Man

Diego Catalán Martina

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Linfocitos B reguladores en autoinmunidad Búsqueda de epitopos T inmunodominantes en artritis reumatoide

Educación

  •  Licenciado en Medicina, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2010 - A la fecha

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad de Chile

    Chile

    2010 - A la fecha


 

Article (36)

Immunosuppressive Mechanisms of Regulatory B Cells
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation.
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis.
TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients.
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T Cells.
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases.
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Neuropilin-1(+) regulatory T cells promote skin allograft survival and modulate effector CD4(+) T cells phenotypic signature
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid A promote allograft acceptance in vivo
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
Blocking of p38 and transforming growth factor ss receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses
An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells
Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis
Emergent therapies for rheumatoid arthritis
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-?) gene and ex vivo lipopolysaccharide-induced TNF-? expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus

Abstract (11)

Identification of T-cell autoantigenic peptides in rheumatoid arthritis as new targets for an antigen-specific dendritic cell-based therapy
Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients
Dexamethasone Pretreatment Followed by an Inoculation of Short-term Lipopolysaccharide-stimulated Dendritic Cells Improves the Response of Murine Collagen-induced Arthritis
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis.
Ex vivo pro-inflammatory cytokines expression in patients with aggressive periodontitis.
Rapid protocol to generate tolerogenic dendritic cells using microbial lipopeptide (BLP).
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis.

Editorial (1)

How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis

EditorialMaterial (1)

Editorial: Searching for immune tolerance Manipulating New Molecules and Exploiting New Concepts on lymphocyte Biology

Proyecto (16)

Determinación del efecto de unidades de concentrados plaquetarios obtenidos de donantes de sangre sobre la modulación de linfocitos T alogénicos
Instituto Milenio en Inmunología e Inmunoterapia, segunda etapa
Citómetro de Flujo Multiparamétrico
Development of an international research network focused on uncovering new molecular targets and evaluating novel cell-based strategies for the therapy of autoimmune diseases
Indagando mecanismos inflamatorios y su relación con el stress oxidativo en pacientes con fibromialgia
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas=> una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide
SEARCHING FOR A VALIDATED CELL-BASED THERAPEUTIC APPROACH FOR THE TREATMENT OF RHEUMATOID ARTHRITIS=>IDENTITIFICATION OF SPECIFIC TOLERANCE MARKERS AND CHARACTERIZATION OF MONOPHOSPHORYL
"Desarrollo, producción y caracterización de anticuerpos recombinantes de origen humano anti MICA con potencial terapéutico para el tratamiento de cáncer gástrico"
FCGAMMA RECEPTORS AND REGULATORY B CELLS=> A NOVEL NETWORK BEHIND THE IMMUNE RESPONSE GOVERNING SYSTEMIC SCLEROSIS
SEEKING FOR MECHANISMS INVOLVED IN THE IL-10 SECRETION BY REGULATORY B CELLS=> IMPLICATIONS FOR THERAPEUTIC INTERVENTIONS ON AUTOIMMUNE DISEASES.
EFECTOS DE LA TERAPIA CON UN ANTICUERPO CONTRA EL RECEPTOR DE IL-6 SOBRE LAS POBLACIONES LINFOCITARIAS Th17 Y Treg EN PACIENTES CON ARTRITIS REUMATOIDE
IDENTIFICACIÓN DE EPITOPOS T INMUNODOMINANTES EN ARTRITIS REUMATOIDE=> BUSCANDO LOS CANDIDATOS PARA EL DISEÑO DE UNA TERAPIA ANTÍGENO-ESPECÍFICA
APPLYING THE KNOWLEDGE ON MURINE TOLEROGENIC DENDRITIC CELLS TO THE DEVELOPMENT OF TOLEROGENIC MONOCYTE-DERIVED DENDRITIC CELLS FROM RHEUMATOID ARTHRITIS (RA) PATIENTS AIMED AT PROVIDING A THERAPEUTIC STRATEGY FOR RA TREATMENT
DESARROLLO DE UN SISTEMA DE EXPRESIÓN OPTIMIZADO PARA LA PRODUCCIÓN DE ANTICUERPOS TERAPÉUTICOS
INSTITUTO MILENIO EN INMUNOLOGÍA E INMUNOTERAPIA
EL FACTOR DE NECROSIS TUMORAL (TNF) EN EL BALANCE DE LOS EJES TH1/TH17=> LECCIONES DESDE LA TERAPIA ANTI-TNF EN ARTRITIS REUMATOIDE

Review (6)

Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
Neuropilin-1 in transplantation tolerance
Emergent therapies for rheumatoid arthritis
Biological therapy based on the use of last generation monoclonal antibodies
49
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

29
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

20
OCTAVIO ARAVENA

Director Científico

I+D+i

MEDICEL SA

Santiago, Chile

18
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

13
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

12
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

9
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

8
Katina Schinnerling

Profesor Investigador

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

6
Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

6
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Carolina Llanos

Profesor Asociado

Inmunología Clínica y Reumatología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

4
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

3
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

3
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

3
Mauricio Campos Mora

Ph.D student

Universidad de Chile

Santiago, Chile

2
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

2
Veronica Ramos

Bioquímico

Inmunologia, VIH y Alergias

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

2
Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

2
Norberto Collazo

Business Developer

Center for Sustainable Biotechnology

Fraunhofer Chile Research

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Luis Mercado

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Andrés Tittarelli

Investigador

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Matias Gutiérrez

Investigador

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile