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Juan Carlos Aguillón Gutiérrez

PROFESSOR

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Immunology of rheumatoid arthritis (RA) / Biology of tolerogenic dendritic cells / New T-cell autoantigen epitopes with potential to design a tolerogenic DC-based treatment for RA / Mechanisms of immunological tolerance / Recombinant antibodies

Educación

  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTY OF VETERINARY AND LIVESTOCK SCIENCES

    SANTIAGO, Chile

    1992 - 1997

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTY OF MEDICINE

    SANTIAGO, Chile

    1997 - 2006

  •   PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTY OF MEDICINE

    SANTIAGO, Chile

    2006 - A la fecha

  •   CHAIRMAN Full Time

    UNIVERSIDAD DE CHILE

    FACULTY OF MEDICINE

    SANTIAGO, Chile

    2004 - 2017

Experiencia Profesional

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2006 - A la fecha

  •   Chairman of Immunology Program Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2004 - 2017

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    1997 - 2005

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    1993 - 1996

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    1992 - 1993

Formación de Capital Humano


POSTDOCTORAL RESEARCHERS

Postdoctoral Trainee: Evelyn Menares associated to the grant ¨Preclinical evaluation and registration of tolerogenic dendritic cells pulsed with autoantigenic peptides (TOLDeC-AP) for an antigen-specific immunotherapy for rheumatoid arthritis¨ from the Fund for the Promotion of Scientific and Technological Development (FONDEF-IDeA-Chile ID18I10243). 2016 - 2018.

Postdoctoral Trainee: Octavio Aravena associated to the grant ¨Auto-antigen peptides presented by tolerogenic dendritic cells: A personalized therapy to re-instruct the immune system of patients with rheumatoid arthritis¨ from the Fund for the Promotion of Scientific and Technological Development (FONDEF-IDeA-Chile ID15I10080). 2016 - 2018.

Fondecyt Post-Doctoral Grant 3150453. Principal Investigator: Katina Schinnerling. Sponsor Investigator: JC Aguillón. Establishment of a humanized mouse model of arthritis: An approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies. November, 2014 – November, 2017.

Conicyt National Competition of Insertion of Advanced Human Capital in the Academy 2011, Grant 791100001. Principal Investigator: Karina Pino. Sponsor Investigator: JC Aguillón. “Strengthening research lines in cellular therapies in autoimmunity and transplantation ". October, 2011 – October, 2014.

SUPERVISION OF Ph.D. M.Sc. THESIS:

18. ASHLEY ANDRÉS FERRIER ESPÓSITO. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Study of the interaction between regulatory B lymphocytes and monocytes by the TIM-1/TIM-1L axis as mechanism of immune regulation: implications in rheumatoid arthritis”. 2019 – In progress.

17. JAXAIRA AMILENE MAGGI ORELLANA. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Identification and characterization of immunodominants T cell epitopes in patients with rheumatoid arthritis”. 2018 – In progress.

16. ROBERTO AQUILES ZÚÑIGA OLATE. Chemistry Doctoral Program, Facultad de Química, Universidad de la República del Uruguay. “Optimization of promoters for antibody production in CHO cells”. 2013 – In progress.

15. JORGE ALEJANDRO BERENDSEN MELLA. Biological Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Role of Siglec 2 and Siglec 10 in the atenuation of signals invloved in the IL-10 secretion by human B lymphocytes”. 2013 – 2016.

14. OCTAVIO ALEXIS ARAVENA MADARIAGA. Biotechnology Doctoral Program, Universidad Andrés Bello. “Study on the function of TIM-1 in the tolerance induction by human regulatory B cells in health and autoimmunity”. 2013 – 2016.

13. PAULINA ANDREA GARCÍA GONZÁLEZ. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Study of molecular networks associated to tolerance in dendritic cells of patients with rheumatoid arthritis and its expression in response inflammatory modulators”. 2015 – 2018.

12. MATÍAS GUTIÉRREZ GONZÁLEZ. Pharmacology Doctoral Program, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Effects of pharmacology induction of UPR and mTOR on the production of recombinant antibodies in CHO cells”. 2013 –2017.

11. BÁRBARA PAZ PESCE REYES. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Effects of tumor necrosis factor and interleukin-6 on the Th1 and Th17 axes in the context of rheumatoid arthritis”. 2010 – 2014.

10. MARÍA CORINA PEÑA JIMÉNEZ. Biological Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Determination of the therapeutical value of de la administración de regulatory dendritic cells administration in the murine model of arthritis by histopathological evaluation of proinflammatory cytokines in articulations samples”. 2008 – 2013.

9. PILAR FRANCISCA GAJARDO ORELLANA. Medical Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Caracterization of Foxp3+ regulatory T lymphocite subset in peripheral blood of patients with nasal polyposis”. 2008 – 2013.

8. JAIME PEÑA ALVAREZ. Engineering Sciences Master Program, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. “CHO cells suspension culture for the production of a chimeric antibody against human tumor necrosis factor”. 2007 – 2011.

7. ALEJANDRO ESCOBAR ÁLVAREZ. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Regulatory dendritic cells modulating the immune response in latex allergy”. 2006 – 2010.

6. DIEGO CATALÁN MARTINA. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Mechanisms involved in the response against citrulinated proteins in rheumatoid arthritis”. 2006 – 2010.

5. ANTONIO SERRANO GÓMEZ. Biochemistry Doctoral Program, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Study of chaperone proteins associated to the MIC molecule in human placent”. 2006 – 2009.

4. ADAM AGUIRRE DUCLER. Biochemistry Master of Science Program. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Modulation of the cellular immune response with tolerogenic dendritic cells in rheumatoid arthritis”. 2004 – 2008.

3. LORENA SALAZAR ARAVENA. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Modulation of the T helper response by immunization with tolerogenic dendritic cells in collagen induced murine arthritis”. 2003 – 2007.

2. FERMÍN GONZÁLEZ BERGAS. Master of Science Program. Facultad de Odontología, Universidad de Chile. “Association of IL-1 y TNF? polymorphisms with aggressive periodontitis”. 2004 – 2007.

1. LORENA FERREIRA ARANGUREN. Clinical Immunology Specialist Program. Facultad de Medicina, Universidad de Chile. “Cloning and preliminary evaluation of the diagnostic potential of recombinant Tc45, a Trypanosoma cruzi antigen”. 1997 – 1999.

SUPERVISION OF GRADUATE STUDENTS:

25. GABRIELA TAMARA UBILLA OLGUÍN. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2014 – 2018.

24. ASHLEY ANDRÉS FERRIER ESPÓSITO. Facultad de CIencias, Universidad de Chile. 2013 –2016.

23. LUIS ALFONSO VALENZUELA VILLA. Facultad de Ciencias, Universidad de Chile. 2013 –2016.

22. CAROLINA ELISA SCHÄFER ADRIAZOLA. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2012 – 2015.

21. JAVIER IGNACIO CAMPOS ACUÑA. Facultad de Ciencias, Universidad de Chile. 2013 –2015.

20. JAXAIRA AMILENE MAGGI ORELLANA. Facultad de Ciencias, Universidad de Chile. 2013 –2014.

19. LORENA DEL PILAR HOYOS PARRA. Facultad de Farmacia, Universidad de Concepción. 2010 – 2013.

18. DARÍO DE JESUS VERGARA SALAZAR. Facultad de Medicina, Universidad de Chile. March, 2013 – August , 2013.

17. RODRIGO ALONSO MORALES CASTRO. Facultad de CIencias, Universidad de Chile. 2011 – 2013.

16. PAULINA ANDREA GARCÍA GONZÁLEZ. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2010 – 2013.

15. NORBERTO ANDRÉS COLLAZO MUÑOZ. Facultad de CIencias, Universidad de Chile. 2008 – 2011.

14. NICOLÁS RUIZ-TAGLE PHILLIPS. Facultad de CIencias, Universidad de Chile. 2008 – 2010.

13. DAVID GARATE OYARCE. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2008 – 2010.

12. SERGIO MERCADO ARGANDOÑA. Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. 2008 – 2009.

11. JUAN PABLO MALDONADO ZAVALA. Facultad de Químicas y Biología, Universidad de Santiago de Chile. 2008 – 2009.

10. NICOLE MACARENA ROJAS COLONELLI. Facultad de Químicas y Biología, Universidad de Santiago de Chile. 2007 – 2008.

9. CARLOS CUEVAS LIZANA. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2005 – 2008.

8. PAULA ABELLO CÁCERES. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 2004 – 2007.

7. OCTAVIO ARAVENA MADARIAGA. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2004 – 2006.
6. JIMENA CUENCA MORENO.. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 1999 – 2002.

5. ANA MARÍA GAETE DOÑA. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1998 – 2001.

4. PILAR CAMPOS ORTIZ. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1998 – 2000.

3. CLAUDIO PÉREZ NÚÑEZ. Facultad de Ciencias, Universidad Austral de Chile. 1997 – 2000.

2. ADAM AGUIRRE DUCLER. Facultad de Medicina Veterinaria, Universidad de Concepción. 1995 – 1996.

1. VIVIANA FERREIRA ARANGUREN. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1994 – 1995.



 

Article (74)

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies.
Transcription factor engineering in CHO cells for recombinant protein production.
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNF alpha production in CHO cells
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis.
TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients.
Triatoma infestans Calreticulin: Gene Cloning and Expression of a Main Domain That Interacts with the Host Complement System.
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4+ T Cells.
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases.
Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features.
Gene Expression Profiling of Human Monocyte-derived Dendritic Cells - Searching for Molecular Regulators of Tolerogenicity.
Neuropilin-1(+) regulatory T cells promote skin allograft survival and modulate effector CD4(+) T cells phenotypic signature
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid A promote allograft acceptance in vivo
Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis.
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients.
Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production.
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines.
Blocking of p38 and transforming growth factor ss receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients
An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles
A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-beta plus tolerogenic dendritic cells
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets.
Interleukin 10 decreases MICA expression on melanoma cell surface
Levels of Interleukin-21 in Patients With Untreated Chronic Periodontitis
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy
Presencia de Linfocitos T Reguladores en Periodontitis Crónica
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells
Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease
The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines.
Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis.
Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
Emergent therapies for rheumatoid arthritis
Emergent therapies for rheumatoid arthritis.
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
Papel de los polimorfismos -238 y -308 del promotor del factor de necrosis tumoral alfa en la patogenia y respuesta al tratamiento anti- factor de necrosis tumoral alfa en artritis reumatoide
A simple immunometric assay to assess the feeding habits of Meprai spinolai, a Trypanosoma cruzi vector
A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus
Tumour necrosis factor-alpha (TNF-alpha) levels and influence of 2308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis
An anti-human recombinant tumor necrosis factor alpha (TNF alpha) monoclonal antibody recognizes an epitope in feline TNF alpha
Ex vivo lipopolysaccharide (LPS)-induced TNF-alpha, IL-1 beta, IL-6 and PGE(2) secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis
New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis
Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease
Daily production of human tumor necrosis factor in LPS-stimulated ex vivo blood culture assays
Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
Development of an immunoenzymatic assay for the detection of human antibodies against Trypanosoma cruzi calreticulin, an immunodominant antigen
Tc45, a dimorphic Trypanosoma cruzi immunogen with variable chromosomal localization, is calreticulin
Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes
Immunization with bacterial antigens: piscirickettsiosis
Immunodiagnosis of fasciolosis in horses and pigs using Western blots
Recognition of an immunogenetically selected Trypanosoma cruzi antigen by seropositive chagasic human sera
Immunomodulation of LPS ability to induce the local Shwartzman reaction
Humoral immune response anti K99 pilus from enterotoxigenic Escherichia coli in experimentally inoculated calves
Purification and Preliminary Sequencing of Tc45, an Immunodominant Trypanosoma cruzi Antigen: Absence of Homology with Cruzipain, Cruzain, and a 46-Kilodalton Protein.
Radiolabeling of Small Peptides Bound to a Solid Phase.
A Simple Method for Negative and Positive Selection of Murine and Human IgM-Bearing Lymphocytes Based on the Use of Antibody-Coated Silica Microparticles
An Immunogenetically Defined and Immunodominant Trypanosoma cruzi Antigen
Octadecyl silica: A solid Phase for Protein Purification by Immunoadsorption

Abstract (15)

In Vitro Generated Human Dendritic Cells Exposed to a Potent Maturation Melanoma Cell Lines Lysate Show a Tolerogenic-like Phenotype and Functionality When Exposed to Dexamethasone Prior to the Maturation Stimuli
ANTI-TNF THERAPY INDUCES CHANGES ON T CELLS AND NK CELLS SUB-POPULATIONS IN RHEUMATOID ARTHRITIS PATIENTS
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients
Dexamethasone Pretreatment Followed by an Inoculation of Short-term Lipopolysaccharide-stimulated Dendritic Cells Improves the Response of Murine Collagen-induced Arthritis
Dexamethasone Treated Monocyte-dendritic Cells from Latex Allergy Patients Induce Tolerance to the Major Allergen Hev b 5
Regulation of NKG2D ligand expression by IL-10
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients
Established murine collagen-induced arthritis and IL-17 production are specifically inhibited by a single inoculation of lipopolysaccharide-stimulated dendritic cells
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis.
Ex vivo pro-inflammatory cytokines expression in patients with aggressive periodontitis.
Rapid protocol to generate tolerogenic dendritic cells using microbial lipopeptide (BLP).
TNF-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis
Tumor necrosis factor genetic polymorphism as part of rheumatoid arthritis evolution
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis.

Proyecto (9)

Autoantigenic peptides presented by tolerogenic dendritic cells: a personalized therapy to reinstruct the immune system of patients with rheumatoid arthritis.
Citometría multiparamétrica para la identificación de determinantes moleculares en células involucradas en enfermedades prevalentes en Chile
Desarrollo, producción y caracterización de anticuerpo recombinante humano contra MIC-A con potencial terapéutico para el tratamiento de cáncer gástrico
Identifying immunodominant T-cell antigen-peptides and T-cell responses in rheumatoid arthritis: A further step in the development of an antigen-specific dendritic cell-based therapy to restore self-tolerance
Instituto Milenio en inmunología e inmunoterapia
International research network on characterization of new therapeutic targets for rheumatoid artritis.
Pre-clinical evaluation and registration of tolerogenic dendritic cells pulsed with autoantigenic peptides (TOLDeC-AP) for antigen-specific immunotherapy of rheumatoid arthritis
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas: una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis: Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs)

Patent (2)

Anticuerpo monoclonal contra TNF humano y sus fragmentos; secuencia nucleotídicas que lo codifica, vector y célula que la contienen; composiciones y kit que comprenden el anticuerpo; uso de los mismos y método para su obtención
Promotor con región rica en dinucleótidos, citosina-guanina, vectores, líneas celulares, procedimiento para producir proteína recombinante

Editorial (1)

How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis
101
Juan Aguillón

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

18
OCTAVIO ARAVENA

INVESTIGADOR

INSTITUTO CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE

Santiago, Chile

16
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

15
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

14
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

8
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

8
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

8
Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

6
Carolina Llanos

Profesor Asociado

Inmunología Clínica y Reumatología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

6
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

4
Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

4
Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

3
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

3
Mauricio Campos Mora

Ph.D student

Universidad de Chile

Santiago, Chile

3
Nicolás Dutzan

Assistant Professor

Facultad de Odontología, Departamento de Odontología Conservadora

Universidad de Chile

Santiago, Chile

3
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Universidad de Chile

Santiago, Chile

2
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Matias Gutiérrez

Investigador

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

2
Marcela Gatica

Coordinadora

Decanatura Facultad de Ciencias

Universidad de La Serena

La Serena, Chile

2
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

2
Katina Schinnerling

Profesor Investigador

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

2
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

2
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

2
Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

2
Fermín González

Profesor Asociado

universidad de chile

Santiago, Chile

2
NORBERTO COLLAZO

INGENIERO DE PROYECTO

PROGRAMA DE INMUNOLOGÍA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Antonio Serrano

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

1
Pedro Cattan

full professor

ciencias biologicas animales

UNIVERSIDAD DE CHILE; FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

santiago, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
Luis Mercado

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Luisa Herrera

Profesor Asociado

Incstituto de Ciencias Biomédicas, Programa de Genética Humana

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM

Santiago, Chile

1
Rodrigo Valenzuela

Bioquímico

Hematologia

Hospital del Salvador

Santiago, Chile

1
Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Julio Berrios

Académico Full-time

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile