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Carolina Del Carmen Bizama Soto

Assistant professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Gastrointestinal cancers; Therapeutic target; Intracellular pathways; Patient-derived organoids (PDOs); Precision medicine.

Doctor in Sciences. Applied Cell and Molecular Biology Mention. , UNIVERSIDAD DE LA FRONTERA. Chile, 2010
Bachelor´s degree in Medical Technologist, UNIVERSIDAD DE LA FRONTERA. Chile, 2004
Medical Technologist, UNIVERSIDAD DE LA FRONTERA. Chile, 2004

Assistant Professor Adjunct Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2017 - 2020
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2020 - A la fecha
Postdoctoral Researcher Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago , Chile

2014 - 2016

Thesis student and Postdoctoral Researcher Full Time

Health Innovation Technology Consortium (CTI-Salud)

Santiago, Chile

2007 - 2013
Researcher and Professor Part Time

VentureLab, Escuela de Negocios. Universidad Adolfo Ibánez.

Santiago, Chile

2012 - 2012
Professor Part Time

Universidad Adolfo Ibánez

Santiago, Chile

2007 - 2007
Researcher Assistant Full Time

Neurosciences Laboratory, Universidad de la Frontera

Temuco, Chile

2004 - 2006
Assistant professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2020 - A la fecha

Doctoral Thesis: 2
2019 -2024. Thesis Advisor of Javiera Obreque, PhD. Program of Doctorate in Medical Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. Title of Doctoral thesis: "Evaluation of T cell-mediated suppression of antitumor immune response in organoids derived from patients with gallbladder cancer"

2018-2023. Thesis co-advisor of Luis Vergara, PhD. Program of Doctorate in Sciences with a major in aplied cellular and molecular biology, Universidad de La Frontera, Temuco, Chile. Title of thesis: " Characterization of the proteomic profile of gallbladder cancer patient-derived organoids and its association with Gemcitabine resistance".

Undergraduate Thesis:2

2024 -2024 Thesis advisor of Ayllin Aceituno. Profesional thesis to obtain the professional title of Medical Technologist with a major in morphophysiology and cytodiagnosis, Universidad de Chile, Santiago, Chile. Title: “Characterization of the expression of YAP1, PD-L1, CD44 and CD133 in gastric cancer patient-derived organoids treated with YAP1 inhibitors”.

2019 -2020 Thesis advisor of Ángelo Castillo Córdova. Profesional thesis to obtain the professional title of Medical Technologist with a major in morphophysiology and cytodiagnosis, Universidad de Chile, Santiago, Chile. Title "Evaluation of the pharmacological response in cultures of gallbladder cancer patient-derived organoids".

1. Publicación en Impact Connecting Global Research "Developing the anti-cancer toolbox", June 2018 www.impact.pub. https://www.ingentaconnect.com/content/sil/impact/2018/00002018/00000003/art00008?crawler=true&mimetype=application/pdf.

Patent participation: 2

1. United States Patent Application 20130130354. Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer. Assignee: CONSORCIO INNOVACIÓN Y TECNOLOGÍA EN SALUD (PBCT_06). Application Number:
13/136760. Publication Date:05/23/2013. Filing Date:08/10/2011.

2. United States Patent Application 20140328944. USE OF CTBP1 siRNA FOR THE TREATMENT OF GASTRIC CANCER. Assignee: CONSORCIO INNOVACIÓN Y TECNOLOGÍA EN SALUD (PBCT_06). Application Number:
13/986437. Publication Date:11/06/2014. Filing Date:05/02/2013.

College of Medical Technologists Award 2004

COLEGIO TECNOLOGOS MEDICOS

Chile, 2004

Best ranking in the specialty 2004
Universidad de La Frontera Award

UNIVERSIDAD DE LA FRONTERA

Chile, 2004

Best graduating student in medical technology, 2004
National PhD Scholarship CONICYT/ANID

CONICYT

Chile, 2007

National PhD Scholarship CONICYT, ID Nº 21070552.
CONICYT National Scholarship for Internship Abroad

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2008

CONICYT National Scholarship for Internship Abroad, ID Nº 8070019. Laboratorio de Terapia Celular y Molecular. Fundación Instituto Leloir, Buenos Aires-Argentina. Sponsor: Dr. Osvaldo Podhajcer.
Advanced Course Assistance Scholarship Wellcome Trust

WELLCOME TRUST

Reino Unido, 2016

Advanced Course Genetic Engineering of Mammalian Stem Cells, Wellcome Trust Advanced Course Center, Hinxton, Cambridge, England. This laboratory-based training course will provide a comprehensive overview of the theory and practical laboratory skills required for the genetic manipulation of mammalian stem cells, focusing on human iPS cells. Genome informatics, reagent design and CRISPR-based editing strategies will be covered in interactive practicals and demonstrations, with further discussion and lectures by international experts.


LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
A Novel Gemcitabine-Resistant Gallbladder Cancer Model Provides Insights into Molecular Changes Occurring during Acquired Resistance Vergara-Gomez, Luis; Zhong, Jun; Ili, Carmen; Espinoza, Karena; Repetto, Gabriela; Leal, Pamela Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets Erices, JI, Bizama C, Niechi I, Uribe D, Rosales A, Fabres K, Navarro-Martinez G, Torres A, San Martin R, Roa JC and Quezada-Monrás C Article WOS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America Salvo, Mauricio; Gonzalez-Feliu, Evelin; Toro, Jessica; Maureira, Ignacio; Miranda-Gonzalez, Nicolas; Colombo, Alicia; Spencer, M. Loreto; Morales, Erik Article ISI JOURNAL OF PERSONALIZED MEDICINE (2021)
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia Wichmann, Ignacio A.; Ferreccio, Catterina; Miquel, Juan Francisco Article ISI MOLECULAR ONCOLOGY (2020)
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor Sanchez, Marianela; Montecinos, Viviana P.; Kato, Sumie; Leal, Pamela; Lagos, Marcela Article ISI SCIELO BIOLOGICAL RESEARCH (2020)
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer Vargas, Sergio; Suárez, Felipe; Romero-Calvo, Isabel; Rivera, Vanessa; Leal, Pamela; Aguayo, Gloria; Muñiz, Sabrina Article ISI SCOPUS Cancers (2020)
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate Schroeder, Markus S.; Phalke, Sameer; Shi, Xiaoshan; Subbannayya, Tejaswini; Jaiswal, Bijay S.; Roa, Juan Carlos Article ISI NATURE COMMUNICATIONS (2020)
Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma Riquelme, Ismael; Apud-Bell, Maria; Leal, Pamela; Benavente, Felipe; Vargas, Sergio; Kalergis, Alexis M Article ISI SCOPUS HISTOPATHOLOGY (2019)
Simvastatin interferes with cancer stem-cell plasticity reducing metastasis in ovarian cancer Liberona, MF; Bravo, ML; Gejman, R; Montecinos, V. Article ISI SCOPUS ENDOCRINE-RELATED CANCER (2018)
IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness Fiore, EJ; Bolontrade, M; Bizama, C; Mazzolini, GD Article ISI SCOPUS Oncotarget (2017)
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Polakovicova, I; Carrasco-Veliz, N; Bizama, C Article ISI SCOPUS Clinical Epigenetics (2017)
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer Bizama, C; Kurtz, SE; Tyner, J Article ISI SCOPUS ONCOTARGET (2017)
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naive pT2 gallbladder adenocarcinoma patients Espinoza, J.A; Garcia P.; Bizama, C; Riquelme I.; Weber, H; Macanas, P.; Aguayo, G; Viñuela E.; Roa, J.C; Nervi, B Article ISI SCOPUS HISTOPATHOLOGY (2016)
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway Riquelme I.; Tapia O.; Leal P.; Sandoval A.; Varga, MG; Letelier P; Buchegger, K; Bizama, C; Peek, RM Article ISI SCOPUS CELLULAR ONCOLOGY (2016)
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines Riquelme I.; Tapia O.; Espinoza, J.A; Leal P.; Buchegger, K; Sandoval A.; Bizama, C; Araya J.C.; Roa, J.C Article ISI SCOPUS PATHOLOGY & ONCOLOGY RESEARCH (2016)
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Riquelme I.; Saavedra, K; Weber, H; Garcia P.; Nervi, B; Garrido M.; Corvalyn, AH; Bizama, C Article ISI SCOPUS Oncotarget (2015)
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice Weber, H; Leal P.; Stein S; Kunkel H; Garcia P.; Bizama, C; Riquelme I.; Nervi, B; Grez, M Article ISI SCOPUS Oncotarget (2015)
BRAF gene mutation in wild-type KRAS patients with colorectal cancers Roa, I; Game, A; Bizama, C; Schalper K. Article Revista Médica de Chile (2014)
The low-abundance transcriptome reveals novel biomarkers, specific intracellular pathways and targetable genes associated with advanced gastric cancer Bizama, C; Benavente F; Salvatierra E; Gutierrez-Moraga, A; Roa, I; Mazzolini G.; Gidekel, M. Article ISI INTERNATIONAL JOURNAL OF CANCER (2014)


HSP90 Expression and Antitumoral Activity of Geldanamicin and Its Analog in Gallbladder Carcinoma Valbuena J.; Weber, H; Leal P.; Garcia P.; Bizama, C; Espinoza, J.; Roa, J Abstract ISI LABORATORY INVESTIGATION (2015)


Molecular Genetics of Gallbladder Cancer Bizama, C BookSection (2015)


CENTRO PARA LA PREVENCIÓN Y CONTROL DE CÁNCER Proyecto (2023)
FONDAP- Centro del Cáncer (CECAN) Proyecto (2023)
TUMOR STROMA CELLS REGULATE GALLBLADDER CANCER PROGRESION AND CHEMORESISTANCE. Proyecto (2023)
Tumor stroma cells regulate gallbladder cancer progression and chemoresistance. Proyecto (2023)
EXOSOME-DERIVED PIWI-INTERACTING RNAS (PIRNAS) AND LONG NON-CODING RNA (LNCRNAS) AS NOVEL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF GALLBLADDER CANCER Proyecto (2022)
Exosome-derived piwi-interacting RNAs (piRNAs) and long non-coding RNAs (lncRNAs) as Novel Biomarkers for Diagnosis and Prognosis of Gallbladder Cancer Proyecto (2022)
GENOMICALLY STABLE GASTRIC CANCER: YAP1 AS A PREDICTOR OF STANDARD THERAPY RESPONSE AND NOVEL TARGET FOR PRECISION MEDICINE. Garcia Muñoz, Patricia; Serrano, Carolina; Quezada, Nicolas; Garrido, Marcelo A. Proyecto (2022)
Hippo/YAP1 as a predictor of therapy and novels target for precision medicine using gastric cancer patients-derived organoids. Proyecto (2022)
Millennium Institute on Immunology and Immunotherapy (IMII) Proyecto (2021)
Connecting molecular subtypes of colorectal cancer with extracellular vesicles heterogeneity in patient-derived organoids Pamela Leal Rojas Proyecto (2020)
EULAT Eradicate GBC Justo Lorenzo Proyecto European Union’s Horizon 2020 Research and Innovation Programme (2019)
ESCALON Juan Carlos Roa Proyecto European Union’s Horizon 2020 Research and Innovation Programme (2019)
The modulation of the leukemia-stroma interaction as a new strategy to improve outcomes in acute myeloid leukemia FONDECYT (1181792) Proyecto 2018-2021 Coinvestigador(a)
Circulating exoDNA as a next generation biospecimen for liquid biopsy of pancreatobiliary cancers FONDECYT (1170893) Proyecto 2017-2020 Coinvestigador(a)
Platform of therapy response prediction and drug prediction and drug screening using gallbladder cancer patients-derived organoids. FONDECYT (1171463) Proyecto 2017-2020 Inv. Principal
Desarrollo de un test predictivo de respuesta para LMA basado en la resistencia a quimioterapia conferida por le estroma tumoral de la médula osea Corfo Innova (14IPPID-45692) Proyecto 2016-2016 Investigador(a)
Desarrollo de un test pronóstico para LMA interrogando por primera vez el estroma tumoral Bruno Nervi N Proyecto (2016)
Identificación y validación de biomarcadores pronósticos y blancos terapéuticos de de la vía de señalización Hippo en pacientes con cáncer de vesícula biliar FONDECYT (3140426) Proyecto 2014-2016 Inv. Responsable
Advanced Center for Chronic Diseases (ACCDiS). Proyecto (2013)
Consorcio de Tecnología e Innovación para la Salud. Búsqueda de nuevos marcadores moleculares y blancos terapéuticos para cánceres gastrointestinales PIA (CTE-06) Proyecto 2006-2012 Investigador(a)
Deschampsia Antarctica Desv.=> Prospección de genes y agentes fotoprotectores ultravioletas para uso en la industria farmacéutica. FONDEF (D03I1079) Proyecto 2002-2007 Personal técnico y/o de apoyo
Productos terapeúticos para la disfunción erectil e insuficiencia cardiaca a partir del veneno purificado de Latrodectus Mactans de Chile. FONDEF (D02I1024) Proyecto 2002-2006 Investigador(a)
Efecto in vitro de los radicales libres de oxigeno, generados por leucocitos activados en presencia de bacterias, sobre la funcion del espermatozoide FONDECYT (1010729) Proyecto 2001-2003 Personal técnico y/o de apoyo


Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool Leal, Pamela Review ISI BIOLOGICAL RESEARCH (2023)
The inflammatory inception of gallbladder cancer Espinoza, J.A; Bizama, C; Garcia P.; Ferreccio C.; Javle, M; Miquel, J.F; Koshiol, J; Roa, J.C Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)
Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy Bizama, C; Garcia P.; Weber, H; Leal P.; Nervi, B Review ISI SCOPUS Cancer Treatment Reviews (2015)

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Maria Repetto

Profesora Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

Patricia Macanas

Profesor Asistente Adjunto

Hematology Oncology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

Carmen Ili

Academico Asociado

Scientific and technological Bioresource Nucleus (BIOREN)

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

PAMELA LEAL

Profesor Asociado

Departamento de Ciencias Agronómicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Nicolás Saavedra

Profesor Asociado

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Patricia García

Profesor Asistente

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Juan Calderon

Investigador

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

Carolina Bizama

Assistant professor

Department of Pathology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Manuel Gidekel

GERENTE OPERACIONES Y PRESIDENTE

CONSORCIO DE TECNOLOGIA E INNOVACION PARA LA SALUD

SANTIAGO, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

Eduardo Sagredo

Francisca Sepúlveda

PhD(c)

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Felipe Benavente

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

Sergio Vargas

Investigador

Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

Lorena Rosa

PhD

Departamento de Patología

Pontificia Universidad Católica de Chile

Santiago, Chile

Olga Barajas

PROF. ASOCIADA/MEDICO ONCOLOGO

MEDICINA

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

PABLO PEREZ

Profesor investigador

Programa de Comunicación en Cáncer

Universidad del Desarrollo

Santiago, Chile

Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

Karena Espinoza

Directora

Centro Asistencial Docente e Investigación

Universidad de Magallanes

Punta Arenas, Chile

Javiera Obreque

Investigadora Postdoctoral

CECAN - PUC

Santiago, Chile

Carolina Del Carmen Bizama Soto

Líneas de Investigación

Educación

Doctor in Sciences. Applied Cell and Molecular Biology Mention. , UNIVERSIDAD DE LA FRONTERA. Chile, 2010

Bachelor´s degree in Medical Technologist, UNIVERSIDAD DE LA FRONTERA. Chile, 2004

Medical Technologist, UNIVERSIDAD DE LA FRONTERA. Chile, 2004

Experiencia Académica

Assistant Professor Adjunct Full Time

Assistant Professor Full Time

Postdoctoral Researcher Other

Experiencia Profesional

Thesis student and Postdoctoral Researcher Full Time

Researcher and Professor Part Time

Professor Part Time

Researcher Assistant Full Time

Assistant professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

College of Medical Technologists Award 2004

Universidad de La Frontera Award

National PhD Scholarship CONICYT/ANID

CONICYT National Scholarship for Internship Abroad

Advanced Course Assistance Scholarship Wellcome Trust

Article (20)

Abstract (1)

BookSection (1)

Proyecto (23)

The modulation of the leukemia-stroma interaction as a new strategy to improve outcomes in acute myeloid leukemia

Circulating exoDNA as a next generation biospecimen for liquid biopsy of pancreatobiliary cancers

Platform of therapy response prediction and drug prediction and drug screening using gallbladder cancer patients-derived organoids.

Desarrollo de un test predictivo de respuesta para LMA basado en la resistencia a quimioterapia conferida por le estroma tumoral de la médula osea

Identificación y validación de biomarcadores pronósticos y blancos terapéuticos de de la vía de señalización Hippo en pacientes con cáncer de vesícula biliar

Consorcio de Tecnología e Innovación para la Salud. Búsqueda de nuevos marcadores moleculares y blancos terapéuticos para cánceres gastrointestinales

Deschampsia Antarctica Desv.=> Prospección de genes y agentes fotoprotectores ultravioletas para uso en la industria farmacéutica.

Productos terapeúticos para la disfunción erectil e insuficiencia cardiaca a partir del veneno purificado de Latrodectus Mactans de Chile.

Efecto in vitro de los radicales libres de oxigeno, generados por leucocitos activados en presencia de bacterias, sobre la funcion del espermatozoide

Review (3)