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Ricardo Andrés Soto Rifo

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Virology; HIV; RNA Biology; Epitranscriptomics; Molecular Biology; Inflammation

Educación

  •  Molecular and Cellular Biology, ECOLE NORMALE SUPERIEURE DE LYON. Francia, 2010
  •  Molecular and Cellular Biology, UNIVERSITE CLAUDE BERNARD LYON-1. Chile, 2006
  •  BIOCHEMIST, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2004

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO, Chile

    2013 - 2017

  •   ASSOCIATE PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO, Chile

    2017 - A la fecha

Experiencia Profesional

  •   POST-DOC Full Time

    INSERM

    Lyon, Francia

    2010 - 2012

Formación de Capital Humano


Postdoctorantes

Dr. Daniela Toro Ascuy, Fondecyt post-doctoral grant Nº 3160091 “A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes” (2015-2018)

GRADUATE STUDENTS

1) Mr. Felipe León, Master Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile (2018-present)
2) Ms. Camila Pereira Montecinos, Graduate Program in Biomedical Sciences, Faculty of Medicine, University of Chile (2017-present)
3) Ms. Paulina Aguilera, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
4) Mr. Sebastian Riquelme, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
5) Mr. Bárbara Rojas, Graduate Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile ( 2017-present)
6) Mr. Francisco Garcia, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2014-2019)
7) Ms. Paulina Rubilar Guzmán, Master Research in Molecular and Cellular Biology, Université Claude Bernard Lyon-1, France (2010-2011)

UNDERGRADUATE STUDENTS

1) Mr. Eduardo Isla, Biochemistry, Universidad de Santiago de Chile (2018-present)
2) Mr. Alvaro Thadani Biotechnology Enginner, Universidad de Chile (2016-2018)
3) Ms. Alejandra Leyva, Biotechnology Enginner, Universidad de Chile (2016-2018)
4) Ms. Barbara Rojas, Biotechnology, Universidad Santo Tomás (2014-2016)
5) Mr Alvaro Frohlich, Biochemistry, Pontificia Universidad Católica de Valparaiso (2014-2015)


Premios y Distinciones

  •   Científico Jóven del año

    Sociedad de Biología Celular de Chile

    Chile, 2018

    Este premio lo otorga la Sociedad de Biología Celular de Chile junto a GrupoBios para reconocer al científico jóven del año (menor de 40 años). El año 2018 fue elegido entre más de 20 postulantes.


 

Article (55)

Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group
Neutralizing antibody titers elicited by CoronaVac and BNT162b2 vaccines in health care workers with and without prior SARS-CoV-2 infection
Screening of Natural Products Inhibitors of SARS-CoV-2 Entry
Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence
Accuracy of a RT-qPCR SARS-CoV-2 detection assay without prior RNA extraction
CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev
Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
Escherichia coli HS and Enterotoxigenic Escherichia coli Hinder Stress Granule Assembly
Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile
N-6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication
Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals
RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling
Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile
Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population
Surveillance of seasonal respiratory viruses among Chilean patients during the COVID-19 pandemic
Tellurite Promotes Stress Granules and Nuclear SG-Like Assembly in Response to Oxidative Stress and DNA Damage
The Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency
Bacterial Synthesis of Ternary CdSAg Quantum Dots through Cation Exchange: Tuning the Composition and Properties of Biological Nanoparticles for Bioimaging and Photovoltaic Applications
Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
Meteorological impact on the COVID-19 pandemic: A study across eight severely affected regions in South America
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis
Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis
Strategies for Success. Viral Infections and Membraneless Organelles
A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA
Differences in the internalization of self-inactivating VSVG-pseudotyped murine leukemia virus-based vectors in human and murine cells
Emerging Roles of N-6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication
Epitranscriptomic regulation of viral replication
Infectious pancreatic necrosis virus enters CHSE-214 cells via macropinocytosis
microRNAs stimulate translation initiation mediated by HCV-like IRESes
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells
Translational control of the HIV unspliced genomic mRNA
HIV-2 genomic RNA accumulates in stress granules in the absence of active translation
miRNA repression of translation in vitro takes place during 43S ribosomal scanning
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
The roles of DDX3 in mRNA metabolism
Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs
Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation
Functional mechanisms of the cellular prion protein (PrPC) associated anti-HIV-1 properties
The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression
The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Structural and functional diversity of viral IRESes
Lentiviral RNAs can use different mechanisms for translation initiation
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility

Proyecto (18)

Millennium Institute in Immunology and Immunotherapy
Understanding liquid-liquid phase separation during the retroviral life cycle”
Impact of the N6 methylation of adenosine on the switch between translation and encapsidation of HIV-1 genomic RNA
m6A switches as drivers of retroviral genomic RNA selection for packaging
RNAstasis during HIV-1 replication
Desarrollo de un sistema de screening de alto rendimiento (HTS) para la identificación de inhibidores específicos de la expresión génica de VIH-1
HIV gene expression in the RNA epigenetics era
Molecular pathogenesis of emerging viruses
Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism
A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes
Infectious Pancreatic Necrosis Virus=> Characterization of the receptors and virus entry pathways
The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex
From the nucleus to the ribosome=> deciphering the role of DDX3 in linking nuclear export and translation of the HIV-1 genomic RNA
“Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control”
“Etude de la régulation de l’expression de l’ARNm génomique du virus de l’immunodéficience humaine de type I”
Investigating and Targeting the mechanism of HIV-1 protein synthesis
IRES function
ESTUDIO DEL MECANISMO DE TRADUCCION DE LAS PROTEINAS DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA

Review (4)

New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
Translational Control of the HIV Unspliced Genomic RNA
The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism
60
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

27
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

6
Daniela Toro

Profesor Asistente

facultad de ciencias de la salud

Universidad Autonoma de Chile

Santiago, Chile

6
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

4
Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Francisco Aguayo

Profesor Asociado

Programa de Virología, Instituto de Ciencias Biomédicas (ICBM)

Universidad de Chile

Santiago, Chile

3
Franz Villarroel

Jefe Laboratorio - PI

Departamento de Investigación del Cáncer

Fundación Arturo López Pérez

Santiago, Chile

3
Gonzalo Barriga

Profesor Asistente

Instituto de Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

2
Roxana Gonzalez

Investigador Senior

Fundación Arturo López Pérez

Santiago, Chile

2
Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Aracelly Gaete

Tesista Doctoral

Universidad de Chile

Santiago, Chile

2
Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Carolina Selman

Subdirectora

Unidades de Diagnóstico

Fundación Arturo Lopez Perez

Santiago, Chile

2
María Balcells

Associate Professor

Department of Infectious Diseases of the Adult

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Jose Garrido

Investigador asesor, part time

Universidad San Sebastián

Puerto Montt, Chile

1
MARIO CALVO

Director de Instituto

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
SEBASTIAN REYES

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor de Chile

Santiago, Chile

1
Mauricio Farfán

Profesor Asociado

Departamento de Pediatria y Cirugia Infantil, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile

Universidad de Chile

Providencia, Chile

1
Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

1
Felipe Reyes

Associate profesor - Head of UAB Fish transcriptomics platform

Universitat Autònoma de Barcelona

Barcelona, España

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Juan Hormazabal

Investigador Postdoctoral

Facultad De Medicina

Universidad del Desarrollo

Santiago, Chile

1
Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

1
María Elena Ceballos

Profesor Asistente

Enfermedades Infecciosas del Adulto

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Iván Flores

Post Doc

Progama de Inmunología

Universidad de Chile

Santiago, Chile

1
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Dante Travisany

Profesor Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

1
Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

1
Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

1
Jorge Soto

Asistente de Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

1
Paula Muñoz

Clinical Research Center Director

Universidad del Desarrollo

Santiago, Chile

1
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Eugenio Ramírez

INSTITUTO DE SALUD PÚBLICA DE CHILE

Santiago, Chile

1
Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carolina Beltrán

Postdoc

Virología

Universidad de Chile

Santiago, Chile

1
María Domínguez

Profesora asistente adjunta

Departamento de Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Diego Carrillo

Asistente de investigación

Virologia

Universidad de Chile

Santiago, Chile

1
Glauben Landskron

Academic Researcher

Escuela de Medicina

Universidad Finis Terrae

Santiago, Chile

1
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

1
Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Farides Saavedra

Investigadora

Fundación Ciencia y Vida

Ñuñoa, Chile

1
Alessandra Dellarossa

Asistente de Investigación

Laboratorio de Biología

Centro de Estudios Científicos

Valdivia, Chile

1
Sebastián Riquelme

Estudiante doctorado

Virología

Universidad de Chile

Santiago, Chile

1
Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Roxana Pincheira

Associate Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Andrea Calixto

Full professor

Neuroscience

Universidad de Valparaíso

Valparaiso, Chile

1
Lorena Tapia

Profesora Asociada

Departamento de Pediatría y Cirugía Infantil Norte

Universidad de Chile

Santiago, Chile

1
Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Hugo Marsiglia

Director Relaciones Médicas Internacionales

Fundación Arturo López Pérez

Santiago, Chile

1
carolina iturriaga

Sub Directora Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

1
Marcelo Navarrete

Profesor Titular

Medicina

Universidad de Magallanes

Punta Arenas, Chile

1
FELIPE MELO

Investigador postdoctoral

Genetica Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile