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Ricardo Alejandro Verdugo Salgado

Asistant Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Genetics of complex traits; Genetics of gene expression; Systems Genetics; Population Structure; Chilean ancestry

Educación

  •  Genetics, UNIVERSITY OF CALIFORNIA- DAVIS. Estados Unidos, 2008
  •  Médico Veterinario, UNIVERSIDAD DE CHILE. Chile, 2002
  •  Ciencias Veterinarias y Pecuarias, UNIVERSIDAD DE CHILE. Chile, 2001

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2012 - A la fecha

  •   Postdoc Full Time

    Jackson Laboratory

    Bar Harbor, Estados Unidos

    2008 - 2010

  •   Postdoc Full Time

    INSERM

    Paris, Francia

    2010 - 2012

Experiencia Profesional

  •   Postdoc Full Time

    Jackson Laboratory

    Bar Harbor, Estados Unidos

    2008 - 2010

  •   Postdoc Full Time

    INSERM

    Santiago, Francia

    2010 - 2012

  •   Postdoc Full Time

    Universidad de Chile

    Santiago, Chile

    2012 - A la fecha

Formación de Capital Humano


STUDENT TRAINING EXPERIENCE
Pablo Alarcón Arias (presente). Tesis para optar al grado de Magíster “Evaluación de frecuencias alélicas en variantes encontradas en pacientes chilenos mediante exomas y su relación con patogenicidad”. Programa de Magíster en Genética, Universidad de Chile. Directores de Tesis: Ricardo Verdugo y Rosa Andrea Pardo.

Lourdes López Portillo (presente). Tesis para optar al grado de Doctor “Estudio de interacción del consumo de bebidas azucaradas con riesgo genético de diabetes mellitus tipo 2 y ancestría sobre el riesgo de prediabetes en la cohorte MAUCO”. Programa de Doctorado en Nutrición, Universidad de Chile. Directores de Tesis: Ricardo Verdugo y Andrea Huidobro.

Rocío Mariana Retamales Ortega (presente). Tesis para optar al grado de Doctor “Estudio genómico de riesgo para cáncer gástrico y su asociación con ancestría en la población chilena”. Programa de Doctorado en Ciencias Biomédicas, Universidad de Chile. Directores de Tesis: Ricardo Verdugo y Patricio González Hormazábal.

Patricio Alejando Pezo Valderrama (presente). Tesis para optar al grado de Doctor “Estudio de Señales de Adaptación Biológica en Poblaciones Descendientes de grupos Cazadores Recolectores Marinos de la Patagonia”. Programa de Doctorado en Ciencias Biológicas, mención Ecología y Biología Evolutiva, Universidad de Chile. Directores de Tesis: Mauricio Moraga y Ricardo Verdugo.

Paulina Andrea García González (2018). Tesis para optar al grado de Doctor “Estudio de redes moleculares asociadas a tolerancia en células dendríticas de pacientes con artritis reumatoide, y su expresión en respuesta a moduladores inflamatorios”. Programa de Doctorado en Ciencias Biomédicas, Universidad de Chile. Directores de Tesis: Juan Carlos Aguillón y Ricardo Verdugo.

Pamela Andrea López Contreras (2018). Tesis para optar al grado de Doctor “Evaluation of the role of genes GAS6 and ZIP8 in mediating on a network gene co-expression the effects of smoking on macrophages”. Programa de Doctorado en Ciencias Biomédicas, Universidad de Chile. Director de Tesis: Ricardo Verdugo.

Mario Andrés Apata (2018). Tesis para optar al grado de Magíster en Ciencias Biológicas. “Señales de selección natural en poblaciones andinas expuestas históricamente al arsénico del Desierto de Atacama”. Programa de Magíster en Ciencias Biológicas, Facultada de Ciencias, Universidad de Chile. Directores de Tesis: Mauricio Moraga y Ricardo Verdugo.

Nolberto Zúñiga Contreras (2017). Tesis para optar al grado de Magíster “Efecto de la malnutrición prenatal en la variación natural de los patrones del sueño de Drosophila melanogaster”. Programa de Magíster en Genética, Universidad de Chile. Directores de Tesis: Patricio Olguín y Ricardo Verdugo.

Paloma Soledad Contreras Zúñiga (2015). Memoria de título “Investigación genómica de señales de selección positiva reciente en Aymaras, Pehuenches y Huilliches”. Carrera Antropología, Universidad de Chile. Director de Memoria: Ricardo Verdugo.
Bárbara Patricia Avello Vega (2014; en progreso). Memoria de título “Investigación de las Bases genéticas para el diagnóstico molecular de cáncer de mama a partir de secuenciación de última generación”. Carrera de Tenología Médica, Facultad de Medicina, Universidad de Chile.

Karen Oróstica Tapia (2014). Memoria de Título, “Implementación de métodos de visualización de datos genómicos y transcriptómicos en R”. Necessary to obtain the professional title of Engineer in Bioinformatics, Universidad de Talca.

Karen Oróstica Tapia (2013). Professional practice, “Desarrollo y Debugging del paquete en R ChromPlot”. 30-day training work at the laboratory, necessary to obtain the professional title of Engineer in Bioinformatics, Universidad de Talca.

Alejandro Esteban Blanco Muñoz (2013). Professional practice, “Optimización del diagnóstico molecular de cáncer de mama mediante secuenciación de última generación en pacientes chilenos”. 30-day training work at the laboratory, necessary for obtaining the professional title of Bioinformatician (U. de Talca).

TEACHING EXPERIENCE
Bioinformatics (2012-present). Coordinator of an advanced graduate course on Bioinformatics applied to biomedical sciences. School of Medicine, U. of Chile. Students must have first completed Bioinformatics I at the School of Engineering. He also lectures in other graduate level course in the Medical School in the topics of population genetics, genomics, and regulation of gene expression.

Introducción a la Genómica (30 de Agosto de 2013). Curso de Biología Molecular y Genética de la Especialidad Médica de Nefrología. Escuela de postgrado, Facultad de Medicina, Universidad de Chile. Profesor coordinador: Luis Michea.
Computational Biomedicine (2012). Coordinator of an advanced graduate course biomedical sciences. School of Medicine and Faculty of Engineering, U. of Chile. Part of the Magister in Medical Informatics of the U. of Chile and the University of Heidelberg.

Genetics, Lecturer. Undergraduate course for medical students at the School of Medicine in the University of Chile. Leads practice sessions and gives lectures. March-July 2012.

Taught a lecture titled “Designing microarray experiments in genetics of complex traits” at the International Course on “Genetics of Diseases and Human Populations”, University of Chile, Santiago, Chile, October 24 – 28, 2011. Also prepared a workshop “Tutorial for Testing Differential Expression in R”.

Taught a lecture titled “Designing microarray experiments in genetics of complex traits” and a workshop “Tutorial for Testing Differential Expression in R”, at Institute Pasteur, Paris, France. Received a 4.86 average evaluation from attendees (scale from 1=poor to 5=excellent).

Student Mentor: Summer Student Program, The Jackson Laboratory. June-August 2010. Guided and supervised two intern high-school students on a project titled “Prediction of complex disease phenotypes from genotype and microarray data in soybeans (Glycine max)”.

Taught a lecture titled “Genetical Genomics Workflows” at the Short Course on Systems Genetics, at the Jackson Laboratory, Bar Harbor, Maine. October 24th, 2009. Received a 4.8 grade for the instruction by the attendees (scale from 1=poor to 5=excellent).

Taught a lecture titled “Probe annotations and Genome Coverage in Microarrays” at the Short Course on Systems Genetics, at the Jackson Laboratory, Bar Harbor, Maine. September 26th, 2008.
Student Mentor: Summer Student Program, The Jackson Laboratory. June-August 2009. Guided and supervised an intern high-school student on a project titled “A systems biology approach to the genetic dissection of obesity in a C57BL/6J x C3H/HeJ F2 mouse cross”.

Teaching Assistant: Genetics and Animal Breeding, Department of Animal Science, University of California, Davis (October 2002 to 2007). Responsible for a simulation of dairy herds to be genetically improved by students. Contributed to the development of the program and web interfaces.
Teaching Assistant: Genes and Gene Expression, Department of Biological Sciences, University of California, Davis (2003). Led a discussion session, helping student to solve genetics problems.

Teaching Assistant: Introductory Animal Science, Department of Animal Science, University of California, Davis (2004). Led discussion group, demonstrated basic animal handling, anatomy and physiology practical sessions.

Teaching Assistant: Animal Growth and Development, Department of Animal Science (2006). Held office hours for students to answer questions.

Teaching Assistant: Animal Genetics, Universidad de Chile, Fac. Ciencias Veterinarias y Pecuarias (July 1998 to December 2000).
Responsible for a discussion section: developed problems and exercises in genetics and reinforced course theory and concepts.


Premios y Distinciones

  •   Second best score in his study group

    UNIVERSIDAD DE CHILE

    Chile, 2013

    Recognition for the 2nd place obtained by his project proposal “Discovery of networks of gene expression in monocytes and lymphocytes mediating HDL anti-atherogenic effects in humans” in his study group.

  •   Finalist for the Neel award

    International Genetic Epidemiology Society

    Alemania, 2011

    For the platform (oral) presentation “Graphical modeling reveals a gene expression network linking smoking to atherosclerotic plaques in a prospective human study”. 20th Meeting of the International Genetic Epidemiology Society, Heidelberg, Germany, September 18-20, 2011.

  •   Best poster award

    Institute Fédératif Coeur, muscle, vaisseaux – IFR14

    Francia, 2012

    Best poster award from the Institute Fédératif Coeur, muscle, vaisseaux – IFR14, march 15 2012. This price consists of €500 given to the 2 best poster presentations. Obtained for the work titled “Graphical modeling reveals primary genes in the gene expression network linking smoking to atherosclerotic plaques in a prospective human study” presented at the annual meeting on March 15 2012, Paris, France.

  •   Christine Mirzayan Science & Technology Policy Graduate Fellowship

    The National Academies

    Estados Unidos, 2008

    This fellowship is awarded to outstanding graduates from science or policy graduate schools with interest in policy making and with a record of involvement in social work. It consists of $5,300 granted by the Christine Mirzayan Memorial Fund of the National Academies.

  •   Fulbright Grant

    COMISION FULBRIGHT-CHILE

    Chile, 2002

    This award pursues to finance partially doctorate studies of Chilean students with academic excellence. It consists of $15,000 per year for two years. Administered by the Institute of International Education (IIE), New York.

  •   Academic Excellence Award

    UNIVERSIDAD DE CHILE

    Chile, 2000

    This award is made to students with a grade higher than 5.5 (on a scale of 1-7) and without failed courses in the entire career. Obtained 5.6 and ranked second place in overall grade of the 2000 generation.

  •   Education Abroad Grant

    UNIVERSIDAD DE CHILE

    Chile, 2000

    This grant is made for student with academic merits for studying abroad, and is given by the Programa de Movilidad Estudiantil of the Universidad de Chile. $4,300 (American dollars).


 

Article (33)

Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
Network analyses of modern genomes reconstruct the voyaging paths and timings of the settlement of Polynesia
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations
Development of a small panel of SNPs to infer ancestry in Chileans that distinguishes Aymara and Mapuche components
HLA-DRB1*07:01 and*08:02 Alleles Confer a Protective Effect Against ACPA-Positive Rheumatoid Arthritis in a Latin American Admixed Population
Native American gene flow into Polynesia predating Easter Island settlement
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population
Draft genome sequence data of maqui (Aristotelia chilensis) and identification of SSR markers
HIST1H1E heterozygous protein-truncating variants cause a recognizable syndrome with intellectual disability and distinctive facial gestalt: A study to clarify the HIST1H1E syndrome phenotype in 30 individuals
Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
ADAR1-mediated RNA-editing of 3 UTRs in breast cancer
Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia
Killer cell immunoglobulin-like receptor genotypes in a Chilean population from Talca
The genetic prehistory of the Andean highlands 7000 years BP though European contact
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
Visualization of Results from Systems Genetics Studies in Chromosomal Context
chromPlot: visualization of genomic data in chromosomal context
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2
SASH1, a new potential link between smoking and atherosclerosis
Graphical Modeling of Gene Expression in Monocytes Suggests Molecular Mechanisms Explaining Increased Atherosclerosis in Smokers
Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross
Genetic analysis of complex traits in the emerging Collaborative Cross
Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice
A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci
Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains
Segregation Analysis of a Sex Ratio Distortion Locus in Congenic Mice
Serious limitations of the QTL/Microarray approach for QTL gene discovery
Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone
Importance of randomization in microarray experimental designs with Illumina platforms
Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice
Comparison of Gene Coverage of Mouse Oligonucleotide Microarray Platforms
Selection response of US holstein AI bulls for milk production in Chile and Argentina

Abstract (3)

Genomic identification of recent positive selection in populations from Andean highlands and south-central Chile
Insight into the population history of the Chilean Patagonia through the analysis of ancient and modern genomic data
The transcriptional co-repressor Ski localizes in the pericentromeric region of mitotic chromosomes, regulating the expression of targeted genes at the early G1 phase of the cell cycle

BookSection (1)

Chapter 13: Visualization of Results from Systems Genetics Studies in Chromosomal Contex

Proyecto (32)

