Vicious Cycle Between Periodontitis and Gestational Diabetes Mellitus: Communication via Bacterial Translocation and Extracellular Vesicles
Epidemiology of Odontogenic Tumors
The Therapeutic Effects of Extracellular Vesicles Derived from Treg Induced by RA in Periodontitis: Inhibition of Alveolar Bone Resorption and Promotion of Its Formation Through Modulation of the Periodontal Immune Response
Bacterial Translocation Signatures in Periodontitis: A New Paradigm for the Relationship Between Periodontal and Gut Microbiota and Non-Communicable Diseases
Role of IL-35, all-trans retinoic acid, and T regulatory-derived exosomes in inhibiting the tooth-supporting bone resorption during periodontitis through modulation of the Th17/Treg imbalance
Immunoexpression of EpCAM, Versicano and MCM2-7 complex in ameloblastomas, ameloblastic carcinomas and dental germs
Characterization of Oxidant Status and MMP-Mediated Proteolysis During Progression of Apical Periodontitis In Gingival Crevicular Fluid: A New Tool in the Search Of Early Prognostic Markers?

Review (5)

The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases
Machine learning and deep learning models for the diagnosis of apical periodontitis: a scoping review
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis
Análisis de MMPs en fluidos orales en el diagnóstico complementario de las enfermedades periodontales
Host-Pathogen Interactions in Progressive Chronic Periodontitis
8
RODOLFO PAREDES

Medical Education and Clinical Simulation Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

21
Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

232
Emma Hernandez

Directora

Servicio de Anatomía Patológica

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

1
OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

17
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Denisse Bravo

Profesora Titular

Odontología

Universidad Andrés Bello

Santiago, Chile

1
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

29
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Ana Verónica Ortega Pinto Ortega

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE, FACULTAD DE ODONTOLOGÍA

Santiago, Chile

1
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

4
Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

3
Loreto Abusleme

Associate Professor

Oral pathology and medicine

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Carvajal

Profesora Asistente

Odontologia Conservadora

FACULTAD DE ODONTOLOGÍA UNIVERSIDAD DE CHILE

Santiago, Chile

7
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

18
Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Iris Espinoza

Associated Professor

Departament of Oral Patology and Medicine

Universidad de Chile

Santiago, Chile

9
Timo Sorsa

Visiting Professor of Oral Biology

Institute of Dentistry

Karolinska Institutet

Stockholm, Suecia

6
Taina Tervahartiala

Research Scientist

Biomedicum-Institute of Dentistry

Universidad de Helsinki

Helsinki, Finlandia

2
MANUEL VARAS

Associated Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Cristian Cortez

Docente Investigador

Facultad de Ciencias

Universidad San Sebastián

Santiago, Chile

1
Eduardo Fernandez

Profesor Titular

Deparatamento Odontologia Restuaradora

Universidad de Chile

santiago, Chile

1
Víctor Beltrán

Profesor Asociado

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Cristian Alvarez

Profesor Asistente

Escuela de Medicina Veterinaria

Pontificia Universidad Católica de Chile

Zurich, Chile

2
Macarena Valdes

Académica

Escuela de Salud Pública

Universidad de Chile

Santiago, Chile

5
Fernando Valenzuela

Dermatologo

Dermatología

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Johanna Contreras

Profesor Asistente

Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
JUAN AITKEN

PROFESOR ASISTENTE

PATOLOGIA Y MEDICINA ORAL

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Marcela Alcota

Profesora Asistente

Odontologia Conservadora

Universidad de Chile

Santiago, Chile

6
Mauricio Baeza

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

3
Ian Cavalla

Profesor Investigador

Doctorado Odontología Traslacional

Universidad Andrés Bello

Santiago, Chile

1
Victor Martinez

Profesor de tiempo completo

Periodoncia

Universidad Autonoma de Yucatan

Merida, Chile

6
Valeria Ramirez

PROFESOR TITULAR

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

1
Arnoldo Hernandez

Académico

Anatomia y Medicina Legal

Universidad de Chile

Santiago, Chile

2
Max Monckeberg

Profesor Investigador Asistente.

Ginecología Obstetricia y Biología de la Reproducción.

Universidad de Los Andes.

Santiago, Chile

1
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

2
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

3
Christian Hidalgo

Postdoc

Instituto de Ciencias Agroalimentarias, Animales y Ambientales (ICA3)

Universidad de O'Higgins

San Fernando, Chile

11
Nicolás Dutzan

Associate Professor

Facultad de Odontología

Universidad de Chile

Santiago, Chile

1
Mario Gutiérrez

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Sven Niklander

Profesor Asociado

Patología y Cirugía Oral

Universidad Andrés Bello

Viña del Mar, Chile

1
Gisela Canedo

Investigadora y Profesora

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

1
carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

1
Laura Weber

Co Investigador

Universidad de Los Andes

Santiago, Chile

2
Claudia Brizuela

Research professor

Endodontic

Universidad de Los Andes

Santiago, Chile

4
Maria Valenzuela

Profesor TItular

Bioquimica y Biología Molecular

Universidad de Chile

Santiagao, Chile

1
Franz Strauss

Research Assistant

Department of Reconstructive Dentistry

University of Zurich

Zurich , Suiza

1
Jeannette Mardones

Profesora Adjunta

Odontología Conservadora

Universidad de Chile

Santiago, Chile

1
sabrita chandia

Profesional de apoyo

Departamento de Educacion en Ciencias de la Salud

Universidad de Chile

Santiago , Chile

3
Montserrat Reyes

Profesor Asistente

Patología y Medicina Oral

Universidad de Chile

Santiago, Chile

1
Gustavo Sáenz

Cirujano dentista

Particular

Santiago, Chile

18
Patricia Hernández

Profesor Asistente

Departamento de Odontología Conservadora

Universidad de Chile

Santiago, Chile

3
Constanza Osorio

Profesora Asistente

Universidad de Los Andes

Santiago, Chile

3
Constanza Jiménez

Periodoncista

Odontologia

Red de Salud UC Christus

Santiago, Chile

7
Maria Bordagaray

Instructor

Odontología Conservadora

Universidad de Chile

Santiago, Chile

1
Carolina Rojas

Docente

Universidad de Los Andes

Santiago, Chile

1
Luis Gonzalez

Estudiante de Doctorado

Universidad de Chile

Santiago, Chile

1
Gonzalo Fuentes

Gerente

Fitoquímica Sudamericana Ltda.

Las Condes, Chile

2
Sebastian Castro

Co-Fundador

Fitoquimica Sudamericana Limitada

Santiago, Chile

5
daniela albers

Profesor Asistente Extraordinario

Ciencias biomédicas, ética, investigación y educación

Universidad Los Andes

Santiago, Chile

1
María Baquedano

Encargada de Laboratorio

Medicina Veterinaria

Universidad Andrés Bello

Santiago, Chile

1
Romina Brignardello

Associate Professor

Health Research Methods, Evidence and Impact

McMaster University

Hamilton, Canada