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Katina Schinnerling

Profesor Investigador

Universidad Andrés Bello

Santiago, Chile

Autoinmunidad y tolerancia Rol de microbiota en autoinmunidad Reguladores de tolerogenicidad en células dendríticas Modelo de ratón humanizado para artritis reumatoide (AR) Inmunoterapia para AR basada en células dendríticas tolerogénicas

Ciencias Naturales (Dr. rer. nat.), especialidad Inmunología, FREIE UNIVERSITAT BERLIN. Alemania, 2013
Biología, TECHNISCHE UNIVERSITAT DRESDEN. Alemania, 2007

Investigadora postdoctoral Other

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2014 - A la fecha
Profesor Investigador Full Time

UNIVERSIDAD ANDRES BELLO

Facultad de Ciencias de la Vida

Santiago, Chile

2019 - A la fecha

Investigadora postdoctoral Full Time

Universidad de Chile, Facultad de Medicina, Instituto de Ciencias Biomédicas

Santiago, Chile

2013 - A la fecha
Asistente científico Part Time

Charité - hospital clínico de la universidad, Berlín

Berlín, Alemania

2007 - 2012

Beca de la Fundación Alemana de Becas Académicas (“Studienstiftung des deutschen Volkes”)

Studienstiftung des deutschen Volkes

Alemania, 2004

Beca para estudios universitarios


Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC García-González, Paulina A; Maggi, Jaxaira; Schinnerling, Katina; Sepúlveda-Gutiérrez, Alejandro; Soto, Lilian; Neira, Oscar; Mehdi, Ahmed M; Nel, Hendrik J.; Pesce, Bárbara; Aravena, Octavio; Molina, María Carmen; Catalán, Diego; Thomas, Ranjeny; Verdugo. Ricardo A.; Aguillón, Juan C. Article Front. Immunol. (2019)
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease Epple, HJ; Friebel, J; Moos, V; Troeger, H; Krug, SM; Allers, K; Schinnerling, K; Fromm, A; Siegmund, B; Fromm, M; Schulzke, JD; Schneider, T Article ISI SCOPUS Mucosal Immunology (2017)
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response Garcia-Gonzalez, PA; Schinnerling, K; Sepulveda-Gutierrez, A; Maggi, J; Mehdi, AM; Nel, HJ; Pesce, B; Larrondo, ML; Aravena, O; Molina, MC; Catalán, D; Thomas, R; Verdugo, RA; Aguillón, JC Article ISI SCOPUS Frontiers in immunology (2017)
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease Trotta L.; Weigt K.; Schinnerling K.; Geelhaar-Karsch A.; Oelkers G.; Biagi F.; Corazza G.R.; Allers K.; Schneider T.; Erben U.; Moos V. Article ISI SCOPUS INFECTION AND IMMUNITY (2017)
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells Maggi, J; Schinnerling, K; Pesce, B; Hilkens, CM; Catalán, D; Aguillón, JC Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2016)
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features Garcia-Gonzalez, PA; Schinnerling, K; Sepulveda-Gutierrez, A; Maggi, J; Hoyos, L; Morales, RA; Mehdi, AM; Nel, HJ; Soto, L; Pesce, B; Molina, MC; Cuchacovich, M; Larrondo, ML; Neira, O; Catalan, DF; Hilkens, CM; Thomas, R; Verdugo, RA; Aguillón, JC Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2016)
Role of Dendritic Cells in the Pathogenesis of Whipple's Disease Schinnerling, K; Geelhaar-Karsch A.; Allers K.; Friebel J.; Conrad K.; Loddenkemper C.; Kuhl A.A.; Erben U.; Ignatius R.; Moos V.; Schneider, T. Article ISI SCOPUS INFECTION AND IMMUNITY (2015)
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity Maggi, J; Schafer, C.; Ubilla-Olguin, G; Catalan, D; Schinnerling, K; Aguillón JC Article ISI SCOPUS Frontiers in immunology (2015)
Effect of Age on the CD4(+) T-Cell Impairment in HIV-Infected Persons Without and With cART Schneider, Thomas; Kunkel, Desiree; Allers, Kristina; Geelhaar-Karsch, Anika; Epple, Hans-Joerg; Schinnerling, Katina; Schmidt, Wolfgang; Moos, Verena; Karcher, Heiko; Boesel, Diana Article ISI JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2014)
Macrophages Accumulate in the Gut Mucosa of Untreated HIV-infected Patients Schneider, Thomas; Schuermann, Dirk; Allers, Kristina; Geelhaar-Karsch, Anika; Conrad, Kristina; Schinnerling, Katina; Fehr, Mira; Moos, Verena; Epple, Hans-Joerg Article ISI JOURNAL OF INFECTIOUS DISEASES (2014)
Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens Moos, Verena; Friebel, Julian; Geelhaar-Karsch, Anika; Allers, Kristina; Conrad, Kristina; Schneider, Thomas; Schinnerling, Katina Article ISI INFLAMMATION RESEARCH (2013)
Immunopathology of Immune Reconstitution Inflammatory Syndrome in Whipple's Disease Schneider, Thomas; Kikhney, Judith; Moos, Verena; Loddenkemper, Christoph; Schinnerling, Katina; Kuehl, Anja A.; Friebel, Julian; Erben, Ulrike; Moter, Annette; Fenollar, Florence; Geelhaar, Anika; Raoult, Didier; Feurle, Gerhard E.; Allers, Kristina Article ISI JOURNAL OF IMMUNOLOGY (2013)
Regulatory T Cells in Patients with Whipple's Disease Schneider, Thomas; Friebel, Julian; Schinnerling, Katina; Conrad, Kristina; Geelhaar, Anika; Kuehl, Anja A.; Loddenkemper, Christoph; Erben, Ulrike; Allers, Kristina; Moos, Verena Article ISI JOURNAL OF IMMUNOLOGY (2011)
Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease Schneider, Thomas; Loddenkemper, Christoph; Moos, Verena; Fenollar, Florence; Geelhaar, Anika; Moter, Annette; Allers, Kristina; Raoult, Didier; Schmidt, Carsten; Ignatius, Ralf; Schinnerling, Katina; Kunkel, Desiree Article ISI GASTROENTEROLOGY (2010)
Specific and Nonspecific B-Cell Function in the Small Intestines of Patients with Whipple's Disease Schneider, Thomas; Loddenkemper, Christoph; Geelhaar, Anika; Fenollar, Florence; Schinnerling, Katina; LaScola, Bernard; Moos, Verena; Raoult, Didier; Allers, Kristina Article ISI INFECTION AND IMMUNITY (2010)
The Immune Reconstitution Inflammatory Syndrome in Whipple Disease A Cohort Study Schneider, Thomas; Biagi, Federico; Feurle, Gerhard E.; Blaeker, Hendrik; Schinnerling, Katina; Moter, Annette; Allers, Kristina; Loddenkemper, Christoph; Geelhaar, Anika; Jansen, Andreas; Moos, Verena Article ISI ANNALS OF INTERNAL MEDICINE (2010)


Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism Garcia-Gonzalez, PA; Schinnerling, K; Sepulveda, A; Ubilla-Olguin, G; Soto, L; Neira, O; Medhi, AM; Nel, HJ; Catalán, D; Thomas, R; Verdugo, RA; Aguillón, JC Abstract ISI (2016)
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses Garcia-Gonzalez, P; Neira, O; Schinnerling, K; Sepulveda-Gutierrez, A; Maggy, J; Hoyos, L; Morales, R; Ubilla-Olguin, G; Mehdi, A; Nel, H; Soto, L; Pesce, B; Molina, MC; Cuchacovich, M; Larrondo, M; Catalán, D; Hilkens, CM; Thomas, R; Verdugo, R; Aguillón, JC Abstract ISI (2016)


Establishment of a chimeric human-mouse model of rheumatoid arthritis for pre-clinical testing Schinnerling, Katina; Schäfer, Carolina; Maggi, Jaxaira; Rosas, Carlos; Soto, Lilian; Aguillón, Juan C ConferencePoster (2018)
Human peripheral blood lymphocytes maintain polyclonal and antigen-specific reactivity after engraftment into NOD-scid Il2rγnull mice: first steps towards a humanized model of autoimmune arthritis Schinnerling, Katina; Schäfer, Carolina; Maggi, Jaxaira; Soto, Lilian; Aguillón, Juan C. ConferencePoster (2016)
Human peripheral blood lymphocytes preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a “humanized” model of autoimmune arthritis Schinnerling, Katina; Schäfer, Carolina; Maggi, Jaxaira; Soto, Lilian; Aguillón, Juan C. ConferencePoster (2016)
Human peripheral blood mononuclear cells preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a humanized model of autoimmune arthritis Schinnerling, Katina; Schäfer, Carolina; Maggi, Jaxaira; Soto, Lilian; Aguillón, Juan C. ConferencePoster (2015)
Semi-mature dendritic cells fail to induce a T. whipplei-specific Th1 response in Whipple's disease Schinnerling, Katina; Geelhaar, Anika; Schneider, Thomas; Friebel, Julian; Conrad, Kristina; Allers, Kristina; Loddenkemper, Christoph; Moos, Verena ConferencePoster (2011)
Anti-inflammatory milieu induces unspecific T cell regulation in Whipple's disease Schinnerling, Katina; Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2010)
Inefficient T cell priming by dendritic cells impairs T. whipplei-specific Th1 response in Whipple's disease Schinnerling, Katina; Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2010)
T cell regulation in patients with Whipple's disease Schinnerling, Katina; Geelhaar, Anika; Moos, Verena; Conrad, Kristina; Allers, Kristina; Schneider, Thomas ConferencePoster (2008)


Identificación de especies de la microbiota humana y sus antígenos implicados en la inmunopatogénesis de la artritis reumatoide Schinnerling, Katina Proyecto (2019)
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas: una terapia personalizad a para reinstruir el sistema inmune de pacientes con artritis reumatoide Catalán Martina, Diego Francisco; Aguillón Gutiérrez, Juan Carlos; Soto Saez, Lilian; Schinnerling, Katina Proyecto (2016)
Establishment of a humanized mouse model of arthritis: an approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies Schinnerling, Katina Proyecto (2014)
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis: Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs) Aguillón Gutiérrez, Juan Carlos; Schinnerling, Katina; Soto Saez, Lilian Proyecto (2014)


Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies Schinnerling, K; Rosas, C; Soto, L; Thomas, R; Aguillon, JC Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis Schinnerling K.; Aguillón J.C.; Catalán D.; Soto L. Review ISI SCOPUS CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases Garcia-Gonzalez, P; Ubilla-Olguin, G; Catalán, D; Schinnerling, K; Aguillón, JC Review ISI SCOPUS AUTOIMMUNITY REVIEWS (2016)
Gene expression profiling of human monocyte-derived dendritic cells - searching for molecular regulators of tolerogenicity Schinnerling, K; Garcia-Gonzalez, P; Aguillón JC Review ISI SCOPUS Frontiers in immunology (2015)
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis Schinnerling, K; Soto L.; Garcia-Gonzalez, P; Catalan, D; Aguillón JC Review ISI SCOPUS Autoimmunity Reviews (2015)