Estudio de la variación genética a nivel de genoma completo para la susceptibilidad y la gravedad de COVID-19 en la población chilena
Estructura genética y continuidad ancestral de poblaciones originarias del Norte Chico: estudio genómico de ADN antiguo y actual
Mejoramiento de la Sala de Servidores del Programa de Genética Humana, ICBM para aumentar su capacidad de almacenamiento e instalar un sistema profesional de aire acondicionado
Participación en Congreso Internacional de Genómica de Poblaciones
U-Genoma=> Red de Investigación y Docencia en Genética y Genómica
Genotipificación de Marcadores de Ancestría y de predisposición a enfermedades comunes en Chile: Perfeccionamiento y masificación del Panel de ChileGenomico
Genotipificación de Marcadores de Ancestría y de predisposición a enfermedades comunes en Chile=> Perfeccionamiento y masificación del Panel de ChileGenomico
TumorSec=> Optimización, validación y masificación de un ensayo de secuenciación de genes para mejorar la precisión de terapias oncológicas
U-Genoma: Red de Investigación y Docencia en Genética y Genómica
TumorSec: Optimización, validación y masificación de un ensayo de secuenciación de genes para mejorar la precisión de terapias oncológicas
ADAR promotes breast cancer progression through the regulation of cell cycle and DNA repair related genes
ADAR PROMOTES BREAST CANCER PROGRESSION THROUGH THE REGULATION OF CELL CYCLE AND DNA REPAIR RELATED GENES.
Drosophila Ring in Developmental Adaptations to Nutritional Stress (DRiDANS)
Chilean-French Collaboration for a Systems Genetics Approach to Cardiovascular and Metabolic Genomics
Chilean-French Collaboration for a Systems Genetics Approach to Cardiovascular and Metabolic Genomics
Genomic investigation of the human biodiversity in the pre-Columbian and contemporary Chilean Patagonia
NextSeq 500 Sequencing System
NextSeq 500 Sequencing System
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis: Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs)
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis=> Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs)
SEARCHING FOR A VALIDATED CELL-BASED THERAPEUTIC APPROACH FOR THE TREATMENT OF RHEUMATOID ARTHRITIS=>IDENTITIFICATION OF SPECIFIC TOLERANCE MARKERS AND CHARACTERIZATION OF MONOPHOSPHORYL
SEÑALES RECIENTES DE ADAPTACION GENETICA A CLIMAS EXTREMOS EN POBLACIONES DE CAZADORES RECOLECTORES MARITIMOS DE PATAGONIA Y TIERRA DEL FUEGO.
Señales recientes de adaptación genética a climas extremos en poblaciones de cazadores recolectores marítimos de Patagonia y Tierra del Fuego
BioMed-HPC: RED DE BIOLOGÍA Y MEDICINA COMPUTACIONAL DE ALTO RENDIMIENTO
BioMed-HPC=> Red de Biología y Medicina Computacional de Alto Rendimiento
Genomic investigation of the human biodiversity in the pre-Columbian and contemporary Chilean Patagonia
INCORPORACIÓN DE LA SECUENCIACIÓN DE ÚLTIMA GENERACIÓN EN EL CUIDADO DE LOS PACIENTES CON CÁNCER
Incorporación de la secuenciación de última generación en el cuidado de los pacientes con cáncer
DISCOVERY OF NETWORKS OF GENE EXPRESSION IN MONOCYTES AND LYMPHOCYTES MEDIATING HDL ANTI-ATHEROGENIC EFFECTS IN HUMANS
DISCOVERY OF NETWORKS OF GENE EXPRESSION IN MONOCYTES LYMPHOCYTES MEDIATING HDL ANTI-ATHEROGENIC EFFECTS IN HUMANS
GENÓMICA DE LA POBLACIÓN CHILENA: OBTENCIÓN DE PERFILES GENÉTICOS NECESARIOS EN INVESTIGACIÓN CLÍNICA, SALUD PÚBLICA Y MEDICINA FORENSE
Genómica de la población chilena=> obtención de perfiles genéticos necesarios en investigación clínica, salud pública y medicina forense
54
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

3
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

3
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

2
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

2
OCTAVIO ARAVENA

INVESTIGADOR

INSTITUTO CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Mauricio Moraga

Profesor Asociado

Programa de Genética Humana

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
Katina Schinnerling

Profesor Investigador

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

2
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Bettina Müller

Jefe subrogante

Oncología Médica

Instituto Nacional del Cáncer

Santiago, Chile

1
PATRICIA CASTRO

PROFESORA TITULAR

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

1
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alejandro Jara

Associate Professor

Statistics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Roberto Díaz

Docente e Investigador

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

1
Karen Oróstica

Vigilancia genómica

Genética Molecular

Instituto de Salud Pública

Santiago, Chile

1
Ulises Urzúa

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Omar Reyes

Investigador Adjunto

Instituto de la Patagonia

Universidad de Magallanes

Punta Arenas, Chile

1
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile