Man

Katina Schinnerling

Profesor Investigador

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


Autoinmunidad y tolerancia Rol de microbiota en autoinmunidad Reguladores de tolerogenicidad en células dendríticas Modelo de ratón humanizado para artritis reumatoide (AR) Inmunoterapia para AR basada en células dendríticas tolerogénicas

Educación

  •  Ciencias Naturales (Dr. rer. nat.), especialidad Inmunología, FREIE UNIVERSITAT BERLIN. Alemania, 2013
  •  Biología, TECHNISCHE UNIVERSITAT DRESDEN. Alemania, 2007

Experiencia Académica

  •   Investigadora postdoctoral Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2014 - A la fecha

  •   Profesor Investigador Full Time

    UNIVERSIDAD ANDRES BELLO

    Facultad de Ciencias de la Vida

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Investigadora postdoctoral Full Time

    Universidad de Chile, Facultad de Medicina, Instituto de Ciencias Biomédicas

    Santiago, Chile

    2013 - A la fecha

  •   Asistente científico Part Time

    Charité - hospital clínico de la universidad, Berlín

    Berlín, Alemania

    2007 - 2012

Premios y Distinciones

  •   Beca de la Fundación Alemana de Becas Académicas (“Studienstiftung des deutschen Volkes”)

    Studienstiftung des deutschen Volkes

    Alemania, 2004

    Beca para estudios universitarios


 

Article (16)

Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Role of Dendritic Cells in the Pathogenesis of Whipple's Disease
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
Effect of Age on the CD4(+) T-Cell Impairment in HIV-Infected Persons Without and With cART
Macrophages Accumulate in the Gut Mucosa of Untreated HIV-infected Patients
Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens
Immunopathology of Immune Reconstitution Inflammatory Syndrome in Whipple's Disease
Regulatory T Cells in Patients with Whipple's Disease
Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease
Specific and Nonspecific B-Cell Function in the Small Intestines of Patients with Whipple's Disease
The Immune Reconstitution Inflammatory Syndrome in Whipple Disease A Cohort Study

Abstract (2)

Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses

ConferencePoster (8)

Establishment of a chimeric human-mouse model of rheumatoid arthritis for pre-clinical testing
Human peripheral blood lymphocytes maintain polyclonal and antigen-specific reactivity after engraftment into NOD-scid Il2rγnull mice: first steps towards a humanized model of autoimmune arthritis
Human peripheral blood lymphocytes preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a “humanized” model of autoimmune arthritis
Human peripheral blood mononuclear cells preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a humanized model of autoimmune arthritis
Semi-mature dendritic cells fail to induce a T. whipplei-specific Th1 response in Whipple's disease
Anti-inflammatory milieu induces unspecific T cell regulation in Whipple's disease
Inefficient T cell priming by dendritic cells impairs T. whipplei-specific Th1 response in Whipple's disease
T cell regulation in patients with Whipple's disease

Proyecto (4)

Identificación de especies de la microbiota humana y sus antígenos implicados en la inmunopatogénesis de la artritis reumatoide
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas: una terapia personalizad a para reinstruir el sistema inmune de pacientes con artritis reumatoide
Establishment of a humanized mouse model of arthritis: an approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis: Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs)

Review (5)

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases
Gene expression profiling of human monocyte-derived dendritic cells - searching for molecular regulators of tolerogenicity
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis
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Katina Schinnerling

Profesor Investigador

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

8
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

3
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

3
Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

3
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

2
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

1
CARLOS ROSAS

Profesor Asistente

Ciencias Morfológicas

Universidad San Sebastián

Santiago, Chile

1
OCTAVIO ARAVENA

Director Científico

I+D+i

MEDICEL SA

Santiago, Chile