Man

Ricardo Andrés Soto Rifo

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Virology; RNA Biology; Epitranscriptomics; Molecular Biology; Cellular Biology

Educación

  •  Molecular and Cellular Biology, ECOLE NORMALE SUPERIEURE DE LYON. Francia, 2010
  •  Molecular and Cellular Biology, UNIVERSITE CLAUDE BERNARD LYON-1. Chile, 2006
  •  BIOCHEMIST, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2004

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO, Chile

    2013 - 2017

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO, Chile

    2017 - A la fecha

Experiencia Profesional

  •   POST-DOC Full Time

    INSERM

    Lyon, Francia

    2010 - 2012

Formación de Capital Humano


Postdoctorantes

Dr. Daniela Toro Ascuy, Fondecyt post-doctoral grant Nº 3160091 “A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes” (2015-2018)

GRADUATE STUDENTS

1) Mr. Felipe León, Master Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile (2018-present)
2) Ms. Camila Pereira Montecinos, Graduate Program in Biomedical Sciences, Faculty of Medicine, University of Chile (2017-present)
3) Ms. Paulina Aguilera, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
4) Mr. Sebastian Riquelme, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
5) Mr. Bárbara Rojas, Graduate Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile ( 2017-present)
6) Mr. Francisco Garcia, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2014-2019)
7) Ms. Paulina Rubilar Guzmán, Master Research in Molecular and Cellular Biology, Université Claude Bernard Lyon-1, France (2010-2011)

UNDERGRADUATE STUDENTS

1) Mr. Eduardo Isla, Biochemistry, Universidad de Santiago de Chile (2018-present)
2) Mr. Alvaro Thadani Biotechnology Enginner, Universidad de Chile (2016-2018)
3) Ms. Alejandra Leyva, Biotechnology Enginner, Universidad de Chile (2016-2018)
4) Ms. Barbara Rojas, Biotechnology, Universidad Santo Tomás (2014-2016)
5) Mr Alvaro Frohlich, Biochemistry, Pontificia Universidad Católica de Valparaiso (2014-2015)


Premios y Distinciones

  •   Científico Jóven del año

    Sociedad de Biología Celular de Chile

    Chile, 2018

    Este premio lo otorga la Sociedad de Biología Celular de Chile junto a GrupoBios para reconocer al científico jóven del año (menor de 40 años). El año 2018 fue elegido entre más de 20 postulantes.


 

Article (34)

Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis
A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA
Differences in the internalization of self-inactivating VSVG-pseudotyped murine leukemia virus-based vectors in human and murine cells
Emerging Roles of N-6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication
Epitranscriptomic regulation of viral replication
Infectious pancreatic necrosis virus enters CHSE-214 cells via macropinocytosis
microRNAs stimulate translation initiation mediated by HCV-like IRESes
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
Translational control of the HIV unspliced genomic mRNA
HIV-2 genomic RNA accumulates in stress granules in the absence of active translation
miRNA repression of translation in vitro takes place during 43S ribosomal scanning
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
The roles of DDX3 in mRNA metabolism
Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs
Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation.
Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties
The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression
The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
Functional diversity of viral IRESes
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Lentiviral RNAs can use different mechanisms for translation initiation
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells.

Review (3)

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
Translational Control of the HIV Unspliced Genomic RNA
The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism
27
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

7
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

6
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Aracelly Gaete

Tesista Doctoral

Universidad de Chile

Santiago, Chile

1
Sebastián Riquelme

Estudiante doctorado

Virología

Universidad de Chile

Santiago, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Glauben Landskron

Postdoctoral Researcher Fondecyt 3190931

Academic Direction

Clinica Las Condes

Santiago, Chile

1
Andrea Calixto

Full professor

Neuroscience

Universidad de Valparaíso

Valparaiso, Chile

1
Daniela Toro

Profesor Asistente

facultad de ciencias de la salud

Universidad Autonoma de Chile

Santiago, Chile

1
Francisco Aguayo

Profesor Asociado

Departamento de Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

1
Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada