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Katina Schinnerling

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Autoinmunidad y tolerancia Rol de microbiota en autoinmunidad Reguladores de tolerogenicidad en células dendríticas Modelo de ratón humanizado para artritis reumatoide (AR) Inmunoterapia para AR basada en células dendríticas tolerogénicas

Ciencias Naturales (Dr. rer. nat.), especialidad Inmunología, FREIE UNIVERSITAT BERLIN. Alemania, 2013
Biología, TECHNISCHE UNIVERSITAT DRESDEN. Alemania, 2007

Investigadora postdoctoral Other

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2014 - 2019
Profesor Asistente Full Time

UNIVERSIDAD ANDRES BELLO

Facultad de Ciencias de la Vida

Santiago, Chile

2019 - A la fecha

Investigadora postdoctoral Full Time

Universidad de Chile, Facultad de Medicina, Instituto de Ciencias Biomédicas

Santiago, Chile

2013 - 2019
Asistente científico Part Time

Charité - hospital clínico de la universidad, Berlín

Berlín, Alemania

2007 - 2013
Profesor Investigador Full Time

Universidad Andrés Bello

Santiago, Chile

2019 - A la fecha

Tutoría de tesis de doctorado
2 Doctorado en Biociencias Moleculares (en proceso)
1 Doctorado en Biotecnología (en proceso)

Tutoría de tesis de magíster
1 Magíster en Biotecnología y Ciencias de la Vida (en proceso)

Co-tutoría de tesis postgrado:
1 Doctorado en Biotecnología (en proceso)

Tutoría de tesis de pregrado (terminado):
8 carrera bioquímica
2 carrera ingeniería en biotecnología
1 carrera biología
4 carrera odontología

Beca de la Fundación Alemana de Becas Académicas (“Studienstiftung des deutschen Volkes”)

Studienstiftung des deutschen Volkes

Alemania, 2004

Beca para estudios universitarios


Oral treatment of Whipple's disease with doxycycline and hydroxychloroquine versus intravenous therapy with ceftriaxone followed by oral trimethoprim-sulfamethoxazole in Germany: a phase 2/3, prospective, open-label, randomised, controlled, non-inferiority trial. Moos, Verena; Krüger, J; Allers, Kristina; Moter, Annette; Kikhney, Judith; Kühl, Anja A; Loddenkemper, Christoph; Stroux, A.; Schinnerling, Katina; Schneider, Thomas Article WOS LANCET INFECTIOUS DISEASES (2025)
Segatella copri Outer-Membrane Vesicles Are Internalized by Human Macrophages and Promote a Pro-Inflammatory Profile Sepúlveda-Pontigo, Alison; Chávez-Villacreses, Karissa; Madrid-Muñoz, Cristóbal; Conejeros-Lillo, Sabrina; Parra, Francisco; Melo-González, Felipe; Regaldiz, Alejandro; González, Valentina P.I.; Méndez-Pérez, I.; Castillo-Godoy, Daniela P.; et al. Article ISI (2025)
Human metapneumovirus respiratory infection affects both innate and adaptive intestinal immunity Mendoza-Leon, Maria J.; Schinnerling, Katina; Bueno, Susan M. Article ISI FRONTIERS IN IMMUNOLOGY (2024)
Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Uptake of Tropheryma whipplei by Intestinal Epithelia Schinnerling, Katina; Weigt, Kathleen; Heldt, Claudia; Fromm, Anja; Bojarski, Christian; Siegmund, Britta; Schulzke, Joerg D.; Schumann, Michael Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS) Schinnerling, Katina Article ISI IMMUNITY INFLAMMATION AND DISEASE (2022)
Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC Schinnerling, Katina; Soto, Lilian; Neire, Oscar; Pesce, Barbara; Aravena, Octavio; Carmen Molina, Maria; Catalan, Diego; Carlos Aguillon, Juan Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease Epple, HJ; Troeger, H; Krug, SM; Fromm, A; Siegmund, B; Fromm, M; Schulzke, JD Article ISI SCOPUS Mucosal Immunology (2017)
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response Garcia-Gonzalez, PA; Sepulveda-Gutierrez, A; Mehdi, AM; Nel, HJ; Larrondo, ML Article ISI SCOPUS Frontiers in immunology (2017)
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease Trotta L.; Weigt K.; Oelkers G.; Biagi F.; Corazza G.R. Article ISI SCOPUS INFECTION AND IMMUNITY (2017)
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells Hilkens, CM Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2016)
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features Garcia-Gonzalez, PA; Sepulveda-Gutierrez, A; Mehdi, AM; Nel, HJ; Larrondo, ML; Hilkens, CM Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2016)
Role of Dendritic Cells in the Pathogenesis of Whipple's Disease Schinnerling, K; Geelhaar-Karsch A.; Allers K.; Friebel J.; Conrad K.; Loddenkemper C.; Kuhl A.A.; Erben U.; Ignatius R.; Moos V.; et al. Article ISI SCOPUS INFECTION AND IMMUNITY (2015)
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity Maggi, J; schafer, c; Ubilla-Olguin, G; Catalan, D; Schinnerling, K Article ISI SCOPUS Frontiers in immunology (2015)
Effect of Age on the CD4(+) T-Cell Impairment in HIV-Infected Persons Without and With cART Schneider, Thomas; Allers, Kristina; Geelhaar-Karsch, Anika; Epple, Hans-Joerg; Schmidt, Wolfgang; Moos, Verena; Karcher, Heiko; Boesel, Diana Article ISI JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2014)
Macrophages Accumulate in the Gut Mucosa of Untreated HIV-infected Patients Schneider, Thomas; Schuermann, Dirk; Allers, Kristina; Geelhaar-Karsch, Anika; Conrad, Kristina; Fehr, Mira; Moos, Verena; Epple, Hans-Joerg Article ISI JOURNAL OF INFECTIOUS DISEASES (2014)
Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens Moos, Verena; Friebel, Julian; Geelhaar-Karsch, Anika; Allers, Kristina; Conrad, Kristina; Schneider, Thomas Article ISI INFLAMMATION RESEARCH (2013)
Immunopathology of Immune Reconstitution Inflammatory Syndrome in Whipple's Disease Schneider, Thomas; Kikhney, Judith; Moos, Verena; Loddenkemper, Christoph; Kuehl, Anja A.; Friebel, Julian; Erben, Ulrike; Moter, Annette; Fenollar, Florence; Geelhaar, Anika; et al. Article ISI JOURNAL OF IMMUNOLOGY (2013)
Regulatory T Cells in Patients with Whipple's Disease Schneider, Thomas; Friebel, Julian; Conrad, Kristina; Geelhaar, Anika; Kuehl, Anja A.; Loddenkemper, Christoph; Erben, Ulrike; Allers, Kristina; Moos, Verena Article ISI JOURNAL OF IMMUNOLOGY (2011)
Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease Schneider, Thomas; Loddenkemper, Christoph; Moos, Verena; Fenollar, Florence; Geelhaar, Anika; Moter, Annette; Allers, Kristina; Raoult, Didier; Schmidt, Carsten; Ignatius, Ralf Article ISI GASTROENTEROLOGY (2010)
Specific and Nonspecific B-Cell Function in the Small Intestines of Patients with Whipple's Disease Schneider, Thomas; Loddenkemper, Christoph; Geelhaar, Anika; Fenollar, Florence; LaScola, Bernard; Moos, Verena; Raoult, Didier; Allers, Kristina Article ISI INFECTION AND IMMUNITY (2010)
The Immune Reconstitution Inflammatory Syndrome in Whipple Disease A Cohort Study Schneider, Thomas; Biagi, Federico; Feurle, Gerhard E.; Blaeker, Hendrik; Moter, Annette; Allers, Kristina; Loddenkemper, Christoph; Geelhaar, Anika; Jansen, Andreas; Moos, Verena Article ISI ANNALS OF INTERNAL MEDICINE (2010)


Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism Garcia-Gonzalez, PA; Medhi, AM; Nel, HJ Abstract ISI EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses Sepulveda-Gutierrez, A; Maggy, J; Mehdi, A; Nel, H; Hilkens, CM Abstract ISI ARTHRITIS & RHEUMATOLOGY (2016)


Endocytosis and immunostimulatory effects of Prevotella copri outer membrane vesicles in macrophages Sepúlveda-Pontigo, Alison; Chávez-Villacreses, Karissa; Schinnerling, Katina ConferencePoster (2024)
Characteristic lymphocyte responses to subcellular fractions of the human gut bacterium Prevotella copri in patients with rheumatoid arthritis Madrid, Cristóbal; Pacheco, Daniel; Schinnerling, Katina ConferencePoster (2023)
The link between microbiota and autoimmune inflammation in rheumatoid arthritis Schinnerling, Katina ConferencePoster (2022)
Induction of arthritis-like synovial inflammation in NOD-scid Il2rg null mice functionally engrafted withperipheral blood lymphocytes from rheumatoid arthritis patients Schinnerling, Katina ConferencePoster (2021)
Establishment of a chimeric human-mouse model of rheumatoid arthritis for pre-clinical testing Schinnerling, Katina; Schäfer, Carolina; Maggi, Jaxaira; Rosas, Carlos; Soto, Lilian; Aguillón, Juan C ConferencePoster (2018)
Human peripheral blood lymphocytes maintain polyclonal and antigen-specific reactivity after engraftment into NOD-scid Il2rγnull mice: first steps towards a humanized model of autoimmune arthritis Schafer, Carolina; Maggi, Jaxaira ConferencePoster (2016)
Human peripheral blood lymphocytes preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a “humanized” model of autoimmune arthritis Schafer, Carolina; Maggi, Jaxaira ConferencePoster (2016)
Human peripheral blood mononuclear cells preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a humanized model of autoimmune arthritis Schafer, Carolina; Maggi, Jaxaira ConferencePoster (2015)
Semi-mature dendritic cells fail to induce a T. whipplei-specific Th1 response in Whipple's disease Geelhaar, Anika; Schneider, Thomas; Friebel, Julian; Conrad, Kristina; Allers, Kristina; Loddenkemper, Christoph; Moos, Verena ConferencePoster (2011)
Anti-inflammatory milieu induces unspecific T cell regulation in Whipple's disease Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2010)
Inefficient T cell priming by dendritic cells impairs T. whipplei-specific Th1 response in Whipple's disease Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2010)
T cell regulation in patients with Whipple's disease Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2008)


Effect of Prevotella copri on the intestinal epithelial barrier and the activation of inflammatory immune responses by antigen-presenting cells in patients with rheumatoid arthritis Schinnerling, Katina Proyecto (2022)
Identificación de especies de la microbiota humana y sus antígenos implicados en la inmunopatogénesis de la artritis reumatoide Schinnerling, Katina Proyecto (2019)
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas=> una terapia personalizad a para reinstruir el sistema inmune de pacientes con artritis reumatoide FONDEF (ID15I10080) Proyecto 2016-2018 Investigador(a)
ESTABLISHMENT OF A HUMANIZED MOUSE MODEL OF ARTHRITIS=> AN APPROACH FOR STUDYING AUTOIMMUNE PROCESSES IN VIVO AND TESTING NOVEL THERAPEUTIC INTERVENTION STRATEGIES FONDECYT (3150453) Proyecto 2014-2018 Inv. Responsable
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis=> Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs) FONDECYT (1140553) Proyecto 2014-2018 Coinvestigador(a)
Migration of T cells in the gut mucosa and importance of mucosal CD4+ regulatory T cells for the immunopathogenesis of SIV/HIV infection German Research Foundation (DFG) (SCHN 616/6-1) Proyecto 2012-2014 Coinvestigador(a)
Instituto Milenio de Inmunología e Inmunoterapia (IMII) Iniciativa Científica Milenio (ICM) (IMII P09/016-F) Proyecto 2011-2021 Postdoctorado
Whipple's disease - Investigation of interactions of T cells and antigen presenting cells German Research Foundation (DFG) (DFG grant SFB633 project B09) Proyecto 2009-2015 Investigador(a)
Immunopathogenesis and intervention strategies for mucosal infections German Research Foundation (DFG) (KFO104 TP10) Proyecto 2001-2009 Investigador(a)


Oral Pathobiont-Derived Outer Membrane Vesicles in the Oral-Gut Axis Seguel-Fuentes, Emilio; Aranguiz-Varela, Felipe; Bocaz, Elisa; Bravo, Denisse; Schinnerling, Katina Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies Schinnerling, K Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis Review ISI SCOPUS CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases Review ISI SCOPUS AUTOIMMUNITY REVIEWS (2016)
Gene expression profiling of human monocyte-derived dendritic cells - searching for molecular regulators of tolerogenicity Schinnerling, K; Garcia-Gonzalez, P Review ISI SCOPUS Frontiers in immunology (2015)
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis Schinnerling, K; Soto L.; Garcia-Gonzalez, P; Catalan, D Review ISI SCOPUS Autoimmunity Reviews (2015)