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Patricia Macanas Pirard

Profesor Asistente Adjunto

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

Líneas de Investigación


Tumor microenvironment; Drug resistance mechanism in tumor cells; Drug Interaction, Hematopoietic Cell Transplantation; Acute Myeloid Leukemia; Bone Marrow Microenvironment; Hox genes and cancer, Multi-drug resistance and apoptosis in cancer.

Educación

  •  Medical Biochemistry, University of Surrey. Reino Unido, 2000
  •  Molecular Toxicology, University of Surrey. Reino Unido, 2004

Experiencia Académica

  •   Instructor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2008 - 2017

  •   Profesor Asistente Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Research Fellow Full Time

    Postgraduate Medical School

    Guildford, Reino Unido

    2004 - 2007

  •   Instructor Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2008 - 2017

  •   Profesor Asistente Adjunto Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2017 - A la fecha


 

Article (14)

Metformin protects from oxaliplatin induced peripheral neuropathy in rats
Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome
The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients
Bone Marrow Stromal Cells Modulate Mouse ENT1 Activity and Protect Leukemia Cells from Cytarabine Induced Apoptosis
Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis.
A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer.
A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer.
The effects of cyclooxygenase-2 expression in prostate cancer cells: modulation of response to cytotoxic agents.
Antagonism of HOX/PBX Dimer Formation Blocks the In vivo Proliferation of Melanoma
Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells
Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells.
Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases.
The role of apoptosis in acetaminophen-induced injury.

Patent (1)

MÉTODO EX VIVO PRONOSTICO Y PREDICTIVO DE RESPUESTA DE UN CÁNCER AL TRATAMIENTO CON UN AGENTE ANTITUMORAL.

Proyecto (6)

“Desarrollo de un test multigénico para pronóstico de LMA interrogando al estroma tumoral”
The modulation of the leukemia-stroma interaction as a new strategy to improve outcomes in acute myeloid leukemia
Desarrollo de un test pronostico para LMA interrogando por primera vez al estroma tumoral
Desarrollo de un test predictivo de respuesta para LMA basado en la resistencia a quimioterapia conferida por el estroma tumoral de la médula osea
Preferential mobilization of leukemia precursors from the bone marrow into peripheral blood by the CXCR4 inhibitor AMD3100 in a mouse model
THE INTERACTION BETWEEN LEUKEMIA AND BONE MARROW STROMA PROTECTS THE TUMOR CELLS FROM DRUG INDUCED APOPTOSIS
14
Patricia Macanas

Profesor Asistente Adjunto

Hematology Oncology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

4
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Carolina Bizama

Profesor Asistente

Anatomía Patológica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

1
Patricia García

Profesor Asistente Adjunto

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
ERICK RIQUELME

ASSISTANT PROFESSOR

CENTER FOR INTEGRATIVE BIOLOGY

UNIVERSIDAD MAYOR

SANTIAGO, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile