Man

Mauricio Javier Farfán Urzúa

Profesor Asociado

Universidad de Chile

Providencia, Chile

Líneas de Investigación


Interacción Bacteria-Hospedero; Diagnóstico Molecular; Farmacognética; Microbiota intestinal

Educación

  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

  •   Posdoctoral fellow Full Time

    UNIVERSITY OF MARYLAND

    School of Medicine

    Baltimore, Estados Unidos

    2006 - 2008

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago , Chile

    2008 - A la fecha

  •   Bioquimico Asesor Laboratorio de Biología Molecular Other

    CLINICA LAS CONDES

    Santiago, Chile

    2014 - 2019

Experiencia Profesional

  •   Postdoctoral fellow Full Time

    University of Maryland

    Baltimore, Chile

    2006 - 2008

  •   Profesor Asistente Full Time

    Universidad de Chile

    Santiago, Chile

    2008 - 2014

  •   Profesor Asociado Full Time

    Universidad de Chile

    Santiago, Chile

    2014 - A la fecha

  •   Jefatura Laboratorio de Biología Molecular Other

    Hospital Dr. Luis Calvo Mackenna

    Santiago, Chile

    2008 - A la fecha

  •   Bioqumico Asesor Laboratorio de Biología Molecular Other

    Clinica Las Condes

    Santiago, Chile

    2014 - 2018

Formación de Capital Humano


1.- Director de Tesis alumna Dominique Yañez Osorio, Licenciatura en Bioquimica, 2014
2.- Director de Tesis alumna Mariana Izquierdo Tramón, Licenciatura en Bioquimica, 2013
3.- Director de Tesis alumna Alejandra Vergara Arcos, Magister en Microbiología, 2013
4.- Director de Tesis alumna Lidia Cantero Almeyda, Magister en Microbiología, 2011
5.-Director de Tesis alumna Cristina Cananles Lopez, Licenciatura en Química y Farmacia, 2012
6.- Director de Tesis alumna Carolina Salas Palma, Magister en Bioquímica, 2010
7.- Director de Tesis alumna Alejandra Alvestegui Seelenfreund, Magister en Bioquimica, 2015
8.- Director de Tesis alumno Joan Galdamez, Licenciatura en Química y Farmacia, 2014
9.- Director de Tesis alumna Natalie Espinoza Giacomozzi, Magister en Bioquímica, 2016
10.- Director de Tesis alumno Pablo Gallardo, Licenciatura en Bioquimica, 2017
11-. Director de Tesis alumna Mariana Izquierdo Tramón, Doctorado en Ciencias Biomédicas, 2019
12-. Director de Tesis alumno Joaquin Lopez, Magister en Bioquímica, 2018
13-. Director de Tesis alumna Dominique Yañez Osorio, Magister en Bioquímica, en curso
14.- Director de Tesis alumno Claudio Girón, Magister en Bioquímica, en curso



 

Article (54)

CYP3A5 and UGT1A9 Polymorphisms Influence Immunosuppressive Therapy in Pediatric Kidney Transplant Recipients
Molecular detection of gastrointestinal pathogens among children under 5 years old with diarrhea in a hospital center for rotavirus sentinel surveillance in Chile
Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals
Gut Microbiota-Metabolome Changes in Children With Diarrhea by DiarrheagenicE. coli
Respiratory viral infections during episodes of fever in children undergoing hematopoietic stem cell transplantation
Capacity to adhere to and invade human epithelial cells, as related to the presence of virulence genes in, motility of, and biofilm formation of Campylobacter jejuni strains isolated from chicken and cattle
TLR4 Participates in the Inflammatory Response Induced by the AAF/II Fimbriae From Enteroaggregative Escherichia coli on Intestinal Epithelial Cells
Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia=> a randomized clinical trial.
Intestinal Inflammation in Chilean Infants Fed With Bovine Formula vs. Breast Milk and Its Association With Their Gut Microbiota
Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010
Distinctive Gut Microbiota Is Associated with Diarrheagenic Escherichia coli Infections in Chilean Children
Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial
Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants
Helicobacter pylori cagA plus Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients
Detection of Helicobacter pylori by Real-Time PCR for 16s rRNA in Stools of NonInfected Healthy Children, Using ELISA Antigen Stool Test as the Gold Standard
Detection of Helicobacter pylori by Real-Time PCR for 16s rRNA in Stools of NonInfected Healthy Children, Using ELISA Antigen Stool Test as the Gold Standard.
Filmarray GI (TM) panel for detection of enteric pathogens in stool samples: preliminary experience
Filmarray GI TM panel for detection of enteric pathogens in stool samples: preliminary experience
NPHS2 Mutation analysis study in children with steroid-resistant nephrotic syndrome
Respiratory viral infections and coinfections in children with cancer, fever and neutropenia: Clinical outcome of infections caused by different respiratory viruses
Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia: Clinical Outcome of Infections Caused by Different Respiratory Viruses.
The human gut microbiome of Latin America populations: a landscape to be discovered.
The Role of Fibronectin in the Adherence and Inflammatory Response Induced by Enteroaggregative Escherichia coli on Epithelial Cells
Enterovirus D68 infection, Chile, Spring 2014
Etiologic diagnosis in meningitis and encephalitis molecular biology techniques
Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157=>H7.
Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohernorrhagic E. coli O157:H7
TleA, a Tsh-like autotransporter identified in a human enterotoxigenic Escherichia coli strain
Identification of Cell Surface-exposed Proteins involved in the Fimbria-mediated adherence of Enteroagregative Escherichia coli to Intestinal Cells
Long Polar Fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157:H7.
Participation of integrin α5β1 in the fibronectin-mediated adherence of enteroaggregative Escherichia coli to intestinal cells.
Participation of Integrin alpha 5 beta 1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia
Prospective validation of a risk prediction model for severe sepsis in children with cancer and high-risk febrile neutropenia
The long polar fimbriae os STEC O157: H7 induce expression of pro-inflammatory markers by intestinal epithelial cells.
Encefalitis herpetica neonatal: Valor de la clínica versus la Biología Molecular
Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia
Frequency and clinical outcome of respiratory viral infections and mixed viral-bacterial infections in children with cancer, fever and neutropenia
Neonatal herpes simplex encephalitis: clinical profile versus molecular biology
Comparación de las técnicas de reacción de la polimerasa en cadena en tiempo real y antigenemia para la detección de citomegalovirus en sangre en niños sometidos a trasplantes
Diagnosis of Bacteremia in Febrile Neutropenic Episodes in children with cancer: Microbiologic and Molecular Approach
Molecular mechanisms mediating colonization of Shiga toxin producing Escherichia coli strains
Shigella enterotoxin - 2 is a type III effector that participates in Shigella induced interleukin 8 secretion by epithelial cells
The Long Polar Fimbriae of Enterohemorrhagic Escherichia Coli 0157:H7 binds to Extracellular Matrix proteins
A new multiplex PCR to identify Shigella differentiates S. flexneri from S. sonnei, and detects Shigella virulence determinants
Characterization of the most prevalent colonization factor antigens present in Chilean clinical enterotoxigenic Escherichia coli strains using a new multiplex polymerase chain reaction
Multiplex PCRs for identification and characterizatrion of enterotoxigenic Escherichia coli: detecting colonization factor antigen genes
The major pilin subunit of the AAF/II fimbriae from enteroaggreegative E. coli mediates binding to extracellular matrix proteins
Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli.
Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children
Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children
Preliminary evaluation of DNA damage related with the smoking habit measured by the comet assay in whole blood cells
Molecular characterization of resistance mechanisms to chloramphenicol in Shigella flexneri strains isolated from Chilean children with acute diarrhea
Molecular characterization of resistance mechanisms to chloramphenicol in Shigella flexneri strains isolated from Chilean children with acute diarrhea

BookWhole (1)

Hybrid and potentially pathogenic Escherichia coli strains

CaseReport (1)

Encefalitis herpética neonatal: valor de la clínica versusla biología molecular

Editorial (1)

Diagnostics in medicine in the omics era

Proyecto (16)

DEVELOPMENT OF NEW DIAGNOSTIC OPTIONS FOR ENTEROAGGREGATIVE ESCHERICHIA COLI AS AN IMPORTANT DIARRHEAL PATHOGEN
PLATAFORMA INFORMÁTICA BASADA EN MACHINE LEARNING PARA OPTIMIZAR EL MANEJO DE LOS EPISODIOS DE FIEBRE Y NEUTROPENIA EN NIÑOS CON CÁNCER
VIRAL FACTORS, HOST IMMUNE RESPONSE AND NASOPHARYNGEAL MICROBIOTA AS DETERMINANTS OF THE SEVERITY OF RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH HEMATOPOIETIC STEM CELL TRANSPLANT
BACTERIAL MICROBIOTA STRAINS ASSOCIATED WITH DIARRHEOGENIC E. COLI INFECTION PROMOTES FIMBRIAL-MEDIATED ADHERENCE AND INFLAMMATION INDUCTION OF ENTEROAGGREGATIVE AND SHIGA TOXIN-PRODUCING E. COLI TO INTESTINAL CELLS
CHARACTERIZATION OF NEW GENETIC MARKERS ENCODED WITHIN AN UNDESCRIBED LOCUS OF ADHERENCE AND AUTOAGGREGATION (LAA) PRESENT IN EMERGING CLINICALLY RELEVANT SHIGA TOXIN-PRODUCING E.COLI STRAINS.
GENETIC AND SYSTEMIC BIOMARKERS ASSOCIATED WITH SEVERITY OF INVASIVE FUNGAL DISEASE IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A NEW INSIGHT
IMPLEMENTACIÓN DE UNA PLATAFORMA DE ANÁLISIS DE BIOMARCADORES PARA LA INVESTIGACIÓN EN PEDIATRÍA
CLINICAL SEVERITY AND SPECIFIC GENE EXPRESSION PROFILE IN RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A STEP FORWARD
ASSOCIATION OF FIBRONECTIN WITH THE SECRETION OF PRO-INFLAMMATORY CYTOKIN ES BYINTESTINAL CELLS INFECTED WITH DIARRHEAGENIC E.COLI
ROL DE POLIMORFISMOS DE LA ENZIMA CYP3A5 EN EL METABOLISMO DE TACROLIMUS EN NIÑOS SOMETIDOS A TRASPLANTE RENAL
TOWARDS A MORE RATIONAL APPROACH IN THE COMPREHENSIVE MANAGEMENT OF THE CHILD WITH CANCER, FEVER AND NEUTROPENIA=> FILLING THE GAPS.
IDENTIFICACION OF IMMUNODOMINANT ANTIGENS IN SHIGATOXIN PRODUCING ESCHERICHIA COLI THAT PARTICIPATE IN ADHESION TO HUMAN INTESTINAL CELLS=> SEROLOGICAL CHARACTERIZATION AND POSSIBLE USE AS IMMUNOGENS FOR PROTECTIVE VACCINE DEVELOPMENT
PERFILES TRANSCRIPCIONALES Y DIAGNOSTICO MICROBIOLOGICO MOLECULAR PARA AVANZAR EN EL DIAGNOSTICO DE SEPSIS Y EN LA IDENTIFICACION DEL MICROORGANISMO CAUSAL EN NIQOS CON CANCER, NEUTROPENIA Y FIEBRE
PREVALENCIA DE POLIMORFISMOS EN LA ENZIMA TPMT EN PACIENTES PEDIATRICOS CON LEUCEMIA LINFOBLASTICA AGUDA EN EL HOSPITAL DR. LUIS CALVO MACKENNA
FIBRONECTIN PARTICIPATION IN THE ADHESION OF DIARRHOEAGENIC E. COLI TO INTESTINAL CELLS
VIRULENCE IN ENTEROAGGREGATIVE ESCHERICHIA COLI

Review (1)

Molecular Mechanisms That Mediate Colonization of Shiga Toxin-Producing Escherichia coli Strains
26
Mauricio Farfán

Profesor Asociado

Departamento de Pediatria y Cirugia Infantil, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile

Universidad de Chile

Providencia, Chile

3
Verónica De la maza

Profesor academico

Pediatra y Cirugía

Universidad de Chile

Santiago, Chile

3
roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Yalda Lucero

Profesor Asistente

Programa de Microbiología y Micología; Departamento de Pediatría y Cirugía infantil;

DIVISIÓN NORTE, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE, DEPARTAMENTO DE PEDIATRÍA Y CIRUGÍA INFANTIL-HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

2
Niurka Navarro

Gerente

Innovación y Desarrollo

Nutri-Omics SpA

Samtiago, Chile

2
Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

2
Miguel O'Ryan

Profesor Titular

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Juan Pablo Torres

Jefe Unidad de Investigación Clínica

Pediatría y Cirugía Infantil Oriente

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Juan Ossa

Profesor asistente

Pediatria y Cirugia Oriente

Universidad De Chile, Hospital Luis Calvo Mackenna

Santiago, Chile

2
Mariana Izquierdo

Profesor Asistente

Departamento de Pediatría y Cirugía Infantil Oriente

Universidad de Chile

Santiago, Chile

1
David Montero

Investigador Postdoctoral

Programa Disciplinario de Inmunología. Facultad de Medicina.

Universidad de Chile

Santiago, Chile

1
Leonardo Sáenz

Profesor Asociado

Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

1
Sergio George

Tesista Doctorado en Ciencias Médicas y Especialidad en Pediatría

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Alberto Toso

Médico asistencial

Neonatología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Del Canto

Profesor Asistente

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Romina Valenzuela

Enfermera

Cirugia y pediatria Oriente

universidad de chile

santiago, Chile

1
Guido Mora

Académico/Investigador

Facultad Ciencias de la Salud

Universidad SEK

Santiago, Chile

1
Maria Santolaya

Pediatra infectologa, Profesor titular

Pediatria, Campus Oriente

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, DEPARTAMENTO DE PEDIATRÍA ORIENTE

Santiago, Chile

1
Lorena Tapia

Profesora Asociada

Departamento de Pediatría y Cirugía Infantil Norte

Universidad de Chile

Santiago, Chile

1
Luis Castañeda

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Jorge Morales

Jefe de Farmacia y Farmacia clinica

Farmacia

Hospital Dr. Luis Calvo Mackenna

Santiago, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Milena Villarroel

JEFE CENTRO DE RESPONSABILIDAD

PEDIATRIA

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

1
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile