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María Elvira Balcells Marty

Associate Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


Tuberculosis diagnosis; Tuberculosis epidemiology; Tuberculosis contacts; Tuberculosis transmission; Tuberculosis biomarkers;

Educación

  •  Médico Cirujano (MD), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Tropical Medicine and International Health, London School of Hygiene & Tropical Medicine. Reino Unido, 2003
  •  Infectología adultos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
  •  Medicina Interna, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

  •   Head of Adult Infectious Diseases Postgraduate Training Program Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2011 - 2019

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2008 - 2016

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2016 - A la fecha

  •   Sub-Director of Master’s Degrees programs Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Infectious Diseases and HIV Consultant Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2007 - A la fecha

Formación de Capital Humano


- Postgraduate Research Project (Postítulo de Infectología, P. Universidad Católica de Chile). Direct supervision of Dr. Marcos Huilcamán ( 2012 ). Project Title:
Búsqueda de portación nasofaríngea de M. tuberculosis en contactos intradomiciliarios.

- Postgraduate Research Project (Postítulo de Infectología, P. Universidad Católica de Chile). Direct supervision of Dr. Yazmín Pinos (2019). Project title: "Evaluación de respuesta linfocitaria específica en territorio arterial versus venoso para el diagnóstico de tuberculosis pulmonar activa”.


Difusión y Transferencia


2019, October 15th: Presentation in the XLIV Curso Internacional de Epidemiología y Control de la Tuberculosis, Instituto de Salud Pública (ISP). Santiago, Chile.

2019, May 4th: Presentation at the Regional Infectious Diseases Meeting, Valdivia. Advances in tuberculosis diagnosis.

2019, April 14th: Chair at tuberculosis "hot topics" session in the 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Amsterdam, The Hague

2019, April 9th: Immune basis in the pathogenesis of tuberculosis. Jornadas de Investigación en Medicina Aplicada (JIMA), Pontificia Universidad Católica de Chile, Santiago, Chile.

2018, November 16th: Presentation of Fondecyt project progress results at the annual meeting of the Tuberculosis Program from the Central Metropolitan Health Service (SSMC), Hotel Plaza San Francisco, Santiago, Chile.

2018, November 13th: Oral presentation (Fondecyt results). SLAM-TB Symposium in the 2018 ALAM Congress, Parque Araucano, Santiago, Chile

2018, October 24th: Poster Presentation at The Union (International Tuberculosis and Lung Diseases) Meeting, The Hague. Netherlands.

2018 April 12th: Oral presentation at the "Realidades y Desafíos" National HIV Meeting, Olmué, Chile

2018 March 4th: Oral presentation at the ASADI (Sociedad Argentina de Infectología) conference.


Premios y Distinciones

  •   Adult Infectious Diseases

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2006

    Awarded with Summa cum laude honours in the medical speciality in Adult Infectious Diseases

  •   Tropical Medicine and International Health

    London School of Hygiene & Tropical Medicine

    Reino Unido, 2003

    Awarded with the Frederick Murgatroyd Award to the best student of the year while coursing the Tropical Medicine and International Health Masters Degree (MSc) (2002 - 2003)

  •   Internal Medicine

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2001

    Awarded with Summa cum laude honours in the medical speciality in Internal Medicine (1998 - 2001)

  •   Medical Surgeon

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1997

    Awarded with Summa cum laude honors in the medical degree of medical surgeon (1991 - 1997)

  •   Award for the best work published in a international journal

    SOCIEDAD MEDICA DE SANTIAGO

    Chile, 2018

    Award for the best work published in an international journal for “Regional solar radiation is inversely correlated with incidence and severity of tuberculosis in Chile. Epidemiol Infect.2017jul; 145 (9):1815-1823

  •   Best young investigator award

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2017

    Awarded with "Best young investigator" award by the School of Medicine

  •   Award “100 lider women"

    DIARIO EL MERCURIO

    Chile, 2020

    Premio 100 Mujeres Líderes que entrega anualmente Mujeres Empresarias junto al diario El Mercurio.Premia la trayectoria y liderazgo femenino destacando a mujeres en el ámbito empresarial, ejecutivo, profesional y de servicio público de todo el país.


 

Article (43)

Clinical standards for the diagnosis, treatment and prevention of TB infection
Humoral immune-response to a SARS-CoV-2-BNT162b2 booster in inflammatory arthritis patients who received an inactivated virus vaccine
Reduced immune response to inactivated SARS-CoV-2 vaccine in a cohort of immunocompromised patients in Chile
Vitamin D and cathelicidin levels and susceptibility to Mycobacterium tuberculosis infection acquisition in household contacts
Convalescent Plasma in COVID-19. Mortality-Safety First Results of the Prospective Multicenter FALP 001-2020 Trial
Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile
Rathke's cleft cyst infections and pituitary abscesses: case series and review of the literature
Identification of mycobacteria species through mass spectrometry (MALDI-TOF)
Systematic screening of adult household contacts of patients with active pulmonary tuberculosis reveals high rates of new infections during follow-up
Unraveling the Role of MicroRNAs in Mycobacterium tuberculosis Infection and Disease: Advances and Pitfalls
The lung microbiome, vitamin D, and the tuberculous granuloma: A balance triangle
Tuberculous otomastoiditis: A challenging diagnosis
Diagnostic performance of GM-CSF and IL-2 in response to long-term specific-antigen cell stimulation in patients with active and latent tuberculosis infection
Tuberculosis and impaired IL-23-dependent IFN-gamma immunity in humans homozygous for a common TYK2 missense variant
Association of vitamin D deficiency, season of the year, and latent tuberculosis infection among household contacts
Diagnostic accuracy of the Xpert (R) MTB/RIF cycle threshold level to predict smear positivity: a meta-analysis
Enfermedades Infecciosas y migración. Una responsabilidad compartida.
Evaluación de la técnica Xpert® MTB/RIF para la detección de Mycobacterium tuberculosis complex en muestras extra-pulmonares
Regional solar radiation is inversely correlated with incidence and severity of tuberculosis in Chile
M. tuberculosis DNA detection in nasopharyngeal mucosa can precede tuberculosis development in contacts
Thrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: A case report and review of the literature
A First Insight on the Population Structure of Mycobacterium tuberculosis Complex as Studied by Spoligotyping and MIRU-VNTRs in Santiago, Chile
Atypical mycobacterial infections in five adult patients without evidence of immunosuppression. Making an experience
Cluster of Imported Vivax Malaria in Travelers Returning From Peru
Micobacterias atípicas en cinco pacientes adultos sin evidencias de inmunosupresión: Construyendo una experiencia
Mycobacterium abscessus pulmonary infection during hepatitis C treatment with telaprevir, peginterferon and ribavirin
Pesquisa de infección tuberculosa latente en personal de la salud en cuatro instituciones de salud en Santiago de Chile
Presencia del genotipo Beijing entre cepas del complejo Mycobacterium tuberculosis en dos centros de salud de la Región Metropolitana-Chile
A comparative study for adenosine deaminase and anti-antigen A-60 antibodies detection for the diagnosis of tuberculous meningitis
Clinical and epidemiological profile of tuberculosis in a university hospital in Santiago, Chile
Rapid molecular detection of pulmonary tuberculosis in HIV-infected patients in Santiago, Chile
The first case of tinea faciei caused by Trichophyton mentagrophytes var. erinacei isolated in Chile
Endemic Scrub Typhus-like Illness, Chile
The adaptation methodology of a guideline for the management of adults with community-acquired pneumonia
Hepatitis B, C, Treponema pallidum and Toxoplasma gondii co-infections in HIV infected patients
Neurosyphilis in the patients with and without HIV infection. Description and comparison of two historical cohorts
Tuberculosis en el paciente con infección por virus de inmunodeficiencia humana
A comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile
Prevalence of tuberculosis and its impact on mortality among HIV infected patients in Chile
Pseudo-outbreak of Ochrobactrum anthropi Bacteremia related to cross-contamination from erythrocyte sedimentation tubes
Isoniazid preventive therapy and risk for resistant tuberculosis

BookSection (4)

Signos de Alarma de Infección
Tuberculosis asociada a VIH/SIDA
VIH en UCI
Virus de inmunodeficiencia humana y cerebro

BookWhole (1)

Protocolo de Atención de Pacientes con HTLV-I. MINSAL

CaseReport (1)

Angiomatosis bacilar por Bartonella quintana como primera manifestación de infección por VIH: Report of one case

ComunicacionBreve (1)

Viajeros a Asia

ConferencePoster (7)

Antibody detection against Mycobacterium tuberculosis antigens in saliva from patients with active pulmonary tuberculosis
Detección de anticuerpos contra antígenos específicos de Mycobacterium tuberculosis en muestras de saliva en pacientes con tuberculosis pulmonar activa, un estudio piloto.
Estrategia de seguimiento activo y prolongado revela alto número de casos secundarios de tuberculosis en contactos adultos
Identification of recently acquired tuberculosis infection using QuantiFERON-TB Gold Plus: an exploratory study
MiRNAs differential expression pattern distinguishes uninfected household contacts from those with newly acquired latent tuberculosis infection
Early Tuberculosis Infections Assessed by Serial QuantiFERON TB-Gold Plus testing in a Prospective Cohort of Household Contacts
Identificación de especies de micobacterias por medio de espectrometría de masas basada en Matrix-assisted laser desorption/ionization time-of-flight mass (MALDI-TOF).

Editorial (1)

La relevancia actual de la vacuna BCG en la prevención de tuberculosis infantil

Letter (1)

Successful treatment with echinocandin in an HIV-infected individual failing first-line therapy for Pneumocystis jirovecii pneumonia

Proyecto (9)

Evaluación de la respuesta inmune a vacuna anti-SARS-CoV-2 inactivada en cohorte de pacientes adultos con inmunosupresión adquirida severa.
Strengthening of airborne preventive measures inside households of pulmonary TB cases as a tool to reduce new infections in close contacts.
Effectiveness and safety of convalescent anti SARS-CoV-2 plasma in the treatment of the early phase of novel coronavirus infection (COVID-19) in hospitalized risk patients: an interventional randomized clinical study
Evaluation of specific immunological memory for COVID-19 in convalescent plasma donors and recipients
Determinants for tuberculosis infection acquisition in contacts: exploring the role of nasopharyngeal mucosal environment
Micronutrientes y otros factores de riesgo de infección latente en el contacto de tuberculosis- estudio transversal=> avanzando hacia un cambio en el paradigma en la prevención la tuberculosis en Chile
Association between Mycobacterium tuberculosis strain and specific Th1, Th2 and Th17 human immune response: a way to identify biomarkers that are better predictors of the risk of tuberculosis infection
Estudio Piloto=> Estudio de colonización nasofaríngea por Mycobacterium tuberculosis, en contactos intradomiciliarios de pacientes con tuberculosis bacilífera.
Evaluation of a rapid diagnostic method for tuberculosis detection in patients with HIV/AIDS.

Review (1)

Microbiome Changes during Tuberculosis and Antituberculous Therapy
67
María Balcells

Associate Professor

Department of Infectious Diseases of the Adult

Pontificia Universidad Catolica de Chile

Santiago, Chile

11
Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

3
Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Cinthya Ruiz-Tagle

Research Assistant

Department of Infectious Disease

Pontificia Universidad Católica de Chile

Santiago, Chile

2
LEONARDO CHANQUEO

Jefe Unidad Infectología & Microbiología

Medicina Interna

Hospital San Juan de Dios

Santiago, Chile

2
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

2
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Franz Villarroel

Jefe Laboratorio - PI

Unidades de Diagnóstico

Fundación Arturo López Pérez

Santiago, Chile

2
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

2
Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
María Elena Ceballos

Profesor Asistente

Enfermedades Infecciosas del Adulto

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Alberto Fica

Médico Infectólogo

Medicina

Hospital Base de Valdivia

Valdivia, Chile

1
Alvaro Huete

Jefe Departamento

Radiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

1
Claudia Nicklas

Dermatóloga

Hospital Regional Hernán Henríquez Aravena . Servicio de Salud Araucanía Su

Temuco, Chile

1
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gonzalo Barriga

Profesor Asistente

Instituto de Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

1
Luis González

postdoctorante

Universidad de Chile

santiago, Chile

1
Francesca Zegna Ratá

Docente

Salud

Universidad de Los Lagos

Osorno, Chile

1
Sara Concha

Residente

Departamento de Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica

Santiago, Chile

1
Eugenio Ramírez

INSTITUTO DE SALUD PÚBLICA DE CHILE

Santiago, Chile

1
Aniela Wozniak

Coordinador de Investigación

Dept Laboratorios Clínicos

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Peña

Médico

Medicina

Hospital San Borja Arriarán

SANTIAGO, Chile

1
Marcela Cifuentes

JEFE

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Claudia Cortes

Profesor Asociado

Medicina

Universidad de Chile

Santiago, Chile

1
Rodrigo Hoyos

Profesor Asistente

Enfermedades Infecciosas e Inmunología Pediátrica

Escuela de Medicina, Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

1
Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Thomas Weitzel

Head Travel Medicine Program

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Sergio González

FACULTAD DE MEDICINA. PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carolina Selman

Subdirectora

Unidades de Diagnóstico

Fundación Arturo Lopez Perez

Santiago, Chile

1
KATIA ABARCA

Profesor Titular

Pediatría

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Dante Travisany

Scientist

CMM

Universidad de Chile

Santiago, Chile

1
Roxana Gonzalez

Investigador Senior

Fundación Arturo López Pérez

Santiago, Chile

1
Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile